Homero Vallada

Homero Vallada
University of São Paulo | USP · Psychiatry

MD PhD

About

314
Publications
46,401
Reads
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10,145
Citations
Citations since 2016
58 Research Items
3238 Citations
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
Additional affiliations
October 1999 - present
University of São Paulo
Position
  • Head of Department

Publications

Publications (314)
Article
Full-text available
Objective: Religiosity and spirituality (R/S) have been negatively associated with several mental health problems, including delinquency. The study aimed to investigate the relationship between R/S and interpersonal violence using a systematic review. Methods: We carried out a descriptive systematic review followed by meta-analyses using seven d...
Article
Abnormalities in Ca²⁺ homeostasis in Bipolar Disorders (BD) have been associated with impairments in glutamatergic receptors and voltage-gated calcium channels. Increased anterior cingulate cortex (ACC) glutamatergic neurometabolites have been consistently disclosed in BD by proton magnetic resonance spectroscopy (¹H-MRS). A single nucleotide polym...
Article
Full-text available
Objectives Although previous studies have investigated the role of religiosity in violence outcomes, there is a lack of studies including this aspect as a mediator for violence in childhood and adulthood. This study aimed to investigate the relationship between religiosity and violence in childhood, as well as the possible mediating role of religio...
Article
Spiritual and religious experiences (SREs) are common subjective phenomena related to the awareness of transcendence, which transforms one's perception of life, death and suffering. Despite the high prevalence of SREs worldwide, not enough studies have been conducted beyond Europe and North America. To fill this gap, this study investigates the pre...
Article
Full-text available
Background: Several instruments that measure spirituality present overlaps with positive emotions, impacting the interpretation of their findings. In order to minimize these problems, we aimed to develop, assess the reliability and validate a new scale to evaluate spirituality. Methods: The instrument was designed using a theoretical framework mini...
Preprint
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD case-control sample (N = 14,140 OCD cases and N = 562,117 controls) to date. We explored the genetic architect...
Article
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Chronotype or diurnal preference is a questionnaire-based measure influenced both by circadian period and by the sleep homeostat. In order to further characterize the biological determinants of these measures, we used a hypothesis-free approach to investigate the association between the score of the morningness-eveningness questionnaire (MEQ) and t...
Article
Full-text available
Bipolar disorder (BD) is characterized by unstable mood states ranging from mania to depression. Although there is some evidence that mood instability may result from an imbalance between excitatory glutamatergic and inhibitory GABA-ergic neurotransmission, few proton magnetic resonance spectroscopy (¹H-MRS) studies have measured these two neuromet...
Article
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Approximately 90% of the world’s population is involved in some spiritual/religious practice, and this dimension has a relevant role in life. Many studies demonstrate the associations between spirituality/religiosity (S/R), and physical, mental, and social health. Systematic reviews have indicated positive associations; however, the mechanisms behi...
Article
Full-text available
Background Although there is consensus, in psychiatry, over the inclusion of religious and spiritual aspects when evaluating and treating the patient, investigation of these dimensions is rare. There is evidence as to the relationship between psychiatrists’ religious/spiritual beliefs and their willingness to discuss a patient’s religion and spirit...
Article
Full-text available
Context: Metabolic syndrome (MetS) is a complex condition comprising a 'clustering' of components representing cardiometabolic risk factors for heart disease and diabetes; its prevalence rate is high and consequences serious. Evidence suggests that light exposure patterns and misalignment of circadian rhythms might contribute to MetS etiology by i...
Article
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Although there is a wide array of evidence showing the beneficial effect of religiosity on violence among adolescents, nationwide studies in the general population are scarce. This study aims to explore whether religiosity is associated or not with diminishing violence in a Brazilian population-based representative sample. This observational cross-...
Article
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Studying communities at different stages of urbanisation and industrialisation can teach us how timing and intensity of light affects the circadian clock under real‐life conditions. We have previously described a strong tendency towards morningness in the Baependi Heart Study, located in a small rural town in Brazil. Here, we tested the hypothesis...
Article
Introdução: O crescimento de pesquisas na área de saúde e espiritualidade/religiosidade (E/R) tem sido exponencial. Mais recentemente pode-se observar também um desenvolvimento de estudos sobre intervenção espiritual/religiosa (IER) como tratamento complementar em saúde, cujo objetivo é estimular essa dimensão para benefícios clínicos. Objetivo: Re...
Article
Few studies have investigated the "multiple religious affiliations" phenomenon. This study aims to understand those with "multiple religious affiliations," describing its prevalence and investigating if there are differences in mental health and quality of life between this group and those with a single religious affiliation and those with no relig...
Conference Paper
Full-text available
Introduction Circadian rhythmicity is tightly regulated by clock genes. Polymorphic variations of the human PER3 gene have been shown to influence diurnal preference, sleep homeostasis and the development of mood disorders. However, it is unclear whether polymorphisms in this gene are associated with sleep duration and depression symptoms in real-l...
Chapter
Since the end of twentieth century, a crescent number of studies have reported the influence of religiosity and spirituality on health. In view of this evidence, strategies have been proposed for stimulating this dimension in individuals, especially patients coping with diseases. However, only a few studies manage to apply careful and sound methodo...
Article
Full-text available
Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive...
Article
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Objective: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy contr...
Article
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Cardiometabolic risk factors influence white matter hyperintensity (WMH) development: in metabolic syndrome (MetS), higher WMH load is often reported but the relationships between specific cardiometabolic variables, WMH load and cognitive performance are uncertain. We investigated these in a Brazilian sample (aged 50–85) with (N = 61) and without (...
Article
Background Semantic verbal fluency is broadly used in both clinical and non-clinical research, mainly because its sensitivity to several neurobiological conditions associated with cognitive impairment. In order to provide additional insights into genetic component contributing to normal variation on speech production, we conducted a Genome-Wide Ass...
Article
Background DNA methylation has been increasingly recognized in the etiology of drug dependence. Due to the difficulties in assessing brain tissue in living humans, peripheral cells such as blood and saliva have been explored as alternatives to explore the involvement of DNA methylation in drug dependency. Here, we characterized DNA methylation chan...
Article
Background Abuse and dependence on cocaine and its smoked form, crack, is an important public health problem. To better understand the interaction between genes and the environment, we analyzed methylation changes in the peripheral blood of cocaine/crack dependents. Methods The DNA methylation pattern in the peripheral blood of 23 cocaine and crac...
Article
Background There is already a number of reports correlating the effect of parents’ ages with the risk of schizophrenia, but studies looking for an association between parental age and Bipolar Disorder (BD) are scarce and with inconsistent findings. BD has recently been related to a process of accelerated aging, with studies showing association with...
Article
Background Genetic markers of susceptibility for anxiety and depression have been elusive. Increased sample size, utilizing symptoms rather than disorders and, exploring genetic covariability between pairs of traits are known approaches to increase the power of GWAS and have been used isolatedly. We have previously demonstrated a strong genetic cov...
Article
Background There is a significant interest in the contribution of the circadian timing system to individual differences in a wider range of behaviour. This is in part because sleep complaints and disturbances of the circadian timing system are common in psychiatric disorders. Based on diurnal preference, people can be divided into chronotypes with...
Article
Background Lithium salts have a well-established role in the treatment of psychiatric disorders as major affective disorders and more recently Alzheimer disease. Experimental and clinical studies have provided evidence that lithium may exert neuroprotective effects at therapeutically and sub therapeutically doses. In animal model and cell culture m...
Article
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Banyak literatur menilai adanya hubungan antara religiusitas / spiritualitas dan kesehatan, beberapa penelitian telah menyelidiki penerapan klinis pembuktian. Tujuan dari makalah ini adalah untuk menilai dampak intervensi agama / spiritual (RSI) melalui uji klinis acak (RCT). Metode Tinjauan sistematis dilakukan dalam database berikut: PubMed, Scop...
Article
Bailly et al. (2018) examined the trajectory of spirituality in a cohort of 567 non-institutionalized older adults living in Tours, France, during a period of five years. The measurements for spirituality (Daily Spiritual Experience Scale, DES), social support (Satisfaction with Social Support subscale of the Duke Social Support Index), and accommo...
Article
Full-text available
Abstract The present study aims to investigate how different levels of spirituality and religiousness (high spirituality and high religiousness –S/R, high spirituality and low religiousness –S/r, low spirituality and high religiousness s/R and low spirituality and low religiousness – s/r) are associated with quality of life, depressive symptoms, an...
Article
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Objective: To examine the relationship between psychiatrists’ religious/spiritual beliefs and their attitudes regarding religion and spirituality in clinical practice. Methods: A cross-sectional survey of religion/spirituality (R/S) in clinical practice was conducted with 121 psychiatrists from the largest academic hospital complex in Brazil. Resul...
Article
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Background Although many studies suggest that religiosity is a protective factor against drug use, there is little information on its effect on drug consumption patterns of those who do use drugs. Aims We aimed to examine if there is any relationship between religiosity during childhood and adolescence, and drug consumption in adult crack users....
Article
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Although the basis of religious studies start with demographics, nation-wide data are often extracted from face-to-face interviews (leading to a social-desirability bias) and in studies not originally designed to assess religion. This study aims to understand the religious landscape in Brazil and to investigate the feasibility of carrying out a rep...
Article
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Objective To examine whether religious and spiritual interventions (RSIs) can promote physical health and quality of life in individuals. Methods The following databases were used to conduct a systematic review: PubMed, Scopus, Web of Science, EMBASE, PsycINFO, Cochrane, and Scielo. Randomized controlled trials that evaluated RSIs regarding physic...
Data
List of excluded articles. List of the excluded articles in the selection articles process. (DOCX)
Data
PRISMA 2009-checklist. Checklist of the items of the article following PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). (DOC)
Data
Search strategy. Boolean expression with the key words used for the search of the articles are presented for each database used. (DOCX)
Article
Two obsessive–compulsive disorder (OCD) genome-wide association studies (GWASs) have been published by independent OCD consortia, the International Obsessive-Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and the OCD Collaborative Genetics Association Study (OCGAS), but many of the top-ranked signals were supported in only one stu...
Article
Full-text available
Calcium channels control the inflow of calcium ions into cells and are involved in diverse cellular functions. The CACNA1C gene polymorphism rs1006737 A allele has been strongly associated with increased risk for bipolar disorder (BD) and with modulation of brain morphology. The medial prefrontal cortex (mPFC) has been widely associated with mood r...
Article
Full-text available
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65–75 years (n = 156), subdivided in three CVR subgroups using the Framingha...
Article
Full-text available
Sleep is modulated by several factors, including sex, age, and chronotype. It has been hypothesised that contemporary urban populations are under pressure towards shorter sleep duration and poorer sleep quality. Baependi is a small town in Brazil that provides a window of opportunity to study the influence of sleep patterns in a highly admixed rura...
Article
Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the morningness–eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart St...
Article
Full-text available
Background Although there is evidence of a relationship between religion/spirituality and mental health, it remains unclear how Brazilian psychiatrists deal with the religion/spirituality of their patients. Aims To explore whether Brazilian psychiatrists enquire about religion/spirituality in their practice and whether their own beliefs influence...
Article
Full-text available
Purpose Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the...
Article
Full-text available
The present study aims to describe the characteristics of the complementary religious treatment conducted by Spiritist centers in the city of São Paulo (Brazil), to understand how physical and mental health problems are addressed and how the directors of these centers differentiate between persons with spiritual experiences from those with psychiat...
Article
Full-text available
Recent studies have demonstrated that lithium (Li) exerts neuronal protective and regenerative effects both in vitro and in vivo. However, the effects of long-term Li treatment in the brain areas associated with memory impairment of elderly bipolar patients are still unknown. The aim of this study was to compare the hippocampal volumes of elderly b...
Article
Full-text available
To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age±SD 42±16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to...
Article
Bipolar disorder (BD) has been consistently associated with abnormalities in the Glutamate/GABA-Glutamine cycle. Magnetic resonance spectroscopy (MRS) studies have reported increased brain Glutamate (Glu) and Glx (Glu+Glutamine) in subjects with BD. However, data on separate measures of GABA and Glutamine (Gln) in BD are sparse due to overlapping r...
Article
Full-text available
Despite the extensive literature assessing associations between religiosity/spirituality and health, few studies have investigated the clinical applicability of this evidence. The purpose of this paper was to assess the impact of religious/spiritual interventions (RSI) through randomized clinical trials (RCTs). Method A systematic review was perfor...
Article
Spiritism has been strongly connected with mental health in Brazil. However, there is a lack of descriptions of spiritual treatment provided by thousands of Brazilian Spiritist centers. The present study aims to describe the spiritual care for depression provided by one large Spiritist center in São Paulo, Brazil. This is a descriptive study carrie...