Hsiao-Chi Chuang

Hsiao-Chi Chuang
Taipei Medical University | TMU · School of Respiratory Therapy

BSc. MSc. PhD.
PhD position is avaliable for application.

About

220
Publications
20,965
Reads
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2,837
Citations
Introduction
Dr Hsiao-Chi Chuang is the head of Inhalation Toxicology Research Lab (ITRL). The overall aim of the ITRL is to understand the pathophysiology and repairing in pulmonary diseases. Specifically, the ITRL research interests are: 1. Environmental lung disease; 2. Aerosol therapy for lung disease; 3. Developmental biology of lung.
Additional affiliations
September 2016 - present
Taipei Medical University
Position
  • Professor (Associate)
August 2016 - present
Taipei Medical University
Position
  • Professor (Associate)
February 2013 - August 2016
Taipei Medical University
Position
  • Professor (Assistant)
Education
October 2008 - October 2011
Cardiff University
Field of study
October 2003 - June 2005
September 1999 - June 2003
China Medical University
Field of study

Publications

Publications (220)
Article
In recent years, the Internet of Things and low-cost sensor technologies have been applied to establish low-cost sensor networks for monitoring single pollutants in the environment. Few studies have developed a mixed-sensor system for simultaneous measurements of particles and noise, but the influences of meteorology and other pollutants are not ta...
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Full-text available
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in chronic lung disease patients throughout the world. Mesenchymal stem cells (MSCs) have been shown to regulate immunomodulatory, anti-inflammatory, and regenerative responses. However, the effects of human-umbilical-cord-derived mesenchymal stem cells (hUC-MS...
Article
Coal combustion emits large amounts of PM2.5 (particulate matter with a diameter of ≤ 2.5 μm), and the emissions from different coal types differ. Clean fuels are essential in reducing PM2.5 emissions and their respiratory effects on human. This study compared PM2.5 emissions and their chemical components from four types of coal (i.e., bituminous r...
Article
Exhaust emissions from gasoline vehicles are one of the major contributors to aerosol particles observed in urban areas. It is well-known that these tiny particles are associated with air pollution, climate forcing, and adverse health effects. However, their toxicity and bioreactivity after atmospheric ageing are less constrained. The aim of the pr...
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Obstructive sleep apnea (OSA) is associated with seasonal variations. The objective of this study was to examine associations of ambient relative humidity (RH) and temperature on sleep parameters. We conducted a cross-sectional study by retrospectively recruiting 5204 adults from a sleep center in Taipei, Taiwan. Associations of 1-night polysomnogr...
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The effects of air pollution on sleep and dementia remain unclear. The objective of this study was to investigate the effects of air pollution on cognitive function as mediated by the sleep cycle. A cross-sectional study design was conducted to recruit 4866 subjects on which PSG had been performed. Fifty of them were further given a cognitive funct...
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Full-text available
Purpose Body composition is considered to be associated with obstructive sleep apnea (OSA) severity. This cross-sectional study aimed to examine associations of overnight body composition changes with positional OSA. Methods The body composition of patients diagnosed with non-positional and positional OSA was measured before and after overnight po...
Article
Air pollution has been reported to be associated with chronic obstructive pulmonary disease (COPD). Our study aim was to examine the mediating effects of air pollution on climate-associated health outcomes of COPD patients. A cross-sectional study of 117 COPD patients was conducted in a hospital in Taiwan. We measured the lung function, 6-min walki...
Article
Many volatile organic compounds (VOCs) are used for experiments at universities, and most of them contain benzene, toluene, ethylbenzene, xylene, and an extraction solvent of dichloromethane. This study aimed to investigate the indoor concentrations of these five compounds in different locations on campus and to evaluate possible health risks for f...
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Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic mortality. The objective of this study was to investigate the therapeutic potential of a novel potent histone deacetylase (HDAC) inhibitor MPT0E028 on emphysema. Materials and Methods: A mouse model of porcine pancreatic elastase (PPE)-induced emphysema was orally...
Article
Background: Benzo[a]pyrene (BaP), a toxic carcinogen, is associated with various adverse effects but is rarely discussed in muscle-related disorders. This study investigated in vitro and in vivo effects triggered by BaP exposure in muscles and hypothesized that exposure might induce conditions similar to sarcopenia due to the shared mechanism of ox...
Article
Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in directing T-cell responses and are involved in the pathogenesis of allergic asthma. Acteoside, an active phenylethanoid glycoside, is widely distributed in many medicinal plants. Herein, we explored the immunomodulatory effects of acteoside on bone marrow-derive...
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Emerging evidence witnesses the association of air pollution exposure with sleep disorders or the risk of obstructive sleep apnea (OSA); however, the results are not consistent. OSA patients with or without a low arousal threshold (LAT) have different pathology and therapeutic schemes. No study has evaluated the potential diverse effects of air pol...
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Air pollution is widely viewed as a serious threat to human health and a contributor to deaths. Air pollution appears to be linked to the progression of emphysema, according to epidemiological data. The objective of this study was to examine associations between air pollution and the progression of emphysema using a meta-analysis. A meta-analysis w...
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It is still unknown whether long-term inhalation of indoor air pollutants from ambient essential oil is associated with increased cardiopulmonary events. We recruited 200 healthy homemakers to conduct a prospective observation study in Northern Taiwan. We measured heart rate (HR), systolic blood pressure (SBP), diastolic BP (DBP), peak expiratory f...
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The association between lung deposition of particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) from welding fumes and lung function is unclear. We conducted a cohort study with a follow-up of 4 years in 115 shipyard workers to investigate the incidence rate of chronic obstructive pulmonary disease (COPD), and to evaluate the ef...
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The correlation between lung cancer incidence and air pollution has been established in previous research, but the other detail impact of air pollution to lung cancer is still under investigation. This study aimed to explore if air pollution affected the subtype and staging of lung cancer. At the same time, we investigated the effect of individual...
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Background There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O 2 desaturation during exercise in COPD patients with emphysema is unclear. Our aims were to estimate the prevalence of O 2 desaturation during exercise...
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Despite rapidly evolving pathobiological mechanistic demystification, coupled with advances in diagnostic and therapeutic modalities, chronic obstructive pulmonary disease (COPD) remains a major healthcare and clinical challenge, globally. Further compounded by the dearth of available curative anti-COPD therapy, it is posited that this challenge ma...
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Cigarette smoke (CS) is a risk factor for chronic obstructive pulmonary disease. We attempted to investigate fully the possible effects of CS on kidney cells. We found that the viability of a human kidney proximal tubular epithelial cell line (HK-2 cells) was decreased after treatment with CS extract (CSE). In particular, the effects of CSE at low...
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Background Long-term exposure to PM2.5 (particulate matter with an aerodynamic diameter of ≤ 2.5 μm) is associated with pulmonary injury and emphysema in patients with chronic obstructive pulmonary disease (COPD). We investigated mechanisms through which the long noncoding RNA lnc-IL7R contributes to cellular damage by inducing oxidative stress in...
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Background Although recent studies have indicated an association between obstructive sleep apnea (OSA) and air pollution, they have reported inconsistent results. Moreover, few studies investigated the effects of short-term air pollution exposure. Objective To estimate the health effects of short- and long-term exposure to traffic air pollution on...
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We investigated roles of Hippo signaling pathway components in alveolar type II cells (AECII) after zinc oxide nanoparticle (ZnONP) exposure. ZnONPs physicochemistry was characterized using field emission-scanning electron microscopy (FE-SEM) and energy-dispersive X-ray (EDX) microanalysis. ZnONP deposition in human respiratory tract was estimated...
Article
Tire and road wear microplastics (TRWMPs) in road dust are a key source of atmospheric particulate matter and have an adverse impact on human health and the environment. In this study, samples of particulate matter with a diameter of 2.5 μm or less (PM2.5) in road dust were collected from eight megacities in China to determine the TRWMP content, in...
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Fine particulate matter (PM2.5) has been linked to cardiopulmonary disease and systemic effects in humans. However, few studies have investigated the particle bioreactivity in Chinese megacities during haze episodes. The objective of this study was to determine the contributions of chemical components in PM2.5 to particle bioreactivity in Chinese m...
Article
The significance of this work is that ambient PM2.5 is a direct transmission mode for influenza virus infection to the human alveolar epithelium. The concentration of PM2.5 was 11.7 ± 5.5 μg/m³ in Taipei during 24 December 2019–13 January 2020. Approximately 79% of inhaled PM2.5 is able to reach the upper-to-lower airway, and 47% of PM2.5 is able t...
Article
Adverse human health effects caused by fine particulate matter (PM2.5) were reported; however, source-specific PM2.5 and its bioreactivity need to be assessed to understand regional human impacts. The objective of this study was to investigate the contributions of PM2.5 to particle bioreactivity in Taichung City, an urban area of west-central Taiwa...
Article
Particulate matter with aerodynamic diameters ≤1 μm (PM1) in the atmosphere, especially that which is emitted from anthropogenic sources, can induce considerable negative effects on the cardiopulmonary system. To investigate the chemical emission characteristics and organic sources in Yuen Long (Hong Kong), both offline and online approaches for PM...
Article
Allergic asthma is induced by T helper 2 (Th2) responses and allergen-specific immunoglobulin E (IgE). In asthma, regulatory T (Treg) cells play a crucial role in controlling immune homeostasis, and induction of Treg cells is a good strategy to treat Th2-mediated allergic asthma. Schisandrin B (Sch B), the main component isolated from Schisandra ch...
Article
An association between short-term indoor exposure to fine particles (PM2.5) and acute respiratory effects has been reported. It is still unclear whether long-term indoor exposure to PM2.5 is associated with pulmonary events. This study recruited 1023 healthy adult homeworkers to conduct a prospective observational study from 2010 to 2021. Four repe...
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Epidemiological studies identified the relationship between air pollution and pulmonary tuberculosis. Effects of lung-deposited dose of particulate matter (PM) on culture-positive pulmonary tuberculosis remain unclear. This study investigates the association between lung-deposited dose of PM and pulmonary tuberculosis pleurisy. A case-control study...
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The effects of the restriction policies on human mobility and on the prevention of SARS-CoV-2 (coronavirus disease 2019 (COVID-19) transmission were reported. The efficiency of human mobility restriction due to the social distancing measures of cities on preventing SARS-CoV-2 spread remains unclear. The objective of this study was to investigate th...
Preprint
Full-text available
Background: The influence of welding-associated air pollutants on workers’ health is mainly regarded as a core issue in public health and occupational medicine. Previous studies have indicated that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. This study aim...
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Background: Chronic obstructive pulmonary disease (COPD) continues to pose a therapeutic challenge. This may be connected with its nosological heterogeneity, broad symptomatology spectrum, varying disease course, and therapy response. The last three decades has been characterized by increased understanding of the pathobiology of COPD, with associa...
Article
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Source-apportioned particle concentrations are necessary to properly evaluate the health impacts of air pollution. In this study, a measurement station was established at an urban roadside in northern Taiwan to the investigate lung deposited surface area (LDSA) concentration, a relevant metric for the adverse health effects of aerosol exposure, alo...
Article
PM2.5 Road dust samples were collected from 10 representative cities in southern and northern China for examination of chemical components and oxidative stress levels in A549 cells. Downtown road dust was abundance of heavy metals, EC and PAHs compared to nondowntown road dust. Source apportionment also revealed the relative higher contribution of...
Article
Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of prolife...
Preprint
Full-text available
The effects of air pollution on sleep and dementia remain unclear. The objective of this study was to investigate the effects of air pollution on cognitive function as mediated by the sleep cycle. A cross-sectional study design was conducted to recruit 4866 subjects on which PSG had been performed. Fifty of them were further given a cognitive funct...
Article
Full-text available
Background: Systemic manifestations and comorbidities are characteristics of chronic obstructive pulmonary disease (COPD) and are probably due to systemic inflammation. The histone methyltransferase SUV39H1 controls the Th1/Th2 balance. We previously reported that reduced SUV39H1 expression contributed to abnormal inflammation in COPD. Here, we ai...
Article
Full-text available
Exposure to road dust particulate matter (PM) causes adverse health impacts on the human airway. However, the effects of road dust on the upper airway epithelium in humans remain unclear. We investigated the involvement of the epidermal growth factor receptor (EGFR) after PM with an aerodynamic diameter of < 2.5 μm (PM2.5)-induced E-cadherin disrup...
Article
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Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were shown to have potential for immunoregulation and tissue repair. The objective of this study was to investigate the effects of hUC-MSCs on emphysema in chronic obstructive pulmonary disease (COPD). The C57BL/6JNarl mice were exposed to cigarette smoke (CS) for 4 months followed by a...
Article
Full-text available
Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM 2.5 ) exposure and Alzheimer’s disease (AD), the PM 2.5 -induced neuron toxicity and associated mechanisms were not fully elucidated. The present study assessed brain toxicity in 6-month-old female triple-transgenic AD (3xTg-AD) mice follow...
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Full-text available
The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of PM2.5 (≤ 2.5 μm), NO2, and O3 level of exposure with the presence of emphysema in 86 chronic obstructive pulmonary disease (COPD) patients. Exposure to th...
Article
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The novelty of this study is that it identified the associations between PM2.5 deposition in the lung and the degree of emphysema in different lung lobes of COPD patients, especially in the right middle lobe and both upper lobes https://bit.ly/3k21ri0.
Article
The mass, chemical composition and toxicological properties of fine particulates (PM2.5) emitted from cooking activities in three Hong Kong based restaurants and two simulated cooking experiments were characterized. Extracts from the cooking PM2.5 elicited significant biological activities [cell viability, generation of reactive oxygen species (ROS...
Article
Full-text available
Background Exposure to air pollution exerts direct effects on respiratory organs; however, molecular alterations underlying air pollution-induced pulmonary injury remain unclear. In this study, we investigated the effect of air pollution on the lung tissues of Sprague-Dawley rats with whole-body exposure to traffic-related PM 1 (particulate matter...
Preprint
Full-text available
Background: Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibitio...
Article
Full-text available
Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM2.5) has been linked to adverse health outcomes in welding workers. The objective of this study was to investigate associations of chronic exposure to metal fume PM2.5 in shipyard workers with health outcomes. A longitudinal study was conducted to determine the effects of metal fume PM2...
Article
This study aims to investigate the association of air pollution with overnight change in 4body composition and sleep-related parameters. Body composition of 197 subjects in New Taipei city was measured before and after sleep by bioelectric impedance analysis. Air pollutant data were collected from Taiwan Environmental Protection Administration. Sle...
Article
Full-text available
Vinyl chloride (VC) is classified as a group 1 carcinogen to humans by the International Agency for Research on Cancer, and inhalation is considered to be an important route of occupational exposure. In addition, increasing numbers of studies have observed adverse health effects in people living in the vicinity of petrochemical complexes. The objec...
Article
Air pollution is associated with sleep-related breathing disorders; however, the effects of air pollution on depression in patients with SRBDs remain unclear. A cross-sectional study was conducted to collect polysomnographic (PSG) data and Beck Depression Inventory-IA (BDI-IA) responses from 568 subjects with SRDBs in a sleep center in 2015 to 2017...
Article
Full-text available
To provide long-term air pollutant exposure estimates for epidemiological studies, it is essential to test the feasibility of developing land-use regression (LUR) models using only routine air quality measurement data and to evaluate the transferability of LUR models between nearby cities. In this study, we developed and evaluated the intercity tra...
Article
Land-use regression (LUR) models have been used to estimate particle mass concentration (PMC), but few studies apply it to predict particle number concentration (PNC) at different sizes. This study aimed to determine both PMC and PNC throughout one year to establish predictive models in Taichung, Taiwan. The annual averages of PM10, PM2.5, and PM1...
Article
Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) is a type II acute-phase protein; however, the role of pulmonary ITIH4 after exposure to air pollution remains unclear. In this study, we investigated the role of ITIH4 in the lungs in response to air pollution. ITIH4 expression in bronchoalveolar lavage fluid (BAL) of 47 healthy human subjects an...
Article
Toxicological studies have demonstrated the associations between fine particle (PM2.5) components and various cytotoxic endpoints. However, few studies have investigated the toxicological effects of source-specific PM2.5 at the individual level. To investigate the potential impact of source-specific PM2.5 on cytotoxic effects, we performed repeated...
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Full-text available
Air pollution has been recognized to be a risk factor for lung cancer. The objective of this study was to investigate the effects of air pollution on heavy metal alterations in the pleural effusion of lung cancer patients. Pleural effusion was collected from patients with lung cancer and congestive heart failure (CHF). One-year average levels of pa...
Article
Organic compounds in fine particles play major roles in cardiopulmonary diseases. A study was conducted to determine the characteristics and cytotoxicity of organic aerosols (OA) in an urban roadside area in Hong Kong. Chemical components in nonrefractory submicron aerosol (NR-PM1) were observed using a Quadrupole Aerosol Chemical Speciation Monito...
Article
Abnormal activation of transforming growth factor (TGF)-β is a common cause of fibroblast activation and fibrosis. In bleomycin (BLM)-induced lung fibrosis, the marked expression of phospho-Src homology-2 domain-containing phosphatase (SHP) 2, phospho-signal transducer and activator of transcription (STAT) 3, and suppressor of cytokine signaling (S...