Henning Langer

Henning Langer
Weill Cornell Medical College | Cornell · Division of Endocrinology Diabetes and Metabolism

Phd

About

27
Publications
4,321
Reads
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397
Citations
Citations since 2016
24 Research Items
324 Citations
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20162017201820192020202120220204060
20162017201820192020202120220204060
Additional affiliations
May 2018 - December 2021
University of California, Davis
Position
  • PostDoc Position
October 2014 - May 2018
Charité Universitätsmedizin Berlin
Position
  • PhD Student
March 2013 - October 2014
Maastricht University
Position
  • Research Assistant
Education
October 2014 - October 2018
Charité Universitätsmedizin Berlin
Field of study
  • Biomedical Research
September 2013 - September 2014
Maastricht University
Field of study
  • Human Biology
August 2011 - May 2012
University of California, Davis
Field of study
  • Neurobiology, Physiology and Behavior

Publications

Publications (27)
Article
Full-text available
Desminopathy is the most common intermediate filament disease in humans. The most frequent mutation causing desminopathy in patients is a R350P DES missense mutation. We have developed a rat model with an analogous mutation in R349P Des. To investigate the role of R349P Des in mechanical loading, we stimulated the sciatic nerve of wild-type litterm...
Article
Full-text available
Background: Cannabidiol (CBD) is becoming increasingly popular for the treatment of clinical conditions including as an aid for muscle recovery. Previous work demonstrated that CBD exhibited mild effects on skeletal muscle, with a tendency to increase anabolic signaling and decrease inflammatory signaling. Methods: To gain mechanistic insight and e...
Article
Full-text available
The molecular responses to acute resistance exercise are well characterized. However, how cellular signals change over time to modulate chronic adaptations to more prolonged exercise training is less well understood. We investigated anabolic signaling and muscle protein synthesis rates at several time points after acute and chronic eccentric loadin...
Article
Full-text available
Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARα activity in the liver. Restoring hepatic PPARα activity with fenofibrate increased circulating ketones and delayed muscle and white adipose tissue wasting. W...
Article
Full-text available
The tumor suppressor p53 is thought to play a key role in the maintenance of cell size and homeostasis, but relatively little is known about its role in skeletal muscle. Based on its ability to suppress cell growth, we hypothesized that inhibiting the function of wild-type p53 through the overexpression of a dominant-negative p53 mutant (DDp53) cou...
Preprint
Full-text available
We have previously identified a series of molecular brakes that slow muscle growth. One potential molecular brake is SIRT1, which is activated by a negative caloric balance. In this work, we identified natural product inhibitors of SIRT1 and tested their effects on load-induced increases in muscle fiber cross-sectional area (fCSA) using an incomple...
Preprint
Muscle mass and strength are predictors of longevity. We have previously identified a series of molecular brakes that slow muscle growth in response to stress. One potential stress that we hypothesized would limit muscle growth is caloric stress through the activation of SIRT1. We therefore identified natural product inhibitors of SIRT1 and tested...
Preprint
Full-text available
Desminopathy the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria, and connects the z-discs and the sarcolemma. We created a rat model with a mutation in R349P DES , analog to the most frequent R350P DES missense mutation in humans. To...
Article
Fracture induces systemic bone loss in mice and humans, and a first (index) fracture increases the risk of future fracture at any skeletal site more in men than women. The etiology of this sex difference is unknown, but fracture may induces a greater systemic bone loss response in males. Also sex differences in systemic muscle loss after fracture h...
Article
Full-text available
Cannabidiol (CBD) has proven clinical benefits in the treatment of seizures, inflammation, and pain. The recent legalization of CBD in many countries has caused increased interest in the drug as an over-the-counter treatment for athletes looking to improve recovery. However, no data on the effects of CBD on the adaptive response to exercise in musc...
Article
Full-text available
Background Desminopathy is a clinically heterogeneous muscle disease caused by over 60 different mutations in desmin. The most common mutation with a clinical phenotype in humans is an exchange of arginine to proline at position 350 of desmin leading to p.R350P. We created the first CRISPR‐Cas9 engineered rat model for a muscle disease by mirroring...
Article
Full-text available
The mechanisms accounting for the loss of muscle function with obesity and type 2 diabetes are likely the result of a combination of neural and muscular factors. One muscular factor that is important, yet has received little attention, is the protein machinery involved in longitudinal and lateral force transmission. The purpose of this study was to...
Article
Full-text available
Perturbations in skeletal muscle metabolism have been reported for a variety of neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve and the associated muscle atrophy is unclear. We have analyzed rat tibialis anterior (TA) four weeks after unilateral constriction injury to the sciatic nerve (DMG) and in the c...
Article
ON SARCOPENIA: THE CONVOLUTION OF THE TERM TO THE EDITOR: For a few millennia, the Greek term (lacking flesh) has been used to designate probable medical conditions: the extremely pale gaunt figure of Democritus, as well as his erratic antisocial behavior, impelled the city senate to invite Hippocrates to treat the philosopher (5). Similarly, poor...
Article
Full-text available
Muscle loss is a severe complication of many medical conditions such as cancer, cardiac failure, muscular dystrophies and nerve damage. The contribution of myofibrillar protein synthesis (MPS) to the loss of muscle mass after nerve damage is not clear. Using deuterium oxide (D2O) labeling, we demonstrate that MPS is significantly increased in rat m...
Article
Skeletal muscle atrophy is a primary clinical symptom associated with many diseases such as cachexia, sarcopenia, diabetes, neurodegenerative disorders and myopathies. This article is protected by copyright. All rights reserved.
Article
Introduction: We have previously shown that protein ingestion prior to sleep increases overnight muscle protein synthesis rates. Whether prior exercise further augments the muscle protein synthetic response to pre-sleep protein ingestion remains to be established. Objective: To assess whether resistance-type exercise performed in the evening inc...
Article
Full-text available
Background: Muscle mass maintenance is largely regulated by basal muscle protein synthesis and the capacity to stimulate muscle protein synthesis after food intake. The postprandial muscle protein synthetic response is modulated by the amount, source, and type of protein consumed. It has been suggested that plant-based proteins are less potent in...
Article
Full-text available
ABSTRACT: THIS ARTICLE REVIEWS THE AVAILABLE LITERATURE ON WHICH PROTEINS, AMINO ACIDS, OR COMBINATION OF BOTH SEEM TO BE OPTIMAL TO ENHANCE HYPERTROPHY AFTER RESISTANCE EXERCISE IN YOUNG ADULTS. DEPENDING ON THE CONTENT OF ESSENTIAL AMINO ACIDS AND PARTICULARLY LEUCINE, EITHER AN IMMEDIATE INGESTION OF ~20 G MILK PROTEIN FOLLOWED BY A SIMILAR AMOU...
Article
Full-text available
Background: Anemia is a major complication of end stage renal disease. The anemia is mainly the result of impaired formation of erythrocytes due to lack of erythropoietin and iron deficiency. Compelling evidence, however, points to the contribution of accelerated erythrocyte death, which decreases the life span of circulating erythrocytes. Erythro...

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