Hiroki Higashiyama

Hiroki Higashiyama
The University of Tokyo | Todai · Department of Molecular Cell Biology

PhD
[ Evolutinary morphology of vertebrates ] : Craniofacial morphology. Cardiac development. Hepatobiliary organs.

About

25
Publications
6,148
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142
Citations
Citations since 2017
22 Research Items
133 Citations
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Introduction
My research interest is the morphological evolution of vertebrates. Now I am working on the evolutionaly developmental study for the craniofacial structures, such as the skeletons, trigeminal nerve, and nasolacrimal duct, especially of the amniotes.
Additional affiliations
April 2017 - present
The University of Tokyo
Position
  • Researcher
April 2014 - March 2017
The University of Tokyo
Position
  • Researcher

Publications

Publications (25)
Article
Full-text available
Cover illustration. Morphology of the trigeminal nerve is closely related to the embryonic composition of the jaw or oral apparatus of vertebrates. In this issue of the Journal of Morphology, Higashiyama and Kuratani (pp. 17-38) investigate the development of the maxillary nerve, a component of the trigeminal nerve, generally regarded as a branch s...
Article
Full-text available
The vagus nerve, or the tenth cranial nerve, innervates the heart in addition to other visceral organs, including the posterior visceral arches. In amniotes, the anterior and posterior cardiac branches arise from the branchial and intestinal portions of the vagus nerve to innervate the arterial and venous poles of the heart, respectively. The evolu...
Article
The gallbladder is the hepatobiliary organ for storing and secreting bile fluid, and is a synapomorphy of extant vertebrates. However, this organ has been frequently lost in several lineages of birds and mammals, including rodents. Although it is known as the traditional problem, the differences in development between animals with and without gallb...
Article
Full-text available
Significance The anatomical framework of the jaw has traditionally been thought to be highly conserved among vertebrates. However, here we show that the therian-unique face (muzzle) evolved via a drastic alteration of the common pattern of the tetrapod jaw. Through comparative morphological and developmental analyses, we demonstrated that the theri...
Article
Full-text available
The gallbladder excretes cytotoxic bile acids to the duodenum through the cystic duct and common bile duct system. Sox17 haploinsufficiency causes the biliary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos. However, the molecular and cellular mechanisms in the Sox17-haploinsufficient gallbladder and liver in the etiology...
Preprint
Hagfish (Myxinoidea) are a deep-sea taxon of cyclostomes, the extant jawless vertebrates. Many researchers have examined the anatomy and embryology of hagfish to shed light on the early evolution of vertebrates; however, the diversity within hagfish is often overlooked. Hagfish have two lineages, Myxininae and Eptatretinae. Usually, textbook illust...
Preprint
Full-text available
Coronary arteries are part of the vascular system that nourishes the heart; they are generally considered a synapomorphy of jawed vertebrates. However, the so-called coronary arteries originated from different body parts in amniotes and other groups, and the evolution of these arteries remains unclear. Here we propose that the amniote coronary arte...
Article
Full-text available
The anatomical framework of the jawbones is highly conserved among most of the Osteichthyes, including the tetrapods. However, our recent study suggested that the premaxilla, the rostralmost upper jaw bone, was rearranged during the evolution of therian mammals, being replaced by the septomaxilla at least in the lateral part. In the present study,...
Preprint
Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification of cardiac NCCs remain largely unknown. Using single-cell (sc) and spatial transcriptomics, we demonstrate multi...
Preprint
Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification of cardiac NCCs remain largely unknown. Using single-cell (sc) and spatial transcriptomics, we demonstrate multi...
Article
Full-text available
Although the gallbladder is one of the characteristic component of the vertebrate body, it has been independently lost in several lineages of mammals and birds. Gallbladder loss is a widely reported phenomenon; however, there have been few descriptive comparisons of entire hepatobiliary structures between birds with and without a gallbladder. Here,...
Article
Full-text available
Bats are the second-most speciose group of mammals, comprising 20% of species diversity today. Their global explosion, representing one of the greatest adaptive radiations in mammalian history, is largely attributed to their ability of laryngeal echolocation and powered flight, which enabled them to conquer the night sky, a vast and hitherto unoccu...
Article
Full-text available
Neural crest cells (NCCs) give rise to various tissues including neurons, pigment cells, bone and cartilage in the head. Distal-less homeobox 5 (Dlx5) is involved in both jaw patterning and differentiation of NCC-derivatives. In this study, we investigated the differentiation potential of head mesenchyme by forcing Dlx5 to be expressed in mouse NCC...
Article
Background: The vertebrate jaw is thought to have evolved through developmental modification of the mandibular arch. An extant jawless vertebrate, the lamprey, possesses a structure called "velum" - a mandibular arch derivative - in addition to the oral apparatus. This leads us to assess the velum's possible contribution to the evolution of jaws....
Article
Biliary atresia (BA) is a rare neonatal disease characterized by inflammation and obstruction of the extrahepatic bile ducts (EHBDs). The Sox17‐haploinsufficient (Sox17+/−) mouse is an animal model of BA that encompasses bile duct injury and subsequent BA‐like inflammation by the neonatal stage. Most Sox17+/‐ neonates die soon after birth, but some...
Article
Full-text available
Biliary atresia (BA) is characterized by the inflammation and obstruction of the extrahepatic bile ducts (EHBDs) in newborn infants. SOX17 is a master regulator of the fetal EHBDs formation. In mouse Sox17+/- BA models, SOX17 reduction causes cell-autonomous epithelial shedding together with the ectopic appearance of SOX9-positive cystic duct-like...
Article
Full-text available
Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation...
Preprint
Full-text available
Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation...
Article
In mouse conceptus, two yolk-sac membranes, the parietal endoderm (PE) and visceral endoderm (VE), are involved in protecting and nourishing early-somite-stage embryos prior to the establishment of placental circulation. Both PE and VE membranes are tightly anchored to the marginal edge of the developing placental disk, in which the extraembryonic...
Article
The biliary tract is a well-branched ductal structure that exhibits great variation in morphology among vertebrates. Its function is maintained by complex constructions of blood vessels, nerves, and smooth muscles, the so-called hepatobiliary system. Although the mouse (Mus musculus) has been used as a model organism for humans, the morphology of i...

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