Hideya NakamuraOsaka Metropolitan University · Department of Chemical Engineering
Hideya Nakamura
Doctor of Engineering
About
131
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Introduction
I am working on advanced computational modeling of powder handling processes. I am also working on powder handling processes for all-solid-state battery. I am also working on nanoparticle-cell interactions to understand how does the nanoparticles physicochemically interact with lipid bilayers.
For more details, please see https://www.omu.ac.jp/eng/chemeng3e/member/nakamura/index.html
Additional affiliations
April 2010 - March 2015
October 2008 - March 2010
University of Frolida
Position
- Post doc associate
Publications
Publications (131)
Nanoparticles (NPs) have attracted significant attention as carriers for the delivery of drugs, genes, and macromolecules for biomedical and therapeutic applications. These technologies require NPs to be delivered to the...
We have proposed a hot-melt kneading process using sulfur and porous carbon to produce composite cathodes for all-solid-state batteries. In this study, we investigated a key parameter to control the structure of composite particles obtained from the hot-melt kneading process. Furthermore, we investigated the correlation between composite-particles...
The calculation methods of Discrete Element Method (DEM) for wet powder flow are diverse, and lacking a unified assessment. In this study, four calculation methods, combining two approaches for bridge formation distance and liquid bridge force during particle contact, were applied to a rotating drum mixer. Comparisons of the results revealed the si...
Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a tablet compact with sufficient strength is determined based on empirical rules. Therefore, a metho...
Powder compression is the process of obtaining pellets by directly applying pressure to powder beds. The densification phenomenon involving the plastic deformation of particles is still unclear. In this study, the powder compression process of the binary mixture of powder with different plasticity was calculated by using the discrete element method...
Continuous wet granulation using a twin-screw granulator has attracted much interest in the pharmaceutical industry. The physical properties of granules prepared through the twin-screw granulation process depend on the several factors, such as screw and barrel geometries, operating conditions, and formulations of raw materials. In particular, it is...
Because the cell membrane is the main barrier of intracellular delivery, it is important to facilitate and control the translocation of extracellular compounds across it. Our previous molecular dynamics simulations...
Powder mixing is an important operation in many industries. Numerical simulations using the discrete element method (DEM) have been widely used to analyze powder-mixing processes. However, one of the current limitations of the DEM simulation is its high computational cost. Recently, approaches that combine machine learning models and numerical simu...
In this study, we investigated milling characteristics of sulfide solid electrolytes (SEs) for all-sold-state lithium ion batteries (ASSLIBs). Subsequently, we employed the milled SEs as guest particles for dry coating of cathode active material (AM), and examined the influence of SE size distribution on ASSLIB performance. Our finding revealed tha...
The discrete element method (DEM) is widely used to analyze powder mixing processes, however DEM simulation is limited by the computing capability. Hence, we proposed an original model, namely Recurrent Neural Network with Stochastically calculated Random motion (RNNSR), to simulate the powder mixing with low computational cost. RNNSR combines recu...
A rotary tableting machine is used for the continuous tableting process. Tableting conditions often result in capping, leading to serious problems during production. Several studies have been conducted to predict the tablet capping tendency. However, as most previous studies were conducted using a compaction simulator, there is a lack of technology...
All‐solid‐state lithium‐sulfur (ASS‐Li/S) batteries have recently attracted considerable attention owing to their high energy density and safety. To produce the cathode of an ASS‐Li/S battery, sulfur (the cathode active material) must be combined with a conductive additive (electron conductor) because of the electronic insulating property of sulfur...
Wet granulation plays an important role in the processing of fine ore powder. Water content is a critical process parameter that determines the granule properties during wet granulation. However, in the ironmaking industry, various types of iron ore powder imported from different regions are blended, quicklime powder is added as a binder, and used...
All-solid-state lithium-ion batteries (ASSLIBs) are promising candidates for next-generation electric vehicle batteries. The contact interface between the active material (AM) and solid electrolyte (SE) is an important factor that affects the performance of ASSLIB. Composite particles, which are SE-coated AM particles, can form electrodes with larg...
Twin-screw granulators for continuous wet granulation have attracted interest in the pharmaceutical industry. The physical properties of granules and tablets prepared through the twin granulation process depend on several factors, such as screw and barrel geometries, operating conditions, and formulations of raw materials. The fill level has been r...
In the pharmaceutical industry, tablets are manufactured using rotary tableting machines. Recently, die wall pressure in a single-punch press was measured to understand the compaction mechanism and predict tableting failure. However, die wall pressure measurements in rotary tableting machines have not been studied. Two challenges exist in measuring...
All-solid-state lithium-ion batteries (ASSLIBs) are promising candidates for next-generation batteries because of their various attractive properties. The uniform mixing of active materials (AMs) and solid electrolytes (SEs) is important for high-performance ASSLIBs. However, most AMs and SEs have poor flowability owing to their small particle size...
Generally, a carrier that contains or binds to a drug is required for DDSs. Although it is common to use liposomes and polymeric micelles as carriers, the loading of drugs in these carriers is relatively low. This study investigates the application of metal-organic frameworks (MOFs), which are a new class of porous materials, to drug carriers. UiO-...
Wet granulation of iron ore powders is a key process in ironmaking. In wet granulation, it is important to determine the optimum content of water added to the original ore powders. To determine the optimum water content, it is important to understand the saturation state in wet ore powder, which can be done by measuring the agitation torque of the...
A great issue in the development of an all-solid-state lithium-ion battery (ASSLIB) is the fabrication of a composite electrode with good contact between active materials (AMs) and solid electrolytes (SEs). To overcome this challenge, it is important to develop a powder processing technology that produces composite particles of AMs and SEs. In this...
Granulation plays an important role in various manufacturing sectors, including the chemical, pharmaceutical, and agricultural sectors. Computer simulation by coupling a discrete element method (DEM) and a population balance model (PBM) is a promising method for the rational design and operation of granulation processes. However, the agglomeration...
Numerous efforts have been devoted to improving the solubility of poorly water-soluble drugs. Recently, it was reported that the use of metal-organic frameworks (MOFs), which are a new class of porous materials consisting of metal ions and organic ligands, is effective in improving the solubility of poorly water-soluble drugs. Our previous study de...
The sustained-release formulations consist of many components, such as the active pharmaceutical ingredient, excipient, binder, lubricant, and polymer, leading to the complex dissolution process. The objective of this study is the elucidation of the rate-determining step in the dissolution process by direct optical observation. The composite partic...
In all-solid-state lithium-ion batteries (ASS-LIBs), the electrode structure is an important factor that determines the battery performance; in particular, the formation of contact interface between the active material (AM) and solid electrolyte (SE) is an important issue associated with ASS-LIBs. Although we previously reported the formation of in...
Recent improvements in computing capabilities have made numerical simulation of the behavior and the heat transfer of many particles possible via the Discrete Element Method (DEM). However, even with current computational capabilities, it is still difficult to simulate particle behavior and the heat transfer for manufacturing equipment as rotary ki...
In this study, a neural network (NN) was applied to a continuous manufacturing process of tablets to predict the tablet physical properties based on a twin-screw granulation operating conditions and tableting pressure. The hyperparameters in the NN model were optimized to accurately predict the tablet physical properties. The constructed NN model s...
All-solid-state lithium-ion batteries (ASS-LiB) have garnered attention as the next-generation secondary batteries owing to their high safety and energy densities. The ASS-LiBs are composed of inorganic solid electrolytes, instead of an organic liquid electrolyte. Therefore, interstitial voids deteriorate the battery capacity, which is a serious pr...
Recent improvements in computational capabilities have made numerical simulation of the particle behavior and heat transfer in a rotary kiln reactor possible via the discrete element method (DEM). However, even with current computational capabilities, it is still difficult to simulate particle behavior and heat transfer in a rotary kiln reactor on...
There is a great demand for understanding the layering granulation of coarse and fine iron ore particles. For the understanding, a numerical simulation can be powerful approach. We here proposed a numerical simulation method, by which the deposition of fine particles with water on the surface of a coarse particle can be simulated. In the proposed m...
There is a huge demand for the development of a coarse-grained model of a discrete element method (DEM) to perform a numerical simulation of a high-shear mixer with large-scale production. Recently, we developed a coarse-grained method for granular shear flow (CGSF) for coarse-graining dense granular shear flow. Using the CGSF, we here perform a co...
Nanoparticles have attracted much attention as a carrier for drug, gene, and macromolecule delivery in next-generation biomedical and therapeutic technologies. In delivery applications, nanoparticles tend to have negative charge due to the negative charge of biomolecules used as delivery cargo, while biological cell membranes are also negatively ch...
A dry coating technology to produce composite electrode of an all-solid-state battery has been proposed. First, from the viewpoint of the powder technology, the fundamental concept of the dry coating is introduced. Second, a feasibility study on the dry coating process was conducted by using a cathode active material particle (LiNi1/3Co1/3Mn1/3O2,...
Dry powder inhalers (DPIs) have been widely used to treat respiratory diseases due to the large absorption site in a human lung. Understanding the fluid and particle deposition behaviors from the device to human respiratory system is essential to improve the efficiency of DPIs. In this study, an adhesion model of particles against liquid layer was...
Metal-organic frameworks (MOFs) are a new class of porous materials consisting of metal ions and organic ligands. The present study demonstrated a novel improvement technology of drug solubility based on MOFs. Zeolite imidazolate framework-8 (ZIF-8) was selected as a model MOF, while the analgesic and antipyretic indomethacin (IDM) was selected as...
In this study, the compression characteristics of bimodal cohesive particles were investigated using a discrete element method (DEM) simulation. The compression and packing processes were simulated under different conditions of size ratios of 1–4 and fine particle mixing ratios of 0–0.5. The cohesive force was expressed using the surface energy pro...
Numerical analysis via the DEM has been applied to various powder processes. To obtain simulation results of high reliability, a calibration method for the input DEM parameters must be established. This paper therefore proposes a calibration procedure for non-spherical cohesive particles. The rolling friction coefficient and surface energy for cohe...
Spray drying process is widely used to produce particulate materials in the pharmaceutical industries, such as porous materials for direct compression, solid dispersion for improvement of drug dissolution properties, micro encapsulation to stabilize active compounds, taste masking, preparation of dry powder for inhalation. However, as many factors...
There is a great demand for numerically simulating the layering granulation of iron ore, in which multiple fine ore particles adhere simultaneously to the surface of a single coarse ore particle. This paper presents such a simulation method by coupling a discrete element method (DEM) and a population balance model (PBM). To calculate the high aggre...
Dry powder inhalations (DPIs) have gathered attention as a treatment for respiratory diseases due to the large effective absorption area in a human lung. A cascade impactor is generally used to investigate the inhalation performance of DPIs. For the improvement of the efficiency of DPIs, understanding the particle motion and deposition behavior in...
Powder mixing process plays an important role in chemical industries. In manufacturing sectors, there is a great demand for developing a coarse-grained model of a discrete element method (DEM) to perform DEM simulations of powder mixing processes at the manufacturing scale. Herein, we present a coarse-grained method for granular shear flow (CGSF)....
This study investigated the particle adhesion mechanism in a capsule of dry powder inhaler (DPI) based on a combined computational fluid dynamics and discrete element method (CFD–DEM) approach. In this study, the Johnson–Kendall–Roberts (JKR) theory was selected as the adhesion force model. The simulation results corroborated the experimental resul...
Spray drying is a fundamental process in several industries. As many factors affect the particulate product property in complex manners, optimal operating conditions have been determined through trial and error. In a spray dryer, numerous sprayed droplets form a tear-shaped droplet aggregate (droplet group), in which each droplet evaporates at a di...
In wet granulation processes, a particle adhesion mediated by a liquid bridge is one of the quite important phenomena. In an actual process, the liquid bridge shows dynamic motion due to motion of the particles. Therefore, understanding of a particle-particle adhesion by such a dynamic liquid bridge is an important issue. We have conducted a direct...
Flexible metal-organic frameworks (flexible MOFs) are known to exhibit a step-wise adsorption behavior induced by structural transition. This adsorption behavior is referred to as the “gate” adsorption behavior as it resembles the opening and closing of a gate. Gate adsorption behavior has been reported to originate from the balance between stabili...
In this review, a dry coating technology to produce composite electrode of an all-solid-state battery is presented. Firstly, from the view point of the dry powder mixing, fundamental concept of the dry coating is reviewed. Secondly, our recent progress in the dry coating technology for cathode active material and sulfide solid electrolyte is presen...
In this study, we present a dry coating process to produce a core-shell composite particle for an all-solid-state lithium battery, where a single particle of the active material is coated with solid electrolytes. LiNi1/3Co1/3Mn1/3O2 (NCM) and Li3PS4 (LPS), which are typical cathode active material and sulfide solid electrolyte, were used. A dry imp...
In biomedical technologies that use nanoparticles, the nanoparticles are often required to translocate across a cell membrane. Application of an external electric field has been used to increase the cell membrane permeability; however, damage to the cell is of great concern. In this review, our recent molecular dynamics simulation study of the nano...
A numerical study of the tableting process using a finite element method (FEM) is important to quantitatively understand the structural change inside the tablet and the mechanism of tableting failures such as capping, picking, lamination, and sticking. In the pharmaceutical field, the Drucker-Prager Cap (DPC) model is used most widely to demonstrat...
Dry powder inhalation (DPI) has attracted much attention as a treatment for respiratory diseases owing to the large effective absorption area in a human respiratory system. Understanding the drug particle motion in the respiratory system and the deposition behavior is necessary to improve the efficiency of DPI. We conducted computer simulations usi...
A novel population balance model (PBM) in which particle collision frequency function was determined through the coupling of the discrete element method with computational fluid dynamics was proposed to investigate the mechanisms of granule growth and breakage in fluidized bed granulation. The collision analysis revealed that the collision frequenc...
Owing to their step-wise adsorption behavior induced by structural transition, soft metal-organic frameworks (soft MOFs) are used in a wide range of applications. However, they suffer from poor handling performance because of their submicron size. Hence, it is imperative to improve their flowability in order to render them suitable for industrial a...
In biomedical technologies that use nanoparticles, the nanoparticles are often required to translocate across a cell membrane. Application of an external electric field has been used to increase the cell membrane permeability; however, damage to the cell is of great concern. Using a molecular dynamics simulation, we show that even under a weak exte...
Nanoparticles have been attracting much attention as a key material for new biomedical and pharmaceutical applications. For success in these applications, the nanoparticles are required to translocate across the cell membrane and to reach to inside of the cell. In this article, our computational studies regarding the permeation of nanoparticles acr...
In wet granulation processes, a particle adhesion mediated by a liquid bridge is one of the quite important phenomena. In an actual process, the liquid bridge shows dynamic motion due to continuous motion of the particles. Therefore, understanding of the particle adhesion phenomenon by a dynamic liquid bridge is essential to adequately and precisel...
Nanoparticles have attracted much attention as a key material for new biomedical and pharmaceutical applications. For success in these applications, the nanoparticles are required to translocate across the cell membrane and to reach to inside of the cell. Among several translocation pathways of nanoparticles, the direct permeation pathway has a gre...
Fullerenol C60(OH)n, where multiple hydroxyl groups are chemically bound to surface of a fullerene C60, is a highly potential nanomaterial for biomedical and pharmaceutical applications. To realize such biomedical and pharmaceutical applications, the C60(OH)n is required to be transported on the cell surface and/or to be transported into the cell i...
In a fluidized bed spray granulation, a particle-particle adhesion by a liquid bridge, which shows dynamic motion due to moving particles, is the most fundamental phenomenon. Therefore, understanding of the particle-particle adhesion by such a dynamic liquid bridge is very important to elucidate mechanisms of particle agglomeration phenomenon in th...
We have reported that a dry coating is a very promising process to produce a suitable composite particle for all-solid-state lithium-ion secondary batteries. We here present a parametric study of this dry coating process for further optimization and improvement. In the dry coating process, electrode particles were coated with solid electrolyte (SE)...
The aim of this study is to develop a novel milling system using supercritical carbon dioxide (SC-CO2) for the improvement of dissolution characteristics of water-poorly soluble drugs. SC-CO2 possesses high potential in the application of nanotechnology, due to the attractive properties of SC-CO2 fluid such as cheap, inert and non-polluting. In add...
In wet granulation processes, a liquid bridge formed between particles is not static but dynamic due to continuous motion of the particles. Therefore, understanding of the particle-particle adhesion by a dynamic liquid bridge is an important issue. We here conducted a direct numerical simulation of the particle-particle adhesion by a dynamic liquid...
Abstract To synthesize nitrogen-doped carbon nanofibers (N-CNFs) at high growth rates and low temperatures less than 673 K, nickel species (metallic nickel and nickel oxide) supported on alumina particles were used as the catalysts for an acetonitrile catalytic chemical vapor deposition (CVD) process. The nickel:alumina mass ratio in the catalysts...
Nanoparticles (NPs) have been attracting much attention for biomedical and pharmaceutical applications. In most of the applications, NPs are required to translocate across the cell membrane and to reach the cell cytosol. Experimental studies have reported that by applying an electric field NPs can directly permeate across the cell membrane without...
We here present a dry coating of electrode particle with a model material of sulfide solid electrolytes for all-solid-state secondary batteries. LiNi1/3Co1/3Mn1/3O2 (NCM) was used as a host particle. Sodium sulfate (Na2SO4) was selected as a model material of sulfide solid electrolytes and used as a guest particle. Three different processes, which...
In powder handling processes treating wet powders (e.g. wet granulation, coating, and drying), a liquid bridge formed between particles is not static but dynamic due to continuous motion of the particles. Therefore, understanding of a particle-particle adhesion by such a dynamic liquid bridge is an important issue. We here conducted a numerical sim...
Granulation of drug particles for dry powder inhalation was conducted by means of a novel granulation method, named as Advanced Freeze Granulation by Supercritical Fluid. In this method, drug particles were micronized and granulated by the following steps: 1) drug particles were micronized by beads milling in a supercritical carbon dioxide (SC-CO2)...
An innovative technology to enhance drug dissolution rate was proposed in this study. Poorly water-soluble ibuprofen was ground in a bio-compatible and amphiphilic co-polymer solution made from 2-methacryloyloxyethyl phosphorylcholine (MPC) and butylmethacrylate (BMA) by using a novel multi-ring type wet grinding system. The dry particle of ibuprof...
Nitrogen-doped carbon nanocoils (CNCs) with adjusted morphologies were synthesized in a one-step catalytic chemical vapour deposition (CVD) process using acetonitrile as the carbon and nitrogen source. The nickel iron oxide/nickel oxide nanocomposites, which were derived from nickel-iron layered double hydroxide (LDH) precursors, were employed as c...
An impact pulverizer is widely employed for dry milling of powders in many industrial sectors. However, effect of the equipment geometry on grinding performance of the impact pulverizer is still unknown. This paper presents systematic analysis of effect of the stator geometry of an impact pulverizer on its grinding performance. Three types of stato...