Hirohisa Ono

Hirohisa Ono
nishijima hospital · neurosurgery

About

21
Publications
1,933
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477
Citations
Citations since 2016
2 Research Items
253 Citations
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201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050

Publications

Publications (21)
Article
Introduction: Molecular hydrogen (H2) has emerged as a therapeutic medical gas that exerts multiple functions. H2 inhalation has been approved as safe, and some clinical studies showed that it effectively improved conditions of patients with a variety of disorders such as stroke, heart infarction, chronic obstructive pulmonary disease, cancer, and...
Article
Full-text available
Background: Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized controlled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, we evaluate the H2 treatm...
Article
Abstract BACKGROUND AND PURPOSE: Acute communicating hydrocephalus and cerebral edema are common and serious complications of subarachnoid hemorrhage (SAH), whose causes are poorly understood. Using a mouse model of SAH, we determined whether soluble epoxide hydrolase (sEH) gene deletion protects against SAH-induced hydrocephalus and edema by incre...
Article
Full-text available
In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenera...
Article
Full-text available
We have treated 4 patients of acute erythematous skin diseases with fever and/or pain by H2 enriched intravenous fluid. We also added data from two volunteers for assessing the mode of H2 delivery to the skin for evaluation of feasibility of H2 treatment for this type of skin diseases. All of the four patients received intravenous administration of...
Article
Full-text available
In acute stage of cerebral infarction, MRI indices (rDWI & rADC) deteriorate during the first 3-7 days after the ictus and then gradually normalize in approximately 10 days (pseudonormalization time), although the tissue is already infarcted. Since effective treatments improve these indices significantly and in less than the natural pseudonormaliza...
Article
Lumbar radiculopathy caused by lesions outside the spinal canal, such as far lateral lumbar disc herniation (FLLDH) and lumbar foraminal stenosis (LFS), are not rare conditions. Over the past 6 years, we have treated 5 patients with FLLDH and 8 with LFS. Last year, the incidence of FLLDH and LFS among patients undergoing lumbar surgery patients was...
Article
Low back pain and subsequent disabilities are common. A lumbar spinal fusion procedure is an effective treatment with autologous bone grafts, but harvesting the bone from the iliac crest is associated with risks of complications. New treatments using stem cells together with osteoconductive and otesoinductive materials have made the procedure safer...
Article
A double-blind study was conducted at 48 neurosurgical services in Japan to investigate the usefulness of OKY-046, an imidazole derivative and a thromboxane synthetase inhibitor, on cerebral vasospasm and cerebral ischaemic symptoms in patients with ruptured cerebral aneurysms. OKY-046 was administered in two daily doses of 80 mg (L group) and 400...
Article
Although extracranial-intracranial (EC-IC) artery anastomosis seems to result in symptomatic improvement in certain types of cerebrovascular ischemic disease, this procedure can also be associated with significant morbidity, some of which paradoxically may be the direct result of a patent bypass. A review of the last 51/2 years at the Oregon Health...
Article
A technique is described for placement of ventricular shunt catheters which allows later nonoperative relief of obstruction within the proximal catheter. Operative revision of occluded ventricular catheters may often be avoided by percutaneous aspiration and irrigation of foreign material, thus decreasing the morbidity associated with shunt revisio...
Article
The excitatory and inhibitory postsynaptic responses of Aplysia ganglion cells were elicited by either stimulating cholinergic afferent fibers or by topically applying acetylcholine (ACh) to the cell under study. The responses were evaluated as an increase in membrane conductance and compared before, during, and after perfusion with Li+-Ringer. Exc...
Article
✓ A case of pulmonary aspergillosis resembling bronchogenic carcinoma with extension to the thoracic vertebrae is presented. Therapy is discussed and the need for awareness of this potentially fatal infection stressed.
Article
Techniques for shiunt revision are presented in detail.Percutaneous management of the obstructed ventricular end prevented the operative revision with minimal morbidity.Fogarty catheter technique is described for removal of atrial end obstruction
Article
Two cases of eternal carotid artery steal were presented with clinical data.Evaluatio of collateral circulatio through the external carotid artery using electromagnetic flow meter was emphasized to prevent this complicatin

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