Hiroyuki Kashiwagi

Hiroyuki Kashiwagi
Shonan Kamakura General Hospital · Hepato-Biliary-Pancreatic Surgery

About

62
Publications
5,937
Reads
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996
Citations
Citations since 2016
22 Research Items
379 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Additional affiliations
October 2004 - June 2008
Washington University in St. Louis
Position
  • Researcher
April 2004 - April 2007
Tokai University
Position
  • Professor (Assistant)

Publications

Publications (62)
Article
Full-text available
Several large-scale studies have assessed the endovascular and surgical treatments for nonocclusive mesenteric ischemia (NOMI); nonetheless, the prognostic factors for NOMI remain unclear. In this single-center study, we retrospectively reviewed the electronic medical records of 197, 149 patients were retrieved from the inpatient database of our ho...
Article
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Background: The incidence of acute empyema has increased in various countries; some elderly patients with acute empyema have contraindications for surgery under general anesthesia. Therefore, suitable management based on a patient's clinical condition is required. Methods: We evaluated the different surgical and nonsurgical therapeutic approache...
Article
Full-text available
Introduction There are no reports regarding sigmoid colon strangulation caused by bilateral fallopian tubes, which is a rare type of large bowel obstruction. Herein, we report a case of successful laparoscopic treatment of sigmoid colon strangulation. Presentation of case A 54-year-old woman presented to our hospital with intermittent abdominal pa...
Preprint
Full-text available
Of the 1061 patients of coronavirus disease-2019 admitted to our field hospital, eight patients (0.75%) had pneumothorax. The mean age of incidence was 79.9 years; six of these patients (75%) died. Although pneumothorax is a rare complication of coronavirus disease-2019, it suggests a poor prognosis in elderly patients.
Article
Full-text available
Introduction and importance Blunt abdominal aortic injury (BAAI) resulting from blunt abdominal trauma is rare; therefore, there are no standard guidelines for its treatment. Herein, we report the successful treatment of BAAI via endovascular aortic repair (EVAR) performed immediately after emergency laparotomy to repair a bowel injury. Case prese...
Article
Full-text available
Introduction There are limited reports regarding renal paratransplant hernia (RPH), which is a rare type of internal hernia. Herein, we report a case of successful laparoscopic treatment of RPH. Presentation of case A kidney transplant recipient presented to our emergency department with a 6 -h history of abdominal pain and vomiting. The patient h...
Article
We report a case of intraductal papillary mucinous carcinoma (IPMC), which was diagnosed as a ruptured cyst. The patient was an 82-year-old man with abdominal computed tomography (CT) showing multiple cystic lesions with substantial components in the tail of the pancreas and a small amount of ascites around the lesions. A ruptured pancreatic cyst w...
Article
Full-text available
Aim Bleeding in the small bowel rarely occurs, and its treatment is challenging. Surgery is sometimes required in unstable patients; however, intraoperative identification of the bleeding site is extremely difficult. Many methods have been reported, but no standard strategy has been established yet. Here, we aimed to assess the safety and feasibili...
Article
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Background: Pre-operative kidney function is known to be associated with surgical outcomes. However, in emergency surgery, the pre-operative kidney function may reflect chronic kidney disease (CKD) or acute kidney injury (AKI). We examined the association of pre-operative CKD and/or AKI with in-hospital outcomes of emergency colorectal surgery. M...
Article
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Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are extremely rare lesions that are difficult to diagnose before surgery. We report the case of a 26-year-old patient with a recent episode of left abdominal pain who presented with a large cyst in the pancreatic body. Laboratory res...
Article
A 62-year-old woman, who suffered from abdominal pain, was examined by colonoscopy as an outpatient in the Department of General Internal Medicine in our hospital. The colonoscopy indicated a tumor in the lower rectum, thereby an endoscopic mucosal resection was performed on the same day. Pathological findings indicated a neuroendocrine tumor (NET)...
Article
Full-text available
Introduction: Small intestinal metastasis from oesophageal carcinoma is rare. We report a case of small intestinal metastases from oesophageal carcinoma presenting as a perforation and discuss the aetiology with other cases of small intestinal metastasis from oesophageal carcinoma reported in previous literature. Presentation: An 86-year-old man...
Article
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Introduction Liver gas gangrene is rare and has a low prognosis. This case, reports a successful treatment of hepatic gas gangrene using an open drainage technique, followed by antibiotics and hyperbaric oxygen therapy (HBO). Presentation of the case An 82-year-old male with a history of left hepatectomy and bile duct resection for hilar cholangio...
Article
Introduction: Lumbar arterial bleeding is a severe condition. Surgical exploration is not indicated because of its rich collateral flow. Transarterial embolization (TAE) is reportedly effective, but there have been cases of failure. It may be a time-consuming procedure for patients with multiple bleeding sources or those with poor vital signs. In...
Article
Full-text available
Background: In Japan, laparoscopic distal gastrectomy (LDG) is common for early gastric cancer. Formerly, we used to verify the location of the marking clip to decide the proximal incisional line with our hand, through a small epigastric incision. In 2015, we introduced intracorporeal reconstruction and started to decide the incisional line using...
Article
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Introduction: Symptomatic or complicated liver cysts sometimes require surgical intervention and laparoscopic fenestration is the definitive treatment for these cysts. We performed minimally invasive surgery, hybrid natural orifice transluminal endoscopic surgery (NOTES) without scarring, for a huge liver cyst. Presentation of case: An 82-year-o...
Article
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Background/objective: Patients with left-sided malignant colorectal obstruction require emergency treatment. Emergency stoma surgery has traditionally been recommended, however many stomas became permanent, decreasing patient quality of life. Recently, self-expandable metallic stents (SEMS) and transanal decompression tubes (TDT) have become widel...
Article
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Introduction: Adventitial cystic disease is relatively rare vascular disease, frequently occurred in the popliteal artery. No definitive treatment has been established yet. Prentation of case: A 53-year-old woman presenting intermittent claudication of the right leg was diagnosed as adventitial cystic disease of popliteal artery. Percutaneous ba...
Article
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Introduction: Liver gas gangrene is a rare condition with a highly mortality rate. It is mostly associated with host factors, such as malignancy and immunosuppression. Presentation of case: A 57-year-old female was admitted to our hospital with abnormalities of her serum hepato-biliary enzymes. She had a history of hypertension, diabetes mellitu...
Article
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Jejunostomy is performed in some cases because of various reasons such as a patientʼs inability to feed orally, as well as in cases in which total gastrectomy has been performed, or cases of end-stage gastric cancer. However, jejunostomy is difficult to manage because of continuous tube feeding and long catheter. We attempted pouch Roux-en-Y jejuno...
Article
Empyema with fistula usually resists conservative treatment such as thoracic cavity drainage and administration of antibacterial agents, thus it often requires surgeries such as fenestration, omental/muscle filling, and thoracoplasty. However, due to advanced age and poor condition, conducting invasive surgeries is often difficult in elderly patien...
Article
Full-text available
INTRODUCTION The laparoscopic repair of a rare diaphragmatic Morgagni hernia using the reduced port approach is described. PRESENTATION OF CASE An 85-year-old female presented with a 2 days history of upper abdominal discomfort and loss of appetite. We diagnosed her condition as a Morgagni hernia by morphological studies and performed laparoscopic...
Article
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Background: Although recent trends in laparoscopic procedures have been toward minimizing the number of incisions, four or five ports are normally required to complete laparoscopic gastrectomy because of the complexity of this procedure. Multi-channel ports, such as the SILS port (Covidien, JAPAN), are now available and are crucial for performing...
Article
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One major challenge in the development of cancer therapeutics is the selective delivery of the drugs to their cellular targets. In the case of pancreatic cancer, the σ-2 receptor is a unique target that triggers apoptosis upon activation. We have previously developed a series of chemical compounds with high affinity for the σ-2 receptor and showed...
Article
Full-text available
Most liver cysts are asymptomatic and tend to have a benign clinical course. However, symptomatic or complicated liver cysts sometimes require surgical intervention. The laparoscopic approach is crucial and provides definitive treatment for such cysts. Recently, a trend of laparoscopic procedure has been toward minimizing the number of incisions. W...
Article
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An important mechanism by which pancreatic cancer avoids antitumor immunity is by recruiting regulatory T cells (Tregs) to the tumor microenvironment. Recent studies suggest that suppressor Tregs and effector Th17 cells share a common lineage and differentiate based on the presence of certain cytokines in the microenvironment. Because IL-6 in the p...
Article
Pancreatic adenocarcinoma carries an ominous prognosis and has little effective treatment. Several studies have demonstrated that the potently antiapoptotic phosphatidyl inositol 3'-kinase (PI3K)-protein kinase B/AKT pathway is active in pancreas cancer. A recent study identified an endogenous AKT antagonist, carboxyl terminal modulator protein (CT...
Article
Full-text available
We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashion. Here, we examined whether sigma-2 receptor ligands potentiate conventional chemotherapies such as gemcitabine and paclitaxel. Mouse (Panc...
Data
Table S1 – Serum toxicology and cytology of mice treated with the sigma-2 ligand, SV119, and conventional chemotherapy. Peripheral blood was drawn from tumor-bearing mice 24 hours after treatment with a single dose of SV119 and conventional chemotherapy (gemcitabine or paclitaxel). Cytologic and serum chemistry evaluations were performed by the ani...
Article
Full-text available
BACKGROUND: We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer. Furthermore, we have demonstrated that sigma-2 receptor specific ligands induce apoptosis in a dose-dependent fashion. Here, we examined whether sigma-2 receptor ligands potentiate conventional chemotherapies such as gemcitabine and paclitaxel....
Article
Suppression of apoptosis is central to the development of cancer and is associated with resistance to modern adjuvant treatments. Therefore, molecules and pathways of apoptotic processes are critical targets for the development of anti-cancer therapeutics. Since apoptosis is executed by intracellular proteins, molecular approaches must incorporate...
Article
Full-text available
Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-cancer therapeutics. The sigma-2 receptor has been found to be over-expressed in some types of malignant tumors, and, recently, small molecule li...
Article
Full-text available
Abstract Background Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-cancer therapeutics. The sigma-2 receptor has been found to be over-expressed in some types of malignant tumors, and, recen...
Article
Segmental resection of the duodenum has been reported in only several facilities in Japan. We report two cases of adenocarcinoma of the ampulla of vater, which were treated safely by segmental resection of the duodenum sparing the pancreas. In recent years there are four different procedures in the surgical management for ampullary tumors, Endscopi...
Article
A 78-year-old female was admitted to our hospital due to the progressive dyspnea on effort. Blood gases analysis revealed hypoxia and echocardiogram showed that ventricular septum was oppressed to the left ventricle and the estimated systolic pressure of pulmonary artery was up to 60 mmHg. An X ray and computed tomography of chest showed no evidenc...
Article
Full-text available
Aneurysms of the superior mesenteric artery branches are rarely reported, even among them colic artery aneurysms are seldom. We report a case of 78-year-old male with ruptured dissecting aneurysm of middle colic artery. The patient complained abdominal pain and nausea during hospital stay for renal stone. The patient suddenly developed severe abdom...
Article
脂肪肉腫は下肢,後腹膜に好発する腫瘍で,腸間膜原発は稀である.今回われわれは腸間膜原発脂肪肉腫の1例を経験したので報告する.症例は42歳男性で便通異常,腹部膨満感を主訴に来院した.下腹部に弾性硬で圧痛と可動性を有する小児頭大の腫瘤を触知した.腹部超音波では骨盤内に隔壁を有する一部充実性の14×11×7 cm大の嚢胞性腫瘤を認めた.血管造影では上腸間膜動静脈の進展,圧排のみで腫瘍濃染は認められなかった.入院後,腹痛が出現し腹部CTで腫瘤の増大と高吸収域を認め,嚢胞内出血の診断で緊急手術を施行した.腫瘤は回盲部を中心に回結腸間膜内に存在し,赤褐色で嚢胞内に凝血塊が充満していた.腫瘤の可動性は良好で容易に後腹膜から剥離できた.腫瘤切除および回結腸切除を行い腫瘤は完全に摘出された.病理組織検査では線...
Article
Sialyl Lex antigen, a member of a family of high molecular weight glycoproteins, is a ligand for E-selectin and may play an important role in tumor metastasis. However, expression patterns of sialyl Lex have not yet been established in human gallbladder carcinomas. In this study, we analyzed the clinicopathological significance of sialyl Lex expres...
Article
We conducted middle pancreatectomy in 2 patients who had small pancreatic cancer measuring 1 cm in diameter. Case 1 : A 72-year-old woman seen for epigastralgia was found in ultrasonic examination to have a tumor on the pancreatic body. Further examination led to a diagnosis of small pancreatic cancer, necessitating middle pancreatectomy. The patho...
Article
Sialyi Lex (FH6) and sialyl Lea (CA19—9) antigens, members of a family of high molecular weight glycoproteins, are ligands for E-selectin and may play important roles in tumor metastasis. However, expression patterns of sialyl Lex and sialyl Lea have not been established in human extrahepatic bile duct cancer. In this study, we examined sialyl Lex...
Article
Full-text available
Undifferentiated spindle and giant cell carcinoma of the common bile duct has not been reported previously. We present here a case of 71-year-old man with the undifferentiated spindle and giant cell carcinoma of the common bile duct, including immunohistochemical findings. A nodular infiltrating tumor was located at the lower portion of the extrahe...
Article
The number of surgically resected cases of extrahepatic bile duct cancers has been increased because of the recent advances in imaging diagnoses and operative procedures. However, morphological characteristics of the extrahepatic bile duct cancers have not yet been defined. In this study, we reviewed 102 surgically resected cancer cases for clarify...
Article
われわれは後腹膜原発が疑われた無色素性悪性黒色腫(amelanotic malignant melanoma: AMM)の1例を経験したので報告する.症例は68歳,男性. 1995年5月より左背部痛を自覚,増強してきたため近医受診.腹部超音波およびCT上,約8cm大の膵体尾部に隣接する腫瘤性病変が認められ当院紹介入院となった.入院時皮膚・眼球・消化管精査で異常所見なし.腹部CTで腹腔内には多数のリンパ節腫脹もみられたことから,膵上皮性腫瘍のほか,悪性リンパ腫や間葉系腫瘍なども疑われた.確定診断を目的として腹腔鏡下リンパ節生検を施行した.腹腔内には10mm大の小結節が散在しており,これを一部採取し病理組織診断を行った結果,メラニン顆粒がほとんど認められない無色素性悪性黒色腫の組織像であった.後...
Article
稀な腹壁膿瘍を併発した回盲部癌の1例を経験した.症例は63歳,男性.平成14年8月近医より腹部腫瘤精査目的で,当院紹介.入院時から,炎症反応の上昇を認め,腹部に発赤を伴うようになった.大腸内視鏡で,上行結腸に全周性の狭窄を認め,生検の結果, adenocarcinomaの診断.腹部CTで回盲部腸管壁の肥厚,腹壁にair fluid levelを伴うlow density areaを認め,腹壁膿瘍の診断でドレナージを施行した.瘻孔造影で回腸が描出された.開腹時,腫瘤は,回盲部に一塊となって存在し,回盲部切除に加え,腹壁を一部合併切除した.摘出された標本は,大きさ10×8 cmのtype 2病変で,潰瘍底は回腸末端に存在し,病理組織学的には,粘液を多量に含む中分化型腺癌, se, n 2, st...
Article
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression of epidermal growth factor receptor (EGFR) was suggested to be associated with malignant transformation of pancreatic cancer. We examined EGFR expression in 77 cases of i...
Article
A 44-year-old man was admitted to hospital because of sudden severe postprandial right epigastric pain. Abdominal echography showed multiple calculi in the gallbladder and evidence of a probable septum at the neck. Based on the results, tentative diagnoses were made of gallbladder calculosis with associated gallbladder curvature or malformation, an...
Article
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be a potential regulator of tumor growth and metastasis. We examined TSP-1 expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the correlation between the TSP-1 expression pattern and clinicopathologi...
Article
The patient was a 55-year-old male in whom peritoneal dialysis had been introduced for chronic renal failure since 42-years-old. He developed hematomesis suddenly during the hospitalization for ileus caused by sclerosing peritonitis. Endoscopic examination showed a circular peeled esophageal mucosa, so called "mucosal bridge", and some coagulations...
Article
The majority of pancreatic malignant tumors are adenocarcinomas of the ductal type (ductal cell carcinomas) and combined tumors consisting of different tumor components are very rare. We present here a rare case of acinar cell carcinoma with apparent foci of endocrine differentiation. A 46-year-old man underwent pylorus-preserving pancreatoduodenec...
Article
Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. To date, nine apomucins (MUC1-8, and MUC5B) have been identified. Recent studies have demonstrated that MUC1 is expressed in tumors of various human organs, and may function as an anti-adhesion molecule that inhibits cell-to-cell...
Article
Sialyl Le(a) antigen (CA19-9), a member of a family of high molecular weight glycoproteins, was originally described as a gastrointestinal- and pancreatic-specific tumor marker. Recent studies have demonstrated that sialyl Lea is a ligand for E-selectin and may play an important role in tumor metastasis. However, expression patterns of sialyl Le(a)...
Article
DF3 (MUC 1) is a member of a family of high molecular weight glycoproteins. Recent studies have demonstrated that DF3 is expressed in tumors of various human organs, and may function as an anti-adhesion molecule that inhibits cell-to-cell adhesion, inducing tumor metastasis. However, expression patterns of DF3 have not yet been established in human...
Article
Carcinoembryonic antigen (CEA) is a good marker of colorectal cancer. Recent studies have demonstrated that CEA may function as a metastatic potentiator by different pathways; i.e., modulation of immune responses, facilitation of intercellular adhesion and cellular migration. However, expression patterns of CEA have not yet been established in huma...
Article
Thrombospondin-1 (TSP1) is one of the extracellular matrix glycoproteins that affect cell adhesion, motility and growth. Based on its effects on tumors, TSP1 is thought to be a potential regulator of tumor growth and metastasis. In this study, we examined TSP1 expression in human gallbladder adenocarcinoma and its clinicopathological significance....

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