Hongbing Deng

Hongbing Deng
Wuhan University | WHU · School of Resources and Environmental Science

Dr

About

150
Publications
15,511
Reads
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5,481
Citations
Introduction
Skills and Expertise
Additional affiliations
November 2012 - present
Wuhan University
Position
  • Professor (Associate)
October 2010 - November 2012
Huazhong Agricultural University
Position
  • Lecturer

Publications

Publications (150)
Article
Full-text available
Electrical signal controlled drug release from polymeric drug delivery system provides an efficient way for accurate and demandable drug release. In this work, insulin was loaded on inorganic nanoplates (layered double hydroxides, LDHs) and coated on a copper wire by co‐electrodeposition with chitosan. The formed structure in chitosan composite hyd...
Article
To meet the requirement of personalization, there is an urgent need to develop a simple, efficient and versatile manufacturing method for customized contact lens manufabrication. Here, we report a novel electrofabrication methodology (i.e., electrodeposition) for the fabrication of hydrogel contact lenses, which can induce covalent cross-linking be...
Article
The discovery of facile methods to create complex lamellar structures in hydrogels, which mimic the exquisite structures in nature, remains a great challenge. In this work, an ordered lamellar structured hydrogel from the stimuli-responsive amino-polysaccharide chitosan is fabricated by an electro-assembly process, during which the diffusion of OH-...
Article
Immunoglobulin Y (IgY) proves advantageous to IgG in prophylaxis and diagnosis. Quantification of IgY is therefore becoming a topic of interest. Here, we demonstrate a piezoelectric biosensor with carboxymethyl chitosan (CMCS) as the immobilization matrix. Gelation and hydrophilic nature of CMCS are favored to form a crosslinked matrix for antibody...
Article
Full-text available
Due to mechanical instability, surface wrinkles form spontaneously in plants, animals and human beings for propagation and enhanced surface functionality. However, there remains tremendous challenge in mimicking such exquisite structure at a micro/nanoscale in lab. Herein, we report an approach to converting an electrodeposited chitosan hydrogel fi...
Article
Solar desalination has been recognized as an emerging strategy for solving the pressing global freshwater crisis. However, salt crystallization at the photothermal interface frequently causes evaporator failure. In addition, arbitrary discharge of concentrated brine produced during desalination results in potential ecological impacts as well as was...
Article
Hydrophilic-hydrophobic Janus chitosan coating was facilely fabricated by one-step electrodeposition in HCl/ethanol solvent. The face of chitosan coating attached to the electrode demonstrates a compact structure while the other face away from the electrode demonstrates a porous structure, which endows the chitosan coating asymmetric wettability. T...
Article
An innovative formaldehyde sensor based on CuO/ZnO composite nanofibrous mats (C-NFMs) coated quartz crystal microbalance (QCM), which is capable of stable determination of formaldehyde gas at ambient temperatures sensitively and selectively, has been successfully fabricated. Triaxial and highly porous C-NFMs with high surface area (126.53 m² g⁻¹)...
Article
In recent years, nanoparticles (NPs) derived from the self-assembly of natural polysaccharides have shown great potential in the biomedical field. Here, we described several self-assembly modes of natural polysaccharides in detail, summarized the natural polysaccharides mostly used for self-assembly, and provided insights into the current applicati...
Article
Inspired by the gradient hygroscopic structure of carrotwood seed pod, patterned anisotropic structure was created in polysaccharide hydrogel by an anodic electrical writing process. Locally released Fe²⁺ was oxidized to Fe³⁺ and chelated with chitosan chains in the written area, resulting in a gradient structure in the hydrogel. The asymmetrical s...
Article
TiO2 based photocatalyst with sufficient reusability for the degradation of water pollutants remains a challenge. Here, we report a composite chitosan-based aerogel containing TiO2 nanoparticles, multiwalled carbon nanotubes and layered silicate rectorite with sufficient mechanical strength for Rhodamine B degradation. The aerogel with homogeneous...
Article
Pelvic floor dysfunction (PFD) is a common gynecological problem that affects millions of women. Current treatment strategies are to restore the normal anatomical structure by non-operative procedures (such as pelvic floor myoelectric stimulation) or surgery (such as vaginal mesh implantation). Although vaginal meshes can provide effective, long-te...
Article
The anthropogenic release of highly toxic heavy metals into the environment presents a huge challenge for ecosystems and human society. Recoverable and efficient adsorption materials could be obtained by trapping inorganic adsorbents (e.g., TiO2 nanoparticles and rectorite (REC)), in a natural polymer matrix. In this study, a series of cellulose-Ti...
Article
Developing novel, lightweight and biocompatible mesh for pelvic organ prolapse, a gynecological disease, has attracted the global interest of biomedical researchers. In our study, polycaprolactone and nylon 6 mats with excellent mechanical properties were fabricated via co-electrospinning. Positively charged chitosan with antimicrobial properties a...
Article
Various materials are utilized as artificial substitutes for bone repair. In this study, a silk fibroin (SF) hydrogel reinforced by short silica nanoparticles (SiNPs)‐distributed‐silk fibroin nanofibers (SiNPs@NFs), which exhibits a superior osteoinductive property, is fabricated for treating bone defects. SF acts as the base part of the composite...
Article
In order to highly simulate the chondrocyte extracellular matrix, electrospinning and layer-by-layer (LBL) self-assembly techniques were applied in this study. Polycaprolactone (PCL) with good mechanical property was selected as the substrate, while D-glucosamine sulfate (GAS) and collagen type I (COL) with chondroprotective properties were coated...
Article
Layer-by-layer self-assembly (LBL) is an effective method to prepare potential biomaterial with multilayer coatings, and few reports have focused on the variation of oriented microstructure during LBL process. In this study, polycaprolactone (PCL) and type І collagen (COL) were electrospun to oriented nanofibrous mats, and chitosan (CS) and COL mol...
Article
Full-text available
In this study, we report the fabrication of nitrogen rich activated nanosized carbon with hierarchical micro/mesoporous and ultrahigh specific surface area by template-free and one-step carbonization-activation method, which greatly simplified the process and avoided the waste of reagents. Chitin nanoparticles were prepared by a mechanical induced...
Article
Repair of cartilage legions remains a big challenge for clinicians due to the limit self-regeneration ability of cartilage. A SF-based scaffold that reinforced by the SF–chitin hybrid nanofibers and impregnated with TGF-β1 is developed to mimic extracellular matrix and facilitate cartilage regeneration. The composite scaffold with an excellent bioc...
Article
Efficient, convenient, economical and environmentally friendly materials have always been the first choice for solving environmental problems. In this work, stable carbonized and ordered hollow nanofiber aerogels were obtained under the action of directional freezing and calcination. The benzoxazine monomer (BA) in the nanofiber was polymerized in...
Article
Osteomyelitis is a complex disease in orthopedics mainly caused by bacterial pathogens invading bone or bone marrow. The treatment of osteomyelitis is highly difficult and it is a major challenge in orthopedic surgery. The long-term systemic use of antibiotics may lead to antibiotic resistance and has limited effects on eradicating local biofilms....
Article
Full-text available
The emerging solar desalination technology is considered as one of the most promising strategies to ensure water security. However, with the proceeding of solar desalination, salt crystallization on the surface of solar evaporators caused by increasing salinity of seawater will result in a decrease in the evaporation rate. Thus, it is still challen...
Article
Full-text available
The ability to pattern and actuate hydrogels is essential for biomimetics, soft robotics, and biosensors. Here an electrical writing technique with the capability to create both surface and across thickness patterns in dynamic chitosan‐H+/agarose hydrogel by electronically generated pH gradient is introduced. The diffusible pH cues deprotonate and...
Article
Full-text available
Periosteum provides nourishment to bones and facilitates osteogenesis. The structural and functional impairment of periosteum can cause bone regeneration difficulties. Artificial periosteum with suitable mechanical properties and chemical composition can effectively guide bone tissue regeneration. In this study, a polycaprolactone (PCL)/carboxymeth...
Article
Full-text available
Bone tissue engineering has become one of the most effective methods for treating bone defects. In this study, an electrospun tissue engineering membrane containing magnesium was successfully fabricated by incorporating magnesium oxide (MgO) nanoparticles into silk fibroin and polycaprolactone (SF/PCL)-blend scaffolds. The release kinetics of Mg²⁺...
Article
Biological meshes have always posed a challenge in biological medicine, for which nanocomposites with enhanced biocompatibility and mechanical properties may be beneficial. In this study, lysozyme (LY) and collagen (Col) were alternately deposited on silk fibroin (SF) and nylon 6 (N6) composite nanofibrous mats using a layer-by-layer (LBL) self-ass...
Article
Adenosine (Ade) has been identified to stimulate bone formation. However, the use of Ade is severely limited by the accompanying side effects and its very short half-life in vivo. This study aimed to fabricate an efficient drug-delivery system to reduce the undesirable side effects and enable the clinical application of Ade for treating large bone...
Article
Chitin is the second abundant natural polysaccharide, and the development of chitin and its derivatives have received more and more attention. Glucosamine sulfate (GAS) obtained by the hydrolysis of chitin can promote the growth of chondrocytes. The coaxial electrospinning technology had been utilized to encapsulated GAS into the core of polycaprol...
Article
Promoting bone regeneration and repairing defects are urgent and critical challenges in orthopedic clinical practice. Research on bone substitute biomaterials is essential for improving the treatment strategies for bone regeneration. Chitin and its derivative, chitosan, are among the most abundant natural biomaterials and widely found in the shells...
Article
Full-text available
Developing an ideal wound dressing material which could accelerate wound closure and achieve scarless wound healing was the ultimate goal of numerous researchers. In this study, biomimetic silk fibroin (SF)/polycaprolactone (PCL) matrices were fabricated via co-electrospinning and positively charged chitosan (CS) and negatively charged type I colla...
Article
The construction of polymeric nanocomponents into hierarchical structure poses great importance for subsequent biomedical applications. Herein, we report for the first time the electro-assembly of chitin nanoparticles (14 nm ± 3 nm from TEM) to construct thick and free-standing hydrogel, which can be further dried to obtain high porous and tough ae...
Article
Treatment of massive bone defects are still a significant challenge to orthopedists. Here, we have engineered synthetic porous AuPd alloy nanoparticles (pAuPds) as hyperthermia agent for in situ bone regeneration through photothermal therapy (PTT). After being swallowed by cells, pAuPds produced a mild localized heat (MLH) (40~43 °C) under the irra...
Article
The research and development of environmentally friendly and nontoxic biomass products has become an important topic of worldwide concern. In this study, natural materials were used for producing a kind of antibacterial mats. Cellulose acetate (CA) mats prepared by electrospinning technology were converted to cellulose mats via alkali hydrolysis. C...
Article
The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth factors which are expressed in a coordinated cascade of events. The aim of this study was to create a dual growth factor-release system that allows for time-controlled release to facilitate bone regeneration. We fabricated core-shell SF/PCL/PVA nanofibrous mats us...
Article
As medical practitioners' interest in hydrogels continues to grow, their new expectations in terms of mechanical properties, biocompatibility and durability are changed. Here, we demonstrated a new strategy to improve both mechanical properties and self-recovery of double network (DN) hydrogels by introducing a self-healing network, consisting of c...
Article
TiO2, as a kind of traditional photocatalytic material, has been widely used in wastewater treatments due to its cost-efficiency, high stability and low toxicity. However, it could hardly be reused and might lead to secondary pollution. In the study, porous electrospun polycaprolactone (PCL) fibrous mats were used as carriers for the capacity and d...
Article
The antibacterial materials with biodegradable and biocompatible nature have unveiled novel prospects to combat the bacterial infection, which has always been a troubling and challenging issue in the biomedical field. In this study, chitosan (CS) and Titanium dioxide (TiO2) microparticles were well immobilized on polylactic acid (PLA) mats by elect...
Article
Novel antimicrobials with well biocompatibility are urgently needed for human public health protecting. Here, the silk fibroin (SF) nanofibrous mats coated with carboxymethyl chitosan (CMC), both extracted from natural polymers, were fabricated by combining electrospinning and electrostatic layer-by-layer (LBL) self-assembly techniques. The amphote...
Article
To expand the template options of immersive electrostatic layer-by-layer self-assembly (LBL), which requires hydrophilic and protonation substrates, an environmentally friendly and simple plasma pretreatment that enhances the surface charge and wettability of superhydrophobic mats is employed to effectively assist LBL. With positively and negativel...
Article
Natural-based nanocomposites are competitive and promising materials for biomedical applications due to their biocompatibility. Herein, a novel natural-based composite was fabricated by alternately depositing lysozyme (LY) and albumin egg (AE) on electrospun cellulose nanofibrous mats via layer-by-layer self-assembly (LBL) technology. To indicate t...
Article
Full-text available
The development of physical approaches and green technologies to construct novel chitin materials is essential for exquisite utilization of the renewable and valuable resource of chitin. In the present study, chitin nanogels were simply fabricated from chitin solution dissolved in 8% NaOH/4% urea aqueous solvent by high speed stirring. The mechanic...
Article
Oily wastewater is a worldwide problem threatening the environment and humans. High flux and low-energy consumption separation of oil and water is urgently required but still faces great challenges. In this study, nanofibrous membranes with superhydrophilic and underwater superoleophobic surfaces were fabricated by grafting acrylic acid onto plasma...
Article
Pelvic floor dysfunction diseases (PFD) become more prevalent with the increase of elderly population, and complications of pelvic floor reconstructive surgery (e.g. infection and exposure of mesh) have been troubling to patients and gynecologists. In this study, the nanofibrous mats were prepared by alternately depositing chitosan (CS) and silk fi...
Article
Natural polymer cellulose acetate (CA) and natural rectorite (REC) were employed to fabricate nanofibrous mats and then immobilized with biosorbent saccharomyces cerevisiae (SCV) to construct a sandwich-like structure. The hydroxyl and carbonyl groups in the CA endowed the nanofibrous mats with a strong affinity for removing heavy metals, allowing...
Article
Full-text available
Historically, paper is the medium to write information. Here, the concept of writing is expanded from the addition of mass (i.e., ink) onto a static polysaccharide medium (i.e., paper), to the addition of electrical energy to a dynamically reconfigurable polysaccharide medium. Specifically, a dual‐responsive interpenetrating polysaccharide network...
Article
Full-text available
Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair has emerged as a potential regenerative strategy for MI. This study aimed to design a cardiac patch to improve the retention of the engrafted stem cells and pro...
Article
Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility and the favorable capability of enhancing attachment, proliferation and differentiation of chondrocytes. These properties make it suitable for the fabrication of scaffold and a broad range of silk fibroin-based biomaterials for cart...
Article
In this study, a series of hydroxypropyl chitosan (HPCS)/soy protein isolate (SPI) composite films (HCSFs) with different SPI contents were developed via crosslinking, solution casting, and evaporation process. Effects of the SPI content on the structure and physical properties of the HCSFs were characterized by Fourier transform infrared spectrosc...
Article
Seafood wastes contain important bioactive polysaccharides that are good candidates for food additives. In this work, cellulose was isolated from the waste of brown algae (BA) after alginate extraction and was demonstrated to be cellulose I with a weight-average molecular weight (Mw) of 2.69 × 10⁵. The results of scanning electron microscope (SEM)...
Article
Platelet-rich plasma (PRP) is used in therapy for bone tissue repair because an abundance of osteogenesis-related growth factors can be released from the concentrated platelets. However, its clinical use is limited because growth factors, temporally released from PRP, are degraded rapidly. This study aimed to incorporate PRP-derived growth factors...
Article
Injectable polymethylmethacrylate (PMMA) bone cement is alluring because it allows a minimally invasive surgical approach, reducing both the cost of treatment and patient discomfort. However, several documented drawbacks have necessitated the design of a more versatile version with adorable properties for future application. In this study, to amend...
Article
The search for biodegradable and biocompatible materials applied to the antibacterial field has become a significant topic of interest worldwide. In this study, the electrospinning and electrostatic layer-by-layer self-assembly (LBL) techniques were applied to achieve composite mats with enhanced physical and biological properties. Electrospun silk...
Article
In this study, ethylene glycol diglycidyl ether (EGDE)-crosslinked hydroxyethyl cellulose (HEC)/soy protein isolate (SPI) composite sponges (EDHSS) were constructed by the combination of blending, crosslinking and freeze-drying. The sponges were characterized by FTIR, wide-angle X-ray diffraction (XRD), solid-state ¹³C NMR, scanning electron micros...
Article
Various composite materials are now used as artificial tissue substitutes, and are defining new frontiers in tissue engineering. In the present study, composite membranes based on silk fibroin (SF) were fabricated to form a synthetic periosteum. The fabricated membranes were physicochemically characterized by their morphology, porosity, biocompatib...
Article
Chitosan (CS) has a high amine group content, while polyacrylonitrile (PAN) contains cyano-groups that can be easily converted to amine groups. Herein, a novel adsorbent consisting of PAN-CS mats was successfully prepared via the shoulder-to-shoulder electrospinning and electrospraying techniques, which could eliminate the obstacle of selecting a c...
Article
A self-healable hydrogel with recoverable self-healing and mechanical properties is reported. The hydrogel (coded as ACSH) crosslinked by Schiff base linkage contains two polysaccharides of acrylamide-modified chitosan (AMCS) and oxidized alginate (ADA). Self-healing and mechanical properties are heavily influenced by the crosslinking time. The hyd...
Article
In this study, we report the electrodeposition of a chitosan/layered double hydroxides (LDHs) hydro-membrane for protein release triggered by an electrical signal. The electrodeposition was performed in a chitosan and insulin loaded LDHs suspension in the absence of salt. A free-standing chitosan/LDHs hydro-membrane was generated on the electrode w...
Article
Chitosan (CS), as a kind of well characterized biopolymer, has been used for heavy metal adsorption due to its low cost and high efficacy. However, when used directly, chitosan particles had small surface area and weak mechanical strength which is unfavorable to metal adsorption and reused. Besides, it cannot be easily recycled that may cause a sec...
Article
In order to understand the chemical structure of chitin-based acrylate superabsorbent polymers (SAP), chitin was dissolved in NaOH aqueous solution via freezing-thawing cyclic treatment without urea, subsequently, a transparent hydrogel was prepared by copolymerizing the alkali-chitin solution and acrylic acid directly. The effects of the degree of...
Article
A series of ultrafine polyvinyl alcohol (PVA)/graphene oxide (GO) nanofibrous scaffolds (PGNSs) with different GO content (0, 0.25, 0.5, and 1.0%) was fabricated via an electrospinning process. The morphology, composition, mechanical behavior, surface wettability and protein adsorptivity of these scaffolds were investigated. The results showed that...
Article
Search for cost-effective and high-strength dye adsorbents has become an urgent problem in wastewater treatment. Natural polymers such as chitosan and cellulose are low-cost and can be fabricated as hydrogels for dye adsorption, but these hydrogels usually have weak strength. Here, novel high-strength and highly cost-effective hydrogels with a high...
Article
The demand for designing antibacterial materials was quite substantial in packing and biomedical materials fields. Chitosan had a wide utilization to satisfy this demand. In this study, by incorporating lysozyme (LY) − rectorite (REC) into chitosan films, the ultimately obtained hybrid films can own the enhanced antibacterial properties and still r...