Hesham Elnazer

Hesham Elnazer
University of Sussex · Brighton and Sussex Medical School

MD, MBBCh, MRCPsych

About

23
Publications
5,228
Reads
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129
Citations
Additional affiliations
July 2016 - July 2018
Kemsley National Centre for Brain Injury Rehabilitation
Position
  • Consultant
Education
October 2016 - October 2020
University of Southampton
Field of study
  • Clinical Neurosciences

Publications

Publications (23)
Preprint
Full-text available
Abstract The human sexual response is a complex physiological process which involves different neural, paracrine, autocrine and endocrine mechanisms. Previous studies have revealed complex associations between sexual dysfunction, mood symptoms, and treatment with antidepressant drugs6. It has proven difficult to accurately identify the incidenc...
Article
Background: Prolonged stress has been associated with elevated levels of circulating proinflammatory cytokines. Cyclo-oxygenase-2 inhibitors such as celecoxib exert anti-inflammatory effects and may enhance the response to antidepressant drug treatment in patients with depressive disorders, but their effect on anxiety symptoms in patients with anx...
Article
Background Hair cortisol concentration (HCC) can be used to periodically assess hypothalamic–pituitary–adrenal (HPA) axis function, and appears correlated with prolonged exposure to stress. Methods Serial assessment (at Baseline, Week 6 and Week 12) of participants ( n = 35) with anxiety disorders by psychopathological rating scales, with assays o...
Preprint
Abstract Background. Hair cortisol concentration (HCC) can be used to periodically assess hypothalamo-pituitary-adrenal axis function, and appears correlated with prolonged exposure to stress. Methods. Serial assessment (at Baseline, Week 6 and Week 12) of participants (n=35) with anxiety disorders by psychopathological rating scales, with assays...
Article
Background: Approximately 40% of women and 30% of men describe sexual dysfunction, although recognition in medical settings is suboptimal, due to problems in reporting and eliciting concerns relating to sexual function and satisfaction. Screening questionnaires may help to support this aspect of clinical practice. The Arizona sexual experiences sca...
Article
Full-text available
Background Approximately 40% of women and 30% of men describe sexual dysfunction, although recognition in medical settings is suboptimal, due to problems in reporting and eliciting concerns relating to sexual function and satisfaction. Screening questionnaires may help to support this aspect of clinical practice. The Arizona sexual experiences scal...
Thesis
Previous studies have revealed complex associations between sexual dysfunction, depressive symptoms, and treatment with antidepressant drugs, and provide evidence linking depression, neuroinflammation and hypothalamo-pituitary-axis (HPA) dysregulation. However, little is known about the prevalence of sexual dysfunction or incidence of treatment-eme...
Conference Paper
Full-text available
Epidemiological studies indicate that approximately 40% of women and 30% of men report sexual difficulties but recognition in medical settings is sub-optimal, possibly due to problems in describing and eliciting concerns relating to sexual function (Baldwin et al 2015). Screening questionnaires may help to support this aspect of clinical practice (...
Article
Behavioural changes associated with epilepsy can be challenging for patients and clinicians. Evidence suggests an association between aggression and epilepsy that involves various neurophysiological and neurochemical disturbances. Anti-epileptics have variable effects on behaviour and cognition that need consideration. Early detection and careful c...
Thesis
Full-text available
Background Obsessive-compulsive disorder (OCD) is typically a chronic and distressing mental disorder, often comorbid with major depression and anxiety disorders. Disturbances of serotonergic and dopaminergic function are known to be important in the pathophysiology of the condition, but the role of potential disturbances in hypothalamo-pituitary-a...
Poster
Full-text available
TITLE Clinical Problem Based Learning Introduction to final year medical students unused to this approach AIMS AND HYPOTHESIS To explore the usefulness of clinical problem based learning (CPBL) in teaching final year medical students who had not previously been exposed to this model. BACKGROUND Although CPBL has been positively evaluated in UK medi...
Poster
Full-text available
Abstract Psychiatry and Neurology used to be practiced jointly as Neuropsychiatry up until the nineteen sixties. Psychiatry since then lost most of its physical components with psychological and social theories predominating. Neuropsychiatry continued to exist with a strong medical component, dealing with mental health problems attributable to the...
Chapter
Epilepsy was considered to be commonly associated with aggression historically. It has also been emphasized in medicolegal settings. However, the link between epilepsy and directed aggression is now noted to be less clear-cut even though brief and non-directed aggression can occur not so uncommonly. Aggression in epilepsy could be linked to a numbe...
Conference Paper
Full-text available
Introduction: Obsessive-compulsive disorder (OCD) is typically a chronic and distressing mental disorder, which is often comorbid with major depression and anxiety disorders. Disturbances of serotonergic and dopaminergic function are known to be important in the pathophysiology of the condition, but the role of potential disturbances in hypothalamo...
Article
Objective Lithium treatment remains an important part of the management of many patients with bipolar disorder, but the incidence of treatment-emergent sexual dysfunction with lithium is uncertain, and little is known about how it might be managed.Method Systematic computerised literature search of preclinical and clinical studies.ResultsThirteen r...
Article
Background: The move from inpatient to community services in mental health has sparked debate internationally but the evidence base for successful service models is sparse. Aim: To evaluate the impact of bed reduction on quality of services when accompanied by redesign of community services. Methods: Qualitative and quantitative data were coll...
Conference Paper
Full-text available
Patients’ beliefs about Bipolar Disorder have a major role to play in the improvement of management and concordance but are relatively unexplored. A questionnaire aimed at exploring relevant patients’ beliefs (BABAD), was designed for this study based on relevant literature and in consultation with service users, carers, mental health professionals...
Article
Background: Adverse effects of antidepressant drug treatmenton sexual function are well documented but the effects of antidepressants on sperm production have not been researched extensively. Methods: A narrative of an interventional case report of sperm parameters in a 30-year-old Caucasian man with a diagnosis of mixed depressive and anxiety d...
Article
Anxiety disorders Anxiety disorders are common and distressing medical conditions, which typically arise in adolescence or early adult life. They can persist for many years, reducing quality of life, limiting academic and occupational achievement, and being responsible for considerable economic pressures. Although a range of psychological and pharm...
Poster
Full-text available
AIMS AND HYPOTHESIS Techniques derived from CBT-p could be safely and effectively delivered by case managers to their clients with persistent psychosis in community mental health agencies. BACKGROUND Case managers spend more time with clients with schizophrenia than any other professional group in most clinical settings in the United States. It is...
Poster
Full-text available
Abstract General medical practitioners (GP’s) can play an important part in reducing suicide and deliberate self harm. This study examines the frequency and nature of consultations with general medical practitioners prior to episodes of self harm. We found that a high percentage of patients had recently been to see their GP with problems of a psych...
Article
Full-text available
MacDonald & Elphick[1][1] have lucidly described the proposed introduction of Payment by Results into mental health. They mention, however, that ‘concerns include the validity and reliability of the MHCT’ (mental health clustering tool), and there is also the major issue of how cost can be

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Projects

Project (1)
Project
The identification of hair markers to find in-vivo evidence of pathophysiological markers, to include AD-related proteins and enzymes. As a pilot study, the main aims to investigate whether we can extract enough Tau and cytosol aminopeptidase from peripheral biological samples from patients with AD. If the procedure proves successful, we can then extend to a full study bigger cohort and extend to other proteins.