Hiba Najeh

• Lecturer at University of Basrah

Angiogenesis is essential for many tumours to grow and metastasise, including breast tumours. Captopril, an Angiotensin-Converting Enzyme inhibitor is known to have anti-angiogenic activity. Recently, novel derivatives of captopril that include thiosemicarbazide moiety have shown enhanced ACE inhibition activity compared to captopril. This study ai...

The close association between inflammation and cancer inspired the synthesis of a series of 1,3,4‐oxadiazole derivatives (compounds H4‐A‐F) of 6‐methoxynaphtalene. The chemical structures of the new compounds were validated utilizing Fourier‐transform infrared, proton nuclear magnetic resonance, and carbon‐13 nuclear magnetic resonance spectroscopi...

Abstract The close association between inflammation and cancer inspired the synthesis of a series of 1,3,4‐oxadiazole derivatives (compounds H4‐A‐F) of 6‐methoxynaphtalene. The chemical structures of the new compounds were validated utilizing Fourier‐ transform infrared, proton nuclear magnetic resonance, and carbon‐13 nuclear magnetic resonance sp...

This study presents a comparative analysis of the phytochemical compositions of the flowers and fruits of Capparis spinosa L. (Flora Iraq) sourced from Basra, southern Iraq. Soxhlet extraction and maceration methods were employed to prepare extracts for comparative phytochemical yield assessment. Total phenolic and flavonoid contents were quanti...

A series of (2-methyl-3-(substituted thio)propanoyl)proline (2-7) were evaluated in-vitro for antioxidant activity and anticoagulant activity. The antioxidant were determined using the most common models, 2,2-Diphenyl-1-picrylhydrazyl (DPPH), H2O2, and reducing power method. The better radical scavenging antioxidant activity was observed with compo...

In vitro evaluation of new thiosemicarbazide derivatives of captopril as ACE inhibitor, and in silico pre- ADMET study.

Citation: Alsaad H, Kubba A, Tahtamouni LH, Hamzah AH (2022) Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3-dimethyl aminobenzoic acid) moiety. Pharmacia 69(2): 415-428. Abstract A series of 1,2,4 triazole derivatives (H7-12) have been synthesized by reacting an e...

The antibiotic resistant crisis is a worldwide phenomenon that threatens the global health. The misuse and overuse of antibiotics as well as the inadequate development of new antibacterial drugs have all drove the evolution of resistance. Thus, the development and discovery of novel antibacterial agents is a critical field within medicinal chemistr...

Objective: Inflammation and pain are normally present concomitantly, which requires using a combination of anti-inflammatory and pain killer medications. This could potentially decrease patient adherence to such combinations. Therefore, there is an urgent need to develop combinations of anti-inflammatory and analgesic therapies. This study is desig...

A series of new captopril thiosemicarbazide derivatives (2-7) were evaluated in vitro for ACE inhibitor activity, using developed colorimetric assay as a simple, sensitive, and cost-effective method. Compounds (4 and 7), substituted with an electron-withdrawing group, showed good ACE inhibition activity, compared to non-substituted derivatives, and...

A series of thiosemicarbazide derivatives of captopril, a well-known angiotensin-converting enzyme inhibitor ACEI, have been synthesized by reaction of hydrazide of captopril with different phenylisothiocyanate substituents. The synthesized compounds were characterized using FTIR, 1HNMR and CHNS analysis. The final derivatives were tested for antip...

The free –COOH present in NSAIDs is thought to be responsible for the GI irritation associated with all traditional NSAIDs. Exploitation of mutual prodrugs is an approach wherein the NSAID is covalently bounded to a second pharmacologically active carrier/drug with the ultimate aim of reducing the gastric irritation. In this study some NSAIDs were...