Hong-Duo Chen

Alopecia is considered a widespread yet troubling health issue, with limited treatment options. As membranous structures derived from cells carrying proteins, nucleic acids and lipids, exosomes functionally medicate intercellular communication and alter the responses of recipient cells, resulting in disease restraint or promotion. Exosomes have bro...

Background The adhesive properties of vitiligo melanocytes have decreased under oxidative stress., cytoskeleton proteins can control cell adhesion. Paeoniflorin (PF) was proved to resist hydrogen peroxide (H2O2)-induced oxidative stress in melanocytes via nuclear factorE2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Objectives This stu...

The present review was conducted to investigate the possibilities in realizing novel nanostructured tissues containing functional molecules that can be commercialized as solid products (without using emulsifiers and preservatives) for cosmeceutical and nutraceutical applications. After considering the principal concepts regarding skin and mucous fe...

Background Fractional carbon dioxide (CO2) laser has been considered to be an add-on to conventional treatments of vitiligo. Objective: This study aimed to evaluate the optimal energy and density of the fractional CO2 laser system in stable non-segmental vitiligo (NSV) patients. Method: 48 patients were treated with fractional CO2 laser and sequent...

Macrophages, which serve as a bridge between innate and adaptive immunity, play an important role in sporotrichosis. Sporothrix schenckii infections can produce immune responses such as macrophage polarization and inflammatory factor secretion. In the early stages of inflammation, the expression of DAB2 in macrophages is increased, which controls t...

Carotenoids protect organs, tissues, and cells from the damaging action of singlet oxygen, oxygen radicals, and lipid peroxides. This systematic review was sought to evaluate the influence of oral carotenoids on antioxidant/oxidative markers, blood carotenoids levels, and lipid/lipoprotein parameters in human subjects. A comprehensive review of rel...

Approximately 75% of textile waste is generated annually worldwide, as there is a dearth of viable recycling strategies. It has been estimated that textile industries can be responsible for approximately 20% of global water pollution. As a consequence, if not properly managed, the cost of waste management of textile waste will be trillions of dolla...

Background: Most plane warts are recalcitrant to treatment. Both cryotherapy and local hyperthermia have been applied to treat plane warts. However, no direct comparative study on their respective efficacy and safety has ever been performed. Objective: To assess the efficacy and safety of local hyperthermia at 43±1°C versus liquid nitrogen cryot...

Approximately 75% of textile waste is generated annually worldwide, as there is a dearth of viable recycling strategies. It has been estimated that textile industries can be responsible for approximately 20% of global water pollution. As a consequence, if not properly managed, the cost of waste management of textile waste will be trillions of dolla...

Background Actinic keratosis (AK) is a precancerous disease, caused by ultraviolet radiation (UV). Objective To analyze the clinical and pathological characteristics of AK in four areas with different ultraviolet radiation intensities. Methods 1188 diagnosed AK patients, from January 2000 to July 2015, in dermatology department of four hospitals...

Objective To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO2 laser system (AFL) treating skin photoaging. Methods Thirty-two subjects were assigned to the treatment group (TG) or the control group (CG), respectively, applied test product (resveratrol essence) or control product twice daily for 6 months. Each s...

This study is to determine the role of the fractional CO2 laser in topical drug delivery and the impact of local immune responses. Experimental rabbit nails were treated with fractionated CO2 laser at varied fluencies of 20 mJ, 25 mJ, and 30 mJ and half of which were coated with rhodamine B (RhB). Histological examination was performed by hematoxyl...

Pomegranate extract (PE) and its polyphenols have been reported to show skin protective effects but their cytoprotective effects against methylglyoxal (MGO)-induced DNA damage and cell dysfunctions are unclear. Herein, we evaluated whether PE, punicalagin (PA), ellagic acid (EA), and urolithin A (UA), can alleviate MGO-induced DNA damage in human k...

Beauty and wellness remain for both women and men an important target also because global attractiveness is considered a cue indicating the ability to maintain beauty and wellness. Consequently neuromarketing has occurred as an innovative mean to interact with consumer's trend, actually looking for high-quality and natural cosmetics and food. By th...

Background Rosacea is a chronic inflammatory skin disease whose psychological consequences severely affect patient’s quality of life. Objective To identify candidate genes of rosacea for potential development of new target therapies. Methods Gene Expression Omnibus datasets were retrieved to obtain differentially expressed genes (DEGs) between ro...

Background: Persistent infection by high risk human papillomavirus (HPV) is the leading cause of cervical intraepithelial neoplasia and cervical carcinoma. Local hyperthermia at 44ºC has been proven efficacious to clear cutaneous or anogenital warts caused by HPV infection. This study aims to assess the effect of hyperthermia at 44ºC on the cleara...

Background Pemphigus is a rare but life-threatening autoimmune skin disease characterized by blistering on skin and/or mucous membranes. The physiological process of blister formation involves IgG antibodies against the desmogleins (Dsgs) and desmocollins (Dscs). Additional autoAbs have also been suggested to mediate the disease heterogeneity, such...

Background There is an increasing demand for fat reduction and body contouring procedures. Noninvasive radiofrequency devices have been used to tighten skin and treat cellulite, but there are few studies confirming their efficacy for abdominal fat reduction. Objective This study explored the effects of four noninvasive radiofrequency (RF) treatmen...

Subcutaneous panniculitis‐like T cell lymphoma (SPTCL) is an extremely rare subtype of primary cutaneous T cell lymphomas mimicking panniculitis. Clinically, patients are usually presented with subcutaneous nodules, which usually leads to initial misdiagnosis as a benign cutaneous condition. Here, we report a 40‐year‐old female who presented with s...

Healing after mammalian skin injury involves the interaction between numerous cellular constituents and regulatory factors, which together form three overlapping phases: an inflammatory response, a proliferation phase and a remodelling phase. Any slight variation in these three stages can substantially alter the healing process and resultant produc...

Background. Hyperthermia in combination with DnaJA4-knockout (KO) obviously affects the anti-viral immunity of HaCaT cells. The mechanisms of this process are not yet fully explored. However, it is known that DnaJA4 interacts with actin cytoskeleton after hyperthermia. Our aim was to investigate the effects of DnaJA4 on F-actin in HaCaT cells follo...

Both SIRT1 and UVA radiation are involved in cellular damage processes such as apoptosis, senescence and ageing. MicroRNAs (miRNAs) have been reported to be closely related to UV radiation, as well as to SIRT1. In this study, we investigated the connections among SIRT1, UVA and miRNA in human skin primary fibroblasts. Our results showed that UVA al...

Background Infraorbital dark circles (DC) are defined as a symptom that presents darkness under infraorbital eyelids. The objective of this study was to evaluate the efficacy and safety of nano‐microneedle‐assisted phenylethyl resorcinol (PR) for the treatment of infraorbital dark circles. Methods Twenty female participants were randomized to two...

Background: Human papillomaviruses (HPVs), a group of non-enveloped small viruses with double-stranded circular DNA which lead to multiple skin diseases such as benign warts, are commonly seen in clinics. The current HPV detection systems aim mainly at mucosal HPVs, however, an efficient clinical approach for cutaneous HPVs detection is lacking....

Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) controls; ii) IL18 knockout (KO) contr...

Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in the regulation of oxidative st...

Introduction Reactive carbonyl species including methylglyoxal (MGO) are oxidation metabolites of glucose and precursors of advanced glycation end products (AGEs). They are important mediators of cellular oxidative stress and exacerbate skin complications. Published data supports that certain phenolic compounds can exert cellular protective effects...

Paeoniflorin (PF) possesses multiple biological functions including anti-oxidization. PF is the major bioactive ingredient of total glycosides of paeony (TGP), which could promote re-pigmentation of vitiligo. The study was sought to investigate the effects and potential signaling pathways of PF on hydrogen peroxide (H2O2)-induced oxidative stress i...

Background Hyperthermia up‐regulates DNAJA4, a member of heat shock proteins (HSPs) 40 family, in human keratinocytes and HPV infected tissue. DNAJA4 deficiency enhances grow arrest induced by hyperthermia. Clusterin (CLU) and phosphorylated ERK (p‐ERK) play a role in regulating cell proliferation and apoptosis, under environmental stress. Objecti...

通过对比新型模具包埋方法与传统包埋方法，观察新型模具包埋方法在低温冷冻组织包埋存储方面如：操作时间、OCT包埋剂使用量、样本体积、样本查找难易程度、空间占用量的效果，证实新型模具设备及包埋方法在低温冷冻组织包埋中的实用价值。.

The continuous degradation and depletion of the planet’ natural raw materials with the increasing production and consume of nonbiodegradable plastics, used as packaging material for cosmetics also, are stimulating the growth of the so-called green movement of consumers who are finding more economic and sustainable products respective of environment...

Bacterial infection is a common wound complication that can significantly delay healing. Classical local therapies for infected wounds are expensive and are frequently ineffective. One alternative therapy is photodynamic therapy (PDT). We conducted a systematic review to clarify whether PDT is useful for bacteria‐infected wounds in animal models. P...

Background: The application of fractional Q-switched ruby laser (FQSRL) or intense pulsed light (IPL) on Café-au-lait macule (CALM) is rational and the data are lacking. Objective: To evaluate the efficacy and safety of FQSRL and IPL in CALM. Methods: The patients with CALM who were treated with FQSRL or IPL were retrospectively observed from April...

Background Cutaneous melanoma (CM) is the deadliest form of skin cancer. Numerous studies have revealed that microRNAs (miRNAs) are expressed abnormally in melanoma tissues. Our work aimed to assess multiple miRNAs using bioinformatic analysis in order to predict the prognoses of cutaneous melanoma patients. Methods The microarray dataset GSE35579...

The mask, formulated as cream, ointment, lotion, serum, or sheet, is just a vehicle that delivers "actives" to the skin with the main scope to quickly improve its appearance and quality. This category of cosmetics, packed in different ways and by different materials, is selected according to skin type, so that for example clay and mud masks suit oi...

Background: Striae gravidarum is a common skin condition resulting after pregnancy, caused by fibroblast dysfunction. Although not considered a disease, it may be considered cosmetically unpleasant to sufferers and remains as a therapeutic challenge to date. Objective: To evaluate the efficacy and safety of a sublative bipolar fractional radiofr...

In this study, the anti-inflammatory mechanisms of Quercetin (Que) on atopic dermatitis (AD)-like skin lesions was examined. The left ear of mice was applied with MC903, followed by Que. administration daily on the ear for 8 days. Then macroscopic and histologic examination was performed to detect the severity of skin lesions. In the skin section o...

Candida albicans is a commensal fungus that associates with human hosts. Under normal circumstances this interaction does not produce any severe life-threatening disease, as macrophages of the innate immune system will result in its clearance. However, disorders may arise in immunosuppressed individuals. To understand the bioactivity of Candida alb...

The cover image is based on the Special Issue Article Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome by Ming‐Han Mu et al., https://doi.org/10.1111/dth.12815. Cover design credit: Rui‐Qun Qi. Photo credit: Min‐Han Mu and Yi‐Ning Wang. Institution credit: The First Hospital of China Medical University.

Pomegranate phenolics have been reported to exert skin beneficial effects but their mechanisms of action remain unclear. Herein, we investigated a standardized commercial pomegranate extract (PE; Pomella®) and its phenolics including punicalagin (PA), ellagic acid (EA), and urolithin A (UA) for their protective effects against hydrogen peroxide (H2...

Background: Large-scale retrospective studies of light/laser in treating nasal rosacea were lacking. Objective: The study was aimed to perform a decade retrospection of the patients with nasal rosacea who were treated with light/laser devices. Methods: A study between 2008 and 2017 was performed retrospectively. Categorization of rosacea type...

Background:. As a potent pro-inflammatory cytokine of the interleukin (IL)-1 family, IL-18 was elevated in early active and progressive plaque-type psoriatic lesions and that serum or plasma levels of IL-18 correlated with the Psoriasis Area and Severity Index (PASI). Although results from previous studies have established that IL-18 may aggravate...

A female Cushing's syndrome patient had been suffering from extensive viral warts for months. She was diagnosed with flat warts, common warts and plantar warts. The plantar warts on her right foot were initially treated using local hyperthermia at 44°C for 30 minutes according to a defined protocol, followed by treatment targeting a common wart on...

Background: Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. Purpose: To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. Method: The PubMed, Cochrane Library, EMBASE, CNKI (China Nation...

Background Extramammary Paget’s disease (EMPD), a rare skin malignancy with non-specific manifestations, is often misdiagnosed as eczema of scrotum or tinea cruris. Although the diagnosis of EMPD could be confirmed by biopsy, it can be delayed as patients are reluctant to receive invasive operations. Herein, we investigated the serum miRNA expressi...

Background Dissecting cellulitis of the scalp (DCS) is difficult to be treated and 5‐aminolaevulinic acid photodynamic therapy (ALA‐PDT) is considered to be a potential treatment for inflammatory skin diseases. Objective To analyze the efficacy and safety of ALA‐PDT on DCS. Materials and Methods The treatment areas of DCS patients were incubated...

Abstract is missing (Short communication)

Objectives: To explore potential effects of recombinant human fibroblast growth factor 20 (rhFGF20) in the growth of cultured mouse vibrissal follicles. Results: The growth of cultured mouse vibrissal follicles was significantly induced by rhFGF20 in a dose dependent pattern in the in vitro vibrissal follicle organ culture model. However, too hi...

Background: Hyperthermia is an effective treatment against cancer and human papillomavirus (HPV) infection. Previous studies have shown that heat shock proteins are crucial to the action of hyperthermia. Objectives: To examine the effects of hyperthermia in combination with DNAJA4-deficiency on human keratinocytes and Condyloma acumunatum (CA) t...

Our previous studies have demonstrated that ultraviolet radiation‐induced skin photo‐aging is associated with collagen degradation, dehydration, and inflammation. While the cellular and molecular mechanisms through which UV induces skin aging are still being unraveled, active compounds, including those natural products, are being sought to attenuat...

Categorization of differentially expressed proteins of stable vitiligo compared to control. (a) The top 15 proteins with molecular function. (b) The top 15 proteins involved in biological processes. (c) The top 15 proteins in pathway enrichment. (d) The top 15 proteins of cell component. The log-transformed enrichment scores for molecular function,...