Hitendra M Patel

Hitendra M Patel
Sardar Patel University · Department of Chemistry

Doctor of Philosophy
Professor, Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar388120. Gujarat, India

About

35
Publications
3,472
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
434
Citations
Introduction
Dr Hitendra M. Patel is a Professor of Chemistry at the Department of Chemistry of the Sardar Patel University, V. V. Nagar 388 120, Gujarat, India. He was an Elected Member of the Organic Division Council and was admitted as a Fellow of the Royal Society of Chemistry, London in 2020. He acts as Editor and Board member in many international high reputed journals. He has 24 and 17 years of experience in Teaching and Research respectively. He worked as an Expert reviewer in many Journals.
Additional affiliations
February 2015 - September 2022
Sardar Patel University
Position
  • Associate Professor (Full)

Publications

Publications (35)
Article
A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres. A collection of 10 compounds was evaluated against glioma cell lines, with compound 4j exhibiting promising g...
Article
Herein, a solvent-free synthesis of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1H)-(thi)ones was explored. The main advantages of this study are that pure products are readily obtained through an easy workup and without using any separation technique and in good yields (66-80% yield), All the synthesized products were characterized by ¹H and ¹³...
Article
Full-text available
We report a one-pot two-step synthesis of a bioactive 6-amino-2-pyridone-3,5-dicarbonitrile derivative using natural product catalysts betaine and guanidine carbonate. Anti-cancer bioactivity was observed in specific molecules within the library of 16 derivatives. Out of the compounds, 5o had the most potent anti-cancer activity against glioblastom...
Article
Full-text available
Herein, acetic acid mediated multicomponent synthesis of novel 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-one (2,4-dimethoxy-THPQs) was reported. Single-crystal XRD analysis of four newly developed crystals of 2,4-dimethoxy-THPQs and their DFT study were also reported. The structure of all molecules was optimized using DFT B3LYP/6-31G(d)...
Preprint
Full-text available
Herein we report a one-pot two-step synthesis of a bioactive 6-amino-2-pyridone-3,5-dicarbonitrile derivative using natural product catalysts betaine and guanidine carbonate. Upon identification of the anticancer bioactivity of the compound, we carried out structure-activity relationship and rationally designed a library of 16 derivatives. Out of t...
Article
Full-text available
Proteasome-addicted neoplastic malignancies present a considerable refractory and relapsed phenotype with patients exhibiting drug-resistance and high mortality rates. To counter this global problem, novel proteasome-based therapies are being developed. In the current study we extensively characterize TIR-199, a syrbactin-class proteasome inhibitor...
Preprint
Proteasome-addicted neoplastic malignancies present a considerable refractory and relapsed phenotype with patients exhibiting drug-resistance and high mortality rates. To counter this global problem, novel proteasome-based therapies are being developed. In the current study we extensively characterize TIR-199, a syrbactin-class proteasome inhibitor...
Preprint
Full-text available
Herein, Solvent-free synthesis of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1 H )-thi(ones) was explored. The main advantages of this study are that pure product comes in hand with easy workup and without using any separation technique, a good amount of yield, and formation of product in crude form. We developed a single crystal of 4c , and we...
Preprint
p>A series of novel pyrano[2,3-c]pyrazoles were synthesized and screened for their potential to inhibit kinases and exhibit anti-cancer activity against primary patient derived glioblastoma 2D cells and 3D neurospheres. A collection of 10 compounds were evaluated against glioma cell lines, with compound 4j exhibiting promising glioma growth inhibit...
Article
In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97% yield. The antiproliferative assay was carried out for all synthesized dihydropyri...
Article
Full-text available
Green synthesis of pyrazolo[3,4-b]quinolinones was designed using bioproduct pyridine-2-carboxylic acid (P2CA) as a green and efficient catalyst. The multi-component reaction of aldehydes, 1,3-cyclodiones and 5-amino-1-phenyl-pyrazoles regioselectively produced pyrazolo[3,4-b]quinolinones in excellent yield (84–98%). Recyclization of the catalyst w...
Article
Full-text available
A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1′H-spiro[pyrazolo[4,3-f]quinoline-8,5′-pyrimidine]-2′,4′,6′(3′H)-triones (d.r. up to 20 : 1 (syn : anti)) and tetrahydro-8H-pyrazolo[4,3-f]pyrimido[4,5-b]quinoline-8,10(9H)-diones via formation of selective multiple C–C bonds...
Article
A one-pot procedure for the preparation of functionalized 1,4-dihydropyridines by three-component reaction using substituted heterocyclic aldehydes, ammonium acetate, and substituted β-ketoesters catalyzed by L-proline was described. Present protocol offers excellent yield up to 92%, flexibility with different substitution, convenient operation, an...
Article
Nowadays, synthesis of novel nitrogen-bearing heterocyclic scaffolds is a challenging and demanding task as well. In our present work, we demonstrated a novel one-pot pseudo four-component reaction of 3,4-methylenedioxyaniline, N,N-dimethylbarbituric acid, and aryl/heteroaryl aldehyde for the regioselective construction of functionalized 6,8-dihydr...
Article
Full-text available
In this study, we successfully explored the effect of steric hindrance on the one-pot reaction of different aryl aldehydes with malononitrile and N-substituted 2-cyanoacetamide in the presence of piperidinium acetate as the catalyst. It involved the Knoevenagel condensation of the aldehyde and malononitrile to produce arylidene malononitrile as an...
Article
Full-text available
Herein our team explored a promising synthetic trail to Functionalized pyrazolodihydropyridine core using hydroxyl alkyl ammonium ionic liquid via one-pot fusion of 3-methyl-1-phenyl-1H-pyrazole-5-amine, different heterocyclic aldehydes and 1, 3-Cyclic diones. The aimed compounds were obtained by Domino-Knoevenagel condensation and Michael addition...
Article
Full-text available
Herein, we established a straightforward synthetic route for biological relevant [1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)one scaffolds using the group‐assisted purification (GAP) chemistry via one‐pot and three component reaction of 3‐Amino‐5‐methylthio‐1H‐1,2,4‐triazole (1), Aryl aldehyde(2 a–g), and 1,3‐cyclodione (3 a–b) using L‐proline and aqueou...
Article
In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. The present approach shows the significant outcomes such as yield up to 94%, catalyst‐free reaction, easy workup procedure and shorter period of reaction time. In this work we also highlighted the...
Article
Background We report here an efficient synthesis of new Mannich products 4(a-m) in excellent yields via multi-component reaction for the condensation of 5-bromothiophene- 2-carboxaldehyde (5-BT-2C), 2,4-dihydroxybenzophenone (2,4-DHBP) and primary/secondary amine derivative using Ethyl Ammonium Nitrate (EAN) as ionic liquid, which is reusable and p...
Article
Full-text available
A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting materials as 5-bromothiophene-2-carboxaldehyde and ammonium acetate were used at room temperature under solven...
Article
Background: We developed Multicomponent synthesis for novel Mannich products with biologically active quinoline nucleolus under solvent free condition. This methodology provided us good amount of yield with the exception of chromatographic separation. The structure of novel compounds (4d1-d13) was characterized by elemental, mass,¹H-NMR,¹³C-NMR and...
Article
Background: In these study we report here one-pot multi-component and solvent free Mannich reaction of U.V. absorbing material, five member heterocyclic ring system and amides/carbamates has been efficiently catalyzed by recyclable ethyl ammonium nitrate as ionic liquid at ambient temperature to produce mannich compounds in high yields. This method...
Article
Full-text available
Novel acid mono azo and mordent acid mono azo dyes were synthesized by the coupling of diazonium salt solution of different aromatic amines with 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid. The resulting dyes were characterized by spectral techniques like elemental analysis, IR, 1H-NMR and UV visible spectroscopy. The dyeing performance of all...
Article
Full-text available
The novel mordent and disperse heterocyclic dyes were prepared by coupling of various diazo solution of aromatic amines with 1-[(2-butyl-2,3-dihydrobenzofuran-3-yl)]-1-(4-hydroxyphenyl)methanone. The resultant mordent and disperse heterocyclic dyes were characterized by elemental analyses, IR and 1H-NMR and 13C-NMR spectral studies. The UV-visible...
Article
Full-text available
Aniline derivatives were diazotized and coupled with 3-aminocrotononitrile to give the corresponding 2-arylhydrazono-3-ketiminobutyronitriles. Cyclization of these arylhydrazono derivatives with hydrazine monohydrate afforded 5-amino-4-arylazo-3-methyl-1H-pyrazoles which were subsequently diazotized and coupled with malononitrile to yield a series...
Article
Full-text available
Novel heterocyclic acid and mordant acid dyes were synthesised by the coupling of a diazonium salt solution of different aromatic amines with 2-butyl-3-(4-hydroxybenzoyl)benzofuran. The resulting heterocyclic acid dyes were characterized by elemental analysis, IR, H-1-NMR and C-13-NMR spectral studies and UV-Vis spectroscopy. The dyeing performance...
Article
Full-text available
In the field of dye industries, heterocyclic compounds can play the important role to synthesis the various acid and mordent dyes which can give the variety of shades to different fabrics. Here, new heterocyclic acid and mordent acid dyes were synthesized by the coupling of diazonium salt solution of different aromatic amines having acidic groups w...
Article
Full-text available
Solvent dyes have been prepared by the coupling of diazo solution of different aromatic amines with 2-hydroxy-4-n-octyloxybenzophenone. The resultant dyes were characterized by elemental analysis as well as IR and 1H NMR spectral studies. The UV-Visible spectral data have also been discussed in terms of structure property relationship. The printing...
Article
Full-text available
Novel acid mono azo and mordent acid mono azo dyes were synthesised by the coupling of diazonium salt solution of different aromatic amines with 2-hydroxy-4-methoxybenzophenone. The resulting dyes were characterized by spectral techniques, i.e., elemental analysis, IR, 1H-NMR and UV–visible spectroscopy. The dyeing performance of all the dyes was e...
Article
Full-text available
Novels disperse and mordent azo dyes were prepared by coupling of various diazo solutions of aromatic amines with 2-hydroxy-4-methoxy-benzophenone. The resultant dyes were characterized by elemental analyses, IR and 1 H NMR spectral studies. The UV-visible spectral data have also been discussed in terms of structural property relationship. The dyei...
Article
Full-text available
Novel acid azo and mordent acid azo dyes have been prepared by the coupling of diazo solution of different aminonaphthol sulphonic acids and aromatic amino acids with 2,4-dihydroxybenzophenone. The resultant dyes were characterized by elemental analysis as well as IR and 1H NMR spectral studies. The UV-visible spectral data have also been discussed...
Article
Full-text available
The novel mordent and disperse heterocyclic dyes were prepared by coupling of various diazo solution of aromatic amines with 2-Butyl-3-(4-hydroxybenzoyl)benzofuran. The resultant mordent and disperse heterocyclic dyes were characterized by elemental analyses, IR and NMR spectral studies. The UV-visible spectral data have also been discussed in term...

Questions

Question (1)

Network

Cited By

Projects