Hongliang Feng

Guangzhou Medical University | gzhmc

Aim Knowledge of how circadian rhythm influences brain health remains limited. We aimed to investigate the associations of accelerometer‐measured circadian rest‐activity rhythm (CRAR) with incident dementia, cognitive dysfunction, and structural brain abnormalities in the general population and underlying biological mechanisms. Methods Fifty‐seven...

Introduction Previous evidence suggested that the alteration of rest-activity pattern occurred in patients with isolated rapid eye movement behavior disorder (iRBD), a prodromal stage of α-synucleinopathy with implication to future phenoconversion. Nonetheless, it remains unclear whether this rest-activity pattern alteration has already emerged in...

Background Individuals with type 2 diabetes mellitus (T2DM) are more vulnerable to social disconnection compared with the general population; however, there are few relevant studies investigating this issue. Aims To investigate whether social isolation or loneliness may be associated with subsequent risk of developing major adverse cardiovascular...

Background: The health effects of rest-activity rhythm are of major interest to public health, but its associations with health outcomes remain elusive. We aimed to examine the associations between accelerometer-measured rest-activity rhythm amplitude and health risks among the general UK population. Methods: We did a prospective cohort analysis...

Aims: To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. Methods and results: A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from the UK Biobank between February 2013 and December 2015. We divided sleep duration in...

Objective: The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity (PA) with the risk of incident type 2 diabetes in a population-based prospective cohort study. Methods: Altogether, 88,000 participants (mean age 62.2 ± 7.9 years, mean ± SD) were incl...

Evidence suggests potential links between circadian rhythm and atrial fibrillation (AF). However, whether circadian disruption can predict the onset of AF in the general population remains largely unknown. We aim to investigate the association of accelerometer-measured circadian rest-activity rhythm (CRAR, the most prominent circadian rhythm in hum...

There is a growing interest in the role of timing of daily behaviors in improving health. However, little is known about the optimal timing of physical activity to maximize health benefits. We perform a cohort study of 92,139 UK Biobank participants with valid accelerometer data and all-cause and cause-specific mortality outcomes, comprising over 7...

Context: Insomnia is associated with insulin resistance (IR) in observational studies, however, whether insomnia is causally associated with IR remains unestablished. Objective: This study aims to estimate the causal associations of insomnia with IR and its related traits. Methods: In primary analyses, multivariable regression (MVR) and one-sa...

Background: Social isolation and loneliness have emerged as important risk factors for cardiovascular diseases, particularly during the coronavirus disease pandemic. However, it is unclear whether social isolation and loneliness had independent and joint associations with incident heart failure (HF). Objectives: This study sought to examine the...

Study objectives: The lifestyles change of children and adolescents during the COVID-19 pandemic due to anti-pandemic measures can affect their sleep health. Existing studies have used convenient samples and focused on the initial months of the pandemic, leaving a knowledge gap on changes in young people's sleep patterns under the 'new normal' und...

Aims: To examine the associations of disrupted circadian rest-activity rhythm (CRAR) with cardiovascular diseases and mortality among people with type 2 diabetes. Methods: A total of 3147 participants with baseline type 2 diabetes (mean age 65.21 years, 39.78% female; mean HbA1c 50.02 mmol/mol) from UK Biobank were included. The following CRAR p...

Background We aimed to determine the associations of childhood maltreatment with incident heart failure in later life and explore the potentially modifying effects of genetic risk for heart failure on the associations. Methods and Results This cohort study included adults free of heart failure at baseline enrolled between 2006 and 2010 in the UK B...

Background Circadian dysregulation has long been thought to be a key component in the pathophysiology of bipolar disorder (BD). However, it remains unclear whether this dysregulation constitutes a risk factor, manifestation, or consequence of BD. This study aimed to compare dim light melatonin secretion patterns between unaffected offspring of pare...

Background Lifestyle of children and adolescents have changed extensively during the COVID-19 pandemic due to school suspension and social distancing measures, which can affect their sleep health. Existing studies in the area used convenient samples and focused on the initial months of the pandemic. Method As part of a territory-wide epidemiologic...

Background and objectives: Individuals with a history of recurrent dream-enactment behaviors, but with subthreshold REM sleep without atonia levels for REM sleep behavior disorder (RBD) diagnosis, are currently classified to have prodromal RBD (pRBD). However, the REM sleep elevated EMG diagnostic cut-off, progression trajectory, and long-term neu...

Background: The association between night shift work and prostate cancer is controversial. Evidence shows that genetic and environmental factors both contribute to the development of prostate cancer. It is well-known that melatonin plays a protective role in prostate cancer. MTNR1B rs10830963 influences the dynamics of melatonin secretion, and nig...

Background The coronavirus disease 2019 (COVID-19) has caused widespread panic due to its highly infectious and pandemic transmission. We aimed to evaluate the psychological impact of the COVID-19 outbreak on infected subjects in China. Methods This case-control, survey-based study assessed the psychological status of COVID-19 patients and non-inf...

Study objectives We aimed to investigate the prospective associations of sleep phenotypes with severe intentional self-harm (ISH) in middle-aged and older adults. Methods A total of 499,159 participants (mean age: 56.55 ± 8.09 years; female: 54.4%) were recruited from the UK Biobank between 2006 and 2010 with follow-up until February 2016 in this...

Objective: To compare the mental health and psychological responses in Wuhan, a severely affected area, and other areas of China, during the coronavirus disease 2019 (COVID-19) epidemic. Methods: This cross-sectional study was conducted during February 10-20, 2020. A set of online questionnaires was employed to measure mental health and responses....

Background The risk of neurodegenerative disorders in idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with residual injuries symptoms (RIS) after symptomatic treatment with clonazepam and/or melatonin is unclear. Objective The objective of this study was to determine the rate and correlates of RIS and its association with the...

Objective To investigate the differences in actigraphy‐measured rest‐activity patterns (e.g., sleep‐wake cycle, circadian rest‐activity rhythm, and physical activity) across different stages of α‐synucleinopathy. Methods We compared alterations in 7‐day actigraphy‐measured rest‐activity patterns among patients with clinically diagnosed α‐synuclein...

Background Red blood cell distribution width (RDW) is a strong prognostic marker for various medical conditions, such as ischemic strokes. However, the relationships between higher RDW and the subtypes of white matter hyperintensities (WMHs) remain unclear. Hence, this study aimed to thoroughly evaluate the relationships between RDW and the subtype...

Background and objective Coronavirus disease 2019 (COVID-19) is a new infectious disease with high transmissibility and morbidity. It has caused substantial mental distress to medical professionals. We aimed to compare the psychological impact of the COVID-19 outbreak between frontline and non-frontline medical workers in China. Methods This case-...

Objectives: To investigate whether baseline electromyography (EMG) activity during rapid eye movement (REM) sleep predicts the development of neurodegenerative diseases over time in patients with idiopathic REM sleep behavior disorder (iRBD). Methods: A total of 216 patients with polysomnography-confirmed iRBD were recruited from September 1997...

Aims: Bipolar disorders are highly familial with an estimated heritability of around 80%. The investigation on child and adolescent offspring of patients with bipolar disorders is able to delineate the progression of bipolar disorders. We aimed to establish a largescale cohort to document the evolution of bipolar disorder by using high-risk approac...

Introduction: Sleep and circadian rhythm disturbances (e.g., insomnia and eveningness) are highly prevalent in bipolar disorder. However, whether circadian rest-activity rhythm is altered in bipolar disorder(BD) remains unclear. This case-control study aimed to comprehensively explore whether circadian rest-activity dysregulations exist inpatients...

Background: Accumulating evidence indicates that circadian rhythm, such as rest-activity rhythm and circadian plasma melatonin, is associated with cognitive and neurological functions at different stages of Parkinson's disease (PD). However, whether these associations exist in idiopathic REM sleep behavior disorder (iRBD) remains unknown. Objective...

Background and purpose: Circadian rhythm disturbances are commonly observed at different stages of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. However, whether circadian rhythm is altered in idiopathic REM sleep behavior disorder (iRBD), a widely accepted prodromal stage of neurodegenerative diseases, remains un...

Endothelial progenitor cells (EPCs), as precursors to endothelial cells, play a significant part in the process of endogenous blood vessel repair and maintenance of endothelial integrity. Adiponectin (APN) is an adipocyte-specific adipocytokine. In this study, we aim to test whether we transplant a combined graft of EPCs transfected with the adipon...

This meta-analysis aims to compare percutaneous transluminal angioplasty (PTA) to medical treatment (MT) for symptomatic vertebral artery stenosis (SVAS) treatment. We searched PubMed, Springer, Google Scholar, Clinical Trials, Cochrane Central, Chinese National Knowledge Infrastructure, and China Biological Medicine databases. All relevant compara...

Background: Cerebral small vessel diseases (CSVDs) always coincide with endothelial dysfunction and blood-brain barrier (BBB) damage. However, the detailed mechanisms of CSVD are still unclear and the therapeutic efficacy is not so satisfaction. Granulocyte-colony stimulating factor (G-CSF) can play a neuroprotective role in many neurological dise...

Carotid artery stenosis without transient ischemic attack (TIA) or stroke is considered as “asymptomatic.” However, recent studies have demonstrated that these asymptomatic carotid artery stenosis (aCAS) patients had cognitive impairment in tests of executive function, psychomotor speed, and memory, indicating that “asymptomatic” carotid stenosis m...

The theory of branch atheromatous disease (BAD) has been commonly underused in clinical practice and research since it was proposed in 1989. In this study, we sought to explore clinical characteristics of its substypes and biomarkers for prognosis of BAD. A total of 176 consecutive patients with BAD were classified into two groups: paramedianpontin...

Hyperhomocysteinemia has been associated with cognitive disorders such as mild cognitive impairment, Alzheimer’s disease and vascular dementia. Previous studies showed that levodopa-treated Parkinson’s disease (PD) patients were likely to have elevated homocysteine levels. In addition, epidemiological evidence found that cognitive impairment presen...

Background and Objectives Comprehensive evaluations regarding the benefits of tolvaptan in the treatment of hyponatremia are lacking. The objective of this meta-analysis was to assess the efficacy and safety of tolvaptan in patients with hyponatremia. Methods Pertinent studies were identified by searching PubMed, EMBASE, Web of Science, and the Coc...

This updated meta-analysis was performed to clarify the relationship between phytoestrogens and prostate cancer risk. Twenty one case–control and two cohort studies were finally selected for this meta-analysis, totaling 11,346 cases and 140,177 controls. Analytical results showed that daidzein (OR = 0.85; 95% CI: 0.75–0.96), genistein (OR = 0.87; 9...