Herve Tissot-Dupont

Herve Tissot-Dupont
Assistance Publique Hôpitaux de Marseille | APHM · Service de maladies infectieuses et tropicales

MD, PhD

About

89
Publications
5,535
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
5,642
Citations
Citations since 2017
5 Research Items
1180 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
November 2008 - present
Institute of Research for Development
Position
  • Managing Director

Publications

Publications (89)
Article
Background Maintenance ART with dolutegravir-based dual regimens have proved their efficacy among HIV-1-infected subjects in randomized trials. However, real-life data are scarce, with limited populations and follow-up. Objectives We assessed virological failure (VF) and resistance-associated mutations (RAMs) on dolutegravir maintenance regimens i...
Article
Primary HIV‐1 infections (PHI) with non‐B subtypes are increasing in developed countries while transmission of HIV‐1 harboring antiretroviral resistance‐associated mutations (RAMs) remains a concern. This study assessed non‐B HIV‐1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseille, Southeastern France, in 200...
Article
We report an autochthonous hepatitis E virus (HEV)-hepatitis B virus co-primary infection in a 41-year-old man having sex with men and infected with human immunodeficiency virus (HIV). This case prompts testing for HEV in HIV-infected patients with acute hepatitis even if primary infection with another hepatitis virus is diagnosed.
Article
Tat is a viral protein secreted from HIV infected cells and extra cellular Tat is suspected to prevent destruction of HIV infected cells from cells of the cellular immunity. The effect of anti retroviral therapy (ART) on Tat secretion has never been investigated. In this study, we tested for antibody reactivity against Tat variants representative o...
Article
Full-text available
TO THE EDITOR: Recent outbreaks of Q fever in the Netherlands and the United Kingdom raised public awareness about this ubiquitous bacterial disease known for decades to circulate worldwide (1-4). The disease, which ranges from a self-recovering influenza-like illness to pneumonia and severe meningoencephalitis, myocarditis, or endocarditis, is usu...
Article
Full-text available
Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate. To identify the optimal CD4 cell count at which cART should be initiated. Prospective o...
Article
In May 2007, five patients with Q fever-like symptoms were reported in an agricultural educational center in the rural southern French town of Florac. An investigation was undertaken to identify the outbreak source and risk factors for infection, and to implement control measures. We undertook active case finding. Patients were defined as individua...
Article
Climatic factors (temperature, wind, humidity) and their changes play a major role in the epidemiology of infectious diseases, mainly those vector borne or water-borne. In terms of respiratory tract infections, the role of cold remains controversial, although evident in popular belief: the winter peak is multifactorial, but exposure to cold causes...
Article
Q fever is a worldwide zoonosis caused by the pathogen Coxiella burnetii causing acute and chronic clinical manifestations. The name "Q fever" derives from "Query fever" and was given in 1935 following an outbreak of febrile illness in an abattoir in Queensland, Australia. C burnetii is considered a potential agent of bioterrorism (class B by the C...
Article
Homeless people commonly present with ectoparasite-based pruritus. We evaluated the efficacy of a single dose of ivermectin to reduce the pruritus prevalence in a homeless population. We conducted a randomized, double-blind, placebo-controlled trial from January 2006 to April 2006 in two homeless shelters in the city of Marseille, France. Homeless...
Article
To evaluate safety and efficacy of long-term posaconazole in HIV-infected patients with azole-refractory oropharyngeal candidiasis and/or esophageal candidiasis. In this noncomparative, open-label study, participants received oral posaconazole 400 mg twice daily (bid) for 3 months. Enrolled patients (N = 100) included 60 from a previous 1-month acu...
Article
Q fever is a zoonosis caused by Coxiella burnetii. After a large outbreak occurred in the Chamonix Valley in the French Alps in 2002, an extensive surveillance was conducted, to describe the variations in the clinical expression of acute Q fever according to host factors, as well as to monitor the risk of evolution of acute Q fever to chronic Q fev...
Article
Progressive multifocal leucoencephalopathy due to JC virus is a rare complication of liver transplantation. Only four cases have already been described in the literature. This disease is difficult to differentiate from leucoencephalopathy associated with immunosuppressive drugs such as cyclosporin or tacrolimus. Positive diagnosis of progressive mu...
Article
Progressive multifocal leucoencephalopathy due to JC virus is a rare complication of liver transplantation. Only four cases have already been described in the literature. This disease is difficult to differentiate from leucoencephalopathy associated with immunosuppressive drugs such as cyclosporin or tacrolimus. Positive diagnosis of progressive mu...
Article
Full-text available
Data about anti-malarial drugs prescription practices in Europe and the safety of imported malaria treatments are scanty. In 1999, a French consensus development conference published guidelines for the prevention and treatment of imported P. falciparum malaria. The impact of these guidelines has not been evaluated. To investigate the impact of thes...
Article
Full-text available
In an attempt to determine the prevalence of various skin infections in the homeless population in Marseilles, France, we undertook a case control study. Cases were recruited among institutionalized homeless subjects during two snapshot investigations conducted in January 2002 and 2003 respectively. The control subjects were recruited from among th...
Article
Full-text available
Objective To study the prognosis of HIV-infected patients with virological failure after exposure to three classes of antiretroviral drugs (ARVs). Design Cohort study. Setting: French Hospital Database on HIV. Patients Patients previously exposed to at least two nucleoside reverse transcriptase inhibitors (NRTIs), two protease inhibitors and one...
Article
Q fever is a worldwide zoonosis caused by Coxiella burnetii and presents as both acute or chronic cases. The disease can be transmitted from animal reservoirs to humans by inhalation of infected aerosols. A previous study had revealed a hyperendemic focus in South France. A case-control study was carried-out in this area from 1996 to 1999. Besides...
Article
Homeless people are particularly exposed to ectoparasites, but their exposure to arthropod-borne diseases has not been evaluated systematically. A medical team of 27 persons (7 nurses, 6 infectious disease residents or fellows, 2 dermatologists, and 12 infectious disease specialists) visited the 2 shelters in Marseilles, France, for 4 consecutive y...
Article
Rates of annual influenza vaccination of healthcare workers (HCWs) remained low in our university hospital. This study was conducted to evaluate the impact of a mobile cart influenza vaccination program on HCW vaccination. From 2000 to 2002, the employee health service continued its annual influenza vaccination program and the mobile cart program w...
Article
Full-text available
Q fever, a worldwide zoonosis caused by Coxiella burnetii, can be transmitted from animal reservoirs to humans by the inhalation of infected aerosols. We investigated the epidemiology of Q fever in the Bouches-du-Rhone district of southern France, particularly the role of wind and rainfall in C. burnetii transmission. During the winter of 1998 to 1...
Article
The present study examines the distribution of Hepatitis C virus (HCV) genotypes in Marseille, France in 2001-2002 and evaluates the efficiency of two in house direct sequence PCR protocols based on 5'NC analysis or NS5B analysis. By 5'NC sequencing, the distribution of 535 HCV strains derived from patients attending gastroenterology and AIDS refer...
Article
To determine incidence of non-AIDS-defining cancers (NADC) in HIV-infected patients before (P1) and during (P2) the use of highly active antiretroviral therapy (HAART) relative to that observed in the French general population (FGP) of the same age and sex. Sex- and age-adjusted NADC standardized incidence ratios (SIR), with FGP as reference, were...
Article
Cat scratch disease (CSD) is usually associated with Bartonella henselae infection in patients with a history of cat exposure, but Bartonella quintana may also be a cause of chronic lympadenopathy in patients with cat or flea contact. The lymph node histopathology of CSD and tuberculosis may be indistinguishable. We report herein the first descript...
Article
The aim of the study presented here was to describe the different epidemiological methods used to investigate an outbreak of Q fever that occurred in the spring of 1996 among inhabitants of Briançon, a small town in the French Alps. Three approaches were used: (i) a comparison between a 2-month exhaustive serological survey among blood donors and a...
Article
We report a case of fulminant presentation of thrombotic microangiopathy associated with Hodgkin's lymphoma in an HIV-infected patient. After aggressive therapy with antiretroviral drugs, chemotherapy, and plasmatherapy, complete remission of thrombotic microangiopathy and Hodgkin's lymphoma was observed.
Article
To estimate the seroprevalence of antibodies to Coxiella burnetii among pregnant women and to assess the effect of Q fever on pregnancy outcome. Anonymous seroprevalence survey between March and May 1996 in all gynecological and obstetrical medical departments of South Eastern France. Women were included irrespective of pregnancy outcome (N=12,716,...
Article
The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin le...
Article
Full-text available
We report a second case of laboratory-confirmed infection caused by Rickettsia mongolotimonae in Marseille, France. This rickettsiosis may represent a new clinical entity; moreover, its geographic distribution may be broader than previously documented. This pathogen should be systematically considered in the differential diagnosis of atypical ricke...
Article
HIV infection is associated with cytokine production by monocytes and expansion of a monocyte subset that expresses high levels of CD16. Our study was designed to investigate the effects of anti-retroviral therapies on these immune parameters. Four groups of HIV+ patients were included in the study. The first group comprised drug-naive patients (n...
Article
In order to describe the clinical features and the epidemiologic findings of 1,383 patients hospitalized in France for acute or chronic Q fever, we conducted a retrospective analysis based on 74,702 sera tested in our diagnostic center, National Reference Center and World Health Organization Collaborative Center for Rickettsial Diseases. The physic...
Article
To determine the role of nonmedicated soap as a source of Serratia marcescens nosocomial infections (NIs) in hospital units with endemic S marcescens NI and to examine the mechanisms of soap colonization. University-affiliated tertiary-care hospitals. A prospective case-control study and an environmental investigation were performed to assess the r...
Article
In the present study, we investigated the plasma levels of soluble adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule- (ICAM- ) and vascular cell adhesion molecule-1(VCAM-1) in 24 patients with Mediterranean spotted fever (MSF), 6 of whom with a malignant form. Measurements were performed on blood samples collected before tr...
Article
Full-text available
Typhus and other louse-transmitted bacterial infections in Peruvian sierra communities are known to occur but have not recently been assessed. In this study, 194 of 1,280 inhabitants of four villages in Calca Province in the Urubamba Valley were included. Thirty-nine (20%) of the 194 volunteers had antibodies to Rickettsia prowazekii, whereas 24 (1...
Article
Full-text available
Q fever is a worldwide zoonosis which is caused by Coxiella burnetii and presents as both acute or chronic cases. The disease can be transmitted from animal reservoirs to humans by the inhalation of infected aerosols. The authors investigated the epidemiology of Q fever in the Bouches-du-Rhône district of southern France. The study area was centere...
Article
Q fever endocarditis, caused by Coxiella burnetii, is fatal in 25% to 60% of patients. Currently, treatment with a long-term tetracycline and quinolone regimen for at least 4 years is recommended, although relapses are frequent. Between January 1987 and December 1997, the reference treatment of Q fever endocarditis was compared with one of doxycycl...
Article
Rickettsioses are caused by gram-negative, obligate intracellular bacteria of the family Rickettsiaceae. The presence of rickettsial diseases has been reported from throughout the African continent [1] and the need to define more precisely the epidemiology of rickettsiosis in Africa has been emphasized by the World Health Organisation [2]. In 1996,...
Article
Full-text available
A serological survey was carried out on 429 dogs belonging to the French military in France, French Guyana, Martinique, Senegal and the Ivory Coast. Serology against phase I and II antigens of Coxiella burnetii, the intracellular zoonotic bacterium was performed using indirect immunofluorescence techniques. Specific antibodies were found in dogs fr...
Article
African tick-bite fever is caused by R. africae. All cases reported to date in France have occurred among patients who came from southern Africa, the endemic zone. We report the first case, to our knowledge, of a patient infected in France. A 69-year-old white man who had never left France developed fever and 3 "black spots" on the legs with lympha...
Article
Introduction: Rickettsiosis are emerging, life-threatening infectious diseases that are world-wide distributed and have various manifestations. Most of the time, skin involvement is the prominent feature of clinical manifestations. Clinicians must therefore be well aware of these various clinical pictures. Current knowledge and key points: Knowl...
Article
Background: After a 12-year absence, epidemic typhus has re-emerged among the displaced population of Burundi. Following the outbreak of civil war in 1993, over 760000 people now inhabit refugee camps, under appalling conditions. A typhus outbreak occurred among prisoners in a jail in N'Gozi in 1995. At the time, the disease was not recognised, an...
Article
Introduction Rickettsiosis are emerging, life-threatening infectious diseases that are world-wide distributed and have various manifestations. Most of the time, skin involvement is the prominent feature of clinical manifestations. Clinicians must therefore be well aware of these various clinical pictures. Current knowledge and key points Knowledge...
Article
Due to their Worldwide distribution, the number of species, their behaviour, the specificity of their relationship with their hosts, ticks are able to transmit numerous bacterial, viral or parasitologic diseases to humans. Depending on the disease, they play the of biological vector or intermediate host.
Article
Unlabelled: Chronic recurrent multifocal osteomyelitis (CRMO) is a disorder of suspected--but unproved-infectious etiology. Observation: A girl presented with a typical CRMO involving successively the left fibula, radius, humerus and the right carpus. A Coxiella burnetii infection was indicated during the first attack. Two recurrences occurred i...
Article
Chronic recurrent multifocal osteomyelitis (CRMO) is a disorder of suspected — but unproved — infectious etiology. Observation. A girl presented with a typical CRMO involving successively the left fibula, radius, humerus and the right carpus. A Coxiella burnetii infection was indicated during the first attack. Two recurrences occurred in spite of...
Article
Introduction. - Rickettsiosis are emerging, life-threatening infectious diseases that are world-wide distributed and have various manifestations. Most of the time, skin involvement is the prominent feature of clinical manifestations. Clinicians must therefore be well aware of these various clinical pictures.Current knowledge and key points. - Knowl...
Article
Full-text available
Listeria monocytogenes was isolated from three patients hospitalized in two departments of the same hospital over a two-week period. A nosocomial outbreak of listeriosis was suspected. Patients presented with tenosynovitis, central venous catheter infection, and bacteremia. The first patient had a community-acquired infection, the second a nosocomi...
Article
Immunofluorescent antibody (IFA) testing was performed on sera drawn from 150 pregnant women in the port city of Dar es Salaam, Tanzania. Prevalence of antibodies to Rickettsia typhi was 28%, higher than in any of the 12 other African countries in which serosurveys using IFA testing have been performed. Seroprevalence of antibodies to spotted fever...
Article
Relapsing fevers occur worldwide and are characterized by recurrent episodes of fever and spirochetemia. In central, eastern, and southern Africa, the disease is often caused by Borrelia duttonii, which is transmitted by the soft tick Ornithodoros moubata. We conducted a field investigation in September 1994 at a hospital in Mitwaba, southern Zaire...
Article
Les étiologies des états fébriles dépendent du recrutement du service et des moyens d'investigation disponibles. Dans cette étude prospective, nous avons étudié les étiologies de la fièvre chez 300 malades (117 H, 183 F) consécutifs hospitalisés, durant la période du 1.2.93 au 1.2.94, et pratiqué systématiquement 2 prélèvements pour étude sérologiq...
Article
Full-text available
Trench fever disappeared in industrialised countries after the first world war. However, between 1992 and 1994, there were cases reported in industrialised countries.' Some have been reported in HIV infected patients,2 but most are among homeless people.34 Epidemiological data on Bartonella quintana infection , the transmission of which is favoured...
Article
Risk factors for hip and knee prosthesis infection have been described, but not psoriasis. Eighty five infected patients from different centers and 202 non infected patients were included in a case-control study. Fifteen of 85 infected patients (17.6%), and 2 of 202 (1%) non infected patients had psoriasis. Odds ratio for infection in patients with...
Article
Full-text available
Trench fever is caused by Bartonella (Rochalimaea) quintana, a small gram-negative rod that is transmitted by body lice. Recently, B. quintana infections in homeless patients have been reported in the United States and Europe. From October 1993 to October 1994, the seroprevalence of antibodies to B. quintana was assessed by indirect immunofluoresce...
Article
Full-text available
The male-killing ladybird beetle (LB) bacterium (AB bacterium) was analyzed with specific rickettsial molecular biology tools in the LB Adalia bipunctata strains. Eight phenotype-positive LB strains showing mortality of male embryos were amplified with rickettsial genus-specific primers from the gene for citrate synthase (CS) and the gene for a 17-...
Article
Trench fever, cause by Bartonella quintana, disappeared decades ago. Between 1992 and 1994 about 20 cases were reported in industrialized countries [6, 7]. Some of these cases were associated with HIV infection [5], but most affected the homeless. The epidemiology of B. quintana is unknown in Europe, but infection and transmission are favoured by p...
Article
Trench fever, caused by Bartonella quintana, disappeared decades ago. Between 1992 and 1994 about 20 cases were reported in industrialized countries. Some of these cases were associated with HIV infection, but most affected the homeless. The epidemiology of B. quintana is unknown in Europe, but infection and transmission are favoured by poor housin...
Article
The authors report a case of pleuro-pericarditis during an acute Coxiella burnetii infection. They point out the rarity of this mode of presentation of acute Q fever and the diagnostic difficulties in the absence of focal pulmonary or hepatic signs. The diagnosis was confirmed by serological changes, essentially indirect immunofluorescence. They un...
Article
The prevalences of antibodies reactive with Coxiella burnetii, Rickettsia conorii, and Rickettsia typhi were determined by indirect fluorescent antibody testing of sera from seven African countries. The seroprevalences of antibodies reactive with C. burnetii and R. conorii in countries from North Africa were similar to those reported from southern...
Article
We report two different aspects of Q Fever pneumonia in two patients coming back from the same guided tour in Crete. The first patient presented with an influenzae-like syndrome associated with an interstitial pneumonia. The second patient presented with acute lobar pneumonia and hepatitic cytolysis. Mild thrombocytopenia was observed in both patie...
Article
Current armed conflicts in various countries of the world are the occasion to remind the role of infectious diseases, and mainly typhus, in the outcome of wars. The author recalls the history of typhus and the main conflicts, from the IVth century A. C. to nowadays, the history of the searchers who enhanced the knowledge of the disease, and the arr...
Article
Full-text available
In this report we attempt to evaluate the prevalence of antibodies against Rickettsia conorii, R. typhi, Coxiella burnettii, and Ehrlichia chaffeensis in central Tunisia. Five hundred sera from blood donors, collected between March and June 1993, were tested for these 4 antibodies using an indirect immunofluorescence antibody assay (IFA). Nine perc...
Article
The male-killing ladybird beetle (LB) bacterium (AB bacterium) was analyzed with specific rickettsial molecular biology tools in the LB Adalia bipunctata strains. Eight phenotype-positive LB strains showing mortality of male embryos were amplified with rickettsial genus-specific primers from the gene for citrate synthase (CS) and the gene for a 17-...
Article
In France, one has access to quite precise data fot approximately fifteen zoonoses. The most common viral zoonosis appears to be the hemorrhagic fever with renal syndrome; the reservoir of wich is made of rodents and the endemo-epidemic region is northeastern France. In the same region, the fox rabic enzootic is in the process of becoming extinct t...
Article
Spotted fever rickettsiosis have been identified on the African continent since their historical description in 1909. However, only Rickettsia conorii and R. africae have been described in Africa, and the current techniques for the detection of rickettsiae in ticks are difficult to apply in large field studies. We report here a preliminary study us...
Article
Q fever, a worldwide zoonosis caused by Coxiella burnetii, lacks clinical specificity and may present as acute or chronic disease. Because of this polymorphism, serological confirmation is necessary to assess the diagnosis. Although microimmunofluorescence is our reference technique, the cutoff titers that are currently used to make a diagnosis of...
Article
Since 1972, there have been no reports of Mediterranean spotted fever (MSF) in Greece. In 1991, a seroepidemiologic survey was conducted in three rural villages in the Province of Fokida in central Greece, using both an immunofluorescence assay (IFA) and Western blot to evaluate the prevalence of specific IgG and IgM antibodies to Rickettsia conori...
Article
Due to their worldwide distribution, from hottest to coldest climates, and due to their behaviour, ticks are capable of transmitting numerous human and animal bacterial viral or parasitous diseases. Depending on the disease, they play the role of biological vector or intermediate host. In France, six tick borne diseases are of epidemiologic importa...
Article
We report 29 cases of Q fever, including 22 acute and 7 chronic diseases. The clinical findings are emphasized, and the malignancy of the chronic Q fever is discussed.
Article
Chronic Q fever is seldom recognized; before 1989, only 234 cases had been reported in the literature. The 92 cases of chronic Q fever collected at the French National Reference Center for Rickettsioses from 1982 through 1990 represent the largest series ever reported. The patients included in the study were diagnosed between July 31, 1982, and Aug...
Article
Objective: Chronic Q fever is seldom recognized; before 1989, only 234 cases had been reported in the literature. The 92 cases of chronic Q fever collected at the French National Reference Center for Rickettsioses from 1982 through 1990 represent the largest series ever reported. Patients: The patients included in the study were diagnosed between...
Article
We report the results of a comparison of several epidemiologic and ecologic parameters affecting the incidence and seroprevalence of Mediterranean spotted fever (MSF) in northern, central, and southeastern Marseille, an area endemic for this disease. In northern Marseille, the incidence of hospitalized patients with MSF was 24.2/100,000 persons com...
Article
To study the frequency of Q fever in HIV-infected individuals. A seroprevalence study. French National Reference Centre for Rickettsial Agents, Marseille, France. Five out of the 68 hospitalized cases of Q fever diagnosed in 1987-1989 were also HIV-infected and are described here. Sera from a blood-donor bank (n = 925) and from HIV-positive individ...
Article
To contribute to the knowledge of epidemiologic and clinical features of patients hospitalized with Q fever in France. We conducted a retrospective analysis of 22,496 sera submitted between 1982 and 1990 to the French National Reference Center for Rickettsial Diseases (NRC). The diagnosis of acute Q fever was based on an IgG titer greater than or e...
Article
The authors report the general epidemiologic features of Mediterranean spotted fever (MSF) in the Marseille area (South France). Age was a risk factor, increasing after 50 years, and annual incidence seemed positively correlated with the average temperature of the preceding year and negatively correlated with the number of days with frost of the pr...
Article
Mediterranean spotted fever is endemic in southern France, especially during summer. Clinical diagnosis is generally based upon the presence of a febrile eruption with or without the typical tache noire. Usual laboratory findings, which include thrombocytopenia, elevated levels of hepatic enzymes, and hyponatremia, are not specific to the disease....
Article
The effect of two new macrolides, azithromycin and roxithromycin used either alone or in combination with amikacin rifabutine and 1.25 (HO)2 vitamin D3 was examined in vitro. Macrophage monolayers infected with M. avium complex or M. xenopi were treated with antibiotics or 1.25 (OH)2 vitamin D3 by using different protocols: antibiotics or 1.25 (OH)...

Network