Henri Damon

• Medical Doctor at Hospices Civils de Lyon (Centre Hospitalier Universitaire de Lyon)

Background The efficacy and safety of intrarectal botulinum toxin A (BoNT/A) injections in patients with urge fecal incontinence (FI) were evidenced in a large, multicenter, randomized, placebo‐controlled study (FI‐TOXIN). The aims of the present study were to evaluate the long‐term efficacy and safety of intrarectal BoNT/A injections in a real‐wor...

Introduction The London classification provides standardization for characterization of disorders of anorectal function, although prevalences and clinical impact of these disorders are unclear. Methods An international research consortium was established, including five specialist centers. Prospective data were collected in consecutive adults refe...

Background: Chronic constipation (CC) is a frequent condition, and the first-line treatment includes dietary rules, the use of laxatives, and biofeedback for evacuation disorders. However, almost half of the patients are dissatisfied with their current treatment. We report the first double-blind randomized multicenter trial assessing the effective...

Background: The prevalence of receptive anal intercourse (RAI) is increasing. A few studies, with heterogeneous designs, have investigated the associated risk of fecal incontinence (FI). Aim: The primary objective of this study was to determine FI prevalence in a population of men who have sex with men (MSM) engaging in RAI. The secondary object...

Aim To evaluate the efficacy, Quality of Life (QoL), patient satisfaction and safety of sacral neuromodulation (SNM) with the InterStimTM system for the treatment of faecal incontinence (FI) and establish whether results published predominantly by expert sites are generalisable. Method This is a prospective, multicentre, observational study inviti...

Objective: The aim of this study was to assess the effectiveness of sacral nerve modulation (SNM) in a large cohort of patients implanted for at least 10 years, quantify adverse event rates, and identify predictive factors of long-term success. Summary background data: Few studies have evaluated the long-term success of SNM. Methods: Data coll...

Aim: Irritable bowel syndrome (IBS) is a frequent disease, associating chronic abdominal pain and abnormal bowel habits. The sympatho-vagal balance may be altered in IBS. We tested the effect of transcutaneous auricular stimulation of the left vagus nerve (taVNS) on symptoms and physiological and biological variables. Patients & methods: Twelve IBS...

Objective To assess the efficacy and safety of sacral nerve modulation (SNM) in patients with faecal incontinence (FI) after pelvic radiotherapy in comparison with results of SNM for FI related to other conditions. Methods Prospectively collected data from patients who underwent SNM therapy between January 2010 and December 2015 at 7 tertiary colo...

Aim Faecal incontinence is frequent in the elderly. Little is currently known about the efficacy of sacral nerve modulation in the elderly. The present study aimed to assess the impact of age on the outcome of sacral nerve modulation and on the surgical revision and explantation rates by comparing the results of a large dataset of patients. Method...

Fecal incontinence is more like a symptom than a disease. Clinical form and mechanisms are highly variable. However, first-line treatments are often shared by the majority of patients, compounded of four elements: lifestyle modifications, bowel movement regulation, anoperinal rehabilitation, and transcutaneous electrical nerve stimulation (TENS). L...

Purpose: High resolution anorectal manometry has been developed over the past years, as well as 3D high definition manometry (HDARM). However, the clinical impact of the results obtained with these new technologies remains to be determined. We thus analyzed various HDARM parameters of anal sphincter function and tested their capacity to discrimina...

Chronic constipation is a common symptom that regularly affects the quality of life of adult patients. Its treatment is mainly based on dietary rules, laxative drugs, perineal rehabilitation and surgical treatment. The French National Society of Coloproctology offers clinical practice recommendations on the basis of the data in the current literatu...

L’incontinence anale est un handicap majeur, tant sur le plan médical et psychologique, que sur le plan social et relationnel. Son impact sur la qualité de vie est particulièrement négatif. Contrairement à certaines idées reçues, l’incontinence anale est une pathologie fréquente, touchant toutes les tranches d’âge, les femmes mais également les hom...

Faecal incontinence is a disabling symptom which may be particularly difficult to treat. Recent studies showed that transcutaneous electrical posterior tibial nerve stimulation may improve faecal continence. In this study, we aimed to evaluate the effectiveness of this technique and tried to individualize predictive factors of success. Twenty-four...

Thyroid antibodies are present in more than 15% of patients with primary biliary cirrhosis. Inversely, the prevalence of antimitochondrial antibodies in patients with thyroid antibodies is still unknown. The aim of the present study was to evaluate the prevalence of antimitochondrial antibodies in women positive for thyroid microsomal antibodies. A...

Five cases of Biermer's disease presenting as pancytopenia were observed over a 17-year period. In all cases, haemorrhagic and/or infectious complications occurred. The myelogram revealed qualitative medullary deficiency and laboratory data led to diagnosis. The importance of prompt substitutive therapy is underlined.