Henrietta Nittby

Henrietta Nittby
Lund University | LU · Department of Neurosurgery

Doctor of Medicine

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77
Publications
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837
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Publications

Publications (77)
Article
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Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced. The efficacy of FLASH in relation to conventional radiotherapy (CONV-RT) has not been extensively explored in fully immunocompetent animals. Fully immunocompetent Fischer 344 rats...
Article
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Introduction: To ensure a clinical translation of FLASH radiation therapy (FLASH-RT) for a specific tumor type, studies on tumor control and toxicity within the same biological system are needed. In this study, our objective was to evaluate tumor control and toxicity for hypofractionated FLASH-RT and conventional radiation therapy (CONV-RT) in an i...
Article
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Objectives: Cervical nerve root compression can lead to radiculopathy in the arm. Some studies have reported low accuracy in determining the responsible nerve root in both cervical and lumbar regions. This prospective, observational, pragmatic study aimed to determine the accuracy of the clinical evaluation relative to magnetic resonance imaging (...
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Introduction: Endoscopic third ventriculostomy (ETV) is becoming an increasingly widespread treatment for hydrocephalus, but research is primarily based on paediatric populations. In 2009, Kulkarni et al created the ETV Success score to predict the outcome of ETV in children. The purpose of this study is to create a prognostic model to predict the...
Article
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Background Chronic subdural hematoma (CSDH) is one of the most common neurosurgical diseases. In surgical management of CSDH, there is a lack of standardized guidelines concerning surgical techniques and a lack of consensus on which technique(s) are optimal. Neurosurgical centers have shown a wide variation in surgical techniques. The purpose of th...
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Background Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected “high-risk” patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohor...
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Background Chronic subdural haematoma (CSDH) is one of the most common neurosurgical diseases. A subtype of CSDH is bilateral chronic subdural haematoma (bCSDH) which represents 20–25% of patients with CSDH and has a higher recurrence rate. There is no clear consensus on how bCSDH should be treated regarding upfront unilateral- or bilateral evacuat...
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The aim was to study the level of S-100 in blood samples taken from Fischer-344 rats after exposure to 915MHz CW-microwaves and ELF magnetic fields in TEM-cells. Magnetic field exposure took place with the TEM cell in a Helmholtz coil arrangement of either 50 Hz sinusoidal magnetic field of 5µT, or incoherent magnetic field noise IMF at a maximum a...
Article
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The present study aims to find out if the level of S-100 in blood samples taken from Fischer-344 rats exposed in TEM-cells to microwaves at the 900 MHz band at various modulation frequencies 4, 8.33, 16, 50 Hz and 217 Hz with various peak power output, correlate with albumin leakage through the Blood-Brain Barrier, The results of the present study...
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Background Glioblastoma is the most common primary malignant brain tumor in adults. Previous studies have suggested that CRP (C-reactive protein) could serve as a biomarker candidate as well as a prognostic factor in glioblastoma patients, and we here further investigate its potential role. Materials and methods Publicly available datasets were us...
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We describe a patient with primary CNS lymphomas, awake despite an extreme ICP elevation. A 48-year-old woman presented with headache since 1 month, and bilateral papillary edema was observed. Magnetic resonance imaging revealed diffuse infiltration around the petrous bone. Following external ventricular drainage (EVD) placement, ICP levels of > 90...
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Objectives The aim of the study was to investigate therapeutic efficacy of single- or two-fraction radiotherapy in conjunction with IDO1-inhibition in a syngeneic rat glioblastoma model. IDO is known to cause immunosuppression through breakdown of tryptophan in the tumor microenvironment. Methods Gene expression analyses of IDO in glioblastoma wer...
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Glioblastoma multiforme (GBM) is an aggressive primary brain malignancy with a very poor prognosis. Researchers employ animal models to develop potential therapies. It is important that these models have clinical relevance. This means that old models, propagated for decades in cultures, should be questioned. Parameters to be evaluated include wheth...
Article
Purpose: The complement system has recently sparked more interest in cancer research. The classical pathway is initiated by activation of the C1 complex, which irreversibly can be bound to and inhibited by C1-INH. We have previously shown that C1-INH is upregulated in human glioblastoma (astrocytoma grade IV) on both gene and protein level. We her...
Article
OBJECTIVE The authors aimed to develop the first clinical grading scale for patients with surgically treated spontaneous supratentorial intracerebral hemorrhage (ICH). METHODS A nationwide multicenter study including 401 ICH patients surgically treated by craniotomy and evacuation of a spontaneous supratentorial ICH was conducted between January 1...
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Background Supratentorial intracerebral haemorrhage (ICH) carries an excessive mortality and morbidity. Although surgical ICH treatment can be life-saving, the indications for surgery in larger cohorts of ICH patients are controversial and not well defined. We hypothesised that surgical indications vary substantially among neurosurgical centres in...
Article
Purpose: Glioblastoma multiforme (GBM) or astrocytoma grade IV is the most common type of primary brain tumor in adults. In the present study, we investigate the role of the complement system in the glioblastoma situation in an experimental model, since we have previously been able to show a blockade of this system in the glioblastoma setting. Te...
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Background: Chronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions. Patients diagnosed with CSDH's are often planned for subacute surgery. This means that time from diagnostic CT scan until actual surgery might often be prolonged. There are no previous studies that highlight the effect of delayed intervention in this p...
Article
Objective: Recent research has shown that combining radiotherapy and immunotherapy can counteract the ability of cancer to evade and suppress the native immune system. To optimize the synergy of the combined therapies, factors such as radiation dose and fractionation must be considered, alongside numerous parameters resulting from the complexity o...
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Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, and available experimental and routine therapies result in limited survival benefits. A vulnerability of GBM cells to catastrophic vacuolization and cell death, a process termed methuosis, induced by Vacquinol-1 (VQ-1) has been described earlier. In the present study, w...
Article
A major problem regarding glioblastomas is the capacity of glioma cells to inactivate the body’s immune response. The complement system acts as a functional bridge between the innate and adaptive immune response. Previously, it was thought that the complement system was upregulated in glioblastomas. However, only downstream components were studied....
Article
In a previous study, we have found a synergistic effect of indoleamine-2,3-dioxygenase (IDO1)-inhibition using 1-DL-methyl-tryptophan (1-MT) in conjunction with single fraction radiotherapy (RT) for rat glioblastoma (GBM). Using an adaptation of a mathematical model describing synergistic effects of immunotherapy and RT by Serre et al, that is taki...
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Background Glioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body’s immune response. The complement system acts as a functional bridge between the innate and adaptive immune response. Still, the role of the complement system has almost been forgotten...
Data
The NS1 tumor model, showing the NS1 tumor in fluorescent microscope after inoculation into a syngeneic Fischer 344 rat. (TIF)
Data
Protein structure for C1-IA in humans and rats. (DOCX)
Data
Schematic drawing of the complement reaction, showing (left) the effect of C1-IA and (right) re-establishing the reaction by anti-C1-IA treatment. (TIF)
Article
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Background: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumou...
Article
One of the key problems when treating patients with malignant gliomas is that despite being able to remove the major bulk of the tumour, tumour cells have already spread to local and distant sites of the brain. Previous glioblastoma models used in animals have lately been questioned, not least since they do not have an infiltrative growth pattern,...
Article
Background Subgaleal masses are relatively common in the clinical praxis, and after a trauma to the head, a subgaleal hematoma is usually suspected. However, other differential diagnoses, such as malignant tumors, should be kept in mind despite a history of a previous trauma. Case description and Conclusions We report a case of a subgaleal mass th...
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Background: A postoperative haematoma can be a very serious complication following a neurosurgical procedure. Patients should be informed about the risks of such an event prior to surgery. From a practical point of view, it would be important to know when the patient is most likely to deteriorate and to require surgery because of a postoperative h...
Article
One of the key problems when treating patients with malignant gliomas is that despite being able to remove the major bulk of the tumour, tumour cells may have already spread to distant sites of the brain. The aim of the present study is to develop a GFP positive tumour cell line (named NS1) where these cells could be identified for future treatment...
Article
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Glioblastoma (GBM), or WHO Astrocytoma grade IV, is the most common primary brain tumour in adults. GBM is shown to escape host immune surveillance through many paths, of which expression of indoleamine 2,3-dioxygenase (IDO), leading to induction and accumulation of regulatory T-cells in the tumour microenvironment, has been shown to be of importan...
Article
The rare, potentially life-threatening complication to anterior cervical surgery, oesophageal perforation, occurs after surgical trauma or due to erosion by migrating hardware. Symptoms are hoarseness, dysphagia, neck/throat pain, subcutaneous emphysema and fever. Imaging and endoscopic diagnosis can give false negative results. We present a case o...
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fMRI and EEG are two non-invasive functional imaging techniques within cognitive neuroscience that have complementary advantages to obtain both temporal and spatial information. The multi-source interference task (MSIT) has been shown to generate robust activations of the dorsal anterior cingulate cortex (dACC) on both a single-subject level and in...
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BACKGROUND: Many studies have been performed in animal models in the search for possible treatment alternatives against malignant astrocytomas, including glioblastoma multiforme. One of the key problems when treating patients with malignant gliomas is that despite being able to remove the major bulk of the tumour, we know that tumour cells have alr...
Article
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Background: Nerve-root related dermatomes have been considered to have quite solid anatomical framings. However, especially in the lumbar region, studies have questioned such firm anatomy. Regarding the cervical nerve roots, many studies have shown an overlap between different dermatomes, which of course affects decisions taken in the clinical work...
Article
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Coping with the immune rejection of allotransplants or autologous cells in patients with an active sensitization towards their autoantigens and autoimmunity presently necessitates life-long immune suppressive therapy acting on the immune system as a whole, which makes the patients vulnerable to infections and increases their risk of developing canc...
Article
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Abstract. Effect of 915 MHz electromagnetic fields (EMF) on the blood brain-barrier (BBB) permeability has been studied in Fischer 344 rats of both sexes. Male and female Fischer 344 rats were exposed in a Transverse Electromagnetic Transmission line chamber to microwaves of 915 MHz as continuous wave (CW) and pulse-modulated with different pulse p...
Article
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75 RG2 glioma-carrying Fischer rats were treated by photon activation therapy (PAT) with monochromatic synchrotron radiation and stable thallium. Three groups were treated with thallium in combination with radiation at different energy; immediately below and above the thallium K-edge, and at 50 keV. Three control groups were given irradiation only,...
Article
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The question whether very weak, low frequency magnetic fields can affect biological matter is still under debate. The theoretical possibility of such an interaction is often questioned and the site of interaction in the cell is unknown. In the present study, the influence of extremely weak 60 Hz magnetic fields on the transport of Ca(2+) was studie...
Article
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To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly affect nociceptive responses. In the pres...
Conference Paper
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POS03-27. Radiation Modulated Immune-Response and Abscopal Effect. Bertil R.R Persson, C. Bauréus Koch, G. Grafström, P. Munck af Rosenschöld, C. Ceberg, H. Nittby,B. Widegren, L. G. Salford, Lund University, Sweden ―Non-targetǁ radiation effects in tissues outside the immediate location of the radiation therapy beam, wasoriginally described as ―Ab...
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Since the late 1980s, our group has examined the effects of radiofrequency electromagnetic fields (RF-EMF), including pulse-modulated waves of the type emitted by mobile phones, upon the blood–brain barrier. In more than 2,000 rats, we have repeatedly demonstrated a passage of the rats’ own albumin from the blood through the brain capillaries into...
Article
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The tumor growth rate response was studied on N29 rat glioma tumor cells subcutaneously implanted on both hind legs of Fischer-344 rats. At around 30 days after inoculation, RT was given with 60Co gamma radiation with 4 daily fractions of 5 Gy only to the right-lateral tumors. At days 26, 42, and 54 after inoculation, immunization was performed wit...
Conference Paper
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Radiation therapy (RT) was combined with intraperitoneally injections of syngeneic interferon-gamma secreting cells in rats with intracerebral implanted N29 glioma tumours. RT had no significant effect on the survival time. Immunization increased the survival time 60% (p=0.04). Immunization combined with 5 Gy radiation therapy increased the surviv...
Conference Paper
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Gliom N29 tumours from immunization with interferon-gamma (IFNg) transfected syngeneic tumour cells combined with radiation therapy in rats. Radiation therapy (RT) was combined with intraperitoneally injections of syngeneic interferon-gamma secreting cells in rats with intracerebral implanted N29 glioma tumours. RT had no significant effect on th...
Article
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Single-fraction radiation therapy with 5 or 15 Gy (60)Co gamma radiation was combined with intraperitoneal injections of syngeneic interferon gamma (IFN-gamma)-transfected cells in rats with intracerebral N29 or N32 glioma tumors at days 7, 21 and 35 after inoculation. For intracerebral N29 tumors, single-fraction radiation therapy with 5 or 15 Gy...
Conference Paper
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Bertil R. Persson1, Catrin Bauréus Koch1,2, Gustav Grafström1, Per Engström1, Crister Ceberg1, Henrietta Nittby2, Bengt Widegren3, Leif G. Salford2, 1Medical Radiation Research, Lund, Sweden, 2Dept of Neurosurgery, Lund, Sweden, 3Dept of Tumor Immunology, Lund, Sweden Abstract: Radiation therapy (RT) in combination with Pulsed Electric Field (PEF...
Article
Microwaves were for the first time produced by humans in 1886 when radio waves were broadcasted and received. Until then microwaves had only existed as a part of the cosmic background radiation since the birth of universe. By the following utilization of microwaves in telegraph communication, radars, television and above all, in the modern mobile p...
Article
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We have earlier shown that radio frequency electromagnetic fields can cause significant leakage of albumin through the blood–brain barrier of exposed rats as compared to non-exposed rats, and alsosignificant neuronal damage in rat brains several weeks after a 2h exposure to a mobile phone, at 915MHz with a global system for mobile communications (G...
Article
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In order to mimic the real life situation, with often life-long exposure to the electromagnetic fields emitted by mobile phones, we have investigated in a rat model the effects of repeated exposures under a long period to Global System for Mobile Communication-900 MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed once weekly in a...
Article
Maximal oxygen uptake (Vo(2max)) and the amount of type 1 fibers are interrelated, but the underlying unifying molecular mechanisms are poorly understood. To explore these mechanisms, we related gene expression profiles in skeletal muscle biopsies of 43 age-matched men from published datasets with Vo(2max) and the amount of type 1 fibers and replic...