Hidechika Okada

Hidechika Okada
Nagoya City University | NCU · Department of Immunology

MD

About

939
Publications
37,814
Reads
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25,091
Citations
Citations since 2016
57 Research Items
5885 Citations
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
Additional affiliations
January 2012 - present
Hungarian Academy of Sciences
January 2011 - present
Kawasaki Medical University
April 2004 - June 2014
Choju Medical Institute
Choju Medical Institute
Position
  • Research Director
Description
  • Inhibitory peptide of C5a anaphylatoxin can be a potent regulator of inflammation including sepsis.

Publications

Publications (939)
Article
Full-text available
Regressed germ cell tumors are a rare disease commonly diagnosed with metastatic symptoms without local symptoms in the testis. A 33‐year‐old man with azoospermia was referred to our hospital. His right testis was slightly swollen, and ultrasonography revealed hypoechogenicity of the right testis with decreased blood flow. Right high orchiectomy wa...
Article
This study aimed to assess outcomes of microdissection testicular sperm extraction (MD‐TESE) and identify predictors for sperm retrieval (SR) in patients with non‐mosaic Klinefelter syndrome (NM‐KFS). We retrospectively evaluated 37 patients with NM‐KFS who underwent MD‐TESE. Data of age at operation, body mass index (BMI), testicular volume, serum...
Article
Full-text available
The elder population has increased, introducing the profound medical and social challenge of maintaining health in aging seniors and the need for a medical approach to sustaining physical and mental health. The relationship between diseases and lifestyle-related factors such as diet and exercise are important. A health-conscious lifestyle improves...
Article
Semen analysis has long been used to evaluate male fertility. Recently, several sperm function tests have been developed. Of those, the sperm DNA fragmentation index (DFI), which describes the status of the sperm DNA, is thought to be a suitable parameter for evaluating male fertility. However, there have been no large-scale studies on the sperm DF...
Article
Full-text available
Facilities worldwide offering donor sperm insemination face sperm donor shortages. There are also known dangers of online information about sperm donation and using donated sperm to conceive without the involvement of medical professionals. Therefore, the authors investigated 140 Web sites retrieved by common Japanese search engines using sperm don...
Article
Full-text available
We investigated the feasibility of agarose-gel microcapsules to cryopreserve extremely small numbers of sperm for assisted reproductive technology. Semen samples were collected from 16 patients attending the center for reproductive medicine male infertility clinic at a university hospital. We used agarose microcapsules to cryopreserve extremely sma...
Article
Background/aim: Curcumin is a natural compound of turmeric, which inhibits prostate cancer cell proliferation. This study examined whether treatment of LNCaP prostate cancer cells with the combination of curcumin and dutasteride, a 5-alpha reductase inhibitor, affect proliferation and the amount of testosterone and dihydrotestosterone. Materials...
Article
Objectives: To evaluate whether the long-term usage of mirabegron, which was reported to have potential side effects on male reproductive organs in animal studies, was harmful to spermatogenesis in human testis. Methods: Thirty consecutive patients with spinal cord injury (20-48 years old) who performed clean intermittent catheterization were in...
Article
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Background: X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10-12 embryonic progenitor cells. To date, it remains unclear whether XCI ratios are normally preserved in Klinefelter syndrome (KS) patients with 47,XXY karyotype. Methods: We exam...
Article
Full-text available
As testicular torsion is a medical emergency, it requires quick diagnosis and treatment. Color Doppler ultrasound (CDUS) is useful for the diagnosis of testicular torsion. An accurate diagnosis can be difficult when CDUS indicates the preservation of blood flow in the testis. We examined the accuracy of testicular torsion diagnosis in patients with...
Article
Full-text available
The risk of a gonadal tumor is high in testicular disorder of sexual development (DSD) with the Y chromosome, but cases of DSD without the Y chromosome are extremely rare. We reported a gonadal tumor in a phenotypically male individual with 46, XX testicular DSD. A testicular tumor was incidentally found in a 32-year-old phenotypic male who was pre...
Article
Full-text available
Purpose Cryptorchidism is one of the most common causes of non‐obstructive azoospermia (NOA) in adulthood. Even if early orchidopexy is performed to preserve fertility potential, some patients still suffer from azoospermia. Fertility potential is significantly lower in bilateral than unilateral cryptorchidism. The aims of this study were to identif...
Article
The majority of facilities in Japan that offer artificial insemination as part of assisted reproduction programs currently perform semen collection in the early morning. The total motile sperm count of the semen used in intrauterine insemination is an important factor in achieving successful fertilization and subsequent childbirth. The present stud...
Article
Full-text available
Purpose: Mosaic loss of chromosome Y (mLOY) is a common feature in elderly men. If mLOY can also occur in young men, it may lead to spermatogenic failure due to loss of spermatogenic genes. Indeed, previous studies detected the 45,X/46,XY karyotype in a few young men with spermatogenic failure. The present study aimed to clarify the frequency of c...
Article
Full-text available
Metabolic syndrome is reported to play a role in the genesis and development not only of angina, arteriosclerosis, diabetes, and osteoporosis but also of prostate cancer. Hypercholesterolemia is a strong risk factor in prostate cancer development. The current study was conducted to analyze whether pretreatment serum levels of cholesterol correlate...
Article
Varicocele is a common cause of male infertility. It is reported that low sperm concentration, motility and morphology are indicative of increased sperm DNA fragmentation index (DFI) in men with varicocele. Although research has been conducted into the relationship between varicocele and DFI, little is known about seminal oxidation–reduction potent...
Article
We describe the first case of a 25-year-old patient with gender identity disorder (GID) who underwent cryopreservation of sperm prior to male-to-female (MTF) sex reassignment surgery in Japan. The patient wanted to freeze sperm to keep open the option of conceiving a child in the future. The ethics committee of our institution discussed the case an...
Article
In a previous study of fungal peritoneal injury in peritoneal dialysis (PD) patients, complement (C)-dependent pathological changes were developed in zymosan (Zy)-induced peritonitis by peritoneal scraping. However, the injuries were limited to the parietal peritoneum and did not show any fibrous encapsulation of the visceral peritoneum, which diff...
Article
Full-text available
Pyoderma gangrenosum (PG) is a skin disease characterized by an unknown neutrophilic infiltration in dermis and a nonbacterial destructive ulcer. Post-operative PG is an extremely rare type that occurs around surgical sites during the immediate post-operative period. It is usually diagnosed as surgical site infection at the time of presentation. Th...
Article
On the cover: This cover image, by Shigeru Nakamura et al., is based on the Brief Report STX2 is a causative gene for nonobstructive azoospermia, Pages 830‐833 DOI: 10.1002/humu.23423.
Article
STX2 encodes a sulfoglycolipid transporter. Although Stx2 nullizygosity is known to cause spermatogenic failure in mice, STX2 mutations have not been identified in humans. Here, we performed STX2 mutation analysis for 131 Japanese men clinically diagnosed with non‐obstructive azoospermia. As a result, we identified a homozygous frameshift mutation...
Article
We evaluated the effect of gosyajinkigan in 30 cases of anticholinergic agent or α-1 blockers resistant nocturia with a sign of jinkyo which is the hypofunction of the kidney organ unit at Kampo medicine. As to subjective outcomes, storage symptoms and quality of life (QOL) of International Prostate Symptom Score, and sleep and energy items of King...
Article
Objectives: To analyse the quantitative changes of the prostate and seminal vesicles (SV) on magnetic resonance imaging (MRI) after ejaculation. Methods: Ten healthy young males were enrolled for T2-weighted and T2 mapping MRI before and after two consecutive ejaculations. T2 values of the peripheral zone (PZ) and the central gland (CG) at the m...
Article
Azoospermia affects up to 1% of adult men. Non-obstructive azoospermia is a multifactorial disorder whose molecular basis remains largely unknown. To date, mutations in several genes and multiple submicroscopic copy-number variations (CNVs) have been identified in patients with non-obstructive azoospermia. The aim of this study was to clarify the c...
Article
Purpose: Reactive oxygen species have been suggested as a major contributing factor to cryodamage of the spermatozoa. Accordingly, antioxidant supplementation has been used to yield significantly improved quality of frozen sperm post-thaw. We sought to investigate outcomes with a combination of antioxidants catalase and N-acetylcysteine respectivel...
Article
Genetic factors are responsible for approximately 15% of male infertility. The azoospermia factors AZFa, AZFb (P5/proximal P1), and AZFc (b2/b4) present on Yq are most important for spermatogenesis. Here, we evaluated frequencies of microdeletions of AZFa, AZFb, AZFc in azoospermia due to spermatogenic dysfunction in the Japanese population. The ov...
Article
Objectives: To evaluate the efficacy and safety of once-daily oxybutynin patch for overactive bladder (OAB) patients not tolerating oral antimuscarinic drugs. Methods: We prospectively investigated 43 OAB patients treated with once-daily oxybutynin patches for dry mouth and constipation due to oral antimuscarinic drugs. Results: Oxybutynin patch tr...
Article
Introduction: To evaluate the efficacy and safety of once daily phosphodiesterase type 5 inhibitor (PDE5i) tadalafil as an add-on treatment for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS) refractory to an alpha 1-blocker(α1-blocker). Materials and Methods: This study enrolled men aged >50 years with B...
Article
Advances in multimodal treatment have led to dramatic improvement in cancer treatment outcomes. It is now necessary to consider cancer patients' holistic quality of life. Fertility preservation is the top concern for cancer survivors of reproductive age. Sperm cryopreservation before treatment is recommended for postpubescent men, but many patients...
Article
Objectives: To present a single-center experience with testicular sperm extraction and intracytoplasmic sperm injection for fathering biological children in patients with ejaculatory dysfunction as a result of spinal cord injury. Methods: Testicular sperm extraction was carried out in 52 male patients with ejaculatory dysfunction as a result of...
Chapter
Sperm cryopreservation, the preservation and storage of sperm for future use, is an efficient procedure for the management of male fertility and is now routinely offered to men as a means of preserving their fertility. Cryopreservation should be discussed and offered prior to cytotoxic therapy for not only malignant diseases but also nonmalignant s...
Article
Background Combinations of surgery, radiation therapy, and chemotherapy can achieve high remission rates in patients with cancer, but these treatments can have damaging effects on spermatogenesis. In particular, cytotoxic chemotherapy may lead to irreversible spermatogenic dysfunction. Microdissection testicular sperm extraction (micro-TESE) is the...
Article
Full-text available
Objectives Lower urinary tract symptoms (LUTS) and sexual dysfunction (SDys) are common problems that affect quality of life (QOL) in elderly men. In addition to prescribed drugs, many over-the-counter medications including supplements are used to treat QOL diseases. Phosphodiesterase inhibitors are reported to be effective for both LUTS and SDys b...
Article
Full-text available
Objective: To investigate the usefulness of a novel semen analysis device consisting of a single-ball lens microscope paired with a state-of-the-art smartphone equipped with a camera. Design: Laboratory investigation. Setting: University research laboratory. Patient(s): A total of 50 semen samples obtained from volunteers were analyzed for count, c...
Article
A 36-years-old man with pollakisuria and digestive symptom was referred to our hospital. A blood test showed inclease of serum white blood cell,eosinophil and IgE. Imaging study showed thickening of bladder wall, and endoscopy of bladder and stomach showed severe mucosal edema. Because there was a suspicion of the allergic diseases, we carried out...
Article
Improved performance status (PS) frequently occurs in cancer patients infused with their own lymphokine-activated killer T cells (LAK-T). A culture supernatant of LAK-T (LAK-T sup) administered to 8-week-old rats caused neurogenesis detected by increased 5-ethynyl-2'-deoxyuridine (EdU) staining of brain tissues. Intravenous injection of GM-CSF, a m...
Article
Full-text available
Acute mesenteric ischemia (AMI) is caused by considerable injury in the intestine, which is associated with intestinal ischemia followed by reperfusion (Treat-I/R). To elucidate the mechanisms of I/R injury, we examined role of C5a anaphylatoxin using a C5a inhibitory peptide termed AcPepA, induction of inflammatory cells, and cell proliferation of...
Article
Background: Nonocclusive mesenteric ischemia (NOMI) can evolve in a variety of low-flow states. Although the mechanisms leading to NOMI-related intestinal necrosis are largely unknown, circumstantial evidence suggests that excessive vasoconstriction and complement activation both play important roles in this process. Because targeting of the circu...
Article
Full-text available
We evaluated the effect of hachimijiogan in 30 cases of anticholinergic agent and α-blocker resistant LUTS. International Prostate Symptom Scores (IPSS), QOL scores, Benign Prostatic Hyperplasia Impact Index (BII) scores and urinary 8-OHdG of the patients were statistically much improved. This study demonstrated improvement in urinary symptoms, uri...
Article
Full-text available
We evaluated the efficacy and tolerability of Hachimi-jio-gan (HJG; 八味地黃丸 bā wèi dì huáng wán) and Gosha-jinki-gan (GJG; 濟生腎氣丸 jì shēng shèn qì wán), two traditional Japanese medicines, in 60 patients with lower urinary tract symptoms (LUTS) having cold sensitivity unresponsive to α1-blockers or antimuscarinic drugs. All patients received a mixture...
Article
When sperm cannot be retrieved from the testes of patients with azoospermia due to spermatogenic dysfunction (ASD), there is no rational way for the patient to become a biological father. We investigated the possibility of inducing spermatogenesis in such patients by hormonal therapy with recombinant human follicle-stimulating hormone (rhFSH) alone...
Article
To compare the outcomes of the Politano-Leadbetter and Cohen techniques in laparoscopic pneumovesicum approach for ureteral reimplantation. We retrospectively reviewed the medical records of 24 patients who underwent transvesicoscopic ureteral reimplantation during the period from 2007 to 2014. The patients were treated with either the Cohen or Pol...