Hichem Ben Jannet

Hichem Ben Jannet
University of Monastir | UTM · Faculté des Sciences de Monastir

PhD

About

449
Publications
66,902
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3,679
Citations
Citations since 2017
192 Research Items
2491 Citations
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500

Publications

Publications (449)
Article
Due to the several side effects of synthetic pesticides, including environmental pollution, threats to human health, and the development of pest resistance to insecticides, the use of alternative healthy, available and efficient agents in pest management strategies is necessary. Recently, the use of essential oil obtained from aromatic plants has s...
Article
The phenolic profile of ethyl acetate and methanol extracts from the trunk bark of Pinus pinea growing in Tunisia was determined using Liquid Chromatography coupled to High Resolution Mass Spectrometry (LC-HRMS) method and their anti-α-amylase potential and the mode of inhibition were determined in a kinetic study. Methanol extract was found to be...
Article
Full-text available
In recent decades, the use of herbs and plants has been of great interest, as they have been the sources of natural products, commonly named as bioactive compounds. In specific, the natural compounds from the Capparaceae family which has been proved to have antioxidant, anti-inflammatory, antimicrobial and anti-carcinogenic activities, by several s...
Article
A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed β-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecul...
Article
Since ancient times the oil from date palm pits ( Phoenix dactylifera L.) has been used to heal wounds. In order to prove this traditional usage of the pits, this oil was extracted from the pits of the Tunisian cultivar “Alig” and its physico‐chemical properties and the chemical composition were evaluated. The fatty acid profile, evidenced by GC, a...
Article
This work aimed to extract polysaccharides from Allium roseum bulbs, study and discuss, via in silico analysis, their in vitro inhibitory effects against α-amylase. Indeed, three polysaccharides were sequentially extracted in water, chelating and basic media and were characterized by size exclusion chromatography, GC/MS, FTIR and NMR (1D and 2D) sp...
Article
A novel series of benzopyran derivatives 4, 5, and 6a-i was synthesized via cyclocondensation reaction of hydrazide 3 with some electrophilic species such as 2,4-pentanedione, 2,5-hexanedione, and cyclic anhydrides. The synthesized compounds were characterized by spectroscopic means (¹H NMR, ¹³C NMR, and HRMS) and were assessed for their inhibitory...
Article
Full-text available
In addition to vaccines, antiviral drugs are essential in order to suppress COVID-19. Although some inhibitor candidates have been determined to target the SARS-CoV-2 protein, there is still an urgent need to continue researching novel inhibitors of the SARS-CoV-2 main protease ‘Omicron P132H’, a protein that has recently been discovered. In the pr...
Article
Full-text available
In the present study, we assess tyrosol derivatives bearing 3,5-disubstituted isoxazoles and 1,4-disubstituted triazoles for their ability to inhibit the proliferation of K562 cells derived from leukemia as well as primary chronic myeloid leukemia (CML) cells obtained from the peripheral blood of 15 CML patients including 10 patients with untreated...
Article
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Despite all the progress made to enrich the existing bank of drugs used to treat and cure Alzheimer and cancer patients, there is still a need to research and develop new bioactive candidates with superior efficacy but minimal side effects. In this context, a new series of anti-butyrylcholinesterase (anti-BChE), anti-tyrosinase and cytotoxic succin...
Article
This work describes the design and synthesis of new coumarin-sulfamate derivatives by the action of a series of aliphatic alcohols on (4-hydroxycoumarin-3-carbonyl)sulfamoyl chloride 2, previously prepared by reacting 4-hydroxycoumarin 1 with chlorosulfonyl isocyanate. Different spectroscopic techniques (¹H NMR, ¹³C NMR and ESI-HRMS) were used to c...
Article
To discover new acetylcholinesterase and tyrosinase inhibitors, a series of dialkyl phosphonate-benzopyrimidinones 4a-b was prepared via Michaelis-Arbuzov rearrangement (Arbusov reaction) of benzopyrimidinone chloride 2 with trialkyl phosphate, as well as a series of imidazolidine-benzopyrimidinone derivatives 5a-g synthesized by Mannich reaction o...
Article
A novel non centrosymmetric organic–inorganic hybrid material bis(3-nitrotyrosine) bis(nitrate) (C9H11N2O5)2(NO3)2 denoted 3-NITY-Nitrate has been prepared at room temperature. The crystallographic study shows that the title compound crystallizes in the monoclinic system with P21 space group. Its unit cell dimensions are a = 13.8275 (10) Å, b = 5.7...
Article
The present research aimed to establish the polyphenolic profile and to appraise the antioxidant and anti-α-amylase activities of the EtOAc and BuOH extracts from the aerial parts of Pulicaria vulgaris. Total phenolics and flavonoids of both extracts were quantified. A total of 4 and 19 polyphenolic compounds were identified in the EtOAc (major com...
Article
Full-text available
Cadmium sulfide (CdS) quantum dots (QDs) were homogeneously embedded into chitosan (CTS), denoted as CdS@ CTS, via an in situ hydrothermal method. The intact structure of the synthesized materials was preserved using freeze-drying. The materials were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy, transmission electro...
Preprint
Full-text available
Cadmium sulfide (CdS) quantum dots (QDs) were homogeneously embedded into chitosan (CTS), denoted as CdS/CTS, via an in-situ solvothermal method. The intact structure of the synthesized materials was preserved via separating the materials using freeze-drying. The materials were characterized using X-ray diffraction (XRD), X-ray photoelectron spectr...
Article
Full-text available
Dittrichia graveolens L. Greuter belonging to the Asteraceae family, is an aromatic herbaceous plant native to the Mediterranean region. This plant species has been extensively studied for its biological activities, including antioxidant, antitumor, antimicrobial, antifungal, anti-inflammatory, anticholinesterase, and antityrosinase, and for its pe...
Article
In recent years, there has been a growing interest in the screening of natural active ingredients from Eucalyptus essential oils because of their evident importance in practical utility and their undeniable therapeutic properties. Based on this, the aim of the present study was to investigate the chemical profile of the essential oils of the trunk...
Article
Full-text available
A series of novel naphthopyrano[2,3-d]pyrimidin-11(12H)-one containing isoxazole nucleus 4 was synthesized under microwave irradiation and classical conditions in moderate to excellent yields upon 1,3-dipolar cycloaddition reaction using various arylnitrile oxides under copper(I) catalyst. A one-pot, three-component reaction, N-propargylation and D...
Article
Full-text available
To explore a new set of anticancer agents, a novel series of pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine derivativeshave been designed and synthesized viacyclocondensation reactions of pyrazolo-enaminone with a series of arylidenemalononitriles; compound 5 was obtained from 5-amino-4-cyanopyrazole. The structures of the target compounds were investigate...
Preprint
Full-text available
To explore a new set of anticancer agents, a novel series of pyrazolo[4,3-e]pyrido[1,2-a]pyrimidine derivatives 7a-l have been designed and synthesized via cyclocondensation reactions of pyrazolo-enaminone 5 with a series of arylidene malononitriles; compound 5 was obtained from 5-amino-4-cyanopyrazole (3). The structures of the target compounds 7a...
Article
In the present study, a new series of Schiff bases (4a-h) were designed and synthesized via the treatment of the previously prepared 5-aminopyrazolopyrimidinone 3 with a series of differently substituted arylaldehydes. Compound 3 was obtained from the condensation of pyrazolo[3,4-d]pyrimidinone 2 with hydrazine monohydrate. The structures of the ne...
Article
Full-text available
Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used for therapeutic purposes. As such, isoxazoles have attracted the attention of medicinal chemists b...
Article
Carbohydrates are the main source of calories in most diets, and α-amylase is considered one of the main enzymes that initiate their digestion. The inhibition of α-amylase is therefore considered to be a therapeutic strategy for the treatment of disorders of glucose absorption, such as dental caries, periodontal disease, overweight, obesity and dia...
Article
The present study was carried out in an attempt to synthesize, under classical and microwave irradiation conditions, a new class of cytotoxic 1,2,3-triazole linked flavonols hybrids by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) to afford, in good yields (78-93%), 24 compounds 1′a-i, 2′a-h and 3′a-g, using three previously synthesized highly...
Article
Two series of 3,5-disubstituted isoxazoles (6a–e) and 1,4-disubstituted triazoles (8a–e) derivatives have been synthesized from tyrosol (1), a natural phenolic compound, detected in several natural sources such as olive oil, and well-known by its wide spectrum of biological activities. Copper-catalyzed microwave-assisted 1,3-dipolar cycloaddition r...
Article
Full-text available
Citation: Soltane, R.; Chrouda, A.; Mostafa, A.; Al-Karmalawy, A.A.; Chouaïb, K.; dhahri, A.; Pashameah, R.A.; Alasiri, A.; Kutkat, O.; Shehata, M.; et al. Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly
Article
The importance of the Acacia genus is due to its usage in nutrition, and in folk and modern medicine. They are considered as promising sources of bioactive metabolites displaying beneficial to human health. The chemical and biological investigation of some Acacia species helped in the design of food supplements and drugs. A. cyanophylla has been in...
Article
New benzopyrimidinone derivatives have been synthesized by reaction of 2-aminobenzamide with different acyl chlorides in good yield and their structures were confirmed by ¹HNMR, ¹³C NMR and mass spectrometry. The newly synthesized compounds were studied theoretically by Density Functional Theory (DFT) method with 6-311++G(d, p) basis set, structura...
Article
Full-text available
In this work, a series of anti-tyrosinase and anti-butyrylcholinesterase coumarin derivatives 4a–f and 5a–f were synthesized starting from 4-hydroxycoumarin. The condensation of 2-(arylimin)-4-hydroxycoumarins 3a–f with dimethylformamide dimethyl acetal (DMF-DMA), used as a key reaction, afforded the precursors 4a–f, whose acid treatment led to the...
Article
Full-text available
Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In the search for therapeutic alternatives to treat the cancer disease, a series of hybrid pyrazolo[3 ,4-d]pyrimidin-4(5H)-ones tethe...
Article
A novel series of pyranotriazolopyrimidine derivatives 3a-j was synthesized and characterized by ¹H NMR, ¹³C NMR, and HRMS experimental data. The synthesized compounds were assessed for their inhibitory potential on the α-amylase enzyme. Results showed that seven of the synthesized compounds displayed potent α-amylase inhibitory activity. Compound...
Article
Full-text available
The aim of the present research was to determine the chemical composition and the cytotoxic effects of Tetraclinis articulata trunk bark essential oil (HEE) obtained by steam distillation and five fractions obtained by normal phase silica chromatographic separation. Chemical analysis allowed the identification of 54 known compounds. Relatively high...
Preprint
Full-text available
Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs. In search for therapeutic alternatives to treat the cancer disease, a se-ries of hybrid pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered...
Article
A series of organic extracts obtained from spines, flowers, roots and fruits of two Tunisian species of Opuntia, O. microdasys var. rufida (OMR) and O. leptocaulis (OL) were investigated for their phytochemical composition as well as their neuroprotective, anticholinesterase, cytotoxic and catalase activities. The anticholinesterase activity was as...
Article
Spiro-acetoxylactams as key substrates were obtained straightforwardly by the tandem regioselective reduction/O-acylation of spiro-isoindolinone-imides. The latter were produced in large scale in three steps from homophthalic acid. These imides were useful to provide in one step isoindolinones bearing hydroxymethyl-amide functions, tethered at quat...
Article
Full-text available
The efficiency of essential oil depends upon the chemical nature, composition, and the relative proportion of its functional groups. In some case, individual compounds can exhibit a pertinent effect than do the essential oils. To underline their efficiency according to their chemical structure, five cyclic and acyclic alcohols were tested in vitro...
Article
For several years, chemicals with plant sources are of significant interest mainly for its amazing therapeutic properties and particularly at the structural level. For this reason, a phytochemical investigation and a biological evaluation were performed on the Tunisian Citharexylum spinosum L. tree. The n-butanol extract of flowers from this plant...
Article
Full-text available
Microbial biotransformation is a pertinent strategy to overcome difficulties and problems arising from the chemical synthesis, in order to have access to regiospecific and stereospecific compounds and also explain the inactivity of essential oils or chemicals against some microorganisms. We evaluate in this research work, the bioconversion of (R)-l...
Article
Previously phytochemical investigations carried out on the flowers and trunk bark extracts of Citharexylum spinosum L. tree, allowed the isolation of twenty molecules belonging to several families of natural substances [triterpene acids, iridoid glycosides, phenylethanoid glycosides, 8,3′-neolignan glycosides, together with other phenolic compounds...
Article
This work describes an effective microwave-assisted synthesis of new hybrid regioisomeric molecules N-linked-1,2,3-triazole along with pyranopyrimidinone moiety under copper(I) catalyst, and the evaluation of their anticholinesterase and antibacterial activities. All of the obtained structures have been assigned by means of spectroscopic data (NMR,...
Article
This work describes the valorization of two natural bioactive coumarins via the semi-synthesis of new derivatives and the study of their antibacterial and anticholinesterase potentials. Marmesin 1 and Scopoletin 2 were isolated from the dichloromethane extract of Ferula lutea (Poir.) Maire roots. Esterification of 1 with a series of acid chlorides,...
Article
This work describes the synthesis, characterization and antimicrobial evaluation of a series of new 1,3,4-oxadiazole linked benzopyrimidinones. Their structures were confirmed on the basis of ¹H, ¹³C NMR and ES-HRMS analysis. Their molecular geometry are also studied theoretically by the Density Functional Theory (DFT) method with B3LYP/6–31++G (d,...
Article
Several plant essential oils have been used against diverse insect pests since, unlike conventional pesticides, they pose almost no risk to humans and the environment. For this reason, the essential oil (EO) isolated from the fresh leaves of Crithmum maritimum L. and its fractions (F1–F5) obtained by chromatographic simplification were investigated...
Poster
Phytochemical and biological study of the n-BuOH extract of the Citharexylum spinosum L. flowers: Isolation of a new iridoid glycoside as well as seven known analogues and structure-activity relationship analysis using molecular docking.
Article
Cystic echinococcosis remains a serious public health problem worldwide. Surgery is considered as the first option of treatment. Various investigations were carried out to find a convenient scolicidal agent for reducing the risk of post-surgical recurrence of the disease but most of them are associated with adverse side effects. The present study a...
Article
Full-text available
Melastoma malabathricum or Senduduk Putih is one of the herbs listed under National Key Economic Area (NKEA) of Malaysia. It has the potential to be used as remedies that is rich in natural flavonoids. One of the innovations for extraction in modern technology is Ultrasound-Assisted Extraction (UAE) that showed several advantages. Therefore, this s...
Article
The essential oils of the aerial parts and roots (APEO and REO) of Pulicaria vulgaris subsp. dentata (Sm.) Batt. were analyzed by GC and GC-MS. Twenty-one compounds (97.2% of the total oil composition) were identified in the REO, with γ-irone (39.2%), 7-epi-silphiperfol-5-ene (19.3%), 2,5-dimethoxy-p-cymene (8.5%) and γ-himachalene (8.0%) as main c...
Poster
An in-depth molecular docking analysis was performed in the active pockets of the crystal structures of the enzymes: sirtuin SIRT1 (PDB: 4I5I), butyrylcholinesterase (PDB: 4B0P) and tyrosinase (PDB: 2Y9X), to study the binding modes and to elucidate the interactions of the natural molecule called caudatoside E with the amino acid residues in relati...
Article
Full-text available
Context: The substantial increase in the number of diabetics has encouraged the search for new pharmacological strategies to face this problem. In this regard, triazole and its derivatives have attracted considerable attention for the past few decades due to their pharmacological significance. Objective: Evaluation of the inhibitory activity of α-g...
Article
Full-text available
A series of N-tosyl α-amino acids 2a-e, prepared using a tosyl chloride protecting group, was condensed with (±)-vasicinone 1, isolated from the seeds of the plant Peganum harmala, to generate the corresponding esters 3a-e and 3b′-e′. (±)-Vasicinone 1 was also reacted with chloroacetic acid chloride to afford a new chlorinated ester 4 which was ref...
Article
The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and its synthesis through a four-step sequence starting from tropine. Then, an efficient synthesis of N-(het)aryltropanes derivatives by a sequence of a palladium-catalyzed N-arylationof convolvine has been established. This strateg...
Article
For several years, plant derived substances, in particular essential oils, have been the subject of increasing attention in their safe and ecofriendly application to crops, as a powerful alternative to chemical insecticides. For this reason, the essential oil isolated from flowers of Ferula tunetana, a Tunisian endemic plant, was investigated for t...
Article
This work investigated the polar (PC: protein, amino acid and metabolite) and non‐polar (NPC: fatty acid) compounds and bioactivity characteristics of the EBN harvested from the state of Johor in Malaysia. The electrophoretic gels exhibited 15 protein bands (16‐173 kD) with unique protein profile. Amino acids analysis by AccQ•Tag method revealed 18...
Article
2-substitued-benzopyrimidinones 2 were synthesized in high to excellent yields in a single step via condensation of 2-aminobenzamide 1 with some aryl-aldehydes in the presence of iodine. Cyclocondensation reaction of hydrazides 3 which were obtained in two steps from benzopyrimidinones 2, with some electrophilic species such as 2,4-pentandione, 2,5...
Article
The aim of this study was to characterize the chemical composition of the roots essential oil from Inula viscosa (L.) through its fractionation during extraction, and to evaluate the antibacterial, anticholinesterase, anti-tyrosinase and anti-5-lipoxygenase activities of the isolated oil (REO) and its fractions (R1–R10). The REO and its fractions (...
Article
Mandragora autumnalis Bertol. (Solanaceae family), synonym of M. officinalis Mill., occurs in North Africa and grows natively in Northern and Central Tunisia, in humid to sub‐arid climates. The ripe fruits of mandrake are odiferous with a particular, indescribable, specific odor, shared, to a lesser extent, by the leaves and roots. We carried out a...
Article
A new series of antibacterial pyrazolo-triazolo-pyrimidine derivatives 3a-3i were synthesized in two steps starting from aminopyrazole 1 and characterized by ¹H NMR ¹³C NMR and HRES-MS. Their molecular geometry are also calculated by the Density Functional Theory (DFT) employing B3LYP level with 6-311G (d,p) basis set. All the synthesized compounds...
Article
This work describes the study of the chemical composition and bioactivity of the essential oils (EOs) of the different organs (leaves, flowers, stems and roots) from Eruca vesicaria. According to the GC and GC/MS analysis, all the EOs were dominated by erucin (4‐methylthiobutyl isothiocyanate) with a percentage ranging from 17.9 % (leaves) to 98.5...
Poster
Isolation and biological evaluation of two 8,3'-neolignan glycosides as well as five phenylethanoid glycosides from the ethyl acetate extract of the Citharexylum spinosum trunk bark.
Poster
Full-text available
A set of novel 1,2,3-triazoles incorporated with the natural isocostic acid core (isolated from essential oil of Inula viscosa) were synthesized in excellent yields via Cu-promoted azide-alkyne cycloaddition reaction (CuAAC). Going through the reaction of isocostic acid 1 with the 3-propargyl bromide gave a dipolarophile 2 to access to triazoles 3a...
Article
Full-text available
Citation: Bnina E.B., Hajlaoui H., Chaieb I., Daami-Remadi M., Ben Said M., Ben Jannet H. (2019): Chemical composition, antimicrobial and insecticidal activities of the tunisian Citrus aurantium essential oils. Czech J. Food Sci., 37: 81-92. Abstract: The chemical composition of volatile fractions from leaves, flowers and peels of Citrus aurantium...
Article
A new series of 3-hydroxyflavones (1–46) were synthesized according to the Claisen-Schmidt followed by Algar-Flynn-Oyamada reactions (AFO) in one step. The synthesized flavonoids were characterized by 1H NMR, 13C NMR and DCI-HRMS. All the synthesized compounds were tested in vitro for their 15-lipoxygenase inhibitory and cytotoxic activity against...
Article
The essential oil (EO) of Thymus capitatus , seven fractions (F1–F7) obtained from silica gel chromatography, and several pure EO components were evaluated with respect to in vitro activities against Echinococcus multilocularis metacestodes and germinal layer (GL) cells. Attempts to evaluate physical damage in metacestodes by phosphoglucose isomera...
Article
The chemical composition of the essential oil (LEO) and its volatile fractions (V1–V10) collected during the hydrodistillation process every 15 min from the fresh leaves of I. viscosa (L.), growing in Tunisia, were analyzed by GC‐FID and GC/MS. Eighty‐two compounds, representing 90.9–99.4 % of the total samples, were identified. The crude essential...
Article
A new caryophyllene, named pulicaryenne A (1), along with four other known caryophyllene derivatives (2, 3, 4 and 5) were isolated from the ethyl acetate extract of aerial parts of Pulicaria vulgaris Gaertn. (Asteraceae). All compounds were isolated for the first time from this species. Compound 2 was identified as a new epimer of a known caryophyl...
Presentation
Full-text available
A series of novel pyrazolotriazolopyrimidines3 was synthesized in moderate to excellent yields upon cyclocondensation reaction of iminoether2 using various hydrazides. Structures of all synthesized compounds were established on the basis of 1 H NMR, 13 C NMR and ES-HRMS. These compounds were also screened for their antibacterial activity and the st...
Poster
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Somepyrazolopyrimidinonederivatives3weresynthesizedvia condensation reaction of hydrazide2,which in turnisobtaineduponthreestepsstartingfrom the2-amino-3-cyanopyrazole 1, with a serie of cyclic anhydrides. The structures of all synthesized compoundswere determined by 1 H NMR and 13 C NMR.
Poster
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Poster
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Poster
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The genus Beta that belongs to the Amaranthaceae family gathers 2500 species mostly growing in tropical to cool temperate regions. In Tunisia, only two species of the genus Beta, B. macrocarpa Guss., Fl. Sicul. Prodr and B. vulgaris L., are identified. 1 B. vulgaris subsp. maritima (L.) Arcang. is used as a traditional food and it is also employed...
Presentation
Full-text available