Hsi Yen

Chang Gung Memorial Hospital | CGMH · Department of Dermatology

Nonmelanoma skin cancer (NMSC) comprises mainly basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The association between alcohol intake and NMSC has been inconclusive; therefore the objective of this study is to quantify the relationship between alcohol intake and NMSC using meta-analyses. A systematic literature search of P...

Background: Red and processed meat consumption has been associated with increased risk of several cancers, but association with cutaneous melanoma risk has been inconclusive. Objective: To investigate the association between red and processed meat intake and melanoma risk. Methods: Dietary information was assessed using food frequency question...

Background: An overview of mortality risk associated with psoriasis is lacking. Objective: To perform a systematic review and meta-analysis of mortality risk in psoriasis. Methods: We included studies reporting all-cause or cause-specific mortality risk estimates in psoriasis patients compared with general population or subjects free of psoriasis....

Clinical question/scenario: Is psoriasis associated with dementia or cognitive impairment?. Background: Psoriasis is a multisystemic inflammatory disorder that has an unclear association with cognitive dysfunction. This Critically Appraised Topic synthesizes the results from relevant observational studies. Methods: A systematic literature sear...

Background: Clinical practice guidelines (CPGs) developed with rigorous methods can help optimize clinical care for psoriasis patients. Objectives: To conduct an updated systematic review and comprehensive critical appraisal of global psoriasis CPGs. Methods: A search of MEDLINE and Embase for psoriasis CPGs published between January 1st 2015...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome characterized clinically as an extensive infiltrative maculopapular exanthem accompanied by fever, lymphadenopathy, internal organ involvement, and hematological abnormalities.Generalized, infiltrated papuloplaques with purpuric change, facial edema, and desquamation are su...

Hintergrund: In einigen klinischen Studien war die Einnahme von Cyclooxygenase-2 (COX-2)-Hemmern mit einem erniedrigten Hautkrebsrisiko bei Hochrisiko-Patienten assoziiert. Patienten und methodik: Diese Studie sollte die Frage beantworten, ob die Einnahme von COX-2-Hemmern mit einem erniedrigten Risiko für Basalzellkarzinome (BCC), kutane Plattenep...

Background: Some clinical trials found that cyclooxygenase-2 (COX-2) inhibitor use lowered the risk of skin cancer in high-risk groups. Patients and methods: To determine whether COX-2 inhibitor use is associated with lower risk of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma, we analyzed COX-2 inhibitor use...

Introduction Clinical practice guidelines (CPGs), statements that include recommendations intended to optimise patient care, play a critical role in standardising and improving treatment outcomes based on best evidence. It is currently unclear how many CPGs are available globally to assist clinicians in the management of patients with skin disease....

p>Skin cancer is the most commonly diagnosed type of cancer, with continually rising incidence rates. Cyclooxygenase-2 (COX-2) inhibitor use has been associated with lower risk of several cancers, though epidemiological studies on skin cancer risk have been limited and inconclusive. To evaluate whether COX-2 inhibitor use is associated with decreas...

There are limited studies regarding childhood and adolescent psoriasis in Taiwan. A total of 86 pathologically confirmed cases diagnosed from 1989 to 2017 were retrospectively reviewed. Mean disease onset age was 10.51 years, and plaque psoriasis was the most common type. Compared to studies on Caucasian and other Asian populations, we found a lowe...

Background The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association. Methods We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case–control, cross-sectional, and cohort studies examining the association between psoriasis and v...

Background: Nutrients involved in one-carbon metabolism - folate, vitamins B6 and B12, methionine, choline, and betaine - have been inversely associated with multiple cancer sites and may be related to skin cancer. However, there is a lack of research on the association between intake of these nutrients and cutaneous melanoma risk. The aim of this...

Skin is the largest human organ, our protection against various environmental assaults and noxious agents. Accumulation of these stress events may lead to the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Although modern targeted therapies have ameliorated the management of cutaneous malignancies, a safer, more a...

Background: Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. Objectives: To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. Methods: A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two clinically visible AK wer...

Introduction: Medical students and residents will encounter many cutaneous fungal infections in medical practice. However, the training for identification of medical fungi has been insufficient due to limited lecture-based courses. The objective of this study was to evaluate the impact of using smartphone-based wallpapers in learning the microscop...

Background: Nutrients involved in one-carbon metabolism - folate, vitamins B6 and B12, methionine, choline, and betaine - have been associated with multiple cancer sites. However, no study has assessed the association between these nutrients and risk of melanoma. Thus, the aim of this study was to evaluate the association between intake of these nu...