Hernán De Battista

Hernán De Battista
Universidad Nacional de La Plata | UNLP · Facultad de Ingeniería

PhD

About

150
Publications
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Publications

Publications (150)
Article
Full-text available
Artificial pancreas (AP) algorithms can be divided into single-hormone (SH) and dual-hormone (DH). SH algorithms regulate glycemia using insulin as their control input. On the other hand, DH algorithms also use glucagon to counteract insulin. While SH-AP systems are already commercially available, DH-AP systems are still in an earlier research phas...
Article
Background: The first two studies of an artificial pancreas (AP) system carried out in Latin America took place in 2016 (phase 1) and 2017 (phase 2). They evaluated a hybrid algorithm from the University of Virginia (UVA) and the automatic regulation of glucose (ARG) algorithm in an inpatient setting using an AP platform developed by the UVA. The...
Article
En este trabajo se presenta la experiencia argentina en el problema de regulación de los niveles de glucosa en sangre para pacientes con Diabetes Mellitus Tipo 1 (insulino-dependientes), denominado Páncreas Artificial. El grupo de trabajo ha realizado 3 pruebas clínicas, las primeras en Latinoamérica. Las dos primeras fueron concretadas en 2016 y 2...
Article
Full-text available
The problem of exactly differentiating a signal with bounded second derivative is considered. A class of differentiators is proposed, which converge to the derivative of such a signal within a fixed, i.e., a finite and uniformly bounded convergence time. A tuning procedure is derived that allows to assign an arbitrary, predefined upper bound for th...
Article
Full-text available
This letter illustrates the potential of a new platform for simultaneous remote monitoring of multiple intensive care unit (ICU) and/or quarantined patients. To our best knowledge, this is the first multicenter, multisensor, multipatient, and potentially multitherapy platform for remote glucose monitoring employed in critically ill COVID patients....
Article
Full-text available
Within the development of closed-loop glucose controllers, one of the major risks is insulin induced hypo-glycemia due to controller overreaction. In this paper, a novel strategy based on sliding mode control is proposed in order to reduce hypoglycemic events in glycemic closed-loop control via the subcutaneous route. This is achieved with the use...
Article
Los pacientes en estado crítico con COVID-19 sufren hiperglucemias sostenidas de difícil manejo. A esto se suma el desafío de minimizar la exposición al contagio.En el presente artículo analizamos la evolución metabólica de dos pacientes pediátricos con COVID-19 admitidos en unidad de cuidados intensivos (UCI) para pacientes COVID-19 del Hospital “...
Article
Full-text available
In this work, global optimization techniques based on interval arithmetic are proposed to analyze and synthesize sliding mode (SM) controllers. The proposed methodology allows generating a series of maps, called subpavings, which put in evidence the required relationships among tuning parameters, disturbances and control amplitude to fulfill the su...
Article
This paper addresses the coordinated operation between wind farms and reservoir hydropower plants in networks with weak transmission capacity. The joint operation of the energy sources is captured by a Virtual Power Plant (VPP) representation. With the aim of maximising renewable energy penetration while ensuring a suitable VPP integration, a super...
Article
Full-text available
This work evaluates the potential of using sliding mode reference conditioning (SMRC) techniques as a guide for non-pharmaceutical intervention (NPI) to control the COVID-19 pandemic. In particular, for the epidemiological problem addressed here, it is used to compute the contact rate reduction requirement in order to limit the infectious populatio...
Chapter
In this paper, a new glucose control strategy for patients with type 1 diabetes based on the dynamic simulation of an interval model is presented. Particularly, a safety scheme based on an interval insulin-on-board estimation model for artificial pancreas systems is designed, which includes a combination of soft and hard insulin-on-board constraint...
Preprint
Full-text available
In this work, we review the figures used to characterize an epidemic outbreak most. Particular attention is drawn to epidemic spreading at time-varying transition rates. A time-varying SIR-like model is used to describe the epidemic dynamics, from which closed equations relating parameters and key quantities like reproduction ratio and doubling tim...
Article
Ammonium removal is a key step in wastewater treatment which can be accomplished biologically. An interesting process option for this purpose is coupling partial nitritation with the Anammox process. The goal of the partial nitritation process is to convert half of the ammonium in the influent stream into nitrite, so both can be later converted int...
Preprint
Full-text available
This work evaluates the potential of using sliding mode reference conditioning (SMRC) techniques as a guide for non-pharmaceutical interventions and population confinement to control the COVID-19 pandemic. SMRC technique allows robustly delimiting a given variable in dynamical systems. In particular, for the epidemiological problem addressed here,...
Article
Full-text available
Artificial pancreas (AP) systems have shown to improve glucose regulation in type 1 diabetes (T1D) patients. However, full closed-loop performance remains a challenge particularly in children and adolescents, since these age groups often present the worst glycemic control. In this work, an algorithm based on switched control and time-varying IOB co...
Preprint
Full-text available
The problem of exactly differentiating a signal with bounded second derivative is considered. A class of differentiators is proposed, which converge to the derivative of such a signal within a fixed, i.e., a finite and uniformly bounded convergence time. A tuning procedure is derived that allows to assign an arbitrary, predefined upper bound for th...
Article
Artificial pancreas (AP) systems have shown to improve glucose regulation in type 1 diabetes (T1D) patients. However, full closed-loop performance remains a challenge particularly in children and adolescents, since these age groups often present the worst glycemic control. In this work, a new algorithm based on switched control and time-varying ins...
Conference Paper
Full-text available
The design and implementation of biomolecular feedback control strategies embedded within large biomolecular synthetic systems is one of the key areas of Synthetic Biology. Many important challenges remain to be addressed. Among them, the lack of realizations of existing control algorithms through available biomolecular devices. Thus, proportional-...
Article
A wind turbine load analysis featuring both fatigue and extreme loads for a full range Linear Parameter Varying (LPV) controller is presented in this paper. The National Renewable Energy Laboratory (NREL) 5 MW reference wind turbine is simulated with realistic profiles of turbulent wind, according to the IEC 61400-1 regulation, using several NREL's...
Article
Background Either under standard basal-bolus treatment or hybrid closed-loop control, subjects with type 1 diabetes are required to count carbohydrates (CHOs). However, CHO counting is not only burdensome but also prone to errors. Recently, an artificial pancreas algorithm that does not require premeal insulin boluses—the so-called automatic regula...
Conference Paper
One of the main challenges in automatic glycemic regulation in patients with type 1 diabetes (T1D) is to dispense with carbohydrate counting. In this context, we propose to equip a previously introduced switched Linear Quadratic Gaussian (LQG) controller-the so-called Automatic Regulation of Glucose (ARG) algorithm-with an automatic switching signa...
Article
Second- and higher-order sliding mode techniques are able to avoid the chattering effect associated with first-order sliding. The super-twisting algorithm is one of the most popular second-order sliding mode techniques. Existing modifications of the super-twisting algorithm allow for improved disturbance rejection capability. In this paper, we intr...
Article
The objective of this work is to present a brief review on the international Artificial Pancreas project. In addition, the local project that led to the first Latin American clinical trials with an Artificial Pancreas will be described. These trials were performed in Buenos Aires during 2016 and 2017. The last trial used an algorithm developed in A...
Article
Partial nitritation–anammox process is an interesting process option for biological nitrogen removal from wastewater. Partial nitritation needs to provide about equimolar ammonium and nitrite concentrations as required for the Anammox conversion. This study analyzes the equilibrium points of a stand-alone partial nitritation process as part of a tw...
Article
This work aims to analyze the complementary operation between an existing hydropower plant and a projected wind farm in a remote area of Argentinean Patagonia. With this new generation, the grid element sizes will be insufficient to handle both generation sources at rated. Particulary, a bottleneck will be present at the transmission line and the c...
Article
Microbial lipids are being extensively studied as an alternative to vegetable oils in biodiesel production. For the biotechnological production of biolipids, efficient processes capable of obtaining significant biomass productivity with high lipid titer are required. In this work, we used the Optknock algorithm for the assessment of non-intuitive k...
Article
Advances in genetic manipulation have allowed the overexpression of proteins and insertion of circuits in cells. However, the expected behaviour can be altered by the internal competition for the limited amount of cellular resources. In this work we analyse a feedback strategy based on transcription inhibition that aims to reduce the interaction in...
Article
In wastewater treatment, ammonium removal is a key step which can be done biologically. One method is by coupling a partial nitritation with the Anammox process. The partial nitritation goal is to convert half of the ammonium into nitrite, so ammonium and nitrite can be later converted into dinitrogen gas by Anammox bacteria. To obtain a stable par...
Article
Signal tracking and the related signal derivative estimation are key pieces in feedback control engineered systems. In this work we present a synthetic biomolecular circuit that performs signal tracking with high precision under mild conditions on its parameters. The circuit contains two antithetic motifs in feedback via a push-pull switch motif. W...
Article
The design and implementation of biomolecular feedback control strategies embedded within large biomolecular synthetic systems is one of the key areas of Synthetic Biology. Many important challenges remain to be addressed. Among them, the lack of realizations of existing control algorithms through available biomolecular devices. Thus, proportional-...
Conference Paper
• Abstract—In this work, we evaluate the potentials and limitations of Change-Point Analysis (CPA) tools for evaluating performance in Artificial Pancreas (AP) systems. In particular, we use Mood and Mann-Whitney’s non-parametric tests for detecting changes in scale and location in glucose data distributions. These tools are applied to the results...
Article
Full-text available
Background: Emerging therapies such as closed-loop (CL) glucose control, also known as artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes mellitus (T1DM) management. However, demanding patient intervention is still required, particularly at meal times. To reduce treatment burden, the automatic regulation of glu...
Article
Hydrogen obtained from water electrolysis in addition to being sustainable becomes commercially competitive when a high degree of purity is sought. Ideally such purity is achieved by keeping the electrolyzer on a constant and rated power. To satisfy this objective the assistance of the electric grid to deal with the variability of the wind resource...
Article
Turbidostats are a class of bioreactors gaining interest due to the recent availability of microscale and small-scale devices for characterization and scalingup of the biotechnological systems relevant in the biotech and pharma industries. The goal is to keep cell density constant in continuous operation. Thus, the control law, i.e., the substrate...
Article
Full-text available
A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety loop with Insulin on Board (IOB) constraints. In sil...
Article
The yeast Rhodosporidium toruloides has been extensively studied for its application in biolipid production. The knowledge of its metabolism capabilities and the application of constraint-based flux analysis methodology provide useful information for process prediction and optimization. The accuracy of the resulting predictions is highly dependent...
Article
A novel extremum seeking scheme is proposed for the optimization of the specific growth rate in fed-batch processes with substrate inhibited kinetics. The proposed controller is based on a high order sliding mode algorithm, which uses the gradient of the specific growth rate as switching coordinate. A gradient estimation is obtained through a high...
Article
This work revisits the dynamic behaviour of stirred continuous reactors in which a single bioreaction with unknown kinetics occurs. Conditions on the feeding strategy to avoid washing out the biomass and falling in batch operation are obtained. These conditions derive in a closed positively invariant region including the desired operating point. It...
Article
Background and Objective: Although there has been significant progress towards closed-loop type 1 diabetes mellitus (T1DM) treatments, most diabetic patients still treat this metabolic disorder in an open-loop manner, based on insulin pump therapy (basal and bolus insulin infusion). This paper presents a method for automatic insulin bolus shaping b...
Article
Full-text available
The design of sliding mode (SM) comprises the selection of a sliding manifold on the state space and a switching logic. The sliding manifold design is associated with the desired dynamics and closed loop specifications, whereas the switching logic is designed to drive and keep the state on the prescribe manifold. The classical design can lead to ov...
Chapter
Full-text available
Download from http://www.ancefn.org.ar/biblioteca/libros/26.pdf
Conference Paper
Full-text available
The �first clinical trials using an Artificial Pancreas (AP) in Latin America have been defined in 2 stages. The �first stage was carried out in November 2016 with the UVA controller (developed by the Center for Diabetes Technology and already clinically tested), and the second will be performed during the �first semester of 2017 with the ARG (Auto...
Article
Full-text available
The first clinical trials using an Artificial Pancreas (AP) in Latin America have been defined in 2 stages. The first stage was carried out in November 2016 with the UVA controller (developed by the Center for Diabetes Technology and already clinically tested), and the second will be performed during the first semester of 2017 with the ARG (Automat...
Article
Many biotechnological processes have optimal substrate concentrations where a maximum growth rate is achieved. In this work an extremum seeking controller and a gradient estimator are proposed to maximize the growth rate in fed-batch bioprocesses even when the substrate to growth rate map is unknown. Both the controller and estimator are obtained w...
Article
This paper focuses on the active power control of wind turbines. Modern grid codes increasingly demand active power control in order to guarantee utility grid stability under high wind energy penetration. Active power control provides capabilities to regulate wind power below rated, to maintain a power reserve, to indirectly regulate the grid frequ...
Article
This paper deals with the design of feeding rates for dual-substrate fed-batch processes where the main control objective is the regulation of the microbial growth rate. To this end, feedback of the growth rate error is incorporated to a biomass proportional dual feeding law. A second-order sliding mode observer is used to estimate the growth rate,...
Conference Paper
Full-text available
Many biotechnological processes have optimal substrate concentrations where a maximum growth rate is achieved. In this work an extremum seeking controller and a gradient estimator are proposed to maximize the growth rate in fed-batch bioprocesses even when the substrate to growth rate map is unknown. Both the controller and estimator are obtained w...
Poster
Full-text available
In this work, a closed loop algorithm which combines two different control strategies is presented. First, a Switched Linear Parameter-Varying (SLPV) controller with different switching regions related to hyper- and euglycemia situations is designed, providing stability and performance guarantees. In [1], its closed loop performance has been succes...
Article
Control of grid assistance is proposed in this study for a renewable hydrogen generation system of simple and robust structure. Here, the grid connection serves the dual purpose of minimising the effect of wind power variations in the electrolyser supply as well as maximising the hydrogen production. To regulate the electrolyser current at its rate...
Article
The on-line estimation of non-measurable substances and key process variables is relevant for the real-time monitoring of the bioprocesses. This paper deals with the on-line estimation of microbial growth rate and biomass concentration based on measures of the product concentration. The algorithm does not require a model of the growth rate and it c...
Conference Paper
This work focuses in the estimation of the specific production rate of intracellular products in fed-batch processes, for the case where high cell densities are present. Particularly, a new volume model is proposed for the high cell density case where a large amount of intracellular product is stored. Based on the model ant the on-line volume measu...
Article
Full-text available
This paper addresses the estimation of the specific production rate of intracellular products and the modeling of the bioreactor volume dynamics in high cell density fed-batch reactors. In particular, a new model for the bioreactor volume is proposed, suitable to be used in high cell density cultures where large amounts of intracellular products ar...
Article
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and to...
Article
Full-text available
This paper focuses on the specific growth rate estimation problem in a Polyhydroxybutyrate bioplastic production process by industrial fermentation. The kinetics of the process are unknown and there are uncertainties in the model parameters and inputs. During the first hours of the growth phase of the process, biomass concentration can be measured...
Chapter
Two different operating modes can be clearly identified in wind turbine control systems. In low wind speeds, the main control objective is the energy capture maximization, whereas in high wind speeds it is desired to regulate turbine power and speed at their rated values. The fulfillment of these different control objectives implies the transition...
Article
The distinguishability of the non-measured states is relevant for the design and implementation of state observers. The aim of this study is to examine the observability of a fed-batch multi-substrate process with additive growth rate. Based on the model equations, sufficient conditions to fulfill the observability rank condition were determined. R...
Article
In this work the problem of estimating some variables of interest for monitoring and control of photo-fermentation processes is addressed. The focus is on a batch cultivation of Rhodobacter capsulatus where biohydrogen production rate is represented by a Luedeking-Piret expression. The use of second-order sliding mode algorithms to estimate biomass...
Article
Full-text available
This paper addresses the control of a variable-speed variable-pitch wind turbine in the whole wind speed range. To this end, a linear parameter varying anti-windup (AW) controller is proposed as part of a control structure focused on improving the transition between low- and high-wind speed operations. The control structure is similar to classical...
Conference Paper
The regulation of the biomass specific growth rate is an important goal in many biotechnological applications. To achieve this goal in fed-batch processes, several control strategies have been developed employing a closed loop version of the exponential feeding law, an estimation of the controlled variable and some error feedback term. Moreover, in...
Article
In this work, a control strategy to guarantee a minimum dissolved oxygen concentration in aerobic fed-batch bioprocesses is proposed. The strategy is equally applicable to avoid low oxygen concentrations that might be detrimental for metabolites production, to prevent metabolic changes and to maintain an oxygen level in the culture compatible with...
Article
Specific kinetic rates are key variables regarding metabolic activity in bioprocesses. They are non-linear functions of concentrations and operating conditions and therefore of difficult access for process control. In this paper, a multiple kinetic rates observer based on second-order sliding mode ideas is proposed. The main difference with other p...