Henry E Young

Henry E Young
Dragonfly Foundation for Research & Development · Research & Development

PhD, Post-Doc
Completed 18 clinical studies using fresh isolate technologies with telomerase positive stem cells.

About

126
Publications
64,005
Reads
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3,180
Citations
Introduction
Joined research institute to continue my research with adult telomerase positive stem cells. We are engaged in IRB-approved clinical trials to prove the utility of using fresh isolate adult telomerase positive stem cells to treat chronic diseases and trauma. Recently developed CN-SP to determine it's ability to mimic the fresh isolate technologies for reversing signs and symptoms in individuals with chronic diseases and/or having experienced severe trauma.
Additional affiliations
July 2008 - June 2012
Mercer University School of Medicine
Position
  • Adjunct Professor of Obstetrics & Gynecology
Description
  • Trained residents and attendings in adult stem cell research.
July 2008 - June 2012
Mercer University School of Medicine
Position
  • Adjunct Professor of Anesthesiology
Description
  • Taught gross anatomy, embryology, cell biology, histology and neuroscience to Certified Registered Nurse Anesthesiologist students. Also trained some in adult stem cell research.
July 2005 - present
Mercer University School of Medicine
Position
  • Full Professor of Anatomy
Description
  • Teach Embryology and Gross Anatomy
Education
August 1983 - June 1987
Case Western Reserve University
Field of study
  • Carbohydrate Biochemistry
August 1977 - June 1983
Texas Tech University
Field of study
  • Anatomy
August 1974 - May 1977
University of Arkansas
Field of study
  • Zoology

Publications

Publications (126)
Article
Full-text available
Alzheimer’s disease is an insidious and progressive loss of cognitive memories from present time to distant past, that occurs in reverse chronological order. Basically, losing in reverse order what was learned from birth to a geriatric-aged individual. It usually begins with difficulty in remembering current events, then locations of misplaced item...
Article
Full-text available
Previous studies have reported the presence of endogenous undifferentiated totipotent stem cells within the organs and tissues of various animal species, including the spleen. Since one major function of the spleen is to filter out damaged red blood cells, we wanted to ascertain whether totipotent stem cells existed as a potentially transient circu...
Article
Full-text available
The major risk factor for chronic obstructive pulmonary disease (COPD) is cigarette smoking which drives an inflammatory process that causes loss of function. Cessation of smoking, oxygen therapy, various inhalers, medications to improve vasodilation, antibiotics to combat the frequent lung infections, fluid replacement, exercise rehabilitation pro...
Article
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Age-related macular degeneration (AMD) is an insidious disease characterized by gradual worsening of symptoms, which in time results in a loss of visual acuity in the central area of vision. Macular degeneration does not result in complete blindness, because peripheral vision remains. However, loss of central vision can make it difficult to perform...
Article
Full-text available
Naïve adult endogenous stem cell transplants have been used as a substitute for embryonic stem cells and/or induced pluripotent stem cells for treating individuals with autoimmune, cardiovascular, neurological, orthopedic, pulmonary, renal, and systemic chronic diseases and traumatic injuries. This is primarily due to the absence of moral and ethic...
Article
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Cardiovascular disease is responsible for 30% of all deaths worldwide. Myocardial infarction, due to one or more blocked coronary arteries or their tributaries, presents unique challenges to the field of regenerative medicine. Following a myocardial infarction (MI), the myocardium is often replaced with non-functional scar tissue, resulting in hear...
Article
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Endogenous adult-derived Totipotent Stem Cells (TSCs) and tissue-resident exosomes are major players in the field of regenerative medicine. TSCs provide the undifferentiated building blocks for tissue repair, while exosomes provide the directions on how these building blocks should be used to accomplish this feat, i.e., restoration of fully functio...
Article
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Celiac disease can occur at any age and express a wide variety of signs and symptoms. A gluten-free diet is currently the only effective mode of treatment. While exclusion of gluten from the diet reverses many disease manifestations, it usually does not or is less efficient in patients with refractory celiac disease or associated autoimmune disease...
Article
Full-text available
Early clinical studies with telomerase-positive stem cells demonstrated no response when these stem cells were mixed with lidocaine prior to clinical treatments in multiple individuals. Their stem cells demonstrated a positive response when mixed with normal sterile saline utilizing alternative routes of implantation. We hypothesized that lidocaine...
Article
Full-text available
Numerous studies demonstrated the ability of stem cells in general, and endogenous adult stem cells in particular, to be a positive influence in the field of regenerative medicine. Endogenous naturally-occurring stem cells comprise approximately 50% of all cells in an adult organism. Within this group are two categories of cells based on the absenc...
Article
Full-text available
Osteoarthritis results from mechanical injury to an articular joint. This condition usually requires 20 to 50 years to manifest fully. The presenting symptoms include increasing articular pain, osteophyte formation, and decreasing mobility. Telomerase-positive adult stem cells have been identified in multiple species of animals, including humans. T...
Article
Full-text available
The objectives of the work, based on previous characterization studies, pre-clinical animal models of induced diseases, e.g., Parkinson disease, cardiovascular disease, pulmonary disease, and type-I diabetes mellitus, and early clinical human studies of Parkinson disease, cardiovascular disease, and pulmonary diseases, were to established a set of...
Article
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Idiopathic pulmonary fibrosis (IPF) belongs to a large collection of more than 200 lung diseases known as interstitial lung diseases (ILD). While the cause of IPF is unknown, it has been suggested that inflammation stimulates the formation of fibrotic tissue between the capillaries and alveolar epithelium, inhibiting the exchange of gases. Current...
Article
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Systemic lupus erythematosus (SLE) is a chronic incurable and potentially fatal autoimmune disease. SLE manifests itself with the production of autoantibodies to partially digested nuclear components, cells, and non-cellular material. With any type of tissue insult, there is a release of material from damaged tissues which initiates a cascade of ev...
Article
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Cardiovascular disease, especially ischemic heart disease resulting from coronary artery disease (CAD), is one of the major causes of death and disability in the United States. Even though the dead myocardial cells can be replaced by scar tissue in the healing process, the resulting myocardium cannot function as well as the pre-infarcted myocardium...
Article
Full-text available
Stage-specific antigen-4 (SSEA-4) positive cells and carcinoembryonic antigen-cell adhesion molecule-1 (CEA-CAM-1) positive cells, indicative of pluripotent stem cells and totipotent stem cells, respectively, have been isolated and characterized from the skeletal muscle and blood of adult animals, including humans. The current study was undertaken...
Article
Full-text available
Chronic kidney disease is an increasing public health issue. Prevalence has been estimated to be 8-16% worldwide. Complications include increased mortality including cardiovascular mortality, progression of kidney disease, acute kidney injury, cognitive decline, anemia, disorders of mineral and bone, and fractures. Two types healing cells, pluripot...
Article
Full-text available
Primitive healing cells, i.e., pluripotent stem cells and totipotent stem cells, have been isolated from the skeletal muscle and blood of adult mammals, including humans. The current study was undertaken to determine the location of these cells with respect to normal and regenerating lung parenchyma of the adult rat. Adult rats were euthanized foll...
Article
Full-text available
Pulmonary disease is a source of serous morbidity and mortality. Cell treatments offer hope for rejuvenation and repair of damaged lungs. The possibility of using maintenance cells and/or healing cells to repair damaged lungs has been studied for nearly two decades. This paper reviews pertinent research investigating the different models and approa...
Article
Full-text available
Pluripotent stem cells and totipotent stem cells have been discovered within the skeletal muscle of adult mammals, including humans. The proposed hypothesis is that these stem cells are located ubiquitously throughout the body. Thus, pluripotent stem cells and totipotent stem cells should be located within bone marrow of the adult rat. Adult rats w...
Article
Full-text available
Recent reports demonstrated the presence of primitive endogenous stem cells circulating within adult cat, dog, sheep, goat, pig, cow, and horse peripheral blood. The current study was undertaken to determine whether similar primitive stem cells could be isolated from the peripheral blood of adult humans. Adult humans had their blood withdrawn follo...
Article
Full-text available
Stout et al. [1] reported the presence of primitive endogenous stem cells circulating within adult porcine peripheral blood. The current study was undertaken to determine whether similar primitive stem cells could be isolated from the peripheral blood of adult felines, canines, ovines, caprines, bovines, and equines. Adult cats, dogs, sheep, goats,...
Article
Full-text available
Development of a multicellular organism is accomplished through a series of events that are preprogrammed in the genome. These events encompass cellular proliferation, lineage commitment, lineage progression, lineage expression, cellular inhibition, and regulated apoptosis. The sequential progression of cells through these events results in the for...
Article
Full-text available
Endogenous naturally-occurring totipotent stem cells and pluripotent stem cells have been isolated from the skeletal muscle of adult mammals, including humans. This study was undertaken to determine their particular location within adult rat skeletal muscle and to verify the identity of the stained cells. Adult rats were euthanized following the gu...
Article
Full-text available
This study was designed to test the hypothesis that decellularized pancreatic matrices seeded with adult-derived endogenous stem cells and donor islets provide an optimal environment for islets to secrete insulin in response to a glucose challenge. Adult animals were euthanized following the guidelines of Fort Valley State University-IACUC and Merc...
Research
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Lineage Map of Zygote through differentiated cell types. In addition, our endogenous adult stem cells have the following potentials, i.e,. totipotent stem cells have the equivalent differentiation potential as the blastocyst; our pluripotent stem cells have the equivalent differentiation potential as the epiblast; and out mesodermal stem cells have...
Article
Full-text available
There are two general categories of Pluripotent stem cells, endogenous Pluripotent stem cells and reprogrammed Pluripotent stem cells. Endogenous Pluripotent stem cells are formed during development. There are two subcategories of endogenous Pluripotent stem cells, embryonic stem cells (ESCs) and postnatal (“adult”) stem cells (ASCs). Reprogrammed...
Article
Full-text available
There are two general categories of Pluripotent stem cells, endogenous Pluripotent stem cells and reprogrammed Pluripotent stem cells. Endogenous Pluripotent stem cells are formed during development. There are two subcategories of endogenous Pluripotent stem cells, embryonic stem cells (ESCs) and postnatal (“adult”) stem cells (ASCs). Reprogrammed...
Chapter
Full-text available
Regenerative medicine encompasses, matrix scaffoldings therapy using stem cells, bioactive factors, and/or gene therapy. Regenerative medicine has the potential to alleviate donor shortages, long waits for organ and tissue transplants, and genetic diseases. Adult pluripotent stem cells have the advantage of avoiding the ethical issues associated wi...
Article
Full-text available
Parkinson disease affects ~2% of all people 70 years of age and older. People with Parkinson disease exhibit excessive shaking (tremors) at rest, loss of mental function, loss of involuntary function, and psychiatric problems. A proposed experimental cure for Parkinson disease is the transplantation of healthy nerve cells into the brain. It has bee...
Article
Full-text available
Primitive stem cells have been discovered within the blood of adult mammals such as rodents, porcines, and humans. The current study addressed the issue of primitive stem cells in the blood of adult equines. Blood withdrawal by venipuncture from adult equines was performed following the guidelines of Fort Valley State University IACUC. Ten horses w...
Chapter
Full-text available
Endogenous populations of adult precursor cells have been identified in 13 species of animals, including humans. Adult precursor cells can be divided into two general categories based on particular characteristics. These two categories are stem cells and progenitor cells. The adult stem cell populations consist of totipotent stem cells, pluripotent...
Experiment Findings
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Experiment Findings
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Data
Animal models were developed to test adult pluripotent stem cells and adult totipotent stem cells for neurological, cardiovascular, pulmonary, and metabolic/endocrine repair; the effect of trauma on stem cells within the body; and compounds that will stimulate an increase of adult stem cells in the blood. In separate animal models, cells were destr...
Article
Full-text available
This study was designed to determine if trauma causes the release of adult-derived blastomere-like stem cells (BLSCs) from skeletal muscle into the circulating blood of adult pigs. Experimental procedures followed the guidelines of Fort Valley State University's Institutional Animal Care and Utilization Committee. Pigs were traumatized by splenecto...
Conference Paper
Full-text available
Totipotent and pluripotent stem cells have been isolated from the skeletal muscle of adult mammals, including humans. This study was undertaken to determine their particular location within skeletal muscle and to verify the identity of the stained cells. Adult rats were euthanized following the guidelines of Mercer University's IACUC. Skeletal musc...
Conference Paper
Full-text available
Pluripotent stem cells and totipotent stem cells have been discovered within the skeletal muscle of adult mammals, including humans. The hypothesis examined was that these adult stem cells are also located within the bone marrow of the adult rat. Adult rats were euthanized following the guidelines of Mercer University's IACUC. Bone marrow was harve...
Conference Paper
Full-text available
Pluripotent stem cells and totipotent stem cells have been isolated from the skeletal muscle and dermis of adult mammals, including humans. The current study was undertaken to determine their location in the pancreas of the adult rat. Adult rats were euthanized following the guidelines of Mercer University's IACUC. The pancreases were harvested, fi...
Conference Paper
Full-text available
Currently, pluripotent stem cells and totipotent stem cells have been isolated from the skeletal muscle of adult mammals, including humans. The current study was undertaken to determine their location in the brain of the adult rat. Adult rats were euthanized following the guidelines of Mercer University's IACUC. The brains were harvested, fi xed, d...
Article
Full-text available
Currently the existence of pluripotent and totipotent stem cells is controversial. Our lab has discovered that pluripotent and totipotent stem cells are present within the skeletal muscle and dermis of adult mammals, including humans. These cells are very plastic, more than the lineage specific stem cells accepted to be present at this time. These...
Article
Full-text available
Article
Stem cells isolated from adult tissues may be useful for autologous cell therapy in the nervous system. In the present study we tested the ability of multipotent stem cells isolated from adult muscle to survive and respond to migratory and differentiating cues when transplanted into the adult subventricular zone (SVZ). Prior to transplantation the...
Article
Full-text available
Three categories of precursor cells have been identified in postnatal mammals: tissue-committed progenitor cells, germ layer lineage-committed stem cells and lineage-uncommitted pluripotent stem cells. Progenitor cells are the immediate precursors of differentiated tissues. Germ layer lineage stem cells can be induced to form multiple cell types be...
Article
Full-text available
This report reviews three categories of precursor cells present within adults. The first category of precursor cell, the epiblast-like stem cell, has the potential of forming cells from all three embryonic germ layer lineages, e.g., ectoderm, mesoderm, and endoderm. The second category of precursor cell, the germ layer lineage stem cell, consists o...
Article
Ligands of the glial cell line-derived neurotrophic factors (GDNF)-family are trophic factors for the development and survival of multiple cell types, however their effects on non-neuronal stem cells are unknown. We examined the action of neurturin on a candidate stem cell population isolated from adult skeletal muscles. When grown as spheres, thes...
Article
Full-text available
Four categories of cells have been previously identified in postnatal mammals, including humans. These categories are differentiated cells, cell- and tissue-committed progenitor cells, germ layer lineage-committed stem cells and lineage-uncommitted pluripotent stem cells. Differentiated cells are variable in size. They form the physiological functi...
Chapter
Full-text available
Stem cells are a subcategory of cells designated as “precursor” cells. Precursor cells provide the cellular building blocks to maintain the tissues and organs of the body throughout the life-span of an individual. Precursor cells also provide the cellular building blocks for tissue replacement and repair following injury. There are three basic cate...
Article
Stem cells isolated from adult tissues may be useful for autologous cell therapy in the nervous system. In the present study we tested the ability of multipotent stem cells isolated from adult muscle to survive and respond to migratory and differentiating cues when transplanted into the adult subventricular zone (SVZ). Prior to transplantation the...
Article
Autologous cell therapies in neurodegenerative diseases and stroke will require an efficient generation of neuroprogenitors or neurons. We have previously shown that presumptive neural progenitors can be obtained from a candidate stem cell population isolated from adult skeletal muscle. Here we describe experimental conditions to isolate and charac...