Hooman Azmi

Hooman Azmi
Hackensack University Medical Center | HUMC · neurosurgery

MD, FAANS

About

28
Publications
2,548
Reads
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2,013
Citations

Publications

Publications (28)
Article
Alzheimer's disease (AD) and other forms of dementia can have a large impact on patients, their families, and for the society as a whole. Current medical treatments have not shown enough potential in treating or altering the course of the disease. Deep brain stimulation (DBS) has shown great neuromodulatory potential in Parkinson's disease, and the...
Article
Full-text available
Background Patients with Parkinson's Disease (PD) are at higher risk of complications when admitted to the hospital. Delays in PD medications and use of contraindicated medications contribute to the increased risk and prolong their lengths of stay (LOS). Using a hospital-wide PD protocol, we aimed to ensure PD medications were placed with “custom”...
Article
Full-text available
The treatment of delirium or psychosis in patients with Parkinson's disease (PD) can be complicated by the limited number of pharmacological agents that can be used in this population. Typical and atypical antipsychotics are contraindicated, as they can worsen motor symptoms. The treatment of acute delirium is even more complicated in the hospital...
Article
Background: Patients with Parkinson disease (PD) admitted to the hospital for any reason are at a higher risk of hospital-related complications. Frequent causes include delays in administering PD medications or use of contraindicated medications. The Joint Commission Disease-Specific Care (DSC) program has been used to establish a systematic appro...
Article
Full-text available
Background Intraoperative magnetic resonance imaging (ioMRI) has led to significant advancements in neurosurgery with improved accuracy, assessment of the extent of resection, less invasive surgical alternatives, and real-time confirmation of targeting as well delivery of therapies. The costs associated with developing ioMRI units in the surgical s...
Book
Patients with Parkinson's disease are more susceptible to developing hospital related complications. Healthcare providers equipped with a better understanding of PD and its implications in the hospital can improve the quality of care of this unique patient population and help avoid admissions related complications. Written by two experts in the tr...
Article
Full-text available
Background: Beta blockers, a class of medications that inhibit endogenous catecholamines interaction with beta adrenergic receptors, are often administered to patients hospitalized after traumatic brain injury (TBI). We tested the hypothesis that beta blocker use after TBI is associated with lower mortality, and secondarily compared propranolol to...
Article
The development of navigation technology facilitating MRI-guided stereotactic neurosurgery has enabled neurosurgeons to perform a variety of procedures ranging from deep brain stimulation to laser ablation entirely within an intraoperative or diagnostic MRI suite while having real-time visualization of brain anatomy. Prior to this technology, some...
Article
Neurosurgical laser ablation is a relatively new but rapidly growing application of stereotactic neurosurgery that allows neurosurgeons to treat many previously untreatable conditions with the added benefit of shorter hospitalizations and recovery times. The vast majority of these procedures, however, are performed using a multisite workflow patter...
Article
Full-text available
Background: Interventional magnetic resonance imaging (iMRI) guided deep brain stimulation (DBS) for Parkinson's disease (PD) has been shown to be effective. The costs of a dedicated intraoperative MRI may be prohibitive. The procedure can also be performed in a diagnostic scanner, however this presents challenges for utilization of time when the...
Article
Objective: During the acute and post acute period following a mild traumatic brain injury (mTBI) multiple cognitive processes are negatively affected. Prior studies have reported numerous cognitive domains affected during the acute and post-acute period. Studies have demonstrated cognitive recovery, with subjective and objective assessments, that w...
Article
We examine the effect of intracranial air on stereotactic accuracy during bilateral deep brain stimulation (DBS) surgery for Parkinson's disease (PD). We also assess factors that may predict an increased risk of intracranial air during these surgeries. 32 patients with PD underwent bilateral DBS surgery. The technique used for implantation of the l...
Article
Movement disorders, such as Parkinson's disease, tremor, and dystonia, are among the most common neurological conditions and affect millions of patients. Although medications are the mainstay of therapy for movement disorders, neurosurgery has played an important role in their management for the past 50 years. Surgery is now a viable and safe optio...
Article
Percutaneous procedures for the treatment of pain, such as injection of pharmacological agents, radiofrequency ablations, and implantation of catheters or electrodes, are typically performed under fluoroscopic guidance, taking advantage of reliable osseous landmarks. The use of open MR imaging for guidance of regional pain management procedures has...
Article
We previously demonstrated the capability to obtain functional magnetic resonance imaging (MRI) scans of the motor cortex in healthy volunteers using a low-field mobile operating room-based MRI scanner with 0.12-T field strength. Using an expanded (0.15-T), but still mobile, version of this system, our goal was to acquire data showing activation of...
Article
Full-text available
Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown. Epileptic discharges are in part initiated by a local depolarization shift that drives groups of neurons into synchronous bursting. In an attempt to define the cellular basis for hypersynchronous bur...
Article
Objective and Importance: Anosmia is a frequent complication of surgical treatment of olfactory groove meningiomas (OGMs). The loss of olfaction can significantly impact on patient quality of life, We present 3 patients with incidentally discovered small OGMs who were treated with stereotactic radiosurgery (SRS). All patients have had tumor control...
Article
Full-text available
Anterior cervical decompression and fusion has gained popularity because of its applicability to a variety of cervical spine disorders. The authors of long-term follow-up studies have demonstrated the development of degenerative changes in segments adjacent to fusion. So-called adjacent-segment disease causes symptomatic deterioration in up to 25%...
Article
Recently, magnetic resonance imagers (MRIs) with 3-tesla magnets were approved for clinical use. The spatial accuracy of these high-resolution scanners has yet to be proven. In the present study, a computed tomography (CT)- and MRI-compatible phantom was scanned on a CT, a 1.5-tesla MRI and a 3-tesla MRI scanner. The model was registered to the ima...
Chapter
The advent of magnetic resonance imaging (MRI) has had a tremendous impact on medicine and specifically on the field of neurosurgery. Diagnosis of lesions within the central nervous system (CNS), which not so long ago was dependent on such invasive techniques as pneumoencephalography, cerebral angiography, and gas cisternography, has been revolutio...
Article
Functional magnetic resonance imaging (fMRI) has been used for preoperative planning and intraoperative surgical navigation. However, most experience to date has been with preoperative images acquired on high-field echoplanar MRI units. We explored the feasibility of acquiring fMRI of the motor cortex with a dedicated low-field intraoperative MRI (...
Article
We report two cases of massive intraventricular hemorrhage resulting from subarachnoid hemorrhage. Both patients had experienced a ruptured cerebral aneurysm and were initially moribund. The patients were treated with Guglielmi detachable coiling and then administration of intraventricular tissue plasminogen activator (tPA). Rapid clot resolution w...
Article
Full-text available
Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the poorly coupled cell lines, C6 glioma, HeLa, and U373 glioblastoma, is potentiated 5- to 15-fold by connexin expression. ATP release required purinergic receptor-activate...

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Projects

Projects (2)
Project
Parkinson's patients admitted to the hospital can be subject to increased risks. These risks have been linked to medication errors. Our goal is to improve the care of inpatients with PD, by developing protocols that are hospital wide aimed at improving medication management.