Hira Khan

Dow University of Health Sciences | DUHS · Department of Biochemistry

Acetaminophen (AAP) is an analgesic-antipyretic drug which is considered safe at recommended dose, but its overuse may induce renal and hepatic injuries. Marine macro algae have great potential against drug-induced renal and hepatic dysfunctions. The present study described the reno-protective and hepato-protective effects of the ethanol extract of...

Acetaminophen (APAP) is a widely consumed drug for pain management and treatment of pyrexia. However, beyond its recommended dose, it becomes harmful for health and may induce acute liver dysfunction. Current work is designed to ameliorate the APAP induced liver toxicity which was induced in rats by giving intra-peritoneal injection of APAP (800mg/...

BACKGROUND Kidney dysfunction remains a problem for patients who receive cisplatin chemotherapy. In this study we evaluated the protective role of an edible seaweed Ulva fasciata (U. fasciata) commonly known as sea lettuce, against kidney dysfunction induced by cisplatin. OBJECTIVES OF THE STUDY The objective of this study is to determine the prote...

Objectives: Liver fibrosis is one of the serious health concern around the globe. Persistent exposure to drugs, toxicants, and pathogens may induce liver fibrosis. Marine macroalgae are globally consumed because of nutritive and medicinal value. This study was conducted to evaluate the protective role of two seaweeds Padina pavonia and Caulerpa ra...

Background Diabetes mellitus (DM), an endocrine disease is characterized by increased level of blood glucose. Diabetes may affect other functions of the body and organs including, renal function and lipid metabolism. Pandanus tectorius ( P. tectorius) Parkinson ex Du Roi is a small tree used in folk medicine in treatment of many diseases. Methods...

Background Drug-induced hepatotoxicity is one of the most important causes of liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug is generally considered safe but its overdose may cause liver toxicity. Marine macro-algae (seaweeds) especially brown seaweeds possess unique biological activities including hepatoprotective pot...

Cisplatin is widely used in anticancer therapy, but a substantial percentage of patients who receive the therapeutic dose of cisplatin develop nephrotoxicity. Hepatotoxicity may also develop after a single dose or low repeated doses of cisplatin. Ulva fasciata is an edible seaweed, commonly known as sea lettuces have also been shown various biologi...

Abstract Background: Drug-induced hepatotoxicity is one of the most important causes of liver dysfunction. Acetaminophen (paracetamol) an analgesic-antipyretic drug is generally considered safe but its overdose may cause liver toxicity. Marine macro-algae (seaweeds) especially brown seaweeds possess unique biological activities including hepatoprot...

Cisplatin is considered one of the best anticancer medications often used for the treatment of various cancers even with its adverse effects. Acetaminophen (paracetamol) is a widely used analgesic-antipyretic drug that causes hepatotoxicity at higher than the effective doses. The present study assesses the nephroprotective and hepatoprotective effe...

Background Polysaccharides from seaweeds have been reported to possess biological activities with potential medicinal value. Present study was aimed to investigate hepatoprotective effect of crude sulphated polysaccharides extracted from Sargassum swartzii against acetaminophen-induced liver injury. Methods The polysaccharides from S. swartzii was...

Liver plays a major role in transforming and clearing the chemicals form the body, but same time it is susceptible to the toxicity of these chemicals. Liver diseases are now become major public health problem worldwide, beside viral infection, autoimmune diseases, infectious agents, toxic chemicals and many drugs at higher doses can cause hepatic i...

Seaweed can promote plant growth and also enable them to tolerate drought, disease or frost. In this study, eight seaweeds Stokeyiaindica, Stoechospermum marginatum, Sargassum binderi, Spatoglossum variabile (brown), Melanothamnus afaqhusainii, Solieriarobusta (red), Rhizocloni umimplexum and Halimeda tuna (green) collected from Buleji beach, Karac...

Hepatoprotective and reno-potective effect of Sargassum species was investigated in rats against carbon tetrachloride (CCl4) and acetaminophen (AAP) intoxication. The rats were given ethanol extracts of Sargassum ilicifolium, S. lanceolatum and S.swartzii orally at dose of 200mg/kg b.w. (body weight) daily for 14 days. These seaweed treated rats we...

Seaweeds have been consumed as human food from thousands of years. In this study ethanol extract of 16 different seaweeds were tested for mosquito larvicidal activity against 4th instar larvae of Aedes aegyptii. The ethanol extracts of Padina pavonia and Sargassum ilicifolium caused 50% mortality at 1200ppm concentration. However other seaweeds Hal...

Objective: To assess the hepatoprotective effect of ethanol extracts of Sargassum variegatum (S. variegatum), Sargassum tenerrimum (S. tenerrimum) and Sargassum binderi occurring at Karachi coast against carbon tetrachloride (CCl4) and acetaminophen intoxication in rats. Methods: Sargassum species were collected at low tide from Buleji beach at Kar...

Liver is the main site in the body for intense metabolism and excretion. A number of chemicals and drugs which are used routinely cause liver damage. The present study investigates the antihepatotoxic effect of Physalis peruviana whole ripe fruit, water and ethanol extracts of fruit in normal as well as in carbon tetrachloride (CCl4) intoxicated ra...

Objective: A Cross Sectional population based serological studies was conducted to determine the prevalence and associated risk factors for syphilis women with recurrent miscarriages. Methods: Patient's 5ml whole blood was collected through venepuncture technique. Data were collected by all women answered a questionnaire and by investigating blo...

Nutritionally valuable seaweeds are being used as fresh or dried vegetables or as ingredients in wide variety of prepared foods. Interest in seaweeds has increased markedly through out the world due to their value in nutrition and in medicine. In this study 16 seaweed species collected from Karachi coast were examined for the estimation of ascorbic...

Discovery of anticancer drugs that must kill or disable tumor cells in the presence of normal cells without undue toxicity is an extraordinary challenge. In the past 50 years, number of highly successful drugs based upon fungal metabolites was discovered. Beside producing antibiotics, fungi have a much greater potential for producing other medicina...

Objective: Present study was undertaken to explore the epidemiological and dietary risk factors for hepatitis C disease in Tando Allahyar during June to December 2007. Materials and methods: 140 Hepatitis C patients and 149 controls (age, sex and locality matched with no personal or family history of hepatitis C) were randomly selected from the Tan...

Marine algal community signifies a huge source of compound endowed with ingenious structure and potential biological activities. Cytotoxicity of plant or fungal material is considered as the presence of antitumor compounds. In this study, ethanol extracts of seaweeds Dictyota dichotoma var. velutricata, D. hauckiana, D. indica, Iyengaria stellata,...