Hsin-Hua Chou

• Doctor of Dental Surgery
• Taipei Medical University

The ability of Pluronic F127 (PF127) conjugated with tetrapeptide Gly-Arg-Gly-Asp (GRGD) as a sequence of Arg-Gly-Asp (RGD) peptide to form the investigated potential hydrogel (hereafter referred to as 3DG bioformer (3BE)) to produce spheroid, biocompatibility, and cell invasion ability, was assessed in this study. The fibroblast cell line (NIH 3T3...

In the original publication, there was a mistake in Figure 2a as published [...]

This study examined the uniformity of illuminance field distributions of light guide plates (LGPs). First, the authors designed microstructural patterns on the surface of an LGP. Then, a mold of the LGP with the optimal microstructural design was fabricated by a photolithography method. Micro-injection molding (μIM) was used to manufacture the mold...

The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral and dicalcium phosphate anhydrous using a solid-state reaction followed by heat treatment at a temperature of 1100 °C for 1 h to 7 days. The as-prepared coral an...

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density...

This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hem...

This study aimed to elucidate the local effect and micro-computed tomographic (μ-CT) assessment following bone implantation of an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on femur lateral condyle cortical bone of rabbit models. The innovative α-CSH bioceramic was synthesized through a green processing technology (microwave irrad...

Featured Application The potential application of the work is in the area of acupuncture therapy. The study focuses on the nanostructured surfaces to stimulate connective tissue interaction at the neurological sites for pain therapy. Abstract The objective of this study was to evaluate the biomaterial properties of nano-modified surface acupunctur...

The surface characteristics, microstructures, and biocompatibility of the metal titanium oxide (TiO) film cross-linked with different self-assembled monolayers (SAMs) of phosphonate were elucidated through scanning electron microscopy, atomic force microscopy, X-ray diffractometry, transmission electron microscopy, and in vitro cell culturing assay...

In this study, we developed a three-dimensional (3D) human body model and a body sculpting clothing (BSC) which was fitted onto that body to simulate the biomechanical stress variations of the BSC with different porosity structures using the finite element method. The mechanical properties of the BSC with different porosity structures were also exa...

The study elucidated the wound healing and hair regeneration properties of a conditioned medium prepared from the culture of human hair follicle mesenchymal stem cells (HFMSCs). The wound-healing effects of mesenchymal stem cell-conditioned medium (MSC-CM) were tested in vitro using scratch assays co-cultured with HaCaT keratinocyte and monitored t...

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This study was to elucidate the surface characteristics and in vitro cell behaviors of biomedical titanium (Ti) with the biofunctional surface (nanostructured rutile-Ti dioxide (NanoR-TiO2) layer combined with amino-groups (NH2) and albumin). Biofunctional surface features were analyzed via scanning electron microscopy, atomic force microscopy, and...

In the present study, low-temperature plasma combined with allylamine polymerization approach was used to coat amino-groups on oxide layer of plasma-oxidized biomedical titanium (Ti) for protein immobilization. Scanning electron microscopy, X-ray diffractometer, transmission electron microscopy, X-ray photoemission spectroscopy, secondary ion mass...

The microstructure and surface properties of the optimal nanostructured-gold (ONG) film were characterized using scanning electron microscopy, transmission electron microscopy, X-ray diffraction, nanoindentation and static contact angle evaluation in the present study. A three-dimensional model of human liver was reconstructed using magnetic resona...

The aim of the present study was to investigate the biomechanical behaviors of the pre-shaped titanium (PS-Ti) cranial mesh implants with different pore structures and thicknesses as well as the surface characteristics of the three-dimensional printed Ti (3DP-Ti) cranial mesh implant. The biomechanical behaviors of the PS-Ti cranial mesh implants w...

Oxygen plasma with different treatment powers and durations was utilized to modify the biomedical pure titanium (Ti) surface in the present study. The superficial, microstructural and biological properties of the plasma-oxidized samples were investigated using the electron microscopy, X-ray photoemission spectroscopy, grazing incidence X-ray diffra...

Micro-arc oxidation (MAO) is one of the most potential methods to generate the hybrid micro/nanostructural surfaces on the Ti dental implant because of its simplicity, high efficiency and low cost. The MAO surface-treated Ti (MST-Ti) implants have also been shown to have good biocompatibility by in vitro and in vivo evaluation of the interfacial be...

Objective: Long exposure of argon plasma coagulation (APC) causes thermal damage and apoptosis in tissues. However, whether the APC-induced thermal damage in tissues involves the expression of NF-κB and caspase-3 remains undetermined. In this study, we compared the effect of APC on liver damage at two different exposure time and tested the hypothes...

In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogene...

OBJECTIVES: The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. MATERIALS AND METHODS: The surface characteristic, biomechanical behavior and hemocompatibil...

In this study, the microstructural, mechanical and biological characterizations of the Ti-25Ta (wt.%) alloy were investigated by means of optical microscope, X-ray diffraction, electron microscope, microhardness test, contact angle goniometer and in vitro cytotoxicity assay. As the alloy underwent heat-treatment at temperatures between 700 °C and 1...

Objectives: The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. Materials and methods: The surface characteristic, biomechanical behavior and hemocompati...

Chronic rhinosinusitis (CRS) has raised attentions both in many countries due to its high relapsing rate and the resistance of certain treatments especially antibiotics application on both acute and chronic bacterial rhinosinusitis. The aim of this research is stressing on developing an effective alternative treatment for treating CRS and reducing...

The objective of this study was to investigate the stress distributions of a surface-treated dental implant and bone tissue under physiological loading. For ensuring success of dental implant treatment, one must examine the magnitude and location of the maximum stresses. Stress analysis models were constructed from computer tomography data. Althoug...

Biodegradable calcium phosphate composites consisting of tricalcium phosphate (α-TCP) and hydroxyapatite (HA) were prepared using a two-step sintering method. The ratio of α-TCP/HA was controlled by modulating the sintering temperature. The initial calcination process at 800 °C causes HA dehydroxylation and induces the early transformation of HA in...

Anodic oxidation followed by hydrothermal treatment has been widely applied for surface modification of titanium alloys to precipitate a crystalline hydroxyapatite (HA) layer in order to achieve improved osteoconduction. A majority of the studies in the literature imposed relatively high powers to enhance Ca and P in the anodic oxide film (AOF). Ho...

A porous structural oxide film was formed on titanium-niobium alloys (TiNb) by anodic oxidation after cathodic pretreatment. The effects of titanium hydride compounds on the formation of an oxide film and the structural properties of a TiNb matrix were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electro...

In the present study, plasma nitriding of AISI type 303 austenitic stainless steel (SS) specimens was performed using a microwave system. The nitrided layers were characterized by performing scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and a Vickers microhardness test. The antibacterial activi...

The as-quenched (AQ) microstructure of the Ag-containing alloys was found to be essentially a mixture of austenite (γ) and Ag phases. The Ag phase precipitates had a face-centered-cubic structure and lattice parameter a = 4.09 Å. When the alloy contained Ag ≥0.2 wt%, the mechanical properties were slightly enhanced because of the precipitate streng...

Toll-like receptors (TLRs) are differentially up-regulated in response to microbial infection and chronic inflammatory diseases such as atherosclerosis. Epidemiological data support the idea that periodontal disease may be a risk factor for acceleration of atherosclerosis. Porphyromonas gingivalis, the etiological agent of periodontal disease, inva...

Epidemiological and pathological studies have suggested that infection with the oral pathogen Porphyromonas gingivalis can potentiate atherosclerosis and human coronary heart disease. Furthermore, infection with invasive, but not noninvasive P. gingivalis has been demonstrated to accelerate atherosclerosis in apolipoprotein E-deficient (ApoE−/−) mi...

Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. To directly test the connection between periodontal disease and atherosclerosis, apoE-/- mice were oral...

Many studies have proved that tongue thrusting plays a significant role in the etiology of some orofacial deformities. To learn more about the relationship between tongue function and the form of orofacial structures, it is important to recognize patients with abnormal swallowing patterns. A cushion scanning technique in combination with M-mode ult...

Porphyromonas gingivalis is an oral pathogen that has recently been associated with chronic inflammatory diseases such as atherosclerosis. The strength of the epidemiological associations of P. gingivalis with atherosclerosis can be increased by the demonstration that P. gingivalis can initiate and sustain growth in human vascular cells. We previou...

Recent cross-sectional and prospective epidemiological studies have demonstrated an association between periodontal disease and atherosclerosis and human coronary heart disease. Previously, we have established that the periodontal pathogen Porphyromonas gingivalis is capable of invading aortic, heart, and human umbilical vein endothelial cells (HUV...