
Hernayanti HernayantiJenderal Soedirman University | UNSOED · Biology faculty
Hernayanti Hernayanti
PhD
About
44
Publications
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Introduction
Hernayanti Hernayanti currently works at the Biology faculty, Universitas Jenderal Soedirman. Hernayanti does research in Genetics, Biotechnology and Molecular Biology. Their current project is 'EFEK POLIMORFISME GENA GSTP-1 TERHADAP AKTIVITAS GLUTATION S-TRANSFERASE (GST) PADA INDIVIDU TERPAPAR LOGAM BERAT TIMBAL (Effect of GSTP-1 Gene Polymorphismson Glutation S- Transferase (GST) Activity in Heavy Metals Lead-Exposed Individual)'.
Additional affiliations
January 2017 - September 2017
Publications
Publications (44)
Hyperglycemia in diabetes is associated with obesity and increases the production of free radicals which is the beginning of the development of oxidative stress. This study aimed to determine the effect of cowpea sprout yogurt (CowpeaS-Yo) on body mass index (BMI) and malondialdehyde (MDA) levels in type-2 diabetes mellitus (T2DM) with obese patien...
Jamur Coprinus comatus merupakan salah satu jamur yang dapat berkhasiat sebagai obat. Tubuh buah jamur C. comatus mengandung antioksidan seperti flavonoid, total fenol, tokoferol dan polisakarida, serta beberapa senyawa aktif yang berpotensi sebagai antioksidan, imunomodulator, antikanker, antitumor, hipolipidemik dan hipoglikemik. Flavonoid sebaga...
Campak dan rubella adalah penyakit yang disebabkan oleh virus yang menyerang anak-anak di seluruh dunia. Meskipun vaksinasi telah secara drastis mengurangi jumlah kasus campak dan rubella, wabah telah dilaporkan di daerah-daerah dengan tingkat vaksinasi yang rendah, yang dikaitkan dengan keraguan masyarakat untuk menerima vaksin yang tersedia saat...
Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxic...
This study aims to determine the effect of giving Cowpea bean sprouts yogurt (CowpeaS-Yo) on blood glucose levels and abdominal circumference of patients with type-2 diabetes mellitus (T2DM). This experimental study used a pretest-posttest control group design, with 18 female subjects with T2DM, randomly divided into 2 groups, 9 people each. Group...
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the bacteria that can produce biofilms. Biofilm inhibits the action of antibiotics causing antibiotic resistance. The betel leaf is known as traditional medicine for various antimicrobial therapies. Herein, we report the potency of ethanol extract from betel leaves against MRSA 2983. The...
Coprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant comp...
Background
Hypercholesterolemia due to a high cholesterol diet can increase free radicals resulting in oxidative stress. Superoxide dismutase (SOD) and malondialdehyde (MDA) have been used as the study markers of oxidative stress in cases of hypercholesterolemia. Purple passion fruit contains various compounds that may reduce free radicals. This st...
Context
Edible mushrooms have a long history of use in traditional Chinese or Japanese medicine. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) contains antioxidant and antidiabetic agents.
Objective
To identify the benefits of ethanol extracts of the C. comatus fruit body in streptozotocin-induced hyperglycaemic rats by evaluating their blood...
Coprinus comatus atau jamur paha ayam berpotensi sebagai antioksidan dan antidiabetes. Kondisi hiperglikemia pada penderita diabetes mellitus menyebabkan peningkatan Reactive Oxygen Species (ROS). Sel β pankreas memiliki antioksidan hanya sedikit dibandingkan organ lain. Hal ini menyebabkan stress oksidatif yang memicu reaksi berantai peroksidasi l...
Coprinus comatus, well-known as Shaggy Ink Cap mushroom, is potential herbal medicine. Synthetic medicines sometimes cause side effects; therefore, it is necessary to innovate with herbal medications with minimal side effects. The study evaluated in vitro and in vivo treatments to evaluate the antioxidant effect and activity of C. comatus. The in v...
Gunung Mas Regency, Central Kalimantan Province is one of the endemic filariasis areas with Microfilaria rate of 3.4%. One of the efforts made to control this problem is Mass Drug Administration once a year for 5 years. Currently, the Rapid Diagnostic Test (RDT) method is being developed, a quick and easy diagnostic technique to detect the presence...
Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence. An increase in free radicals and AGEs can cause glomerular cell damage which can lead to inflammation and DM nephropathy. WHO has recommended DM treatment by using herbal medicines that have minimal side effects and have a lot of biological activity to prevent complication...
Cadmium is a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups with four replications, i.e group of he...
Diabetes mellitus (DM) is a metabolic disease in the form of impaired insulin secretion, insulin production, or decreased insulin sensitivity which causes blood glucose levels to increase (hyperglycemia). Hyperglycemia can cause oxidative stress and increase the production of reactive oxygen species (ROS) that cause lipid peroxidation and cell infl...
Carbon tetrachloride (CCl₄) is a chemical that can cause damage to liver cells. One of the natural ingredients developed to reduce liver damage due to chemicals and infections is Chlorella sp. The research aimed to explore the hepatoprotective effect of the antioxidant superoxide dismutase (SOD) by administering Sun Chlorella in Rattus norvegicus C...
Karang Bolong Beach is a beach located at the eastern tip of the island of Nusakambangan Cilacap. Karang Bolong Beach has a substrate type in the coral and composite substrate (fragment coral, rock, and sand). Therefore, a lot of seaweed grows there. This research aims to determine the macroalgae community on different substrates at Karang Bolong B...
Coprinus comatus is known for its antihyperglycemic benefits. This study aimed to identify the effect of bioactive compounds of C. comatus extract as an antidiabetic agent linked to glucagon-like peptide 1 (GLP-1) and antioxidant properties in increasing glutathione (GSH) levels. This study used six groups of Wistar rats (n = 24). Group 1 comprised...
Iron overload in β-thalassemia patients can damage various organs, including the pancreas. Impairment of the pancreas will be causing the failure and reduces insulin secretion, contributing to impaired glucose metabolism to diabetes mellitus in patients with β-thalassemia. This study analysed the correlation between hepcidin and ferritin levels as...
Cadmium is a heavy metal widely used in human life. When it enters the body, cadmium might bind to metallothionein protein and impair renal function. The renal function decrease usually is characterized by raise of β2-microglobulin, creatinine, ureum and uric acid levels, which possibly be cured by lycopene, and antioxidant found in tomato. The obj...
Heavy metals such as Zinc (Zn) in batik wastewater may be reduced with biosorption. Sargassum cinereum and rhizobacteria may be used as a biosorbent as they are cheap, abundant, and easily obtainable. The process of biosorption depends on a biosorbent surface area. A large biosorbent surface area can be made by modifying a tea bag. This study aims...
ABSTRAK Upaya telah dilakukan Pemerintah Republik Indonesia untuk meningkatkan taraf hidup rakyatnya diantaranya dengan melibatkan Perguruan Tinggi dalam pengentasan kemiskinan tersebut. Melalui kerjasama desa binaan yang dimulai tahun 2019, Fakultas Biologi Unsoed telah mendidik, melatih dan mendampingi kader PKK untuk mengoptimalkan program kerja...
Liquid waste of chromium electroplating can cause water pollution if not treated. The negative impact of chromium can be minimized with water weeds such as Salvinia molesta and Salvinia natans. The objective of this research was to compare the effectiveness between S. molesta and S. natans as a phytoremediator and the best time exposure. The resear...
Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negat...
Basil leaves (Ocimum basilicum) is one of the traditional medicinal plants that is used as medicine.This study aims to determine the effect of giving basil leaves on levels of Beta 2 microglobulin, uric acid and kidney histology in white wistar-induced rats in MSG and determine the effective dose of basil leaves in an effort to improve kidney funct...
Limbah batik mengandung logam berbahaya diantaranya adalah Cr, Cu, Zn, dan Mn. Limbah batik yang dihasilkan dari industri tekstil umumnya merupakan senyawa anorganik non-biodegradable, yang dapat menyebabkan pencemaran terutama lingkungan perairan. Logam yang masuk dalam bentuk ion akan diikat oleh protein darah (Metalotionin), disebut ikatan M+Mt....
Cadmium (Cd) is a heavy metal that is toxic to humans. Cadmium will bind to metalotionin in the liver to form Cd+MT bonds, which triggers the formation of free radicals and causes oxidative stress. Oxidative stress characterized by elevating of MDA and decreasing of antioxidant enzyme such as SOD. Gotu kola(Centella asiatica) contains active compou...
Periodontitis is a chronic inflammation on tooth supporting tissues leads to alveolar bone resorption and tooth loss. Increase of alkaline phosphatase (ALP) level is found in periodontitis condition. Potato skin extract is known for its antioxidant and antiinflammation compounds therefore presumably potential as adjuvant therapy for periodontitis....
Auricularia auricula is an edible mushroom cultivated in Indonesia that has been known to have potential properties of bioactive compounds than can be used for medicinal purpose. This study aimed to examine the cytotoxic and apoptosis effect of chloroform extract of A. auricula on cervical cancer cells in vitro. The research design was in vitro exp...
The present of cadmium in the body is nephrotoxic due to it’s effect in increasing urea and creatinine. Tea mistletoe (Scurrula atropurpurea) has quercetin compound that able to become cadmium chelator. This study aims to know the effect and effective dose tea mistletoe as natural chelator in detoxifying cadmium towards urea and creatinine levels o...
Chlorella vulgaris is an algae with high nutrition content. Carbon tetrachloride (CCl4) is a hepatotoxic chemical.The aims of this study were to determine the effect of C. vulgaris extract on the physiological response of liver such as MDA, SOD and GPx activity on rat after induced by CCl4 exposure as well as to determine the effective dose of C. v...
Coprinus comatus has hypoglycaemic and antioxidant activity, and thus also potential for the treatment of diabetes mellitus (DM). The treatment of DM is prolonged and costly and long-term use of the currently available therapeutics carries a risk of development of side effects. This creates an opportunity for application of traditional medicine. Th...
ABSTRAK Kadmium merupakan salah satu logam berat yang bersifat nefroksik dan membahayakan kesehatan manusia, terutama pekerja bengkel las. Kadmium masuk ke dalam tubuh berikatan dengan metalotionin membentuk ikatan Cd+Mt akan terdeposit di organ ginjal dan menginduksi terbentuknya radikal bebas sehingga mengakibatkan peroksidasi lipid yang dapat me...
Button mushrooms (Agaricus bisporus) is an edible mushroom that is most widely cultivated in the world. It contains bioactive compounds that might provide beneficial effects on diabetes mellitus patient. The study aimed to determine the effects of A. bisporus administration on the blood glucose, and malondyaldehyd (MDA) levels as well as superoxide...
Diabetes mellitus (DM) is a metabolic syndrome which occurs when insulin is insufficiently produced or insulin cannot well serve its function. Diabetes is marked with increase in blood glucose level followed by increase in glycosylated hemoglobin level and decrease in insulin level. This research aims to examining the effect of Ganoderma lucidum ex...
ABSTRAK Hyperlipidemia adalah kelainan metabolisme lipid yang ditandai dengan penurunan tingkat High Density Lipoprotein (HDL). Daun alpukat (Persea americana) dan Kelor (Moringa oleifera) berpotensi untuk meningkatkan kadar HDL. Penelitian ini bertujuan untuk mengetahui kombinasi daun alpukat dan daun kelor terhadap kadar HDL untuk model tikus hip...
Cadmium is one of a heavy metal which widely used in human life, especially in the electroplating industry and a mixture of textile materials. Cadmium that enters the body binds to the metallothioneins protein. It can increase the formation of free radical compounds, there by inhibiting enzyme activity such as nitric oxide synthase3. This gene regu...
Subgroup A1 and A2 are the most important in the blood group A. Subgroup A1 has the A antigen more than A2 subgroup, the A2 subgroup can cause misidentification of blood group due to poor A antigen and genetic variation possessed. Misidentification of the blood group will increase the risk of transfusion reactions. This research aims to describe th...
ABSTRAK
Gena GSTP-1 merupakan penghasil enzim glutation S- transferase (GST), yang berfungsi dalam proses detoksifikasi senyawa toksik di hati. Faktor keberadaan polimorfisme gena GSTP-1 akan menyebabkan penurunan ekspresi GST, sehingga proses detoksifikasi terhadap senyawa toksik akan terhambat. Kerentanan terhadap paparan senyawa toksik pada manu...
Plumbum bersifat toksik terhadap manusia. Teh hijau digunakan untuk mengobati penyakit karena mengandung catechin. Tujuan penelitian untuk mengetahui efek catechin ekstrak teh hijau sebagai kelator Pb. Sebanyak 36 ekor tikus Wistar digunakan dalam penelitian ini. Tikus dibagi 6 kelompok, 6 ekor per kelompok. Kelompok I sebagai kontrol negatif. Kelo...
Disturbance on the immune system and deficiency of Zn is two factors which often trigger vaginal candidiasis patient. The aim of the research was to study the effect of virgin coconut oil (VCO) enriched with Zn to the amount of neutrophil and lymphocyte subset cells, and the level of IL-2 and IgG in vaginal candidiasis patient. Thirty women were gr...
Objectives of this research was to know the effect of probiotic A3-51 supplementation on food to the total number of bacteria in kidney and mortality of Oreochromis niloticus after challenge test with Aeromonas hydrophila and Aeromonas salmonicida achromogenes. This research was consisted of two experiment, the first was to know the highest immunit...