Hideoki Uryu

• Chief at Kyushu Medical Center

6007 Background: No standard treatment exists for unresectable locally advanced (LA) or recurrent/metastatic (R/M) salivary gland cancer (SGC). Previous findings suggest that combined androgen blockade (CAB) provides promising clinical activity in patients with androgen receptor (AR)-positive SGC. However, no AR-targeted drug is currently approved...

Background Nivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, the limited rates of long-term survivors (< 20%) demand a robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify a plasma exosome (PEX) mRNA signature,...

Background Olfactory neuroblastoma (ONB) is a rare malignant tumor of the head and neck. Due to its rarity, standard systemic therapy for this condition has yet to be established. In particular, the use of immune checkpoint inhibitors (ICIs) for the recurrent or metastatic (R/M) ONB population remains unclear. Methods We retrospectively evaluated...

Nivolumab paved a new way in the treatment of recurrent or metastatic (RM) head and neck squamous cell carcinoma of (HNSCC). However, the limited rates of long-term survivors (< 20%) demand a robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify a plasma exosome (PEX) mRNA signature, which serves as a compan...

b> Introduction: Metallic stents are widely used to prevent airway obstruction for tracheal stenosis caused by malignant diseases. Although their efficacy has been recognized, there is no established evidence surrounding their long-term safety. We report a case of airway stenosis caused by a metallic tracheal stent. Removal of the stent to secure t...

Induction chemotherapy （ICT） of DTX＋CDDP＋5-FU （TPF） has been reported to be useful as pretreatment preceding standard CDDP combination chemoradiotherapy （CCRT） for head and neck cancer. However, ICT causes many adverse events, and its effectiveness is still controversial. We conducted a study on ICT followed by CCRT in 30 cases of advanced laryngea...

BACKGROUND. Nivolumab paved a new way in the treatment of patients with recurrent or metastatic (RM) head and neck squamous cell carcinoma (RM-HNSCC). However, the limited rates of long-term survivors (< 20%) demand a robust prognostic biomarker. This nationwide multi-centric prospective study aimed to identify a plasma exosome (PEX) mRNA signature...

6093 Background: There is no standard first-line treatment for recurrent/metastatic (R/M) or unresectable locally advanced (LA) salivary gland cancer (SGC). Androgen receptor (AR) overexpression is known to be particularly high (43-92%) in SDC, depending on histology, and has been identified as a potential molecular target for SGC treatment. Howeve...

Chemoradiotherapy （CRT） with cisplatin is a standard treatment for head and neck cancer. However, it is known that administration of platinum agents （such as cisplatin and carboplatin） causes hearing impairment. In this study, pure tone audiometry was performed for 33 head and neck cancer patients who underwent CRT with cisplatin. Hearing tests wer...

Background/aim: Surgery remains the standard treatment for salivary gland carcinoma (SGC). Our study investigated the association between epidermal growth factor receptor (EGFR) status in recurrent/metastatic SGC and the effectiveness of treatment with cisplatin/carboplatin and 5-fluorouracil plus cetuximab (EXTREME). Patients and methods: We re...

Background/aim: The efficacy of programmed cell death 1 (PD-1) inhibitor therapy for patients with recurrent and/or metastatic salivary gland carcinoma (R/M SGC) remains unclear. Patients and methods: We retrospectively analyzed 36 patients with R/M SGC treated with PD-1 inhibitor. The expression of programmed cell death ligand 1 (PD-L1) and mis...

Background: The role of induction chemotherapy (IC) in the treatment of resectable advanced head and neck squamous cell carcinoma has not been elucidated, and the most effective IC regimen for chemoselection is still unknown. At our institute we have not used the triple combination of docetaxel, cisplatin, fluorouracil (TPF) for chemoselection, bu...

Reports of drug-induced interstitial pneumonia caused by Cetuximab have been increasing. Pneumocystis pneumonia is important as a differential diagnosis of drug-induced interstitial pneumonia. We report herein on a 64-year-old man with pneumocystis pneumonia after cetuximab-based bioradiotherapy for laryngeal cancer. After radiotherapy, the patient...

The patient was a 63-year-old woman who had been diagnosed with rheumatoid arthritis over 40 years previously and had been taken methotrexate (MTX) and tacrolimus for 10 years. She visited an ENT clinic due to a left parotid mass and pain in August 201X. Parotid MRI revealed a tumor in the left parotid gland and fine needle aspiration cytology show...

Twenty-two patients (18 males, 4 females) with cancer of the base of the tongue were treated at Kyushu University Hospital during 2004–2011. They were classified by T classification as one case with T1, 8 with T2, 7 with T3, and 6 with T4a. The 3-year survival rates were 75.4% for all patients. The 3-year survival rate was 83.3% for patients treate...

Thirty-nine patients (22 males, 17 females) under 40 years old with head and neck cancer were treated at Kyushu University Hospital during 2004–2013. Oral cancer was observed in 17 patients, nasopahryngeal cancer in 6 patients, salivary gland cancer in 6 patients, sinonasal cancer in 5 patients, mesopharyngeal cancer in 2 patients, and laryngeal ca...

In some cases, the exposure and safeguarding of the internal carotid artery (ICA) are not easy by the maxillary swing approach that is used as a mainstay for the removal of nasopharyngeal tumors. To address this issue, we have developed a new combined transcervical and orbitozygomatic approach. A nasopharyngeal adenocarcinoma arose in a 52-year-old...

Relationship between tumor differentiation and OS or DFS in each tumor site (A,B) Larynx (C,D) Oropharynx (E,F) Hypopharynx

Reconstruction of a tracheal defect is a challenge because it often requires invasive surgery associated with relatively high morbidity. We recently invented a less-invasive method using a modified infrahyoid myocutaneous (IHMC) flap for the reconstruction of a tracheal defect in an 83-year-old male. A tracheal defect, the right half of the cricoid...

Purpose The significance of epidermal growth factor receptor (EGFR) signaling has been recognized in various cancers and anti-EGFR therapies in Japan are currently under consideration in squamous cell carcinoma of the head and neck (SCCHN) similar to colorectal cancer. However, there was no established survey regarding heterogeneous EGFR protein ex...

抄録 二次元CT情報を三次元的に再構築する三次元（3D）CT技術の進歩はめざましく，短時間に高解像度の画像を極めて正確に得ることが可能となっている。当院では複雑な解剖を有する頭蓋底の手術に際して，術前に「なにを見たいのか」を明確にした上で3DCT 構築を行い手術に役立てている。本論文では前頭蓋底と中頭蓋底腫瘍の2症例を通じて，3DCTの構築手順と，術前診断，手術アプローチの決定を含めた術前のシミュレーションに3DCTがいかに有用であるかを解説する。

5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell proliferation and clinical outcome in HNS...

5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutic drugs to treat cancer patients. However, the presence of drug resistant tumor cells may cause a poor response to 5-FU based chemotherapy. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the degradation of pyrimidine bases and is also responsible for the degra...

The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70% of the area of the tumor. Squamous diffe...

Nitric oxide (NO), produced by inducible NO synthase (iNOS), has been suggested to cause oxidative stress, leading to 8-hydroxydeoxyguanosine (8-OHdG) accumulation and subsequent transversion mutation of DNA. The aim was to evaluate iNOS expression and the status of oxidative stress in nasopharyngeal carcinoma (NPC). Seventy-three cases of NPC were...

Sinonasal carcinomas arise from the respiratory epithelium that lines the nasal and paranasal cavities, and are histologically composed of either squamous or cylindrical cell carcinoma. However, molecular analysis with the purpose of distinguishing sinonasal carcinomas from other head and neck squamous cell carcinomas (HNSCCs), which arise from squ...

We report the rare case of HES involving oral cavity associated with esophagus, and gastrointestinal tract, which we succeeded in diagnosing precisely through a biopsy specimen obtained from the lip. A 64-year-old man had dysphagia, swelling of the oral mucosa and the posterior cervical muscles, accompanied by an abdominal pain and diarrhea. Periph...

A goal of treatment for head and neck cancer is cure and preserving appearances and functions, for which an appropriate treatment modality including surgery and chemoradiotherapy should be made. Therefore, it is very important to evaluate the tumor response of the chemoradiotherapy for cure of the disease and organ preservation. A histological eval...