Hsin-Chung Cheng

• DDS, MS, PhD
• Dean at Taipei Medical University

This study examined orthodontic treatment strategies for patients in the mixed dentition phase, with a focus on the advantages and limitations of clear aligners and traditional fixed appliances in addressing complex tooth movements. Herein, three cases were reported to illustrate the complementary strengths of these treatment modalities. In Case 1,...

Background/Purpose Risk management in the health-care industry is a systematic approach for mitigating potential risks and enhancing patient safety. This study examined orthodontists’ perceptions of and attitudes toward risk management in Taiwan. The results provide clinical references informing policies for health-care institutions in Taiwan. Mat...

Background/purpose Traditionally, two-dimensional (2D) frontal and lateral facial views have provided an incomplete understand true three-dimensional (3D) relationships. This study aimed to investigate the 3D changes in orofacial soft tissues during smiling and to examine the influence of craniofacial and dental morphology on these changes. Materi...

Background/Purpose Realization of orthodontists’ practice profiles is crucial for orthodontic development, which has been performed in many countries. This study aimed to realize the practice profiles and affecting factors of orthodontists in Taiwan because there is no similar research in recent decades. Our findings may be important references for...

Background/purpose This study aimed to evaluate the initial implementation of competency-based medical education (CBME) through entrustable professional activities (EPAs) in Taiwan dental education, focusing on tooth extraction EPAs across undergraduate year (UGY), postgraduate year (PGY), and oral and maxillofacial surgery-residency (OS-R) levels....

Background/purpose In skeletal Class III patients, treatment options include camouflage and orthognathic surgery. This study used machine learning to investigate factors influencing dental, skeletal, and soft tissue morphological changes following skeletal Class III orthognathic surgery. Materials and methods A retrospective analysis was conducted...

Background/purpose: Patients' considerations when choosing an orthodontist are influenced by many factors, including background, ethnicity, and location. Accordingly, this study aimed to identify factors influencing patients' considerations when selecting an orthodontist in both Malaysia and Taiwan. Materials and methods: In total, 248 dental stude...

A distinctive method for extraction of the bilateral impacted mandibular second molars (MM2s) and moving the bilateral mesioangularly impacted mandibular third molars (MM3s) to the MM2 positions with appropriate occlusion by orthodontic uprighting and protraction was demonstrated in a 24-year-old woman and a 20-year-old woman, respectively. Althoug...

Polyetheretherketone (PEEK), an organic thermoplastic polymer, has gained interest in dentistry due to its excellent mechanical strength, flexibility, and biocompatibility. Furthermore, the ability to utilize CAD/CAM in the fabrication of PEEK enhances accuracy, reliability, and efficiency while also saving time. Hence, several orthodontic studies...

Anterior open bite (AOB), characterized by the lack of vertical overlap between upper and lower anterior teeth, poses a considerable challenge in orthodontics. The condition depends on many factors that combine to render it difficult to achieve post treatment stability. AOB is commonly classified as dental, skeletal, or functional on the basis of t...

Background/purpose Many patients pursue attractive smiles, and surgical-orthodontic treatment is a common method. We aimed to analyze the changes in smile parameters after surgical-orthodontic treatment in patients with skeletal Class III pattern and identify factors influencing postoperative outcomes. Materials and methods This retrospective stud...

This scoping review investigated the evidence on the three-dimensional analysis of a posed smile in adults to discover any research gaps in this research area. Electronic searches of articles written in English were performed using the four databases of Embase, PubMed, Springer, and Web of Science with publications from 2010 to 2023. Reference list...

Background/purpose Temporary anchorage devices (TADs) are widely used in contemporary orthodontic treatments for anchorage purposes. This research aimed to investigate orthodontists’ attitude toward temporary anchorage devices (TADs) by surveying their TAD usage frequency and pricing and to identify factors influencing TAD usage frequency and prici...

Background: -Spontaneous intracranial hemorrhage (ICH) has high fatality while has few proven treatments. We aim at investigating the association between dental scaling (DS) and the risk of ICH. Methods: -In this cohort study, two cohorts were matched by propensity score based on potential confounders. Data from ICH between January 2008 and Dece...

Background/purpose Polyetheretherketone (PEEK) is known for its strength, flexibility, biocompatibility, and potential as a replacement for metals in dental appliances; however, uncertainty remains about the mechanical characteristics and dimensions of PEEK-made orthodontic fixed lingual retainers (FLRs). This study aimed to determine the optimal s...

Background/purpose An understanding of self-protection related factors is important for dental infection control. This study aimed to investigate factors associated with personal self-protection in infection control among dental care workers. Materials and methods A cross-sectional survey with self-report questionnaire was conducted between Jan an...

Background /purpose: Several factors such as identity, income, and age potentially associated with smile perceptions. This study aimed to identify the factors affecting the smile esthetic perception in different identities (layperson, general dentist and orthodontist) and to detect the extent of their association with smile perception. Materials a...

Abdominal aortic aneurysm (AAA) is a common inflammatory vascular disease. Angiotensin II (Ang II) involves in AAA progression by promoting the proliferation and migration of vascular smooth muscle cells, the degradation of extracellular matrices, and the generation of ROS to lead to vascular inflammation. Carbon monoxide releasing molecule-2 (CORM...

Background/purpose This study assessed the perception and attitude of Mongolians on malocclusion and compared the perceptions with researchers’ perceptions on malocclusion, and this study aimed to determine factors influencing the self-perception of laypeople. Materials and methods In addition, we evaluated the correlation between the subjective a...

Background/purpose Treatment of incisors‘ agenesis is challenging that arouses orthodontists’ interests. The purpose of this study was to compare the craniofacial pattern of individuals with or without congenitally missing mandibular incisors. Materials and methods This retrospective study included patients receiving orthodontic consultation betwe...

Background/purpose The postgraduate year dentist training program (PGYD) officially implemented in 2010. This study aimed to assess PGYD trainees’ subjective satisfaction perception and objective competence performance according to different training institutions (either dental clinics or hospitals). Materials and methods A nationwide cross-sectio...

Background This study seeks to elucidate the impact of COVID-19 on knowledge, attitude, and infection control behaviors among dentists. Methods Changes in knowledge, attitude, and infection control behaviors reported in 2020 (COVID-19 period) were compared to the historical control of the non-COVID-19 period in 2018. A proportional random sampling...

Tongue cancer, a kind of oral cancer, is common in Southeast Asian countries because of dietary habits. However, there is no specific targeted drug that could effectively inhibit oral cancer. WSG, as a water soluble glucose-enriched polysaccharide from Ganoderma lucidum, exerts excellent pharmacological efficacy of anti-lung cancer. However, its an...

Incense burning is a very popular activity in daily life among many parts all over the world. A growing body of both epidemiological and experimental evidences has reported the negative effects of incense use on human well-being, posing a potential threat at public significance. This work is a comprehensive review that covers the latest findings re...

In current study, we have investigated the anti-oral cancer effects of developed functional beverage, which integrates fucoidan complex (FC) with natural/organic ingredients including vegetable juice (V), mulberry (M) and wheatgrass (W), designated as VMW-FC cocktail. FC has been recognized as functional food with nutraceutical characteristics, oth...

Background and objectives The mechanisms of particulate matter (PM) toxicity involve the generation of ROS and upregulation of proinflammatory molecules. Nrf2 is a multifunctional cytoprotective transcription factor that regulates the expression of various antioxidant, anti-inflammatory, and detoxifying molecules, such as HO-1. As surfactin has pot...

Objective To investigate whether overbite affects smile esthetics. Methods This study involved 106 patients with complete pretreatment records. Lateral cephalometric tracings were used to measure hard tissue variables. Frontal smile and upper occlusal photographs were used to measure nine smile esthetic variables: arc ratio, number of teeth, upper...

This study compared the accuracy of static computer-assisted implant surgery (sCAIS) planned through dental surface image registration and fiducial marker registration. Stone models of 30 patients were converted into digital dental casts by using a desktop scanner. Cone-beam computed tomography (CBCT) was performed and superimposed to the digital d...

Objective To evaluate the anti-inflammatory effects of surfactin and underlying mechanisms against particulate matter (PM)-induced inflammatory responses in human gingival fibroblasts (HGFs). Background PM, a major air pollutant, may associate with certain oral diseases possibly by inducing inflammation and oxidative stress. Surfactin, a potent bi...

Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is that they are able to deliver CO to the target site...

Particulate matter (PM), a major air pollutant, may be associated with adverse cardiovascular effects. Reactive oxygen species- (ROS-) dependent proinflammatory cytokine production, such as interleukin-6 (IL-6), is a possible underlying mechanism. Carbon monoxide- (CO-) releasing molecule-2 (CORM-2) which liberates exogenous CO can exert many benef...

Background Dental students have encountered changes in the teaching format amid the SARS CoV-2 pandemic. This study aims to evaluate the attitudes of dental students of one medical university toward online courses and compare them with those of non-dental students amid the SARS CoV-2 pandemic. Methods A cross-sectional survey with a self-report on...

Background Cerebral ischemic events, comprising of excitotoxicity, reactive oxygen production, and inflammation, adversely impact the metabolic-redox circuit in highly active neuronal metabolic profile which maintains energy-dependent brain activities. Therefore, we investigated neuro-regenerative potential of melatonin (Mel), a natural biomaterial...

Objectives To investigate the anticancer effects and underlying mechanisms of surfactin on human oral squamous cell carcinoma (OSCC). Materials and Methods The capacity of surfactin to induce apoptosis, autophagy, and cell cycle arrest of two different human OSCC cell lines was investigated by cell viability, acridine orange staining, and cell cyc...

Introduction This study aimed to analyze differences in esthetic smile preferences between Thai dentists and the general population and determine factors that affect smile perception. For the analysis, in addition to the frontal smile view, the three-quarter and lateral smile views were considered. Methods A computer-based questionnaire was used t...

WSG is a water soluble polysaccharides isolated from Ganoderma lucidum. In this study, we showed that WSG, a glucose-rich polysaccharide with an average molecular mass of approximately 1000 kDa, effectively inhibited cell viability and mobility of lung cancer cells. Functional studies revealed that WSG reduced phosphorylation of ERK1/2 in cells upo...

Traditional Chinese medicines Antler’s extract (A) and Ganoderma lucidum (G) and Antrodia Camphorata (A) have been known to individually contain a plethora of bioactive factors including triterpenoids, polysaccharides etc., exerting various curative impacts such as anti-inflammatory, anti-oxidative, anti-atherosclerotic and anti-viral activities. H...

Besides inhalation, a few studies have indicated that the uptake of nicotine through air or clothing may be a significant pathway of its exposure among passive smokers. Nicotine is well known to exert various physiological impacts, including stimulating sympathetic nervous system, causing vascular disturbances, and inducing cell death. Therefore, w...

Recent reports have indicated the role of highly expressed methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) enzyme in cancers, showing poor survival; however, detailed mechanistic insight of metabolic functions of MTHFD2 have not been well-defined. Therefore, we aimed to examine the metabolic functions and cellular reprograming potential of MTHFD...

Background/purpose The purposes of this study were to develop smile measurements for lateral and oblique view photographs to help in orthodontic analysis and treatment planning, to quantitatively evaluate the relationship between smile esthetics and different types of malocclusion using lateral and oblique view photographs, to identify the cephalom...

Background We aimed to investigate factors associated with personal self-protection in infection control among dental care workers. Methods A cross-sectional survey with self-report questionnaire was conducted between Jan and Dec, 2018. 275 dentists and 298 dental assistants were enrolled from randomly selected dental care settings. Results Complia...

Cancer pathogenesis results from genetic alteration-induced high or low transcriptional programs, which become highly dependent on regulators of gene expression. However, their role in progressive regulation of non-small-cell lung cancer (NSCLC) and how these dependencies may offer opportunities for novel therapeutic options remain to be understood...

Studies examining the effect of operator experience on the accuracy of static guided implant surgery have used postoperative computed tomography (CT) images to measure the error, with inconsistent results. The purpose of this study was to try to clarify this issue by using a measurement method based on the postoperative optical scan. Thirty dentist...

The accuracy of static guided implant surgery (sGIS) using conventional planning workflow has been extensively examined; however, more information is required to justify the application of fully digital planning protocol. The purpose of this study was to investigate the clinical accuracy of sGIS with a fully digital planning workflow. Twenty-one pa...

Background and Purpose: Spontaneous intracranial haemorrhage (ICH) has high fatality or varying degrees of disability while has few proven treatments. This study aims at investigating the association between dental scaling (DS) and risk of ICH. Methods: In this cohort study, two cohorts were matched by propensity score based on potential confounder...

A distal free-end situation could result in insufficient stability of the surgical guide, and could reduce accuracy of the static guided implant surgery (sGIS). The purpose of this study was to investigate the accuracy of sGIS using a combination tooth-and-bone supported stereolithographic (SLA) surgical guide in distal extension situation. Thirty...

Non-healing ulcers are frequently seen in leprosy, which become one of the major causes of disability. For more than a decade, Jinchuang ointment, a traditional Chinese herbal medicine has been successfully used to treat non-healing wounds and pressure sores of diabetics in several hospitals in Taiwan. The recipe of this herbal medicine was first p...

Plaque accumulation and white spot lesions are common adverse effects of fixed orthodontic appliance use. This study compared the effects between enzyme-containing and conventional dentifrices on orthodontic patients. This double-blind randomized controlled trial included 42 orthodontic patients (25 women and 17 men: 22.7 ± 4.2 years) from Taipei M...

Though the cross-induction of either acute kidney (AKI) injury to ischemic stroke (IS) or IS to AKI might not be encountered in the early stages of cerebrorenal syndrome (CRS), both pathologies coexist in late stages. Therefore, we firstly established a late stage CRS rat model by simultaneous induction of both diseases, and further, cerebro and re...

The surface of Ti6Al4V substrate was modified by two ways: micro-powder blasting and co-blast technique. Micro-powder blasting was done using Al2O3 (of three different sizes) or SiC particles. Co-blast technique was done using the same particles co-blasted with hydroxyapatite (HA) particles. The morphology, roughness, deep impact and contact angle...

Objective This study aimed to evaluate compliance with guidelines on hand hygiene by examining five handwashing categories in postgraduate year (PGY) dentists at a university teaching hospital and to evaluate the accuracy rates of handwashing. Methods Through direct observation, trained PGY dentists were monitored throughout their daily care routi...

Background/purpose: Patient safety is a major healthcare challenge. Due to a lack of safety culture knowledge among dental professionals, our objectives were to measure the level of patient safety culture using the Safety Attitude Questionnaire in Chinese (SAQ-C) and identify factors associated with positive attitudes toward patient safety. Mater...

Cancer is a leading cause of mortality and a major public health problem worldwide. For biological therapy against cancer, we previously developed a unique immunotherapeutic platform by combining mesenchymal stem cells with an antigen-specific protein vaccine. However, this system possesses a few limitations, such as improperly immortalized mesench...

Introduction: Smile esthetics is a critical factor for evaluating orthodontic treatment outcomes. In this study, we evaluated the differences in esthetic perceptions and smile variables between extraction and nonextraction treatments for different malocclusions. Methods: Ninety participants were divided into 3 groups according to their pretreatm...

Background/purpose Whether third molars contribute to or aggravate relapse, particularly in the mandibular dental arch, after orthodontic treatment remains controversial. Orthodontic clinicians vary widely in their practice regarding prophylactic third molar removal after orthodontic treatment. The present study systematically reviewed and meta-ana...

Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, such as cell growth, apoptosis and tumorigenesis. However, the functional roles of lncRNAs and mechanistic analysis of their interplays with oncogenic pathways in oral cancer remain largely unknown. In the current study, we examined the significan...

Background/purpose Many factors, including economic, psychosocial statuses and ethnicity, affect patients' decision to seek orthodontic treatment. The present study compared orthodontic patients' motivation, attitude and the factors affecting this motivation in Taiwanese and Thai patients. We investigated the association between the aforementioned...

Endosseous oral implant is applied for orthodontic anchorage in subjects with multiple tooth agenesis. Its effectiveness under orthodontic loading has been demonstrated clinically and experimentally. This study investigates the deformation and stress on the bone and implant for different bite forces by three-dimensional (3D) finite element (FE) met...

The conventional orthodontic power chain, often composed of polymer materials, has drawbacks such as a reduction of elasticity owing to water absorption as well as surface discoloration and staining resulting from food or beverages consumed by the patient. The goal of this study was to develop a surface treatment (nanoimprinting) for orthodontic po...

Background/purpose: Anterior crossbite correction is common in orthodontic treatment; however, few studies have discussed the change with cephalometric measurements. The purpose of this study was to evaluate the dentofacial changes in anterior crossbite correction by using an upper lingual arch with finger springs. Materials and methods: This retro...

Objective This study aimed to quantitatively assess the relationship of smile esthetic variables with various types of malocclusion, and identify the cephalometric factors affecting smile measurements. Methods This retrospective study included 106 patients who were treated with retention at the orthodontic department of Taipei Medical University H...

Background/purpose: Smile esthetics is a critical factor for evaluating orthodontic treatment outcomes. The effects of tooth extraction on smile esthetics and buccal corridor remain controversial and have not been adequately investigated. Therefore, in this systematic review and meta-analysis, we evaluated the aforementioned effects. Materials and...

Nanoporous anodic aluminum oxide (AAO) templates are fabricated using an anodization method. The mean diameter of the nanoporous AAO templates is 100 nm. A molded plastic thin film with nanostructure is fabricated using AAO template as a mold insert by nanoimprint. The surface properties of the molded plastic thin film obtained using various proces...

Background Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque.AimTo evaluate the effect of the maternal use of xylitol gum on MS reduction in infants.DesignA structured literature review and meta-analysis. A random effects...

Intra-operative applications of bone graft substitutes into bone voids support mechanical stability, and accelerate fracture healing. Calcium sulfate bone cement, an injectable substitute, is used widely in non-loading bones with favorable results. In addition, calcium sulfate also serves as a vehicle for antibiotics that treat osteomyelitis or pre...

Endosseous oral implants are used for orthodontic anchorage in subjects with multiple tooth agenesis. Their effectiveness under orthodontic loading has been demonstrated clinically and experimentally. This study examines three-dimensional (3D) finite element (FE) models for bone and implants. A numerical simulation of stress distributions around im...

Background/purpose This study attempted to understand the spreading characteristics of airborne bacterial contaminants during dental scaling treatment. Materials and methods Bacterial aerosols were collected with gelatin filters, in a single-chair clinic during ultrasonic scaling treatments on two patients with periodontitis. Results The results...

This study indicates the micropattern of molded plastic film from a mold insert using ultrasonic micro embossing. A mold insert and plastic film are heated above the glass transition temperature of plastic, and the softened plastic is flowed into the micropattern of a mold insert by applying pressure via a conventional technique. A longitudinal ult...

Nanoporous anodic aluminum oxide (AAO) templates are fabricated using an nodization method. The mean diameters of nanoporous anodic aluminum oxide templates are 100 nm and 200 nm by various processing parameters of the anodization method. A molded plastic thin film nanostructure is fabricated by nanoimprinting using the AAO template as a mold inser...

The effects of various pH values of sodium phosphate buffer solution (PBS), 4.0, 6.0, 8.0, and 9.0 on calcium phosphate cement (CPC) prepared by mixing monocalcium phosphate monohydrate (MCPM), calcium carbonate, and PBS were studied. The phase evolution takes place in three steps: Firstly, the MCPM and calcium carbonate crystals dissolve in the PB...

Hydroxyapatite (HA) coating of hard tissue implants is widely employed for its biocompatible and osteoconductive properties as well as its improved mechanical properties. In this study, a novel micro-blasting process has been used to successfully modify a titanium alloy substrate with a HA treatment using a dopant/abrasive regime. The impact of a s...

Background High-frequency noise from handpieces has caused concerns of hearing loss among dentists. However, data on dentists' workplace noise exposure are inconsistent and the literature on the consequent annoyance is limited. Aim This study evaluated dentists' workplace noise exposure and investigated its role in causing annoyance and its role in...

A hybrid technique combining the radio-frequency magnetron sputtering of silicon and the plasma-enhanced chemical vapor deposition of hydrogenated carbon was developed to synthesize silicon-incorporating diamond-like carbon films. Plasma power was supplied at different levels to a silicon electrode in an Ar/CH4 atmosphere to prepare films having di...

The impact of anti-hypertensive treatment on fetus was unclear, and hence, remains controversial. We set out in this study to estimate the prevalence of adverse pregnancy outcomes, including low birth weight, preterm delivery and small for gestational age amongst women with chronic hypertension, and to determine whether the use of anti-hypertensive...