Hermann Ehrlich

Technische Universität Dresden | TUD

This study reports the synthesis of a nanocomposite consisting of spongin and its applicability in the development of an aptasensing platform with high performance. The spongin was carefully extracted from a marine sponge and decorated with copper tungsten oxide hydroxide. The resulting spongin-copper tungsten oxide hydroxide was functionalized by...

Gallic acid (GA) is one of the most important polyphenols, being widely used in the food, cosmetic, and pharmaceutical industries due to its biological effects such as antioxidant, antibacterial, anticancer, antiviral, anti-inflammatory, and cardioprotective properties. Hence, simple, fast, and sensitive determination of GA is of particular importa...

The measurement of 5-fluorouracil in body fluids is important due to the side effects of this drug that causes neurotoxicity in humans. In this direct, an electrochemical sensor based on the screen-printed electrode (SPE) with cobalt sulfide-graphene nanocomposite (CosGr) was developed for the determination of 5-fluorouracil. The CosGr-SPE presents...

Cationic chitosan is recognized as the most widely studied derivative of chitin, one of the main and the most evolutionary ancient structural biopolymer in nature. The multi-functionality of chitosan, due to its specific physicochemical properties, biodegradability and biocompatibility, is a fundamental factor in the patentability of this biopolyme...

Three-dimensional chitinous scaffolds often used in regenerative medicine, tissue engineering, biomimetics and technology are mostly isolated from marine organisms, such as marine sponges (Porifera). In this work, we report the results of the electrochemical isolation of the ready to use chitinous matrices from three species of verongiid demosponge...

Co3O4 NPs in N-doped porous carbon (Co3O4 [email protected]) materials were prepared by one-pot pyrolysis of a ZIF-67 powder under N2 atmosphere and followed by oxidation under air atmosphere (200 °C) toward promotion catalytic activity and activation of peroxymonosulfate (PMS) to degradation sulfamethoxazole (SMZ). 2-methylimidazole was used as a...

Rising health issues of Worldwide pollution by fossil fuel products are Fostering the development of safer materials such as biopolymers in many sectors such as food, pharmaceutical, medical and environmental industries. Indeed, biopolymers are often safe, biodegradable, cheap and easy to modify. Here we review photocatalysts based on polysaccharid...

Extreme biomimetics is the search for natural sources of engineering inspiration that lead to solutions that are well outside the human comfort zone (temperature, pH, salinity, pressure, etc.). Recent progress in extreme biomimetics has offered a brand-new springboard for the materials and engineering communities to reshuffle traditional approaches...

In this regard, electrochemical sensors based on nanomaterials have been developed according to these requirements. In this work, N-TiO2@[email protected] was used for designing an electrochemical sensor to measure dopamine (DA). The synthesized nanocomposites were characterized using scanning electron microscopy and infrared spectroscopy. The part...

Actin is a fundamental member of an ancient superfamily of structural intracellular proteins and plays a crucial role in cytoskeleton dynamics, ciliogenesis, phagocytosis, and force generation in both prokaryotes and eukaryotes. It is shown that actin has another function in metazoans: patterning biosilica deposition, a role that has spanned over 5...

For the first time, Eu2(WO4)3 nanoparticles (EWNPs) were fabricated and anchored on reduced graphene oxide (RGO) through a sonochemical procedure. The supercapacitive behavior of the product, namely EWNP/RGO was studied using galvanostatic charge-discharge (GCD), cyclic voltammetry (CV) and impedance spectroscopy (ES). Nanostructured EWNP-RGO had a...

Azaperone is a very important phenylbutanone-based neurotransmitter used in the treatment of some animal (veterinary) clinics. This compound has various nerve and tendon stabilizing agents on livestock and animals. Muscular injection of azaperone is used to reduce stress in livestock and reduce their acting. In the present work, Fe 3 O 4 @SiO 2 -NH...

The occurrence of 17α-ethinylestradiol (EE2) in the environment and its removal have drawn special attention from the scientific community in recent years, due to its hazardous effects on human and wildlife around the world. Therefore, the aim of this study was to produce an efficient enzymatic system for the removal of EE2 from aqueous solutions....

The design of sensitive and cost-effective biocomposite materials with high catalytic activity for the effective electrooxidation of glucose plays a key role in developing enzyme-free glucose sensors. The porous three-dimensional (3D) spongin scaffold of marine sponge origin provides an excellent template for the growth of atacamite crystals and im...

Chitin as one of the fundamental structural biological materials widely occurring in broad diversity of uni- and multicellular organisms focuses attention of experts in biomedicine, materials science, and technology. We are the first to present a patentological overview of chitin as a renewable bioactive material that has stimulated the progress in...

Marine sponges were among the first multicellular organisms on our planet and have survived to this day thanks to their unique mechanisms of chemical defense and the specific design of their skeletons, which have been optimized over millions of years of evolution to effectively inhabit the aquatic environment. In this work, we carried out studies t...

Background A basal spicule of the hexactinellid sponge Monorhaphis chuni may reach up to 3 m in length and 10 mm in diameter, an extreme case of large spicule size. Generally, sponge spicules are of scales from micrometers to centimeters. Due to its large size many researchers have described its structure and properties and have proposed it as a mo...

Bacterial diseases are serious problems in the world today. The Staphylococcus aureus (S. aureus) bacterium is one of the most invasive and resistant bacteria that infects humans, making it a common cause of hospital infections. Herein, a very sensitive aptasensor for S. aureus was constructed using nitrogen-doped carbon nano-onions, gold nanoparti...

Collagen filaments derived from the two marine demosponges Ircinia oros and Sarcotragus foetidus were for the first time isolated, biochemically characterised and tested for their potential use in regenerative medicine. SDS-PAGE of isolated filaments revealed a main collagen subunit band of 130 kDa in both of the samples under study. DSC analysis o...

Preparing samples for analyses is perhaps the most important part to analyses. The varied functional groups present on the surface of biopolymers bestow them appropriate adsorption properties. Properties like biocompatibility, biodegradability, presence of different surface functional group, high porosity, considerable absorption capacity for water...

The renewable, proteinaceous, marine biopolymer spongin is yet the focus of modern research. The preparation of a magnetic three-dimensional (3D) spongin scaffold with nano-sized Fe3O4 cores is reported here for the first time. The formation of this magnetic spongin–Fe3O4 composite was characterized by X-ray diffraction (XRD), thermogravimetric ana...

The design of new composite materials using extreme biomimetics is of crucial importance for bioinspired materials science. Further progress in research and application of these new materials is impossible without understanding the mechanisms of formation, as well as structural features at the molecular and nano-level. It presents a challenge to ob...

Biologically induced and controlled mineralization of metals promotes the development of protective structures to shield cells from thermal, chemical, and ultraviolet stresses. Metal biomineralization is widely considered to have been relevant for the survival of life in the environmental conditions of ancient terrestrial oceans. Similar behavior i...

This paper reviews all currently known records of copepod crustaceans of the family Lamippidae (Cyclopoida). The lamippids are highly modified endosymbionts found only on octocorals in the channels of mesoglea and gall-like proliferations of the host tissues. 54 species and 11 genera of copepods have been reported associated with 42 species, 33 gen...

The kinetic parameters of thermal degradation of 3D skeletal biopolymer spongin - isolated from the marine demosponge Hippospongia communis, using thermogravimetric analysis (TG) were evaluated. The kinetic parameters of the pyrolysis in a nitrogen atmosphere were calculated using standard methods, including a model-fitting approach (Coats–Redfern...

This study reports developing novel smart drug delivery systems (DDS) that have great importance in anticancer therapeutics. The magnetic hydroxypropyl methylcellulose (mHPMC) synthesized via in situ method and introduced in the fabrication of tripolyphosphate (TPP)-cross-linked chitosan core-shell nano-carriers ([email protected]). The TPP-cross-l...

The marine sponges of the order Verongiida (Demospongiae: Porifera) have survived on our planet for more than 500 million years due to the presence of a unique strategy of chemical protection by biosynthesis of more than 300 derivatives of biologically active bromotyrosines as secondary metabolites. These compounds are synthesized within spherulocy...

The growing demand for new, sophisticated, multifunctional materials has brought natural structural composites into focus, since they underwent a substantial optimization during long evolutionary selection pressure and adaptation processes. Marine biological materials are the most important sources of both inspiration for biomimetics and of raw mat...

Chitin is the second most abundant biopolymer and functions as the main structural component in a variety of living organisms. In nature, chitin rarely occurs in a pure form, but rather as nanoorganized chitin-proteins, chitin-pigments, or chitin-mineral composite biomaterials. Although chitin has a long history of scientific studies, it is still e...

Selected hypermineralized bones (rostrum and tympanic bullae) have yet to be characterized for diverse species of whales (Cetacea). Hypermineralization in these structures is an example of extreme biomineralization that, however, occurs at temperatures around 36 °C. In this study we present the results of analytical investigations of the specimen o...

The giant bones of whales (Cetacea) are the largest extant biomineral-based constructs known. The fact that the bone can grow up to 7 meters-large raises questions about differences and similarities to other smaller bones. Size and exposure to environmental stress are good reasons to suppose that an unexplored level of hierarchical organization may...

Biocomposites of sponge origin attract scientific attention due to their renewability as well as special properties. Dried skeletons of fresh water demosponge Spongilla lacustris represent unique kind of naturally occurring silica-chitin-based biocomposites with long history of their applications in dermatocosmetics. However, there is still a lack...

The development of novel and effective methods for the isolation of chitin, which remains one of the fundamental aminopolysaccharides within skeletal structures of diverse marine invertebrates, is still relevant. In contrast to numerous studies on chitin extraction from crustaceans, mollusks and sponges, there are only a few reports concerning its...

Molluscan shells are an example of a mineral-based biocomposite material, and most studies to date have focused on understanding their biomineralization mechanisms. Meanwhile, large amounts of these shells are produced as waste globally by seafood which is used by other industries as a source of biogenic calcium carbonates. In this study, we propos...

Chitin, as one of nature’s most abundant structural polysaccharides, possesses worldwide, high industrial potential and a functionality that is topically pertinent. Nowadays, the metallization of naturally predesigned, 3D chitinous scaffolds originating from marine sponges is drawing focused attention. These invertebrates represent a unique, renewa...

In vivo biomimetic biomineralization using living organisms known as biomineralizers is currently a major research trend. Industrially cultivated terrestrial snails, such as the common garden snail Cornu aspersum, represent a simple model organism that is ideal for use in experiments on the regeneration of the calcified shell after the excavation o...

This paper describes the modification of a modified carbon paste electrode (CPE) using nanoparticles of praseodymium erbium tungstate (Pr:Er). The modified electrode was used for the sensitive voltammetric detection of an anticancer drug (5-fluorouracil (5-FU)) using. The modified-CPE was evaluated using cyclic voltammetry (CV), square wave voltamm...

Diverse fields of modern environmental technology are nowadays focused on the discovery and development of new sources for oil spill removal. An especially interesting type of sorbents is those of natural origin-biosorbents-as ready-to-use constructs with biodegradable, nontoxic, renewable and cost-efficient properties. Moreover, the growing proble...

Three-dimensional (3D) biopolymer-based scaffolds including chitinous matrices have been widely used for tissue engineering , regenerative medicine and other modern interdisciplinary fields including extreme biomimetics. In this study, we introduce a novel, electrochemically assisted method for 3D chitin scaffolds isolation from the cultivated mari...

Modern scaffolding strategies include two key ways: to produce requested 3D constructs from corresponding precursors using technological tools, or simply use naturally already prefabricated scaffolds if they originate from renewable sources. Marine sponges inhabit oceans since the Precambrian. These ancient multicellular organisms possess a broad v...

Novel strategies to treat cancer effectively without adverse effects on the surrounding normal tissue are urgently needed. Marine sponges provide a natural and renewable source of promising anti-tumor agents. Here, we investigated the anti-tumor activity of Aerothionin and Homoaerothionin, two bromotyrosines isolated from the marine demosponge Aply...

For the first time, 3D chitin scaffolds from the marine demosponge Aplysina archeri were used for adsorption and immobilization of laccase from Trametes versicolor. The resulting chitin–enzyme biocatalytic systems were applied in the removal of tetracycline. Effective enzyme immobilization was confirmed by scanning electron microscopy. Immobilizati...

The new nanocomposite with various molar ratios along with magnetic properties was fabricated via precipitation (assisted by ultrasonic) procedure. The photocatalytic effects of methylene blue (∼90% degradation for optimized sample in 100 min) for finding the optimized sample performed under visible light irradiation. Moreover, the photo-antibacter...

Structure-based tissue engineering requires large-scale 3D cell/tissue manufacture technologies, to produce biologically active scaffolds. Special attention is currently paid to naturally pre-designed scaffolds found in skeletons of marine sponges, which represent a renewable resource of biomaterials. Here, an innovative approach to the production...

The morphology, chemical, and mineralogical composition of subsurface filamentous fabrics (SFF) from the Deccan Volcanic Province (DVP) were investigated to determine the origin of these spectacular aggregates. SFF occur in a wide variety of morphologies ranging from pseudo-stalactites to irregular fabrics and are classified as SFFIr (irregular) or...

Marine demosponges of the Verongiida order are considered a gold-mine for bioinspired materials science and marine pharmacology. The aim of this work was to simultaneously isolate selected bromotyrosines and unique chitinous structures from A. aerophoba and to propose these molecules and biomaterials for possible application as antibacterial and an...

Chitin is recognized as an evolutionarily ancient and fundamental skeletal construct, commonly found in diverse uni‐ and multicellular (mostly invertebrate) organisms across the globe. This chapter discusses the occurrence and structural peculiarities of chitin from sponges (Porifera), as well as methods for isolating this structural aminopolysacch...

Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this study, we focus our attention, f...

Naturally occurring three-dimensional (3D) biopolymer-based matrices that can be used in different biomedical applications are sustainable alternatives to various artificial 3D materials. For this purpose, chitin-based structures from marine sponges are very promising substitutes. Marine sponges from the order Verongiida (class Demospongiae) are ty...

Fabrication of biomimetic materials and scaffolds is usually a micro- or even nanoscale process; however, most testing and all manufacturing require larger-scale synthesis of nanoscale features. Here, we propose the utilization of naturally prefabricated three-dimensional (3D) spongin scaffolds that preserve molecular detail across centimeter-scale...

Glass sponges (Class Hexactinellida) are described from the Perth Canyon in the eastern Indian Ocean, resulting in 10 genera being recorded, including 11 species, five of which are new to science. In addition, the study resulted in two new records for Australia, Pheronema raphanus and Monorhaphis chuni, and one new record for the Indian Ocean, Walt...

Diverse fields of modern technology and biomedicine can benefit from the application of ready-to-use chitin-based scaffolds. In this work we show for the first time the applicability of tubular and porous chitin from Caribena versicolor spiders as a scaffold for the development of an effective CuO/Cu(OH)2 catalyst for the reduction of 4-nitrophenol...

Pure copper chromite nanoparticles were prepared through an efficient route using copper nitrate and chromium nitrate. For the first time, various amino acids were employed as capping agents in the presence of propylene glycol and ethylene glycol in order to prepare these nanostructures. A number of experiments were performed to examine the effect...

Chitin as a biological material which has been identified in skeletal structures of a broad variety of unicellular (yeast, protists, diatoms) and multicellular (sponges, corals, worms, molluscs, arthropods) organisms is recognized as natural template with good perspectives in modern biomedicine. This chapter provides first insights into prospective...

A glassy carbon electrode (GCE) was modified with a nanocomposite prepared from polymerized β-cyclodextrin (β-CD) and reduced graphene oxide (rGO). The modified GCE is shown to enable the voltammetric determination of traces of levofloxacin (LEV) by various electrochemical techniques. Experimental factors affecting the results including the amount...

Gd³⁺-, Pr³⁺- or Sm³⁺-doped Co-Zn (Co0.5Zn0.5Fe2O4) magnetic ferrites (i.e., Co0.5Zn0.5Gd0.1Fe1.9O4, Co0.5Zn0.5Pr0.1Fe1.9O4 and Co0.5Zn0.5Sm0.1Fe1.9O4) were prepared using a facile sol-gel approach, and the structure, surface morphology and chemical composition of the products were studied by means of scanning electron microscopy (SEM), energy dispe...

The main purpose of this study was to investigate the extraction of essential oils from plants by the supercritical fluid extraction technique. However, other interesting information, regarding the process optimization, is also discussed. Therefore, logical steps were identified to completely describe the process. These steps were divided into thre...

The study is focused on the synthesis of a novel complex of ibuprofen and Platinum(II). The formation of the product was characterized through analytical tools including Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance, ultraviolet–visible spectroscopy, mass spectrometry as well as density functional theory. Using the cont...

Cerium tungstate nanostructure was prepared through precipitation and characterized using field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR), as well as cyclic voltammetry (CV), galvanostatic charge‐discharge, electrochemical impedance spectroscopy (EIS)...

Evolution and multi-functionality of the chitin system in sponges (Porifera) is currently a prime focus in modern experimental zoology including in phylogenetic studies of diverse poriferan taxa. Here, we present the first evidence of chitin in the skeleton of the demosponge originally defined as Dendrilla lacunosa (Porifera: Dendroceratida: Kerato...