Henrik Wiechers

Georg-August-Universität Göttingen | GAUG · Institute for Mathematical Stochastics

1$$ 1 H ENDOR spectra of tyrosyl radicals (Y $$^\bullet$$ ∙ ) have been the subject of numerous EPR spectroscopic studies due to their importance in biology. Nevertheless, assignment of all internal $$^1$$ 1 H hyperfine couplings has been challenging because of substantial spectral overlap. Recently, using 263 GHz ENDOR in conjunction with statisti...

Big data, high dimensional data, sparse data, large scale data, and imaging data are all becoming new frontiers of statistics. Changing technologies have created this flood and have led to a real hunger for new modelling strategies and data analysis by scientists. In many cases data are not Euclidean; for example, in molecular biology, the data sit...

Motivation Reconstructions of structure of biomolecules, for instance via X-ray crystallography or cryo-EM frequently contain clashes of atomic centers. Correction methods are usually based on simulations approximating biophysical chemistry, making them computationally expensive and often not correcting all clashes. Results We propose a computatio...

Molecular structures of RNA molecules reconstructed from X-ray crystallography frequently contain errors. Motivated by this problem we examine clustering on a torus since RNA shapes can be described by dihedral angles. A previously developed clustering method for torus data involves two tuning parameters and we assess clustering results for differe...