Hitesh Jain

• Amity University

Scrub typhus, caused by Orientia tsutsugamushi, is a re-emerging zoonotic disease in the tropics with considerable morbidity and mortality rates. This disease, which is mostly prevalent in rural areas, remains underdiagnosed and underreported because of the low index of suspicion and non-specific clinical presentation. Limited access to healthcare,...

Poor air quality, especially in urban regions among low-and middle-income countries such as India poses a significant healthcare challenge. Amongst urban areas, metropolitan cities garner the utmost importance for air quality related policies and studies with limited studies from tier II cities which are thought to be relatively immune to air pollu...

India has targeted elimination of lymphatic filariasis (LF) through mass drug administration (MDA) by 2027. Mapping of LF endemic areas is a priority for implementation of MDA. Current national LF remapping tool for unsurveyed/uncertain districts, have many limitations. The WHO has recommended a sensitive and rapid remapping protocol (Mini-TAS), th...

Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine. Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and p...

The present research work aimed to formulate and evaluate a gastro retentive in situ gelling system of Nicardipine Hydrochloride using Sodium Alginate as gelling polymer, HPMC K100M as release retard polymer, calcium carbonate as a cross-linking agent, and tri-sodium citrate as fluidity enhancer agent to treat hypertension. The mechanism for the fl...

The objective of research is to develop a mucoadhesive in-situ nasal gel formulation of xylometazoline hydrochloride for the treatment of allergic rhinitis to avoid possible side effects. Mucoadhesive in-situ nasal gel of xylometazoline hydrochloride was formulated by ionic gelation method using xanthan gum as ionsensitive agent and different grade...

COVID-19 serosurvey provides a better estimation of people who have developed antibody against the infection. But limited information on such serosurveys in rural areas poses many hurdles to understand the epidemiology of the virus and to implement proper control strategies. This study was carried out in the rural catchment area of Model Rural Heal...

The aim of present study was to prepared ocular in-situ gel to increase the residence time of drug in cornea for improvement of ocular bioavailability of drug. In situ gel of Loteprednol etabonate was prepared by using carobopol 940 and different grades of HPMC in different ratios by pH triggered method. The prepared in situ gels were evaluated for...

Objectives: Aim of present work is to prepare and evaluate Sustained release microspheres of Acebrophylline for treatment of Asthma. Experimental work: In present investigation, attempt was made to prepare sustained release microspheres of Acebrophylline with different polymer ratio using Ionic gelation method. Drug- excipient compatibility studies...

In today’s world, simply having the capacity to transfer a file from one location to another isn’t enough. Businesses today face multiple security threats and a highly competitive environment. So they need a secure file transfer system to protect and reliably transfer their sensitive, business-critical data. Secure file transfer is a method of data...

This was a population based cross-sectional study carried out to estimate and compare the seroprevalence, hidden prevalence and determine the demographic risk factors associated with SARS-CoV-2 infection among adults in the three largest cities of Odisha, India, and ascertain the association with the progression of the epidemic. The survey carried...

Background & objectives: Anthrax is a zoonotic disease of public health concern in India. One of the key predisposing factors is linked to the behaviour of the community. This study was nested within a baseline survey to understand the risk perception, attitude, socio-cultural and behavioural practices among different communities in an anthrax ende...

Background Major obstetric hemorrhage is the leading cause of maternal morbidity and mortality. In rare cases, life-threatening hematuria in pregnant women may result from invasion of the bladder by the placenta. We present our experience with 18 cases of placenta percreta with suspected bladder invasion. Methods It is a retrospective single-cente...

BACKGROUND A three-dose, oral rotavirus vaccine (Rotavac) was introduced in the universal immunization program in India in 2016. A prelicensure trial involving 6799 infants was not large enough to detect a small increased risk of intussusception. Postmarketing surveillance data would be useful in assessing whether the risk of intussusception would...

Emulgel have emerged as one of the most interesting topical delivery system as it has dual control release system i.e gel and emulsion. Topical applications of drug offers many advantages for delivering drug directly to the site of action and deliver the drug for extended period of time at effected site. The major objective behind this formulation...

Context (Background): While the semen analysis appears to be the cornerstone in the evaluation of male fertility, the testicular size is a cheap, easy, and convenient to measure yet an ignored parameter for predicting the same. There is insufficient literature for identifying the testicular size cutoff among the Indian men. Aims: The study is aime...

Oral route is most preferable and widely used route for the administration of drug. Microballoons becomes novel technology in pharmaceutical field in the floating drug delivery for achieving the gastric retention. Microballoons are also called as hollowspheres which are porous smooth in nature and thus show good floating properties in gastric fluid...

Utilization of herbs for medicinal purpose started in the early history of mankind several thousand years The aim of the present study was to prepare and characterize the spherical crystal agglomerates ofnisoldipine with different polymers like PEG 4000, PEG 6000, PVP and PVP K30 byusing Quassi emulsification solvent diffusion technique for enhance...

Preliposomes are a novel drug delivery system (NDDS). Preliposomes, due to their various forms, require further exploration. These structures can deliver both hydrophilic and hydrophobic drugs for cancer, bacterial infections, fungal infections, immunomodulation, diagnostics, ophthalmic, vaccines, enzymes and genetic elements. Prevesicular drug del...

Solubility of medicine could be a major consider the planning of pharmaceutical formulation result in variable oral bioavailability. The "liquid solid" technique is a new approach for solubility and dissolution enhancement; thereby it increases the bioavailability of poorly soluble drugs. This technique is an efficient method for formulating water...

The objective of co-processed excipients is to improve the functionality of the formulation. In early the introduction of spray dried lactose and avicel had changed the tablet manufacturing process and opened avenues of direct compression tableting. In co-processing of excipients two or more excipients are interact at the sub-particle level. It ove...

Objective: The objective of present work is to formulate the gastro retentive floating tablets containing Orlistat. Experimental work: The floating tablets of orlistat were prepared by direct compression methodusing Polyox WSR 303 sustained release polymer and Sodium bicarbonate as a floating effervescent agent. Optimization was done with 3² factor...

Effective and efficient use of pesticides in the orchards is of concern since many years. With the conventional constant rate sprayers, equal dose of pesticide is applied to each tree. Since, there is great variation in size and shape of each tree in the orchard, trees gets either oversprayed or undersprayed. Real-time variable rate spraying techno...

Leprosy, generally called as Hansen's ailment, is an enervating and ceaseless bacterial malady. As indicated by World Health Organization's report, there were 189,000 uninterrupted occurrences of Leprosy in 2012 with 230,000 new conclusions. Though it is reparable at later stages, an early conclusion expects nerve deliberation and the inadequacies...

Objective: The aim of present work is mask the bitter taste of Naproxen sodium and formulate orodispersible tablets of Naproxen sodium. Experimental work: The bitter taste of drug was masked by using Ion exchange resin orodispersible tablet of Naproxen sodium was prepared by using super disintegrant. All the prepared tablets were evaluated for thei...

A simple and rapid RP-HPLC method has been developed and validated for the simultaneous determination of Levocloperastine fendizoate and Chlorpheniramine maleate syrup formulation. Resolution of the analytes was achieved within 10min, employing a mixture of 10mM mobile phase Buffer (pH 6.5): Acetonitrile (50:50, % v/v) as isocratic mobile phase, pu...

Objective: The aim of the present study was to formulate the floating bilayer tablets of Ketorolac tromethamine, first immediate release layer and second sustained release floating layer which would provide initial loading dose of drug and remain in stomach and upper part of GIT for prolonged period of time in a view to maximize solubility of drug...

Internet of Things (IoT) as another creating and rapidly creating advancement has pulled in loads of thought from by and large starting late. Powerful employments of IoT have been shown in various fields. In any case, IoT is still at its infant youngster stage concerning the applications in thing life-cycle essentialness organization. In this paper...

The effect of client conduct assumes a vital part in the arranging of multi-media cell versatile correspondence systems. Indeed, the nature of administration also known as Quality of Service (QoS) like holding up time and availability that is experienced by every individual client is the fundamental component in the assessment of framework executio...

Neurofibromatosis type-1 (NF-1) is an autosomal dominant disorder, with increased risk of developing benign and malignant tumors of the gastrointestinal tract (GIT). However, the synchronous presence of multiple GIT stromal tumors and duodenal submucosal somatostatinoma, like in this 50-year-old female NF-1 patient, is very rare. She presented with...

Zika virus disease is caused by a virus is transmitted by the bite of an infected female Aedes mosquito. Various species of Aedes mosquito may have the potential to transmit ZIKV, but the most commonly associated with ZIKV is Aedes aegypti. After an infected mosquito bites a human, the first symptoms of ZIKV can develop in 3 to 12 days but it can b...

Nanotechnology, a multi-disciplinary science has received considerable attention in the recent times in the discovery of new chemical entities, diagnosis and treatment of several diseases. Nano-medicine has developed many drug delivering systems like nanoparticles, nano-emulsions, nano-suspensions, nanosponges etc., to overcome the problems of bioa...

UNIM-301 is a polyherbal formulation used in the Unani system of medicine for the treatment of joint pain and rheumatoid arthritis (RA). The objective was to evaluate the anti-inflammatory and antiarthritic activity of UNIM-301 in carrageenan-induced paw edema and complete Freund's Adjuvant (CFA) induced arthritis. The anti-inflammatory and antiart...

Chemical looping combustion (CLC) is an innovative technology to reduce CO2 emissions to the atmosphere from combustion processes that can be used for combustion of cheaply available abundant fuel like coal for the production of clean energy. A detailed thermodynamic analysis of chemical looping combustion of lignite coal using selected oxygen carr...

Sinusitis or rhinosinusitis is inflammation of the paranasal sinuses. It can be due to infection, allergy, or autoimmune issues. Balloon catheter dilation of paranasal sinusostia aims to help open up blocked sinus passages by gently inflating a small balloon, introduced through the nose via a flexible tube. The aim is to restore normal sinus draina...

Stress leads to disease and disease leads to stress, this bidirectional poking relationship urges for the development of stress busters or ailment regulators which can sooth lives. Ethnic groups of south east Rajasthan inherit a vast pharmacopoeia and ingredient/s sourced from the same, forms a baseline of numerable commercial drugs. Present study...

Design of a novel drug is one of the biggest challenges faced by the pharmaceutical industry. Increasing costs of drug development and reduced number of new chemical entities have been a growing concern for new drug development in recent years. A number of potential reasons for this outcome have been considered. One of them is a general perception...

Aim of study was to develop bilayered floating drug delivery for treatment of hypertension by delivering loading and maintenance dose for fast achievement of peak plasma concentration and maintaining the same respectively. The prepared drug loaded bilayered floating tablets were evaluated for pre and post compression parameters. Stability study of...

Objective: Metoprolol Succinate has a short elimination half- life (3-7 hours) and rapidly absorbed in GIT If it is formulated by conventional tablets requires multiple daily administration with resulting inconvenience to the hypertensive patient and the possibility of reduced compliance with prescribed therapy. Methods: Core tablets were prepared...

Objectives: The objective of the present study is to formulate the Colon targeted delivery containing Naproxen for chronopharmaceutical drug delivery system (ChrDDS) for treatment of rheumatoid arthritis, which are influenced by circadian rhythm. Chronopharmaceutical drug delivery system is capable of delivering drug when and where drug required mo...

Pre-sacral epidermoid cysts are rare development cysts resulting from dysembryogenesis mostly diagnosed in middle aged women. We report a case of pre-sacral epidermoid cyst presenting with recurrent perianal sinus in young girl. Generally pre-sacral epidermoid cysts are seen in adult age group but it is rare presentation in young age group. We repo...

Cryptosporidiosis, a gastrointestinal disease caused by a protozoan Cryptosporidium hominis is often fatal in immunocompromised individuals. There is little clinical data to show that the existing treatment by nitazoxanide and paromomycin is effective in immunocompromised individuals.(1,2) Thymidylate synthase (TS) and dihydrofolate reductase (DHFR...

Aquasomes are one of the most recently developed delivery systems; these are nanoparticulate carrier systems with three-layered self-assembled structures. They comprise a central solid nanocrystalline core coated with poly-hydroxyoligomers onto which biochemically active molecules are adsorbed. Three types of core materials are mainly used for prod...

In this paper, a novel support vector machine (SVM) tree is proposed for gesture recognition from the silhouette images. A skeleton based strategy is adopted to extract the features from a video sequence representing any human gesture. In our binary tree implementation of SVM, the number of binary classifiers required is reduced since, instead of g...

There is currently a great deal of world-wide interest in the field of transdermal drug delivery and, consequently, broad classes of drugs are being evaluated for percutaneous absorption potential. The advantages of this mode of drug administration are numerous, the patient convenience and therapeutic optimization of using patch trans-dermal system...

The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. Herbal Cosmetics have growing demand in the world market and is an invaluable gift of natu...

Bicycle use varies from 7% to 15% in large cities to 13–21% in medium and small cities in India. It is observed that cyclists are involved in 5–10% of total road related deaths in medium and large cities. The focus of the paper is to highlight differences and similarities in safety among bicycle users and non-users especially among students and low...

The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Peptides, proteins and DNA-based therapeutics cannot be effectively delivered by conventional means. To control the delivery ra...

In this animal model (Wistar rats of either sex) common bile duct was ligated for 28 days. Rats were treated for 28 days with methanol extract of Cocculus hirsutus. On day 29, blood and liver were collected for biochemical estimation and histopathological studies. Bile duct ligation produced liver fibrosis with generation of reactive oxygen species...

This chapter focuses on Alcoholic Ketoacidosis (AKA), which is characterized by wide gap metabolic acidosis and malnutrition superimposed on chronic alcohol abuse. Ethanol is the precipitating factor by causing repeated vomiting, dehydration, starvation, and metabolically helping ketogenesis. Nausea, vomiting and abdominal pain are the most common...

We present information on an aniline dye marking method for black flies. In the laboratory, adults were sprayed with 2% aqueous solutions of four colors of aniline dyes; brilliant blue and methyl orange gave the best results in longevity trials. In field trials we were able to recapture 1.3% of newly emerged marked and released flies at oviposition...

Secondary electron (SE) imaging of semiconductors reveals contrast between n- and p-type areas that can serve as the basis for a two-dimensional dopant profiling technique. In this article, recent experiments that address sensitivity, spatial resolution, calibration methodology, p/n junction effects, and sample preparation issues are reviewed and d...

Poverty and underemployment are interlocked phenomena in the rural areas of Madhya Pradesh, India. Poverty alleviation programmes, providing assets or wage employment to the rural poor, are remedies to temporarily mitigate the severity of the problem. Reports on the National Rural Employment Programme (NREP) which was conceived to provide a more pe...

Field trials were conducted during 1980 and 1981 to evaluate the systemic granular insecticides disulfoton, phorate, carbofuran, aldicarb and bendiocarb against Thrips tabaci Lind. on onion. Residues in plants at different intervals and in bulbs were determined by gas‐liquid chromatography. Carbofuran at 1.0 kg a.i./ha was most effective, followed...

That no simple correlation exists between the amount of DNA in the cells of different species and the temperature sensitivity of their chromosomes has been reported by Utkhede and Jain (1973). It is well established that RNA synthesis is primed by the DNA in the cell. The present cytochemical studies were planned to investigate the role of increase...

A number of diploid and polyploid species of wheat have been analysed for the sensitivity of their chromosomes to conditions of high temperature. A comparative estimate of deoxyribonucleic acid in the root-tip cells of different species has also been made by the autoradiographic technique. The diploid and hexaploid species differed greatly in tempe...

Summary A case of amyloidosis of epiglottis is reported. The case is of interest because amyloidosis of the larynx is a rare condition. Moreover, the involvement of epiglottis in the localized form is extremely rare.

A number of diploid and polyploid species of wheat have been subjected to the condition of high temperature. The various temperature treatments have been found to induced formation of univalents in a number of Pollen mother cells of different varieties. The distribution of cells showing such univalents has been studied. It has been found that in al...

Multiple osseous metastases in hypopharyngeal carcinoma - Volume 87 Issue 1 - P. L. Bhatia, R. L. Mathur, H. K. Jain

Summary A case of keloid of the whole pinna has been described. Alongwith, the patient had congenital abnormalities of the ear ossicles and the interventricular septum of the heart.

An official journal of the Genetics Society, Heredity publishes high-quality articles describing original research and theoretical insights in all areas of genetics. Research papers are complimented by News & Commentary articles and reviews, keeping researchers and students abreast of hot topics in the field.

Asymmetry of the karyotype combined with x-ray induced interchange ; heterozygosity has been made use of in Delphinium to study the relationship ; between chiasmata and crossing-over. The tranalocation muitiples in two ; heterozygous plants were analyzed for chiasma formation in the interstitial ; segments, and for equational and reductional separa...

THE significance of chiasmata in relation to crossing-over inferred by Janssens was more fully recognized with the development of the partial chiasmatypy theory by Darlington1. Although in recent years mechanisms of crossing-over, very different from that based on the breakage and reunion hypothesis, have been proposed, a direct relationship betwee...

A new karyotype which is both viable and stable has been obtained in Delphinium following X-ray induced chromosomal rearrangements. It shows, on the whole, greater symmetry than the parental karyotype although one of the chromosome pairs was reduced to a minute size. The meiotic sequence in the structural heterozygote and the isolation of the homoz...

1. Chiasma frequency observations in Delphinium showed an interchromosome effect which occurs consistently in a large number of plants. 2. An interplant analysis indicated that significant differences in mean chiasma frequency do not affect the direction or the degree of interchromosome correlation which in the present material was invariably found...