Heri Hermansyah

• Doctor of Philosophy
• Managing Director at University of Indonesia

OPEFB is a waste product from oil palm mills and is abundant in quantity. OPEFB is a lignocellulosic compound containing cellulose, hemicellulose, and lignin. The cellulose in OPEFB can be converted into levulinic acid, while hemicellulose can be converted into furfural. The consumption of furfural and levulinic acid in Indonesia is increasing, and...

Agro-industrial waste in Indonesia is a significant problem for the environment. Optimization of agro-industrial waste utilization is an exciting thing to be researched further. This study aims to utilize agro-industrial waste to optimize laccase enzyme production. The agro-industrial waste used is in the form of bagasse, rice straw, and corn stalk...

Integral Pressurized Water Reactor (IPWR) is gaining attention for use in Indonesia due to lower initial capital investment, sitting flexibility, and high level of inherent safety. IPWR relies heavily on passive cooling systems that have many advantages but lacks operational experience because no one operates commercially. Therefore, it is necessar...

The operational and economic constraints suffered by amine solvents for CO2 removal have motivated the research on an alternative solvent with better performance and cost-effectiveness. Amino acid salt (AAS) has been identified as an interesting green solvent, an alternative to commercial amine solvents. The present work evaluated the physicochemic...

Ion exchange resins and immobilized lipase as heterogeneous catalysts are used to synthesize biodiesel for alternative fossil fuels. The use of ion exchange resins in the solid and activated phase can ease the separation process. Furthermore, resins can be reactivated and used repeatedly, reducing the need for catalysts. On the other hand, an immob...

Succinic acid (SA) has been produced from rice straw (RS) and sugarcane bagasse (SB) as low-cost feedstocks in this study through sequential peracetic acid (PA) and alkaline peroxide (AP) pretreatment assisted by ultrasound and pre-hydrolysis followed by simultaneous saccharification and fermentation (PSSF). The effect of yeast extract (YE) concent...

Fluoride varnish is commonly used as topical fluoride therapy to prevent dental caries. Dental caries is a dissolution of tooth surface caused by the metabolic activity of Streptococcus mutans in the presence of carbohydrates. Fluoride varnishes containing antibacterial agents significantly affect the inhibition zone of Streptococcus mutans. Prior...

Breast cancer is a disease in which cells in the breast mutate and turn malignant, where the mutated cells spread to other parts of the body and develop into secondary cancer. In 2018, there were 58,256 new cases of breast cancer. With improper handling, breast cancer can be lethal, where there are 22,692 deaths in 2018 alone. One type of cancer wi...

Propolis is a resinous substance extracted from the plants around the honeycomb, which can be used to construct, adjust and protect the bee colony. Propolis has been known to have various benefits as traditional medicine. It contains flavonoid, caffeic acid phenethyl ester, cinnamic acid, and artepillin C, which may play a role in the immune system...

Caries is a disease that attacks the hard tissue of teeth that is demineralized due to the presence of organic acids produced by Streptococcus mutans. Fluoride varnish is topical therapy for caries prevention that can remineralize tooth surfaces. The addition of antibacterial agents to fluoride varnishes, especially those derived from natural ingre...

As mentioned in several recent reviews, biomass-based furfural is attracting increasing interest as a feasible alternative for the synthesis of a wide range of non-petroleum-derived compounds. However, the lack of environmentally friendly, cost-effective, and sustainable industrial procedures is still evident. This review describes the chemical and...

Precipitate in B20 fuel stored in storage tanks can accumulate at the bottom level of the tank and affect the fuel filter, clogging in the fuel distribution and engine system. This study examines the precipitate formation prediction in B20 fuel based on the monoglyceride content in biodiesel. This research used a modified CSFT method of ASTM D7501...

The G.A. Siwabessy Multipurpose Reactor (RSG GAS) is a pool‐type research reactor. When the reactor operates, the heat released in the core is removed by the primary cooling system. It is necessary to evaluate this system, because failure can cause worst events such as the melting of reactor fuel and the release of radioactivity to the environment....

Biodiesel is one alternative energy that might be promising to substitute the petroleum-based fuel due to its biodegradability and less toxic level. Biodiesel can be synthesized through the non-alcohol route by substituting the alcohol with methyl acetate using lipase enzyme as the Biocatalyst, which may give less by-product during the reaction. In...

Furfural is a high-selling compound produced from cellulose and hemicellulose conversion, and the level of demand in Indonesia is still high. This research examines the economic process design and calculation of furfural production made from TKS by varying the purification method with the distillation method and the toluene extraction method using...

Oil palm empty fruit bunches (OPEFB) are solid wastes that can be processed into several chemicals, one of which is furfural. Furfural can be used as a solvent and intermediate compound in many chemical industries. Nowadays, furfural needs in Indonesia are fulfilled through import, especially from China. Therefore, developing a furfural plant in In...

Adsorption-crosslinking is one of the immobilization methods to improve the reusability of lipase. It requires amino groups to reduce cross-link immobilization risk so that lipase–support interaction increases and the immobilization is attainable. Also, the amino group on the support is expected to increase lipase performance. This study aimed to a...

Enzymatic hydrolysis of oil palm empty fruit bunch (OPEFB) that has been pretreated by modified pretreatment has been investigated in this study. The OPEFB used was pretreated by using sequential peracetic acid – alkaline peroxide solution. As the modification method, the assistance of pretreatment by ultrasound was conducted, in order to increase...

Objective: This research investigates the antibacterial, anticancer, antioxidant, and antiretroviral activities of the lionfish spine poison extract. Methods: Isolation and purification of the phospholipase A2 (PLA2) protein obtained from the spine poison were conducted through the following stages, including, extraction of the venom by sonication,...

Catalytic hydrotreating process based on NiMo/ɣ-Al 2 O 3 has been conducted in this study using Sunan candlenut oil as the feedstock, in order to obtain renewable diesel products as well as conventional diesel. Hydrotreating process was performed with the variation of several operating conditions including pressure, temperature and weight ratio of...

As a new technology, an ion exchange catalyst as a heterogeneous catalyst became a good potential in exchanging the homogeneous base. A kinetic model based on Eley-Rideal mechanism and irreversible multiple reaction of biodiesel synthesis by using heterogeneous catalyst has been simulated in this work. The aim of this study is to obtain the kinetic...

The concern against long-term health and environmental adverse effects of synthetic pesticides has encouraged the development of biopesticides. Eugenol, a major constituent of clove oil, has been proven as potential bio-pesticides. However, the evaporation and photosensitive properties of Eugenol need to be controlled. Nano-encapsulation is a promi...

Production of bioethanol through several routes from cheap materials such as agricultural solid waste is getting more interesting nowadays. Rice straw is one of the potential agricultural solid wastes that can be used as feedstock for bioethanol production due to a huge amount of availability, especially in South East Asia countries. In this study,...

Rice straw is one of the abundant lignocellulosic waste materials that potentially produce 205 billion liters bioethanol per year in Indonesia. This study examines the health, safety, and environmental aspects of a Bioethanol Production Plant. The main processes involved in the plant are pretreatment, gasification, water-gas shift reaction, carbon...

Diabetes mellitus (DM) is a metabolic disease characterized by an increase in blood glucose level above normal (hyperglycemia). Natural ingredients containing hypoglycemic substances can be used an alternative DM treatment, one of which is bitter leaf (Andrographis paniculata). Sambiloto leaves contain compositions of andrographolide and flavonoids...

As an agricultural country, Indonesia has considerable agricultural potential towards development of the national economy. However, the potential itself must be followed by the improvement quality of the agriculture. Armyworm (Spodoptera sp.) is one of the pests that damages various kinds of plants and leads to harm the agricultural sector. One of...

Microbial Electrolysis Cell (MEC) is a promising technology enabling the sustainable production of hydrogen as energy alternative from renewable sources, such as wastewater, with low energy input. Currently, the applications of MECs are still limited due to the relatively low hydrogen production rate. MEC optimization still focused on the reactor c...

Hydrogen is an alternative energy source that can replace fossil fuels. The latest breakthrough idea for producing hydrogen fuel is by utilizing biomass in bioelectrochemical systems, which is Microbial Electrolysis Cell (MEC). MEC is a method for producing hydrogen gas that is managed from organic materials, including from wastewater. In addition...

Biogas has been one of the promising renewable fuel produced from organic substrates. Cocoa husk has a potential to be a substrate for biogas production. Based on various studies, cocoa husk has the potential as a substrate for methane production from anaerobic co-digestion. However, lower biodegradation efficiency of anaerobic co-digestion of coco...

Flavonoid compounds have many benefits in the health field, one of which is xanthine oxidase inhibitor. Xanthine oxidase is a catalyst in the oxidation of hypoxanthine to xanthine and catalyzes xanthine oxidation and causing uric acid formation. The formation of gout in the body will trigger the onset of arthritis gout, which is swelling in the joi...

Indonesian Government concerns on energy security and independency as driven factors for National development. Some policies had issued to support findings about Potentials of New and Renewable Energy, i.e. by developing biodigester. Generally, biodigesters are large so they are not easy to move or permanently in place. The type of biodigester deve...

The concept of green extraction is present to make the active combination extraction process from plant extracts taking into consideration about the environmental aspects. Green extraction can reduce the use of energy, allowing the use of alternative solvents, and renewed natural products, and ensure extracts and products are safe and of high quali...

Microbial Desalination Cell (MDC) is a developed technology for reducing salt concentration of seawater, so it could be used for people’s daily needs. Since there were many tofu industry in Indonesia, so that the substrate in this research came from model of tofu wastewater. For increasing MDC performance, there was modification in reactor design,...

Today the main source of unsaturated fatty acids especially omega-3 is still from marine fish oil. In this research, Rhizopus oligosporus will be used to produce PUFA (polyunsaturated fatty acids). This research used submerged fermentation method and temperature shift strategy to optimize the production of PUFA. In this result, batch culture of R.o...

Dysmenorrhea (menstrual cramps) is defined as difficult menstrual flow or painful menstruation and the most important cause of chronic pelvic pain. It caused by an increase in prostaglandin which has an inflammatory and painful effect. Flavonoids are constituents that can inhibit the formation of prostaglandins. In this study, extraction of flavono...

Biogas is one of promising renewable fuel produced from several numbers of organic substrates. In fact, biomass as the organic matters has an opportunity to generate a cheaper and cleaner energy than using other resources. Therefore, many researchers have been studied about the production of biogas from various kinds of biomass. In Indonesia, there...

Agriculture is the driving force of the national economy. In addition to aiming to fulfil the lives of the people, the agricultural sector is also useful to boost the image of Indonesia in the eyes of the world. Generally, one indicator or parameter commonly used to show the quality of agriculture is the number of pests that damage plants in certai...

Nitrate (NO3⁻) is one of the most common targets for water quality control. High nitrate concentration in the water systems negatively impact human health and the environment. Excessive nitrate content in the aquatic environment led to a decrease in water quality, which can be evaluated from changes in color, odor, increased turbidity, and reduced...

Cardiovascular disease is one of the biggest killing diseases in the world especially in Indonesia. The percentage risk of people stricken by this disease is so high in community and even causing death. This risk can actually be prevented with dietary addition of consuming unsaturated fatty acid that id often found in fish oil. However, the availab...

Microbial Desalination Cell (MDC) is a developed technology for reducing salt concentration of seawater, so it could be used for people’s daily needs. For increasing MDC performance, there was modification in reactor design, whereas the IEM membranes were arranged in two stacked design, yet in the end of desalination cycle there was a recirculation...

Clean water is one of the main needs in people's life. However, its scarcity has been becoming a major problem. Seawater can be the alternative source for the problem, through desalination system. Previous desalination systems require high cost and energy. One of the low energy technology that can be utilized is the Microbial Desalination Cell, a b...

Objective: This research aimed to encapsulate the propolis through spray drying to overcome problematic handling properties of propolis and to optimize the microencapsulation by using response surface methodology (RSM). Methods: The propolis ethanolic extract (PEE) was microencapsulated by spray drying with maltodextrin and gum arabic. RSM was appl...

Enzymatic biosensor has been paid much attention to the research fields due to its advantage in medical application. As one of the application, we determined the optimum value of cholesterol oxidase against cholesterol. In this work, we studied the behavior of cholesterol oxidation by enzymatic reaction to get the optimum condition for cholesterol...

Sensitivity is the effect of changes in any variables on changes in the risk results. The most common Risk Assessment Methodology in Indonesia is Muhlbauer, Modified Muhlbauer & Risk-Based Inspection. This study evaluated six natural gas distribution pipeline segments. In general, there are two objectives, firstly comparing the risk result between...

Pterois volitans, or commonly referred to lionfish, are fish species originating from Indo-Pacific waters but are becoming invasive in other regions such as the Caribbean and Atlantis. Various efforts have been made to reduce the number of lionfish, and one of them is by utilizing the venom on the spine. The venom extraction of P. volitans spines i...

Pterois volitans is an invasive native predatory fish species in the Indo-Pacific ocean that disrupt the food chain and damage coral reefs which cause ecosystem imbalances. These fish have venomous spines that made them inedible and avoided by a predator. Due to its rapid growth, utilization of this venom can be useful along with controlling the po...

The population of Pterois volitans has caused significant damage to other fish populations and coral reef ecosystems. Population control of P. volitans consumes a considerable cost so that the utilization of these fish needs to be sought to be useful along with controlling the population. This fish is known to contain the enzyme Phospholipase A2 (P...

Fault tree analysis (FTA) is frequently applied to deductively evaluate the safety systems of complex engineering systems such as chemical industries or nuclear facilities. To perform this analysis, generic data are commonly used due to the limitation of historical failure data of the system being evaluated. However, generic data have a degree of u...

Lipase is one of the most used industrial enzymes, which can be produced by Aspergillus niger. Large scale production of Aspergillus niger lipase is more profitable by using solid state fermentation method and utilizing agro-industrial waste as the substrate. Optimization of Aspergillus niger lipase production has been performed in this study. Opti...

Synthesis of biocomposites using polylactic acid (PLA) as the matrix and cellulose fiber from sorghum bagasse as the reinforcement agent has been carried out in this study. The objective was to improve the mechanical properties and biodegradability of PLA. In this study, cellulose fiber has been extracted from sorghum bagasse. Micro and nano-sized...

Production of bio-succinic acid through microbial fermentation using agro-industrial waste has been observed extensively. Large scale production is now being considered since bio-succinic acid has broad range application in several industries including agricultural, food, chemical, metal, and pharmaceutical industry as a precursor, ion chelator, an...

This paper presented the absorption removal efficiency for carbon dioxide (CO 2 ) removal from natural gas using an environmental friendly solvent, potassium carbonate promoted with glycine. Recently, CO 2 capture using this solvent (with precipitating) was studied by previous researchers. However, the precipitates of the solvent increase the poten...

The bioproduct from biomass appears to be major interests for future years given the spectacular and fast advances in microbiology. But the industrial developments of the new bioproducts production struggle to follow this constant and massive creation. Therefore, to estimate the potential of new bioproducts is necessary to pre-design biorefineries...

Cholesterol is contained in many food ingredients from animal origin. One of methods that is used to degrade cholesterol is an enzymatic oxidation. Numerous researcher have been done in cholesterol enzymatic oxidation by used commercial cholesterol as a substrate. In this study, the substrate is obtained by extracting crude cholesterol from fatty f...

Lionfish (Pterois volitans) was classified as an invasive predator native to the Indo-Pacific region that has no natural predators. Lionfish grow fast, making these fish prey on much smaller fish in which causing damage to the marine ecosystem. This research determines the antioxidant potential of lionfish spines venom by isolating the protein from...

Lionfish (Pterois volitans) is an invasive species originating from Indo-Pacific Sea. The rapid growth and the absence of natural predators cause Lionfish to breed rapidly and reduce the native fish populations by up to 80%. Therefore, the study of the Lionfish must be intensified to obtain the usefulness of these animals. Studies that have stated...

Honey is a liquid produced by bees from nectar which contains vitamins, acids, minerals, and enzymes that are useful for the human body because honey is very beneficial, it can be used as an alternative medicine for human’s healthiness. Authentication of honey has primary importance for both industries and consumers because until now, there is no g...

Clove oil originates from leaves, flower, and trunks of clove plant (Syzigium aromaticum) that is volatile and prone to both temperature and light. Clove oil generally uses as medicine due to properties such as analgesic, antibacterial, antioxidant, antifungal, and antivirus. This research aims to decrease the rate of clove oil evaporation by makin...

Lionfish (Pterois volitans) are a fish that live in the Indo-Pacific region. Today, Lionfish have an increasing population and invaded up to the Atlantic Ocean. The invasion of Lionfish was not accompanied by the presence of predators, thus causing damage to the ecosystem and food chain. One of the control efforts that possible be done is the utili...

Lionfish (Pterois volitans) is a native species of the Indo-Pacific Ocean. This species is known as destructive invasive species that invade in many areas. The invasion of Lionfish gives negative impacts on the ecology and economic condition of the invaded regions. Therefore, to reduce the number of Lionfish in the ocean and to attract people to ex...

Lionfish Pterois volitans is a tropical Indo-Pacific native species and invaded on marine ecosystem due to its rapid growth and predatory properties that were highly affecting fish and coral populations. Recent studies show the benefits of natural antioxidants, especially as the prevention of cancer and cardiovascular disease. Crude Venom (CV) was...

Agarwood is the commodity that has the highest economic value in the world, especially its oil. However, agarwood essential oils have a volatile compound component of almost 90%. To overcome this volatility, the agarwood oil can be changed into a solid dosage by encapsulation using maltodextrin and gum arabic through the freeze-drying method. Encap...

Lignocellulosic biomass has great potential as a low-cost source of fermentable sugar for the production of biofuels and high value organic acids. One potential biomass is oil palm empty fruit bunch, since it has high cellulose and hemicellulose content. However, its lignin content can hinder the access of cellulose and hemicellulose during the hyd...

An offshore company intends to develop a new field by installing two wellhead platforms to accommodate the well production from this field. Based on port development plans, the locations of these platforms are closed to port dumping and commercial anchorage areas. This can affect the platform's safety. Therefore, risk assessment and mitigation stud...

Process safety concept is used to deal with accident scenarios occurring as a result of loss containment. There are four tactics of process safety, and due to superior characteristics, the inherent theme is given priority at the preliminary design stage. In open literature, various methods have been proposed to identify the inherent safety level, a...

The kelulut bee (Meliponini) is a subfamily of stingless bees that produce honey. A total of 89 species out of a total of 500 species of kelulut bees are known to originate from the Indo-Australian region. Kelulut bees do not have quality standards so they still refer to the Codex and EU Directive which basically only applied for Apis honey. The Co...

Caffeic acid (CA) could be considered as an important natural anti-oxidant. However, the low solubility and stability of CA in various solvent is limiting the application in industry. It is advantageous to synthesize alkyl ester of caffeic acid based on both their biological function and potential application. One of the caffeic acid derivatives ca...

Adrenaline is an important neurotransmitter in the body that will be released from the body when someone is in emotional state or in state of physical and emotional stress, such as hypoglycemia, work out, and excessive pain in the body. Early diagnosis based on the determination of adrenaline concentration in plasma and urine can prevent unnecessar...

Background and Aim: The authentication of honey is important to protect industry and consumers from such adulterated honey. However, until now, there has been no guarantee of honey's authenticity, especially in Indonesia. The classification of honey is based on the bee species (spp.) that produces it. The study used honey from sting bee Apis spp. a...

Risk assessments of industrial facilities, especially offshore oil and gas companies, are required to consider safety, environmental, financial, and company reputation risks. Risk assessments of normally unmanned installation (NUI) facilities usually do not accommodate personnel or employees. Therefore, a risk value cannot be applied when there is...

Cholesterol oxidase enzyme well known as oxidoreductase enzyme which able to catalyze the transfer of electron from one molecule (the oxidant) to another molecule (the reductant). The kinetic model for cholesterol oxidation by cholesterol oxidase has been demonstrated using first order irreversible reaction with Euler’s method. The aim of this stud...

Cervical and breast cancer are some of the deadliest forms of cancer that may occur in women. According to the Indonesian Ministry of Health, cervical and breast cancer makes up 0.8% of all cancer cases in Indonesia. Conventional treatment methods such as chemotherapy have many disadvantages such as stomach problems, hair loss, darkening of the ski...

Cancer is a deadly disease so that the medicinal treatment constantly developed. Apoptin is a protein molecule that has potential to be used as a cancer drug because of its activity to induce cell death selectively to the cancer cells only. Cloning apoptin has been successfully performed by amplify gene using PCR with 12-histidine and 8-arginine to...

Honey is often used as a sweetener, but its use in medical preparations date from ancient cultures. The majority of honey consists of carbohydrates, such as glucose and fructose. A minor portion is made up of various secondary metabolites, such as vitamins, minerals, amino acids, organic acids, fatty acids, polyphenols, and flavonoids. Based on the...

Apoptin is intensively studied for its potential as a therapeutic protein for cancer treatment since it is capable of inducing apoptosis specifically in cancer cells. Production of apoptin gene on a larger scale is important for the further application, and currently being studied by researchers around the world. In this research, chicken anemia vi...

Objective: Dental caries is caused by demineralization of the tooth surface by organic acids as a result of metabolism of cariogenic bacteria, especiallyStreptococcus mutans. Chewing gum has been proven to help prevent dental caries formation by stimulating salivary flow and thus reducing theavailability of nutrients for cariogenic bacteria.Methods...

Production of lipase enzyme from Rhizopus oryzae was developed by solid state fermentation (SSF) and submerged fermentation (SmF) method in order to yield high amount of lipase enzyme using wheat bran as the substrate. The objective of this research is to obtain the crude lipase enzyme from Rhizopus oryzae by optimizing the operating condition of s...

The objective of this study was to determine the total phenolic content (TPC) and antioxidant activity (AA) of propolis microcapsules from Tetragonula spp. A microplate reader was used to determine TPC and AA. Smooth propolis extract with the highest TPC and AA was used as core material for microencapsulation with maltodextrin and gum arabic as coa...

Biopesticides essential oil-based can be used as a protective alternative to pest attacks. Clove essential oil proven have the ability of insecticides, anti-fungal and anti-bacterial. However, essential oils exhibit high volatility, and rapidly lose their compound when exposed to the atmosphere and are sensitive to the degradation of light, heat, o...