Henning U. Voss

Henning U. Voss
Weill Cornell Medical College | Cornell

Associate Professor of Physics in Radiology

About

221
Publications
39,486
Reads
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12,178
Citations
Citations since 2016
64 Research Items
6891 Citations
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201620172018201920202021202202004006008001,0001,200
201620172018201920202021202202004006008001,0001,200
Introduction
MRI techniques and their application in clinical and preclinical studies. Interested in the exploration of neuronal function and connectivity using advanced MRI techniques and concepts from nonlinear dynamics and time series analysis.
Additional affiliations
November 2003 - present
Weill Cornell Medical College
Position
  • Associate Professor of Physics in Radiology
January 2000 - December 2004
University of Freiburg
January 1997 - December 2003
Universität Potsdam

Publications

Publications (221)
Article
Full-text available
We present a method for the identification of continuous, spatiotemporal dynamics from experimental data. We use a model in the form of a partial differential equation and formulate an optimization problem for its estimation from data. The solution is found as a multivariate nonlinear regression problem using the ACE-algorithm. The procedure is suc...
Article
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Many nonlinear dynamical systems incorporate feedback mechanisms with a time delay.
Article
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The problem of system identification from a time series of measurements is solved by using non-parametric additive models. Having only few structural information about the system, a non-parametric approach may be more appropriate than a parametric one for which detailed prior knowledge is needed. Based on non-parametric regression, the functions in...
Article
Full-text available
Real-time prediction of signals is a task often encountered in control problems as well as by living systems. Here a model-free prediction approach based on the coupling of a relaxation system to a smooth signal is described. The resulting anticipatory relaxation dynamics (ARD) is attracted to a manifold on which its states assume future signal val...
Article
Lack of a body‐sized, bore‐mounted, radiofrequency (RF) body coil for ultra‐high field (UHF) magnetic resonance imaging (MRI) is one of the major drawbacks of UHF, hampering the clinical potential of the technology. Transmit field (B1) nonuniformity and low specific absorption rate (SAR) efficiencies in UHF MRI are two challenges to be overcome. To...
Preprint
Full-text available
A simple motion amplification algorithm suitable for real-time applications on mobile devices is presented. It is based on motion enhancement by moving average differencing (MEMAD), a temporal high-pass filter for video streams. MEMAD can amplify small moving objects or subtle motion in larger objects. It is computationally sufficiently simple to b...
Article
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Objective Following severe brain injury, up to 16% of adults showing no clinical signs of cognitive function nonetheless have preserved cognitive capacities detectable via neuroimaging and neurophysiology; this has been designated cognitive-motor dissociation (CMD). Pediatric medicine lacks both practice guidelines for identifying covert cognition,...
Preprint
Full-text available
The periodically driven harmonic oscillator with damping is one of the most elementary and trusted models in physics and normally applied in its steady state, disregarding specific initial conditions and associated transients. For example, steady state solutions are already sufficient to describe resonance. In some applications transient solutions...
Article
Full-text available
Magnetic resonance guided focused ultrasound (MRgFUS) is a non-invasive therapeutic modality for neurodegenerative diseases that employs real-time imaging and thermometry monitoring of targeted regions. MRI is used in guidance of ultrasound treatment; however, the MR image quality in current clinical applications is poor when using the vendor built...
Article
Species recognition is an essential behavioral outcome of social discrimination, flocking, mobbing, mating, and/or parental care. In songbirds, auditory species recognition cues are processed through specialized forebrain circuits dedicated to acoustic discrimination. Here we addressed the direction of behavioral and neural metrics of Zebra Finches...
Conference Paper
We designed a novel 2D cylindrical high-pass ladder (c-HPL) volume body coil by adding a second dimension in S-I direction to the 1D birdcage concept, given that the latter fails at 7T body dimensions. We compared its performance to the (non-functional) 1D birdcage and transverse electromagnetic (TEM) designs. In silico results showed improved B1 h...
Conference Paper
We propose a two-dimensional cylindrical high-pass ladder (2D c-HPL) volume coil architecture as a new class of radiofrequency coils to be used for 7T Body MR imaging. As a first simplified experimental proof-of-concept we show feasibility in a head sized coil. In silico results show 45% more homogeneous B1 field distribution with 25% lower specifi...
Article
Full-text available
Resting state functional connectivity magnetic resonance imaging (fMRI) is a tool for investigating human brain organization. Here we identify, visually and algorithmically, two prevalent influences on fMRI signals during 440 h of resting state scans in 440 healthy young adults, both caused by deviations from normal breathing which we term deep bre...
Article
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An otherwise healthy two-month-old female C57BL/6J mouse presented with a left-sided head tilt. Differential diagnoses included idiopathic necrotizing arteritis, bacterial otitis media/interna ( Pasteurella pneumotropica, Pseudomonas aeruginosa, Streptococcus sp., Mycoplasma pulmonis and Burkholderia gladioli), encephalitis, an abscess, neoplasia,...
Article
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Purpose To quantify CSF transport kinetics and brain glymphatic distribution using MRI following intrathecal injection of gadolinium contrast in healthy adults. Subjects and methods Eight completely healthy volunteer subjects underwent intrathecal injection of gadolinium via image guided lumbar puncture and serial MRI's at six subsequent time poin...
Article
Full-text available
The eigenvector-eigenvalue identity relates the eigenvectors of a Hermitian matrix to its eigenvalues and the eigenvalues of its principal submatrices in which the jth row and column have been removed. We show that one-dimensional arrays of coupled resonators, described by square matrices with real eigenvalues, provide simple physical systems where...
Article
We consider the inverse problem of estimating the spatially varying pulse wave velocity in blood vessels in the brain from dynamic MRI data, as it appears in the recently proposed imaging technique of Magnetic Resonance Advection Imaging (MRAI). The problem is formulated as a linear operator equation with a noisy operator and solved using a conjuga...
Preprint
Full-text available
The eigenvector-eigenvalue identity relates the eigenvectors of a Hermitian matrix to its eigenvalues and the eigenvalues of its principal submatrices in which the jth row and column have been removed. We show that one-dimensional arrays of coupled resonators, described by square matrices with real eigenvalues, provide simple physical systems where...
Article
Topological properties of solid states have sparked considerable recent interest due to their importance in the physics of lattices with a non-trivial basis and their potential in the design of novel materials. Here we describe an experimental and accompanying numerical toolbox to create and analyze topological states in radiofrequency resonator ar...
Preprint
Full-text available
The study presents a general framework for discovering underlying Partial Differential Equations (PDEs) using measured spatiotemporal data. The method, called Sparse Spatiotemporal System Discovery ($\text{S}^3\text{d}$), decides which physical terms are necessary and which can be removed (because they are physically negligible in the sense that th...
Article
Background: Mechanisms underlying delayed orgasm (DO) are poorly understood; however, known effects of psychotropic medications on sexual function provides a rationale for aberrant central nervous system signaling as a cause. Aim: To compare brain activation between men with normal orgasm and those with lifelong DO during sexual stimulation usin...
Preprint
Full-text available
Topological properties of solid states have sparked considerable recent interest due to their importance in the physics of lattices with a non-trivial basis and their potential in the design of novel materials. Here we describe an experimental and an accompanying numerical toolbox to create and analyze topological states in coupled radiofrequency r...
Article
Purpose: Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using brea...
Article
Full-text available
This paper presents a “structured” learning approach for the identification of continuous partial differential equation (PDE) models with both constant and spatial-varying coefficients. The identification problem of parametric PDEs can be formulated as an ℓ1/ℓ2-mixed optimization problem by explicitly using block structures. Block-sparsity is used...
Article
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Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals charact...
Article
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A filter with delay-induced negative group delay is presented. The filter consists of multiple time-delayed feedback terms, which lead to a negative group delay for frequencies in the baseband. It can be used for the real-time prediction of band-limited signals. The filter is universal as it does not rely on a specific model of the signal. Specific...
Article
Recent studies identify severely brain-injured patients with limited or no behavioral responses who successfully perform functional magnetic resonance imaging (fMRI) or electroencephalogram (EEG) mental imagery tasks [1–5]. Such tasks are cognitively demanding [1]; accordingly, recent studies support that fMRI command following in brain-injured pat...
Article
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The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) of the ApoE gene with human ApoE4 have reduced neocortical cerebral blood flow compared to ApoE3-TR mice, an effect due to reduced vascular density rather than slowin...
Preprint
We consider the inverse problem of estimating the spatially varying pulse wave velocity in blood vessels in the brain from dynamic MRI data, as it appears in the recently proposed imaging technique of Magnetic Resonance Advection Imaging (MRAI). The problem is formulated as a linear operator equation with a noisy operator and solved using a conjuga...
Article
Full-text available
Patients with severe brain injury are difficult to assess and frequently subject to misdiagnosis. ‘Cognitive motor dissociation’ is a term used to describe a subset of such patients with preserved cognition as detected with neuroimaging methods but not evident in behavioural assessments. Unlike the locked-in state, cognitive motor dissociation afte...
Article
A method to upsample insufficiently sampled experimental time series of pseudo-periodic signals is proposed. The result is an estimate of the pseudo-periodic cycle underlying the signal. This "hypersampling" requires a sufficiently sampled reference signal that defines the pseudo-periodic dynamics. The time series and reference signal are combined...
Preprint
A method to upsample insufficiently sampled experimental time series of pseudo-periodic signals is proposed. The result is an estimate of the pseudo-periodic cycle underlying the signal. This hypersampling requires a sufficiently sampled reference signal that defines the pseudo-periodic dynamics. The time series and reference signal are combined by...
Article
The purpose of this study is to determine the effects of high cumulative doses of ultra-small paramagnetic iron oxide (USPIO) used in neuroimaging studies. We intravenously administered 8 mg/kg of 2 USPIO compounds daily for 4 wk to male Sprague–Dawley rats (Crl:SD). Multiecho gradient-echo MRI, serum iron levels, and histology were performed at th...
Article
Full-text available
A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial function, leading to cognitive impairment. The effect depends on expansion of TH17 cells in the smal...
Article
We present a reconstruction method for estimating the pulse-wave velocity in the brain from dynamic MRI data. The method is based on solving an inverse problem involving an advection equation. A space-time discretization is used and the resulting largescale inverse problem is solved using an accelerated Landweber type gradient method incorporating...
Article
The sensitivity of fMRI in identification of eloquent cortical centers in the case of large infiltrative growing tumors and pronounced peritumoral edema may be reduced or significantly limited in some cases. The main cause is an attenuated Blood-Oxygen-Level-Dependent response (BOLD) caused by pathological vascular reactivity and subsequent neurova...
Preprint
Purpose Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath...
Article
Full-text available
In many songbird species, males sing to attract females and repel rivals. How can gregarious, non-territorial songbirds such as zebra finches, where females have access to numerous males, sustain monogamy? We found that the dopaminergic reward circuitry of zebra finches can simultaneously promote social cohesion and breeding boundaries. Surprisingl...
Article
The mitochondrial protein prohibitin (PHB) has emerged as an important modulator of neuronal survival in different injury modalities . We previously showed that viral gene transfer of PHB protects CA1 neurons from delayed neurodegeneration following transient forebrain ischemia through mitochondrial mechanisms. However, since PHB is present in all...
Article
Full-text available
A filter for universal real-time prediction of band-limited signals is presented. The filter consists of multiple time-delayed feedback terms in order to accomplish anticipatory coupling, which again leads to a negative group delay for frequencies in the baseband. The universality of the filter arises from its property that it does not rely on a sp...
Article
Full-text available
Viral vector mediated gene therapy has become commonplace in clinical trials for a wide range of inherited disorders. Successful gene transfer depends on a number of factors, of which tissue tropism is among the most important. To date, definitive mapping of the spatial and temporal distribution of viral vectors in vivo has generally required postm...
Article
Full-text available
Spontaneous recovery of brain function after severe brain injury may evolve over a long time period and is likely to involve both structural and functional reorganization of brain networks. We longitudinally tracked the recovery of communication in a patient with severe brain injury using multimodal brain imaging techniques and quantitative behavio...
Article
Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their neurobiological substrates. Like to other neuropsychiatric disorders, depression is not a unitary disease, but rather a heterogeneous syndrome that encompasses varied, co-occurring s...
Article
Full-text available
We propose that feedback-delayed manual tracking performance is limited by fundamental constraints imposed by the physics of negative group delay. To test this hypothesis, the results of an experiment in which subjects demonstrate both reactive and predictive dynamics are modeled by a linear system with delay-induced negative group delay. Although...
Article
A very simple linear signal predictor that uses past predicted values rather than past signal values for prediction is presented. Therefore, man-made or natural systems utilizing this predictor would not require a memory of input signal values but only of already predicted, internalized states. This delay-induced negative group delay (DINGD) predic...
Article
Full-text available
We analyze the pulsatile signal component of dynamic echo planar imaging data from the brain by modeling the dependence between local temporal and spatial signal variability. The resulting magnetic resonance advection imaging maps depict the location of major arteries. Color direction maps allow for visualization of the direction of blood vessels....
Data
The Benjamini-Hochberg multiple comparisons procedure.
Data
A time lapsed video of the network diffusion model's prediction in a particular normal controls. The upper left panel is the true FC, upper right is the SC, lower left is the predicted FC over time, lower middle is the scatter plot of predicted FC versus true FC over time and the lower right plot is time versus the correlation of predicted and true...
Data
Analysis of the Network Diffusion Model Fit.
Data
Analysis of the impact of distortion correction.
Article
Full-text available
Following severe injuries that result in disorders of consciousness, recovery can occur over many months or years post-injury. While post-injury synaptogenesis, axonal sprouting and functional reorganization are known to occur, the network-level processes underlying recovery are poorly understood. Here, we test a network-level functional rerouting...
Article
Full-text available
Background and purpose: Late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is a uniformly fatal lysosomal storage disease resulting from mutations in the CLN2 gene. Our hypothesis was that regional analysis of cortical brain degeneration may identify brain regions that are affected earliest and most severely by the disease. Materials an...
Article
Full-text available
It is shown that the leaky integrator, the basis for many neuronal models, possesses a negative group delay when a time-delayed recurrent inhibition is added to it. By means of this negative group delay, the leaky integrator becomes a predictor for low-frequency components of the integrated signal. The prediction properties are derived analytically...
Research
Full-text available
Poster at Dynamic Days 2016. Abstract: Summary: Real-time prediction of signals is a task often encountered in control problems as well as by living systems. Here a model-free prediction approach based on the coupling of a linear relaxation-delay system to a smooth, stationary signal is described. The resulting anticipatory relaxation dynamics (...