Hongjie Zhang

• PhD
• Chinese Academy of Sciences

The treatment of osteosarcoma remains challenging due to limitations of chemotherapy. Anticancer peptides present a promising avenue as alternative therapeutic agents; however, they encounter significant drawbacks, including susceptibility to proteolytic degradation and constrained selectivity toward tumor. Herein, a few‐shot peptide screening stra...

Ru‐based catalysts have exhibited significant promise in converting waste plastics into valuable long‐carbon chain products. However, their efficiency is hindered by the uncontrollable cascade hydrogenation, which stems from their exceptional reactivity for C─C cleavage. Herein, we reported a multi‐scale regulation strategy by selectively anchoring...

A defective CeMn solid solution decorated with palladium single atoms (Pd/CeMn-AR) demonstrating improved methane combustion activity and stability was synthesized via a one-pot auto-redox method.

Ru‐based catalysts have exhibited significant promise in converting waste plastics into valuable long‐carbon chain products. However, their efficiency is hindered by the uncontrollable cascade hydrogenation, which stems from their exceptional reactivity for C‐C cleavage. Herein, we reported a multi‐scale regulation strategy by selectively anchoring...

Lead-free metal halides with low toxicity and great stability have garnered significant interest in the photoelectric fields. Nevertheless, undesirable optical properties caused by parity-forbidden transition restrictions or indirect bandgap characteristics limit the applications of lead-free metal halides. Here, benefiting from the introduction of...

Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations of single‐gas strategies constrain their therapeutic efficacy. Here, a photoresponsive dual‐gas nanomedicine is d...

Cancer is one of the leading causes of death worldwide, making the pursuit of effective treatments to prolong patient survival a major concern in modern medicine. Rare‐earth‐based nanomaterials (RENMs) possess unique optical properties, catalytic properties, and high X‐rays absorption capabilities, offering diverse approaches for cancer therapy. He...

Near‐infrared afterglow luminescent inorganic nanomaterials (NIR‐ALINs) possess the unique property of continuing to emit near‐infrared (NIR) luminescence after excitation ceases. They demonstrate excellent photostability, deep tissue penetration, and high imaging signal‐to‐noise ratio (SNR). Additionally, NIR‐ALINs can be re‐excited in vivo using...

Mo2N catalysts exhibit excellent activity and stability in ammonia decomposition reactions. However, the influence of oxygen on its activity is still unknown. In this work, two γ‐Mo2N catalysts with different oxygen content are synthesized using temperature‐programmed nitridation of α‐MoO3. The γ‐Mo2N catalysts are highly oxidized and their ammonia...

Ammonia decomposition reaction (ADR) has been extensively used to generate clear hydrogen in industry. Despite ruthenium (Ru) being the most active catalyst component for ADR, its exceptionally high price imposes severe limitations on its large‐scale application. Therefore, the development of cost‐effective and robust noble‐metal‐free ADR catalysts...

Meticulous engineering and the yielded hyperelastic performance of structural proteins represent a new frontier in developing next‐generation functional biomaterials. These materials exhibit outstanding and programmable mechanical properties, including elasticity, resilience, toughness, and active biological characteristics, such as degradability a...

Chemical conversion of CO2 is providing an opportunity to mitigate the global warming induced by the overconsumption of fossil fuel. Cu has been regarded as one of the most powerful contenders in catalyzing CO2 conversion, yet the precise manipulation of its surface state and the nearby chemical environment continues to pose a formidable challenge....

Chemical conversion of CO2 is providing an opportunity to mitigate the global warming induced by the overconsumption of fossil fuel. Cu has been regarded as one of the most powerful contenders in catalyzing CO2 conversion, yet the precise manipulation of its surface state and the nearby chemical environment continues to pose a formidable challenge....

In recent years, fluorescent materials centered on the second near-infrared (NIR-II) window have emerged as a new research area of interest for prospective biomedical applications. Among the latest generation of NIR-II probes, rare earth nanocrystals (RE NCs) have distinguished themselves by their remarkable optical properties, such as high stabili...

Phytochlorins, a class of plant‐derived tetrapyrroles, show great potential as sonosensitizers in sonodynamic therapy (SDT). The development of new phytochlorin‐based sonosensitizers has significantly improved SDT, yet the absence of specialized sonodynamic systems limits their clinical translation. Herein, a dedicated ultrasound system along with...

“Reactive oxygen species (ROS) engineering” is one of the most promising anti-tumor treatments developed in recent years. Massive explosion of ROS will cause oxidative stress, thereby inducing tumor cell death. However, ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation strategies. In this work, a kind of endogenou...

The cycloaddition reaction of CO2 with epoxide not only effectively reduces the concentration of CO2 in the atmosphere, but also has excellent industrial application value and up to 100% atom utilization, but there are difficulties in separation and recovery of traditional homogeneous catalysts, harsh reaction conditions of traditional heterogeneou...

Based on the understanding of photothermal catalysis, this review summarizes the recent progress of CeO 2 -based multicomponent catalysts for photothermal catalytic CO 2 reduction.

Optical anti-counterfeiting technology based on the multicolor emission generated by the abundant energy levels of rare earth ions shows great potential in the face of increasing information security problems worldwide....

Converting CO 2 to methanol is crucial for addressing fuel scarcity and mitigating the greenhouse effect. Cu-based catalysts, with their diverse surface states, offer the potential to control reaction pathways and generate reactive H* species. However, a major challenge lies in oxidizing active Cu ⁰ species by water generated during the catalytic p...

The methane dry reforming (DRM) reaction can convert CO2 and CH4, both of which contribute to climate change, into syngas, which holds great significance in mitigating specific environmental issues stemming from the greenhouse effect. Nonetheless, the challenges that persist include the substantial energy consumption and the catalyst’s susceptibili...

Chemical conversion has emerged as an effective approach for disposing waste plastics; however, the product diversity in traditional methods leads to pressing challenges in product separation and purification. As a pioneering advancement, the comprehensive transformation of waste plastics into CH4 presents an attractive prospect: directly yielding...

Combining chemo/photodynamic therapy (CDT/PDT) to generate highly harmful reactive oxygen species and cause mitochondria dysfunction is considered a potential strategy to improve the efficiency of anticancer treatment. However, within tumor, the relatively deficient concentration of H2O2, hypoxic microenvironment, and overexpressed reduced glutathi...

Bagworm silk proteins, which contain crystalline structures with large β‐nanocrystal sizes, are ideal candidates for biosynthetic high‐performance fibers. However, the extremely high glycine content and greater molecular weight limit their heterologous expression efficiency and further application exploration. Here, a multi‐module assembly strategy...

Exploring structural phase transitions and luminescence mechanisms in zero‐dimensional (0D) metal halides poses significant challenges, that are crucial for unlocking the full potential of tunable optical properties and diversifying their functional capabilities. Herein, we have designed two inter‐transformable 0D Cu(I)‐based metal halides, namely...

Sonodynamic therapy (SDT) as a non-invasive antitumor strategy has been widely concerned. However, the rapid electron (e⁻) and hole (h⁺) recombination of traditional inorganic semiconductor sonosensitizers under ultrasonic (US) stimulation greatly limits the production of reactive oxygen species (ROS). Herein, we report a unique Zn/Pt dual-site sin...

The reverse water‐gas shift (RWGS) reaction is significant for the resource utilization of CO2. However, this reaction requires high temperatures and metal catalysts are prone to agglomeration, leading to loss of activity. In this work, a Pt catalyst supported on Mo₂N formed via phase transition and metal reverse sintering under a high‐temperature...

Bacterial infections and excessive oxidative stress seriously hinder the healing of skin wounds. Traditional wound dressings can only serve as physical barriers and lack active molecules essential for actively promoting wound healing. Herein, an antibacterial and antioxidant liquid metal inorganic active material is developed for wound repair throu...

Protein fibers are ideal alternatives to synthetic polymers due to their unique mechanical properties, biocompatibility, and sustainability. However, engineering biomimetic protein fibers with high mechanical properties remains challenging, particularly in mimicking the high molecular weight of natural proteins and regulating their complex hierarch...

Three‐way catalysts (TWC) have been extensively studied and practically applied as a promising approach to mitigate vehicular exhaust emissions. However, the current TWC still suffer from issues such as the poor low‐temperature activity and stability. In this paper, the PdRh‐CeZrCo7 catalyst was synthesized by modifying CeZr solid solution with cob...

Burn wound healing is a dynamic and interconnected process, with the complex status of the extracellular matrix (ECM) potentially leading to bacterial infections, drug resistance, or even fatality. However, it remains a grand challenge to assemble a skin‐like material showing similar biological properties as healthy ECM to accelerate burn healing....

Exploring structural phase transitions and luminescence mechanisms in Zero‐dimensional (0D) metal halides poses significant challenges, that are crucial for unlocking the full potential of tunable optical properties and diversifying their functional capabilities. Herein, we have designed two inter‐transformable 0D Cu(I)‐based metal halides, namely...

Nanocatalytic therapy shows great potential for therapeutic interventions. However, therapeutic efficiency is often limited by unsatisfactory enzyme activity and lack of the coordination of immune system. Therefore, engineering nanozymes activity enhancement while activating immune system will be an effective strategy to achieve efficient tumor the...

Although research on photodynamic therapy (PDT) of malignant tumor has made considerable progress in recent years, it is a remaining challenge to extend PDT to the second near‐infrared window (NIR‐II) along with real‐time and accurate NIR‐II fluorescence imaging to determine drug enrichment status and achieve high treatment efficacy. In this work,...

In the pursuit of next‐generation ultrahigh‐energy‐density Li–O2 batteries, it is imperative to develop an electrolyte with stability against the strong oxidation environments. N,N‐dimethylacetamide (DMA) is a recognized solvent known for its robust resistance to the highly reactive reduced oxygen species, yet its application in Li–O2 batteries has...

Rare earth elements (REEs) are essential raw materials vital for the advancement of modern high-tech industries. However, their extraction often leads to environmental concerns. The similar chemical properties of REEs contribute to high energy consumption and significant pollution emissions during the separation process. To address these challenges...

Traditional anti‐counterfeiting luminescent phosphors are usually composed of single‐mode photoluminescence materials, which greatly limits the security of encryption by its static fluorescent pattern. Herein, multi‐mode luminescence properties are achieved including fluorescence and persistent luminescence (PersL) within single host by co‐doping B...

Lysine‐specific peptide and protein modification strategies are widely used to study charge‐related functions and applications. However, these strategies often result in the loss of the positive charge on lysine, significantly impacting the charge‐related properties of proteins. Herein, we report a strategy to preserve the positive charge and selec...

Nanobodies (Nbs) are one of the most promising therapeutics for overcoming immune escape in various diseases, including SARS‐CoV‐2 infection and cancers. However, the small sizes of nanobodies make them prone to renal clearance, thus decreasing circulation half‐life and hindering therapeutic efficacy. Traditional modification technologies, i.e., bi...

Invasive tumors are difficult to be completely resected in clinical surgery due to the lack of clear resection margins, which greatly increases the risk of postoperative recurrence. However, chemotherapy and radiotherapy as the traditional means of postoperative adjuvant therapy, are limited in postoperative applications, such as multi-drug resista...

The variability of CO2 hydrogenation reaction demands new potential strategies to regulate the fine structure of the catalysts for optimizing the reaction pathways. Herein, we report a dual‐site strategy to boost the catalytic efficiency of CO2‐to‐methanol conversion. A new descriptor, τ, was initially established for screening the promising candid...

The variability of CO 2 hydrogenation reaction demands new potential strategies to regulate the fine structure of the catalysts for optimizing the reaction pathways. Herein, we report a dual‐site strategy to boost the catalytic efficiency of CO 2 ‐to‐methanol conversion. A new descriptor, τ , was initially established for screening the promising ca...

Three‐way catalysts are widely used to control criterion pollutant emissions from the increasing gasoline engines. With the stringent requirements of automotive pollutant emission standards in various countries, Rh has become an irreplaceable component of three‐way catalysts due to its superior NOx elimination, high N2 selectivity, and simultaneous...

Establishing efficient CO2 hydrogenation technology based on the reverse water-gas shift (RWGS) reaction can effectively alleviate environmental problems while providing high-value-added products. The development of suitable advanced supports is the key to improving the catalytic activity and selectivity. Herein, we designed and synthesized a new t...

The chemical upcycling method is a promising strategy to alleviate the pollution problem of waste plastics by tapping into their intrinsic value and converting them into high value-added products. Zeolite-based catalysts are one of the surprising and efficient classes of thermocatalytic materials that have recently attracted considerable attention...

Near‐infrared (NIR) phosphors have been widely used in biomedical applications based on their deep tissue penetration. However, the lack of blue‐pumped NIR phosphors with emission ranges beyond 1000 nm has greatly limited the development of NIR phosphor‐converted light‐emitting diodes (pc‐LEDs). Herein, a facile way to boost the luminescence effici...

Lysine‐specific peptide and protein modification strategies are widely used to study charge‐related functions and applications. However, these strategies often result in the loss of the positive charge on lysine, significantly impacting the charge‐related properties of proteins. Herein, we report a strategy to preserve the positive charge and selec...

Lithium-oxygen (Li-O2) batteries have been regarded as an expectant successor for next-generation energy storage systems owing to their ultra-high theoretical energy density. However, the comprehensive properties of the commonly utilized organic salt electrolyte are still unsatisfactory, not to mention their expensive prices, which seriously hinder...

A defect-rich hollow Schottky heterojunction sonosensitizer, constructed by defect engineering and noble metal enrichment, exhibits an amplified treatment effect for sonodynamic therapy due to the inhibition effect of electron–hole pair recombination.

Ferroptosis induction is an emerging strategy for tumor therapy. Reactive oxygen species (ROS) can induce ferroptosis but are easily consumed by overexpressed glutathione (GSH) in tumor cells. Therefore, achieving a large amount of ROS production in tumor cells without being consumed is key to efficiently inducing ferroptosis. In this study, a self...

One-pot tandem catalysis has been regarded as one of the most atomic economic ways to produce secondary amines, the important platform molecules for chemical synthesis and pharmaceutical manufacture, but it is facing serious issues in overall efficiency. New promotional effects are highly desired for boosting the activity and regulating the selecti...

Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant tumors. Photodynamic therapy (PDT) is an emerging treatment modality, and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enh...

Cell mechanotransduction signals are important targets for physical therapy. However, current physiotherapy heavily relies on ultrasound, which is generated by high‐power equipment or amplified by auxiliary drugs, potentially causing undesired side effects. To address current limitations, a robotic actuation‐mediated therapy is developed that utili...

Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 and pyruvate oxidase (POx)‐co‐loaded Cu‐NS single‐atom nanozyme (Cu‐NS@UK@POx), that not only trigger pyroptosis through cascade biocat...

Zeolite-based catalyst hydrocracking of plastics is a potential strategy for mitigating the environmental impacts of plastic wastes and recycling valuable resources, but difficult mass transfer, low concentration of acid sites, and high cost are still barriers to their practical applications. In this paper, we report an excellent hydrocracking cata...

Understanding the synergism between the metal site and acid site is of great significance in boosting the efficiency of bi‐functional catalysts in many heterogeneous reactions, particularly in biomass upgrading. Herein, a “confined auto‐redox” strategy is reported to fix CeO2‐anchored Pt atoms on the inner wall of a ZSM‐5 cage, achieving the target...

The near‐infrared (NIR) persistent luminescence (PersL) materials have attracted widespread attention owing to the unique self‐sustained light with good penetrability. Currently, most of the reported NIR PersL materials are activated by Cr³⁺. Considering the potential toxicity of chromium ions, there is an urgent requirement to explore the Cr³⁺‐fre...

Engineered protein fibers are promising biomaterials with diverse applications due to their tunable protein structure and outstanding mechanical properties. However, it remains challenging at the molecular level to achieve satisfied mechanical properties and environmental tolerance simultaneously, especially under extreme acid conditions. Herein, t...

Synthetic spidroin fibers have not yet attained the same level of toughness and stability as natural spider silks due to the complexity of composition and hierarchical structure. Particularly, understanding the intricate interactions between spidroin components in spider fiber is still elusive. Herein, we report modular design and preparation of sp...

Pyroptosis is an effective anti‐tumor strategy. However, monometallic pyroptosis biotuners have not been explored until now. Here, we discover for the first time that biodegradable monometallic Al can act as a pyroptosis biotuner for tumor therapy. pH‐sensitive Al nanoparticles (Al@P) are obtained by equipping polyethylene glycol‐b‐(poly(methyl met...

Synthetic spidroin fibers have not yet attained the same level of toughness and stability as natural spider silks due to the complexity of composition and hierarchical structure. Particularly, understanding the intricate interactions between spidroin components in spider fiber is still elusive. Herein, we report modular design and preparation of sp...

CO gas therapy has attracted enormous attention in tumor therapy due to the abilities of mitochondrial damage and inhibition of cellular respiration. However, the inefficient and random release of CO greatly limit its application. Taking this into account, the study constructs an acid‐unlocked nanostructure based on MPDA‐MnCO‐GOx@DSNPs, designated...