Horacio Poblete

Horacio Poblete
Universidad de Talca · Center for Bioinformatics and Molecular Simulations (CBSM)

About

8
Publications
818
Reads
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61
Citations
Citations since 2016
8 Research Items
61 Citations
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201620172018201920202021202205101520
201620172018201920202021202205101520

Publications

Publications (8)
Article
Polyoxyethylene sorbitan monooleate is commonly used to obtain stable dispersions of nanoparticles (NPs) such as carbon nanotubes (CNTs) and graphene. However, the mechanism underlying dispersion is poorly understood. The present study aimed at investigating the mechanism of stabilization of carbon NPs (CNPs), namely, single-walled CNTs (SWCNTs), m...
Article
Full-text available
Pseudomonas aeruginosa is a highly pathogenic Gram-negative microorganism associated with high mortality levels in burned or immunosuppressed patients or individuals affected by cystic fibrosis. Studies support a colonization mechanism whereby P. aeruginosa can breakdown the host cell membrane phospholipids through the sequential action of two enzy...
Article
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We report the development, as well as the in vitro and in vivo testing, of a sprayable nanotherapeutic that uses surface engineered custom-designed multiarmed peptide grafted nanogold for on-the-spot coating of an infarcted myocardial surface. When applied to mouse hearts, 1 week after infarction, the spray-on treatment resulted in an increase in c...
Article
Full-text available
Transient receptor potential melastatin 4 (TRPM4) is a Ca2+‐activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which cytoskeletal rearrangement and cell migration are altered, such as metastatic cancer. Here, we identify the K+ channel tetramerizati...
Article
Full-text available
That channels and transporters can influence the membrane morphology is increasingly recognized. Less appreciated is that the extent and free-energy cost of these deformations likely varies among different functional states of a protein, and thus, that they might contribute significantly to defining its mechanism. We consider the trimeric Na+-aspar...
Chapter
Biomimetic nano-engineered materials have emerged as new potential additives for biomedical therapies. However, one of the most critical challenges that remain is the ability to produce responsive nanostructures that respond to external stimuli, enhance existing properties, and introduce new functionalities. In this regard, the use of computational...
Article
Three new collagen mimetic peptides containing the CLK motif as anchoring arms were tested for silver nanoparticle surface stabilization. Our experimental and molecular dynamic data indicate that peptide length has...

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