Himangshu Sarma

Institute of Advanced Study in Science and Technology | IASST · Division of Life Sciences

Background Lakadong turmeric (LKD) from Meghalaya, India, boasts high curcumin levels, but lacks scientific study. Moreover, Curcumin's poor solubility hinders its clinical use in inflammation and wound healing. This study isolated curcumin from LKD, forming a PLGA nanosuspension-based nanogel and explored for its potential anti-inflammatory and cu...

Background: 3D printing is an exhilarating approach to producing 3D pharmaceutical products, in which polymers are allowed to load in the digital model designed by computer-assisted design software in a layer-by-layer. Objective: The study summarizes the recent advancements of 3DP technology in the pharmaceutical field to achieve rapid, personalize...

Practice and Re-emergence of Herbal Medicine focuses on current research in Indian traditional medicine. Chapters cover many facets of herbal medicine, including quality control and experimental validation, intellectual property issues, pharmacovigilance and the therapeutic use of herbal medicine. The book informs readers about the effectiveness of...

Diabetic Foot Ulcers (DFUs) are a devastating micro-vascular complication of diabetes with an increased prevalence and incidence and high rate of morbidity and mortality. Since antibiotics are frequently used to treat DFU, managing the condition has proven to be extremely challenging and may eventually lead to the development of antibiotic resistan...

Oroxylum indicum, a well-known traditional medicinal plant which is used to alleviate various kinds of diseases in Asia. The study aimed to identify bioactive compounds present in O. indicum stem bark using HPTLC technique. Further, the cytotoxic efects of the plant extracts were determined against HeLa (human cervical carcinoma) cell lines....

Verbascoside (VER) is a phenylethanoid glycoside compound found in Clerodendrum species and is an important part of traditional medicine. It is found in the leaves of Clerodendrum glandulosum, which is taken as a soup or vegetable and also utilized in traditional medicine by the people of Northeast India, especially against hypertension and diabete...

Background Diabetic patients suffer from various comorbidities like cardiovascular diseases (CVDs), cancer, obesity, cognitive impairment, gout, leishmaniasis, etc. Objective We aimed to review the pathological links between diabetes and its comorbidities and discuss the justification for using antidiabetic drugs in diabetes and associated comorbi...

Journal of Inorganic and Organometallic Polymers and Materials

The acute anti-inflammatory activity of onion peel-derived gold nano-bioconjugate was already established earlier. The current study was aimed to investigate the acute oral toxicity of onion peel-derived gold nano-bioconjugate (GNBC) for safe therapeutic utilization in vivo. The acute toxicity study was carried out in female mice for 15 days and sh...

Objectives The objective of the present study is to discuss the use of nanomaterials like nanosensors for diagnosing Diabetes and highlight their applications in the treatment of Diabetes.Methods Diabetes mellitus (D.M.) is a group of metabolic diseases characterized by hyperglycemia. Orally administered antidiabetic drugs like glibenclamide, glipa...

Diabetes mellitus is one of the most prevalent metabolic disorders characterized by hy-perglycemia due to impaired glucose metabolism. Overproduction of free radicals due to chronic hyperglycemia may cause oxidative stress, which delays wound healing in diabetic conditions. For people with diabetes, this impeded wound healing is one of the predomin...

Preventive measures to lower the prevalence of type-2 diabetes development using dietary phytochemicals are most realistic. A phytochemical composite derived from whole grain scented joha rice (PCKJ), which is indigenous to the North-eastern Region, India, was investigated to understand its preventive efficacy in rats in which type 2 diabetes was i...

The treatment of infectious diseases and immunizations has experienced a paradigm shift in recent years. With the advent of biotechnology and genetic engineering, not only have various disease-specific biologicals been developed, but an emphasis has also been focused on the effective delivery of such biologicals. The majority of active pharmaceutic...

Species of Clerodendrum are a well-known medicinal plant in the Indian traditional system of medicines for its multi-purpose use in the management of various diseases or disorders. For scientific validation of the traditional claims, this study aimed to delineate the antioxidant properties and phenolic contents of methanolic leaf extracts of five s...

COVID-19 and its causative organism SARS-CoV-2 paralyzed the world and was designated a pandemic by the World Health Organization in March 2020. The worldwide health system is trying to discover an effective therapeutic measure since no clinically authorized medications are present. Screening of plant-derived pharmaceuticals may be a viable techniq...

SARS-CoV-2 has affected socioeconomic activity in every country around the world since its outbreak began in 2019. 3.5 million people have died worldwide as of now, including 3.2 lakh in India. The cytokine storm significantly contributes to COVID mortality. To put it simply, the virus causes an uncontrolled release of cyto-kines, which results in...

Phytoantioxidants refer to chemicals of plant origin such as flavonoids (flavones, flavonones, flavonols, flavononol, isoflavones, and flavan‐3‐ols) and other polyphenols (phenolic acids, stilbenes, lignans, and tannins). Phytoantioxidants have been reported to act against parasitic diseases (malaria, dengue, chikungunya, leishmaniasis, Zika virus,...

Background: Cardiovascular disorders (CVDs) are the most prominent killer in the twenty‐first century. Antioxidant therapy has represented an effective strategy for the treatment of CVDs. However, the conventional phytoantioxidant agents showed limited in vivo effects owing to their nonspecific distribution and low retention in target sites. Object...

Tamilnadia uliginosa (Retz) Tirveng and Sastre (Rubiaceae) is a small edible medicinal plant utilized in traditional remedies. The review aims to report the current information of T. uliginosa based on its botanical and taxonomic description, traditional use, active phytoconstituents, pharmacological use and toxicity. The information on T. uliginos...

Tamilnadia uliginosa (Retz) Tirveng and Sastre (Rubiaceae) is a small edible medicinal plant utilized in traditional remedies. The review aims to report the current information of T. uliginosa based on its botanical and taxonomic description, traditional use, active phytoconstituents, pharmacological use and toxicity. The information on T. uliginos...

In the 21 st century, cardiovascular diseases (CVDs) constitute the leading cause of death. It is difficult for potential CVD therapies to be successful since CVDs cannot be effectively or cheaply treated with existing therapy. To formulate and transport therapeutically active molecules to treat a variety of ailments, innovative drug delivery carri...

Background:Glucosidase is a catalytic enzyme that catalyzes, specifically hydrolyses, the carbohydrates to free glucose units in blood in the last step of carbohydrate metabolism. So far, many compounds with α-glucosidase inhibitory activity for example, acarbose, voglibose etc., have been accounted and commercialized for diabetes therapy. However,...

Background Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is reported to have several health-promoting effects including antioxidant, anti-inflammatory, diabetic, antineoplastic properties, gastrointestinal, neuropsychological, metabolic and cardiovascular disorders. Aims The aim of the present work was...

The traditional healers of different parts of India use goat urine for the treatment of tuberculosis. On the basis of ethnomedicinal claims, two plant species namely Hydrocotyle sibthorpioides and Carica papaya were extracted with raw (fresh) and photo-activated goat urine as a menstruum. The present study reports the in vitro antimycobacterial act...

Background Since primitive times, plants have been extensively utilized in conventional remedies for primary health care. It is observed that medicinal plants have a variety of bioactive components, and they have become an alternative choice for synthetic medications to treat various diseases. Objective Major objective of this review article is to...

A sensitive and reliable high-performance thin-layer chromatography (HPTLC) method has been developed to simultaneously estimate quercetin and gallic acid in Annona reticulata L. The methanolic extract of the leaf of A. reticulata L. was performed to detect standard marker compounds like quercetin and gallic acid by the automatic TLC applicator. Th...

PurposesCardiovascular diseases (CVDs) are the most prominent killer in the twenty-first century. The success of promising therapeutics for CVDs is challenging, as traditional treatments are not cost-effective or efficient in curing CVDs. Computer-aided drug design (CADD) has egressed as an effective means of formulating drugs to treat several dise...

Background Since primitive times, plants have been extensively utilized in conventional remedies for primary health care. It is observed that medicinal plants have various bioactive components. It becomes an alternative choice for synthetic medications to treat diarrhea and dysentery, which are the primary waterborne diseases with high mortality ra...

Background: The pulmonary delivery of active ingredients in the form of large cohesive powder formulations is gaining significant importance in the field of pulmonary drug delivery. The pulmonary delivery of powder doses has promising advantages; however, it also comes with unique challenges. The success of pulmonary delivery of drugs depends on in...

Many herbal drugs have shown promising activity for respiratory diseases. This chapter discusses the various aspects of solid lipid nanoparticles (SLN) for pulmonary delivery of herbal drugs and their evaluation. Various components are used for preparation of solid lipid nanoparticles. Triglycerides, partial glycerides, fatty acids, steroids, and w...

Annona reticulata Linn. is well-known for its health-promoting properties. Plant parts such as the leaves, bark, seed, and root of this plant are utilised as folk medicine in Assam's rural areas to cure a variety of diseases. Annona reticulata leaves were gathered, identified, dried, and ground into a coarse powder before being extracted with meth...

Diabetes mellitus is one of the most prevalent metabolic disorders and has been a leading cause of death in the last few decades. Oral hypoglycaemic agents are mostly used in the treatment of diabetes, but the main drawback of these agents is that they have some unavoidable side effects. Nowadays, researchers are mainly focusing on unexposed medici...

Allergic conjunctivitis (AC) is an inflammation of the conjunctiva due to allergens that come in contact with the eye. Seasonal AC and perennial AC are the most commonly encountered subtypes. Each can be identified by itching, tearing, and swelling or inflammation of the eye, and these symptoms can contribute to decreased quality of life for patien...

Molecular testing and the development of targeted therapies have revolutionized the treatment of non-small cell lung cancer (NSCLC). Despite the advantages of molecular testing in patients with NSCLC and guideline recommendations, there is no specific standard testing method, resulting in variable testing practices based on institution protocol and...

In this study, chemical, biological and toxicity profile of hydromethanolic extracts of different parts (leaf, stem and root) of Clerodendrum glandulosum Lindl. were investigated simultaneously for the first time. Total phenolic and flavonoid contents were estimated spectrophotometrically. Untargeted metabolomics was performed using GCÀMS and HPLC-...

Background: The solid oral dosage forms containing bitter drugs need improved palatability for administration. Formulation scientists have given attention to the improvement of taste masking technologies and utilised various strategies. Objective: The present work aimed to mask the bitter taste of Promethazine Hydrochloride by formulating Oral Dis...

Background The leaves of Annona reticulata Linn. have been traditionally used by the tribes of Assam as a source of medicine to mitigate a range of health ailments including diabetes and obesity. Objectives The current study aimed to evaluate the anti-diabetic and anti-hyperlipidemic potential of bioactive fractions isolated from the methanolic ex...

Background: Traditional or folk or indigenous medicine concerns the health practices, knowledge and faith of different indigenous communities. It is the application of a single or combination of parts of plants, animals and mineral-based medications to diagnose, cure, mitigate or prevent illnesses or diseases. The traditional medicine has a wide ap...

Drug discovery and formulation development are time-consuming and costly processes. These processes consume billion dollars and take many years for completion with involvement huge amount of resources. With the advancement of software-based studies, one can screen many candidate molecules for drug discovery in a short span of time. These computatio...

Background: Cancer is a life-threatening global problem with high incidence rates. Prioritizing the prevention of cancer, chemopreventive agents have drawn much attention from the researchers. Objective: This review focuses on discussion of the progress in the development of chemopreventive agents and formulations related to the prevention of or...

In spite of the progresses in science and technology, India is well-known for its traditional system of medicine. Traditional use of medicine is practiced since the era of vedic. The Indian traditional system of medicine such as Ayurveda, Siddha, and Unani has a very rich history of their effectiveness. As India is a rich repository of herbal and m...

Background: Gout is complex form of chronic arthritis disease where monosodium urate monohydrate (MSU) deposits in synovial fluid and other body tissues. Corticosteroids, uricosuric agents, Colchicine and non-steroidal anti-inflammatory drugs (NSAID's) are administered via systemic route to treat gout. Colchicine is an alkaloid obtained from the pl...

Hypertension is a cardiovascular disorder characterise by rise in the arterial blood pressure. Although various conventional dosage forms are available in the market to treat hypertension. But these conventional dosage forms facing the problems of high first pass metabolism leading to poor bioavailability and less therapeutic efficacy [1]. To overc...

Background: Nanotechnology has the potential to increase the selectivity and potency of chemical, biological and physical approaches for eliciting cancer cell death while minimizing collateral toxicity to non-malignant cells. Moreover, nano carrier allows more surface area and have potential to increase solubility, enhance bioavailability, improve...