Henry J. González-Torres

Universidad Simón Bolívar (Colombia) · Faculty of Health Sciences

Introduction: Mesoamerican nephropathy is a tubule-interstitial nephropathy whose etiology is still unknown. However, clinical cases like Mesoamerican nephropathy have been described in other geographically distant and ethnically diverse regions. Still, they all have a common factor: the intensity of heat and rural physical labor. Objective: To stu...

Pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) is a rare condition characterised by microangiopathic haemolytic anaemia and kidney injury from thrombotic microangiopathy. P-aHUS occurs in approximately 1 in 25,000 pregnancies and is strongly related to complement dysregulation and pregnancy-related disorders, such as preeclampsia,...

Introduction Coronavirus disease 2019 (COVID-19) induces organic damage mainly through the patient’s immune overreaction. Hemoperfusion (HPF) can remove inflammatory cytokines and can reduce the negative effects of cytokine storm in COVID-19. We compared the mortality rate, inflammatory response, and acute kidney injury (AKI) prevalence among patie...

Coronavirus disease 2019 (COVID‑19) induces organic damage mainly through the patient’s immune overreaction. Hemoperfusion (HPF) can remove inflammatory cytokines and can reduce the negative effects of cytokine storm in COVID‑19. We compared the mortality rate, inflammatory response, and acute kidney injury (AKI) prevalence among patients suffering...

Introduction: Frailty is a clinical syndrome characterized by a decrease in strength, resistance and body physiological condition, making the individual more vulnerable, and increasing his/her risk of dependence and death. Kidney transplant (KT) is currently the best end-stage renal disease therapeutic alternative for certain individuals. Frailty...

Introduction: Gattinoni et al. have recently introduced a new parameter: the “alactic base excess” (ABE). ABE is equivalent to the number of strong acids, other than lactate, which are present in the plasma in abnormal concentrations, negative ABE being associated with higher mortality in sepsis. Hemoperfusion (HPF) is an extracorporeal procedure t...

We developed and standardized an efficient and cost-effective in-house RT-PCR method to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluated sensitivity, specificity, and other statistical parameters by different RT-qPCR methods including triplex, duplex, and simplex assays adapted from the initial World Health Organiza...

Triple-negative breast cancer (TNBC) occurs more frequently in young (<50 years) non-Hispanic black and Hispanic/Latina women. It is considered the most aggressive subtype of breast cancer, although, recently, immune infiltrate has been associated with long-term survival, lower risk of death and recurrence, and response to neoadjuvant chemotherapy....

Chronic kidney disease (CKD) is set to become the fifth global cause of death by 2040. This illustrates the many unknowns regarding its pathogenesis and therapy. A key unknown relates to the therapeutic impact of the interaction between CKD and the gut microbiome. The normal gut microbiome is essential for body homeostasis. There is evidence for mu...

Cirrhotic patients can develop acute kidney injury (AKI), and chronic kidney disease (CKD). Therefore, renal functional evaluation is crucial in cirrhotic patients. However, serum creatinine and urea levels, as well as measured or estimated glomerular filtration rate is not reliable renal functional markers in these patients compared to other patie...

Introduction Atypical hemolytic uremic syndrome (aHUS) is a rare and genetically mediated systemic disease most often caused by uncontrolled and chronic complement activation that leads to systemic thrombotic microangiopathy, renal and extra-renal damage. Materials and methods This is descriptive, retrospective and multicenter study, which reports...

This paper describes the main characteristics of coronavirus diseases 2019 (COVID-19) patients suffering from acute kidney injury (AKI) assisted at a high complexity clinic in Barranquilla, Colombia. The patients included in this study (n = 48) were those with a positive diagnosis of COVID-19 confirmed by polymerase chain reaction detection of seve...

Our study aimed to describe the glomerular diseases, both primary glomerular disease (PGD) and secondary glomerular disease (SGD) in the Colombian Caribbean based on the first regional Colombian Nephropathy Registry (NEFRORED®). A descriptive and retrospective study of adult patients with glomerular diseases from the Colombian Caribbean region was...

Background: Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, represents 10%-20% of all breast cancers and occurs more frequently in young Non- Hispanic Black and Latina women. TNBC is highly immunogenic due to the relatively high levels of tumor infiltrating lymphocytes (TILs) which in turn has been associated with...

La anemia hemolítica más frecuente en la población mundial es la anemia de células falciformes, con una incidencia de 1/600 recién nacidos en Estados Unidos y en España algunas regiones con incidencia de 1/5000 neonatos; en Colombia no hay registros con respecto a la incidencia y prevalencia. La transmisión de la ACF es autosómica dominante. Los ho...

La nefropatía por IgA es la enfermedad glomerular primaria crónica más prevalente en todo el mundo, caracterizada por anomalías urinarias persistentes (hematuria microscópica y/o proteinuria) o episodios recurrentes de hematuria macroscópica en concomitancia con infecciones del tracto respiratorio superior. La epidemiología es variable según la dis...

IntroductionFrailty is a multicausal syndrome characterized by a decrease in strength, resistance and physiological function, which makes the individual vulnerable and dependent, and increases his/her mortality. This syndrome is more prevalent among older individuals, and chronic kidney disease patients, particularly those on dialysis. Dialysis dos...

IgA nephropathy is the most prevalent primary chronic glomerular disease in the world. It is characterized by persistent urinary anomalies (microscopic hematuria and/or proteinuria) or recurrent episodes of macroscopic hematuria in concomitance with the upper respiratory tract. The epidemiology varies according to geographical location. In Colombia...

Type 2 diabetes mellitus (DM2) is a chronic condition that affects more than 400 million individuals worldwide. In DM2 patients, an appropriate glycemic control slows the onset and delays the progression of all its micro and macrovascular complications. Even though there are several glucose-lowering drugs, only approximately half of patients achiev...

Geriatrics has classically described four entities of its own, naming them “geriatric giants” because of their high prevalence and great impact on the senile health. These four significant syndromes are delirium, gait disorders and falls, immobility syndrome, and incontinence. Additionally, older people are predisposed to suffer from salt and water...

Crohn's disease (CD) results from an aberrant immune response against the commensal microbiota in genetically susceptible hosts. However, the nature of the immune defects, the microflora involved and the genetic susceptibility remain incompletely defined and controversial. Extraintestinal manifestations occur in up to 25-35% of patients and general...

To present a COVID-19 case series with clinical admission criteria to Intensive Care Unit. Patients information was obtained from medical records, and daily clinical evaluation whereas diagnosis was carried out through paraclinical studies in blood, urine, PCR and diagnostic images in 4 patients with different comorbidities and epidemiological link...

Acute kidney injury (AKI) is a heterogeneous group of conditions characterized by a sudden decrease in the glomerular filtration rate. Even though many strategies have been proposed to achieve an early AKI diagnosis and its effective treatment, both objectives remain unachieved. Consequently, AKI prevention continues to be the best “therapeutic” st...

Objetivo: Determinar el impacto sobre la resistencia bacteriana de la revisión previa de la prescripción de antibióticos por parte del servicio farmacéutico en hospitales de mediana y alta complejidad del departamento del Atlántico (Colombia). Metodología: Se analizaron los valores de resistencia de bacterias Gram positivas, Enterobacterias y Gram...

Abstract: Objective: To present a COVID-19 caseserieswithclinical admissioncriteriato Intensive Care Unit. Methods: Patientsinformation wasobtainedfrom medical records, and daily clinical evaluationwhereas diagnosis wascarried out through paraclinical studies in blood, urine, PCR and diagnostic images in4 patients with different comorbidities and e...

Crohn's disease (CD) results from an aberrant immune response against commensal microbiota in genetically susceptible hosts. However, the nature of immune defects, the microflora involved, and genetic susceptibility remain incompletely defined and controversial. This review seeks to describe the present state of association between CD and renal dis...

Glomerular filtration rate (GFR) and proteinuria-albuminuria are the renal functional parameters currently used to evaluate chronic kidney disease (CKD) severity. However, tubular secretion is another important renal functional parameter to be taken into account since proximal tubule (PT) secretion, in particular, is a crucial renal mechanism for e...

SUN-366 MYCOPHENOLATE MOFETIL VERSUS CYCLOPHOSPHAMIDE AS INDUCTION TREATMENT AND MORTALITY IN A SERIES OF CASES WITH LUPUS NEPHRITIS IN THE CARIBBEAN COLOMBIAN REGION Aroca, G1,2 , PEÑA-VARGAS, WA*3 , Gonzalez-Torres, HJ3 , Iglesias-Gamarra, A4 , García-Toloza, R2 , Conde-Manotas, JC5 , Acosta-Almanza, A6 , Musso, CG7 , Cadena-Bonfanti, A2,5 1 Univ...

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of th...

Objetivo: se buscó determinar la prevalencia del trastorno por déficit de atención e hiperactividad (TDAH) en niños de entre 6 a 17 años escolarizados en Barranquilla, para hacer una caracterización epidemiológica del trastorno en la región Caribe colombiana. Materiales y métodos: se tomaron 383 niños de una institución educativa a los que se les...

Introduction The kidneys contribute to maintain plasma osmolality in normal range by achieving the adequate daily osmolar urine excretion (DOUE). An equation has been described for estimating the expected daily urine volume necessary to excrete the osmolar load required to keep serum osmolality in normal range. According to this equation, a differe...

The aim of this study was to identity in silico the relationships among microRNAs (miRNAs) and genes encoding transcription factors, ubiquitylation, DNA methylation, and histone modifications in systemic lupus erythematosus (SLE). To identify miRNA dysregulation in SLE, we used miR2Disease and PhenomiR for information about miRNAs exhibiting differ...

Evaluar la asociación del polimorfismo FCGR2B-I232T con la aparición de nefritis lúpica (NL) en pacientes con LES en una población del Caribe colombiano. Métodos: Estudio de casos y controles, con evaluación del genotipo FCGR2B-I232T en 26 pacientes con NL, 22 pacientes con LES y 44 controles sanos; se obtuvo DNA genómico mediante sangre total. Se...

lesión renal aguda (LRA), clásicamente, se la define como un grupo heterogéneo de afecciones caracterizadas por una disminución repentina en la tasa de filtración glomerular (TFG), expresada como un aumento en la creatininemia (creatininemia ≥ 0,3 mg/dl en 48 horas o creatininemia ≥ 1,5 veces respecto de su valor basal dentro de los primeros 7 días...

La diuresis constituye el parámetro clínico funcional renal más importante y simple de obtener de la práctica clínica, tanto en el paciente adulto como pediátrico.1 Habitualmente se evalúa de la diuresis la magnitud de su flujo (volumen emitido por unidad de tiempo), considerándose entonces una diuresis insuficiente (oliguria) a un flujo urinario ≤...

Even though there are many definitions of acute kidney injury (AKI), it is classically defined as a heterogeneous group of conditions characterized by a sudden decrease in glomerular filtration rate (GFR), expressed as an increase in serum creatinine (serum creatinine ≥ 0.3 mg/dl within 48 hours or serum creatinine ≥ 1.5 times baseline within the p...

Even though, a different degree of RR recovery was docu-mented associated with different immunosuppressant thera-peutic schedules (months of treatment and sort of immuno-suppressant drugs), basal hyperfiltration was significantly reduced in all the treated patients (Table 1).It is worth pointing out that, our patients had basal high CC (hyperfiltra...

Antecedentes: El uso de los agentes antimicrobianos en la terapéutica de las enfermedades infecciosas, ha constituido un acontecimiento sin precedentes, este modificó favorable-mente el panorama de la morbilidad y mortalidad del adulto. Desde hace unos años existe una gran preocupación por el incremento de la resistencia a los antimicrobianos, por...

Background Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal...

OBJECTIVE: To evaluate the immunosuppressive treatment response to modified Ponticelli regimen (MPR) and oral corticosteroid (OC) plus tacrolimus (TAC) in patients with primary membranous nephropathy (PMN). METHODS: Retrospective cohort analytical study. Adults patients (>18 years old) with diagnosis of refractory PMN (>50% increase in serum creati...

Art, by virtue of its symbolic power, may function as a cognitive instrument and even as an aid in the scientific research process, especially in the phase of hypothesis generation and data analysis given its ability to induce creative and intuitive thinking. In this article, we propose a method to put such concept into practice based on the exposu...

Membranoproliferative glomerulonephritis (MPGN) is a pattern of mesangial hypercellular glomerular lesion with thinning of the glomerular basement membrane and endocapillary proliferation, mediated by immunoglobulin and the complement system of the mesangium and capillary endothelium. Objective: To assess the response to pharmacotherapy in patients...

Introducción: La evaluación de la contractilidad segmentaria es un marcador importante para determinar la extensión de la enfermedad coronaria manifestada a través de un evento isquémico cardiaco. La resonancia magnética cardíaca es el patrón estándar para evaluar dicha motilidad; sin embargo, debido al elevado número de exámenes, la disponibilidad...

Background: Renal biopsy is the gold standard for the diagnosis and classification of lupus nephritis (LN). However, a consecutive biopsy can predict the clinical course and optimize the therapeutic strategies. Objectives: To compare the histopathological findings with clinical responses. Patients and Methods: Thirty patients with active LN were...

La nefropatía mesoamericana (NM) es una forma de nefropatía crónica de etiología desconocida originalmente descrita en América Central, donde esta condición es una causa importante de morbilidad y mortalidad1. Se sospecha que NM es una enfermedad multifactorial, y se han propuesto varios factores, incluyendo estrés por calor (deshidratación severa...

Evaluar la percepción de la calidad de vida(CV) en pacientes con Nefritis Lúpica (NL).Materiales y Métodos: Estudio analítico, de cohorte longitudinaly retrospectiva, El seguimiento estuvo centradoen un modelo de gestión de riesgo en una clínica del CaribeColombiano. La escala GENCAT utilizada permitió evaluarocho dimensiones: Bienestar Emocional (...

Renal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It’s estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian p...

Numbers of genes that have been shown to be regulated bymiRNAs in patients with Class IV lupus nephritis. (DOCX)

Quality of Like. Lupus Nephritis

La transfusión es la infusión de componentes de sangre o sangre entera en el torrente sanguíneo, considerado una medida terapéutica, de la que se debe tener un conocimiento fisiológico claro y preciso en la edad pediátrica. El propósito de las transfusiones es proporcionar los elementos sanguíneos en cantidad suficiente y con la mayor capacidad fun...

Patient records are useful tools for measuring medical quality and knowing the distance between current scientific evidence, applicable in daily clinical practice. They allow reaching large sample sizes, under real clinical practice conditions and longer follow-ups than clinical trials. The clinical manifestations, evolution, survival and prognosis...

Background and aims Among the organs involved in-the SLE, we can highlight the renal damage, as the largest contributor to mortality in SLE patients is estimated that nearly-50% of SLE develop kidney disease in the first years of diagnosis. Class-IV lupus-nephritis (LN-IV) is the class of lupus nephritis most common in Colombian-patients with syste...

Background and aims Lupus Nephritis is one of the most serious complications of SLE with a prevalence of 65%, it is diagnosed in the first five years of SLE and is uncommon after 10 years. Between 5% and 25% of cases have Chronic Renal Disease (CKD) after 5 years. Methods NEFRORED begins in 2008 as a multicenter registry of prospective observation...

Background and aims The objective of this study was to analyse the impact of lupus nephritis (NL) on the quality of life of 30 patients from the coast clinic in the city of Barranquilla, Colombia, diagnosed with this disease. Methods To evaluate the patients‘ quality of life, the GENCAT scale was used as the instrument of study and three controls...

Background and aims Our objective was to create a model for the characterisation, classification and management, according to the protocols, of patients with lupus nephritis, which is done in real time and with the generation of alerts at the right time, which allows inferring that we will obtain a Better quality of life of the patients, reduction...

Objective: To evaluate the perception of quality of life (QL) in patients with Lupus Nephritis (LN). Materials and Methods: Analytical, longitudinal and retrospective cohort study. The follow-up is focused on a risk management model in a clinic in the Colombian Caribbean. The GENCAT scale is the result of a high performance care plan: Emotional Wel...

Background: Membranoproliferative GN (MPGN) represents a pattern of injury seen on light microscopy. Recent advances in understanding of the underlying pathobiology have led to a proposed classification scheme based on immunofluorescence findings. Given recent advances in our understanding of the role of the alternative pathway of complement in MPG...

Background: The Membranoproliferative Glomerulonephritis (MPGN) is the third of fourth leading cause of End-stage renal disease among the glomerulonephritides. However, the benefits of immunosuppression treatment and the prognosis in patients with MPGN are often unknown due to a lack of controlled clinical trials. Methods: The retrospective study w...

The most common hemolytic anemia in the world population is sickle cell anemia, with an incidence of 1/600 newborns in the United States and Spain some regions 1/5000 incidence of infants; in Colombia there are no records regarding the incidence and prevalence. ACF transmission is autosomal dominant. Homozygotes (SS) do not synthesize Hb A and poss...

La obesidad es un factor de riesgo de desarrollo y progresión de enfermedad renal crónica (ERC). En Latinoamérica existen pocos estudios donde se relacionen los estadios de ERC y grados de obesidad. Objetivo: El objetivo de estudio es evaluar la asociación de obesidad con la enfermedad renal crónica de pacientes atendidos en la consulta externa de...

Colombia is one of the most biodiverse countries in anuran species, however, many of them are in a vulnerable situation. This has the added problem that for most of them the genetic wealth and possible variations between biotopes is unknown. The aim of this study was to characterize the karyotype of Leptodactylus insularum present in a fragment of...

La fórmula HUGE (Hematocrito, Urea y Género), permite diferenciar la disminución de filtrado glomerular por envejecimiento de la producida como consecuencia de la enfermedad renal crónica.

La obesidad es un factor de riesgo de desarrollo y progresión de enfermedad renal crónica (ERC). En Latinoamérica existen pocos estudios donde se relacionen los estadios de ERC y grados de obesidad. Objetivo: El objetivo de estudio es evaluar la asociación de obesidad con la enfermedad renal crónica de pacientes atendidos en la consulta externa de...

Membranoproliferative Glomerulonephritis C3 Deposits: Clinicopathological Study Luis A. Castillo, 1 Eduardo I. Navarro,2 Ismael Lopez,2 Kelly Camacho,2 Mayra Olivero,2 Ismael Lopez,2 Gustavo Aroca Martinez,1,2 Henry J. Gonzalez Torres,2 Raul Garcia. 1,2 1Nephrology, Clínica de la Costa, Barranquilla, Atlántico, Colombia; 2Medicine, Univ Simón Bolí...

Introduction. Systemic lupus erythematosus(SLE) is an autoimmune disease in which the innate and adaptive response plays a significant roll, mainly mediated by cytokines. Lupus nephritis -LN-is the most severe complication associated with SLE. Objective. To identify differential expression of cytokines profiles and circulat-ing chemokines in plasm...

Introduction. Lupus nephritis is the most common glomerulonephritis in the Colombian Caribbean region, despite there is less published information about its evolution and clínico-pathotogical aspects Objective. To evaluate prognosis, survival and renal function of patients with LN residing in the Colombian Caribbean region controlled between 2008-...

Objective: To evaluate the genotoxic effects of complex mixtures of hydrocarbons in gasoline stations’s workers in Barranquilla (Atlantico, Colombia) using the alkaline Comet Assay (CA).Materials and methods: Study was transversal, prospective inferential of case and control. The controls were 15 persons without occupationally exposed to hydrocarbo...

Background. SLE patients have increased atherosclerosis that is not adequately explained. We previously discovered that pro-inflammatory HDL (piHDL) associate with the presence and progression of carotid plaque in SLE. Although HDL function is stable over months, it is unknown whether piHDL is stable over years, and it is also unknown what features...