Henner Hollert

Henner Hollert
Goethe-Universität Frankfurt am Main · Institute of Ecology, Evolution and Diversity

Univers. Prof. Dr. rer. nat.

About

668
Publications
158,210
Reads
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15,484
Citations
Introduction
University Professor at Goethe University in Frankfurt , SETAC Fellow , Head of Department for Evolutionary Ecology and Environmental Toxicology, until sept. 2019 Co-Head of Institute for Environmental Research, RWTH Aachen University, Adjunct Professor Chongcing University China Concurrent Professor • School of Environment, Nanjing University, China Honorary Professor • 111 Program, Tongji University, China Editor in Chief Environ Sci Europe (Open Access, SpringerNature Publisher) Subject Editor Journal of Soils and Sediments Editor Science of the Total Environment - STOTEN
Additional affiliations
October 2019 - present
Goethe-Universität Frankfurt am Main
Position
  • Head of Department
Description
  • Head of the Department Evolutionary Ecology and Environmental Toxicology, Faculty Biological Sciences, Goethe University Frankfurt | Campus Riedberg, Biologicum | room 3.317 | Max-von-Laue-Str. 13 60438 Frankfurt am Main | Germany
September 2007 - September 2019
RWTH Aachen University
Position
  • Head of Department
Description
  • Head of the Institute of Environmental Research (together with Prof. Dr. Andreas Schäffer)
June 2001 - August 2007
Universität Heidelberg
Position
  • Research Assistant
Education
September 1997 - June 2001
Universität Heidelberg
Field of study
  • Biology
May 1992 - July 1997
Universität Heidelberg
Field of study
  • Biology & Geography
October 1990 - June 1997
University of Heidelberg)
Field of study
  • Biology

Publications

Publications (668)
Article
Full-text available
The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planeta...
Article
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Background Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order of magnitude higher than that in other media, which means that all living animals breathing with lungs (including humans) cannot escape the fate of inhaling microplastics. However, there is no direct evidence to...
Article
Risk assessment of hydrophobic organic compounds (HOCs) is difficult because maintaining a well-defined exposure during aquatic toxicity testing is challenging due to the limited water solubility and various loss processes such as volatilization, biodegradation and sorption. Passive dosing techniques help to overcome these challenges by providing a...
Article
Microplastics are small plastic fragments that are widely distributed in marine and terrestrial environments. While the soil ecosystem represents a large reservoir for plastic, research so far has focused mainly on the impact on aquatic ecosystems and there is a lack of information on the potentially adverse effects of microplastics on soil biota....
Article
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The use of explosives has led to a widespread distribution of 2,4,6-trinitrotoluene (TNT) and its by- and degradation products in the soil on former production and testing sites. The investigation of those large contaminated sites is so far based on a few selected soil samples, due to high costs of conventional HPLC and GC analysis, although huge d...
Article
In (eco-)toxicological studies the light/dark transition (LDT) test is one of the most frequently used behaviour assays with zebrafish eleutheroembryos. However, study results vary regarding data presentation and analysis and mostly focus on a limited amount of the recorded data. In this study, we investigated whether monitoring two behavioural out...
Article
Soil microbial communities which are essential for soil ecosystems can be disturbed by a manifold of environmental variables, including pesticides. Among others, fungicides are frequently applied as effective crop protection...
Article
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Background The environmental impact of pesticides has been an increasingly discussed issue over the last decades. Constant usage of pesticides presents a burden for soil and causes a decrease in its health, including the negative effects on earthworms which are indicators for soil quality. The objective of this research was the assessment of the ef...
Article
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Background Pesticides are washed from agricultural fields into adjacent streams, where even short-term exposure causes long-term ecological damage. Detecting pesticide pollution in streams thus requires the expensive monitoring of peak concentrations during run-off events. Alternatively, exposure and ecological effects can be assessed using the SPE...
Article
Full-text available
Background The application of chemical dispersants is a common remediation strategy when accidental oil spills occur in aquatic environments. Breaking down the oil slick into small droplets, dispersants facilitate the increase of particulate and dissolved oil compounds, enhancing the bioavailability of toxic oil constituents. The aim of the present...
Article
Wastewater treatment plant effluents and releases from rainwater overflow basins can contribute to the input of genotoxic micropollutants in aquatic ecosystems. Predominantly lipophilic genotoxic compounds tend to sorb to particulate matter, making sediment a source and a sink of pollution. Therefore, the present study aims to investigate the genot...
Article
The impact of pesticide mixtures on various soil parameters has been extensively studied, whereas research on effects in the aquatic environment is scarce. Furthermore, investigations on the consequences of chemical mixtures on the biodegradation kinetics of parent compounds remain deficient. Our research intended to evaluate potential effects by c...
Article
Mental illnesses affect more than 150 million people in Europe and lead to an increasing consumption of neuroactive drugs during the last twenty years. The antipsychotic compound, clozapine, is one of the most used psychotropic drugs worldwide, with potentially negative consequences for the aquatic environment. Hence, the objectives of the study pr...
Article
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Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology,...
Article
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For specific primary modes of action (MoA) in environmental non-target organisms, EU legislation restricts the usage of active substances of pesticides or biocides. Corresponding regulatory hazard assessments are costly, time consuming and require large numbers of non-human animal studies. Currently, predictive toxicology of development compounds r...
Article
A key aspect of the transformation of the economic sector towards a sustainable bioeconomy is the development of environmentally friendly alternatives for hitherto used chemicals, which have negative impacts on environmental health. However, the implementation of an ecotoxicological hazard assessment at early steps of product development to elabora...
Article
Wastewater treatment plants (WWTPs) remain an important primary source of emission for endocrine-disrupting compounds in the environment. As an advanced wastewater treatment process, ozonation is known to reduce endocrine-disrupting activity. However, it remains unclear to which extend improved wastewater treatment may reduce the endocrine-disrupti...
Article
Artificial sediment used in studies according to OECD 218/219 (Sediment Water Chironomid Toxicity Test Using Spiked Sediment/Water) does not necessarily mirror the characteristics of natural sediments. To investigate the influence of sediment characteristics on the spatial-temporal behaviors of bixafen (KfOM = 2244 mL/g), fluopyram (KfOM = 162 mL/g...
Article
The assessment of the exposure of aquatic wildlife to complex environmental mixtures of chemicals originating from both point and diffuse sources and evaluating the potential impact thereof constitutes a significant step towards mitigating toxic pressure and the improvement of ecological status. In the current proof-of-concept study, we demonstrate...
Article
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Shore nourishments have been carried out worldwide for several decades and are nowadays seen as an almost routine coastal protection measure. However, the recent paradigm shift to an Integrated Coastal Zone Management (ICZM) and to an Ecosystem Approach to Management (EAM) requires new concepts, models and tools for the implementation of more susta...
Article
Micropollutants (MPs), especially endocrine disrupting compounds (EDCs), are mainly released from WWTPs into surface water bodies and can subsequently lead to adverse effects in biota. Treatment with ozone proved to be a suitable method for eliminating such MPs. This method was implemented at the WWTP Aachen-Soers by commissioning the largest full-...
Article
Environmental contaminants pose serious health threats to marine megafauna species, yet methods defining exposure threshold limits are lacking. Here a 3-pillar chemical risk assessment framework is presented, based on (1) species- and chemical-specific lifetime bioaccumulation modelling; (2) non-destructive in vitro and in vivo toxicity threshold a...
Article
While it is well recognized that the frequency and intensity of flood events are increasing worldwide, the environmental, economic, and societal consequences of remobilization and distribution of pollutants during flood events are not widely recognized. Loss of life, damage to infrastructure, and monetary cleanup costs associated with floods are im...
Article
Standardized laboratory tests with a limited number of model species are a key component of chemical risk assessments. These surrogate species cannot represent the entire diversity of native species, but there are practical and ethical objections against testing chemicals in a large variety of species. In previous research, we have developed a mult...
Article
In the last decade, mirtazapine has become an important antidepressant in clinical use and has also been found at many different environmental sampling sites. Several homologies between the zebrafish Danio rerio and humans, combined with a number of advantages for behavioural and gene expression research using zebrafish embryos, make their use for...
Article
Full-text available
Over the last two decades, effect-directed analysis (EDA) gained importance as a seminal screening tool for tracking biological effects of environmental organic micro-pollutants (MPs). As EDA using high-performance liquid chromatography and bioassays is costly and time consuming, recent implementations of this approach have combined high-performanc...
Article
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The increasing concern over bisphenol A (BPA) has directed much attention toward bisphenol F (BPF) and bisphenol S (BPS) as BPA alternatives for the development of “BPA-free” products. Consequently, BPS and BPF were frequently detected in surface water, sediment, sewage effluent, indoor dust, and even in food and biological fluids in humans. Thus,...
Article
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For decades, we have known that chemicals affect human and wildlife behavior. Moreover, due to recent technological and computational advances, scientists are now increasingly aware that a wide variety of contaminants and other environmental stressors adversely affect organismal behavior and subsequent ecological outcomes in terrestrial and aquatic...
Article
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In situ burning (ISB) is discussed to be one of the most suitable response strategies to combat oil spills in extreme conditions. After burning, a highly viscous and sticky residue is left and may over time pose a risk of exposing aquatic biota to toxic oil compounds. Scientific information about the impact of burn residues on the environment is sc...
Article
Green toxicology is a novel approach increasingly applied for the development of materials and chemicals that are more benign to the environment and human health than their conventional counterparts. It includes predictive eco-toxicological assessments of chemicals during the early developmental process to exclude adverse effects. In the present st...
Article
Full-text available
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the hazard assessment of ED effects on the thyroid system, regulatory decisions mostly rely on amphibian studies. Here, we used transcriptomics and proteomics for identifying molecula...
Article
Flooding and other sediment disturbances can lead to increases in sediment resuspension. In this context, it is of central importance to understand the kinetics of release from these sediments and the uptake of pollutants, such as polychlorinated biphenyls (PCBs) and polychlorinated dioxins and furans (PCDD/Fs), into aquatic organisms. In the prese...
Article
A novel active sampling method enabled determination of sediment depth profiles revealing the spatial distribution of model compounds N,N-dimethylsulfamide, fluopyram and bixafen (low, medium, high adsorption affinity) in sediment microcosms according to OECD Test 218/219 (Sediment-Water Chironomid Toxicity Test Using Spiked Sediment/Spiked Water)....
Preprint
Full-text available
Background Pesticides are washed from agricultural fields into adjacent streams where even short-term exposure causes long-term ecological damage. Detecting pesticide pollution in streams thus requires the expensive monitoring of peak concentrations during run-off events. Alternatively, exposure and ecological effects can be assessed using the SPEA...
Article
Full-text available
This special issue of STOTEN is dedicated to presenting the results of the WWF-Australia “Rivers to Reef to Turtles” project, which focused on investigating pollutants in the environment, food and bodies of green turtles (Chelonia mydas) on the Great Barrier Reef (GBR). The project brought together organic and inorganic trace chemical analysis, bio...
Article
Investigating environmental pollution is important to understand its impact on endangered species such as green turtles (Chelonia mydas). In this study, we investigated the accumulation and potential toxicity of selected persistent organic pollutants (POPs) and naturally occurring MeO-PBDEs in liver, fat, kidney and muscle of turtles (n=30) of diff...
Article
Full-text available
Although withdrawn from the market in the 1980s, polychlorinated biphenyls (PCBs) are still found ubiquitously in the aquatic environment and pose a serious risk to biota due to their teratogenic potential. In fish, early life-stages are often considered most sensitive with regard to their exposure to PCBs and other dioxin-like compounds. However,...
Article
This study presents a high-throughput (HTP) micronucleus assay in multi-well plates with an automated evaluation for risk assessment applications. The evaluation of genotoxicity via the micronucleus assays according to international guidelines ISO 21427-2 with Chinese hamster (Cricetulus griseus) V79 cells was the starting point to develop our meth...
Preprint
Full-text available
Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the hazard assessment of ED effects on the thyroid system, regulatory decisions mostly rely on amphibian studies. Here, we used transcriptomics and proteomics for identifying molecula...
Article
Full-text available
Tamara Grummt passed away on January 26, 2020 in Oelsnitz/Vogtland, Germany. Tamara was one of the scientific pioneers in the field of environmental toxicology, namely genotoxicity and hygiene of drinking and bathing waters. Her passing is not only a great loss to environmental research and to the global environmental toxicology community—we have l...
Article
Numerous environmental pollutants have the potential to accumulate in sediments, and among them are endocrine-disrupting chemicals (EDCs). It is well documented that water-borne exposure concentrations of some potent EDCs, more specifically estrogenic- active compounds (ECs), can impair the reproduction of fish. In contrast, little is known about t...
Article
Full-text available
Meeting ecological and water quality standards in lotic ecosystems is often failed due to multiple stressors. However, disentangling stressor effects and identifying relevant stressor-effect-relationships in complex environmental settings remain major challenges. By combining state-of-the-art methods from ecotoxicology and aquatic ecosystem analysi...
Article
Metabolism has to be considered during the toxicological assessment of chemical and environmental samples because it is an important process in the mammalian liver. It can be assessed in vitro via liver homogenates called S9-fractions, an external metabolic activation system. However, the external metabolic activation systems can vary greatly in th...
Article
Bioanalytical equivalents (BEQs) of mixtures and environmental samples are widely used to reflect the potential threat of pollutants in the environment and can be obtained by bioassays or using chemical analysis combined with relative potencies (REPs). In this study, the relationships between bioassay-detected BEQs (Bio-BEQs) and chemically analyze...
Article
To avoid potential risks of biofuels on the environment and human, ecotoxicity investigation should be integrated into the early design stage for promising biofuel candidates. In the present study, a green toxicology testing strategy combining experimental bioassays with in silico tools was established to investigate the potential ecotoxicity of bi...
Article
Full-text available
In this study, few different evaluation concepts were used for the assessment of genotoxic potential at the stretch of the Danube River identified as a significant hotspot of pollution originated through the untreated wastewaters. Three sites were chosen: one site upstream of the wastewater outlet in Novi Sad (Serbia), one at the outlet of wastewat...
Article
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In vitro assessment of genotoxicity as an early warning tool for carcinogenicity mainly relies on recording cytogenetic damages (micronuclei, nucleoplasmic bridges) in tumour-derived mammalian cell lines like V79 or CHO. The forecasting power of the corresponding standardised test is based on epidemiological evidence between micronuclei frequencies...
Article
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In biological systems (cell culture media, cells, body fluids), drugs/toxicants are usually not freely dissolved but partially bound to biomolecules; only a fraction of the chemical is free/unbound (fu). To predict pharmacological effects and toxicity, it is important that the fu of the drug is known. As the differences between free and nominal con...
Article
Many environmental pollutants pose a toxicological hazard only after metabolic activation. In vitro bioassays using cell lines or bacteria have often no or reduced metabolic activity, which impedes their use in the risk assessment. To improve the predictive capability of in vitro assays, external metabolization systems like the liver S9 fraction ar...
Article
Wastewater-based monitoring of the spread of the new SARS-CoV-2 virus, also referred to as wastewater-based epidemiology (WBE), has been suggested as a tool to support epidemiology. An extensive sampling campaign, including nine municipal wastewater treatment plants, has been conducted in different cities of the Federal State of North Rhine-Westpha...
Article
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The Partnership for Chemicals Risk Assessment (PARC) is currently under development as a joint research and innovation programme to strengthen the scientific basis for chemical risk assessment in the EU. The plan is to bring chemical risk assessors and managers together with scientists to accelerate method development and the production of necessar...
Article
Fish strongly rely on olfaction as a variety of essential behaviors such as foraging and predator avoidance are mediated by the olfactory system. Cadmium (Cd) is known to impair olfaction and accumulate in the olfactory epithelium (OE) and bulb (OB) of fishes. In the present study, the acute toxicity of Cd on olfaction in zebrafish (Danio rerio) wa...
Poster
Full-text available
Currently, the pollution of surface water with micropollutants (MP) is one of the most crucial environmental problems. The inability of wastewater treatment plants (WWTP) to remove these MPs has become a growing concern. Effluent discharges still contain hormone active substances, which have the potential to elicit adverse effects on aquatic organis...
Article
Full-text available
Genotoxicity assessment is of high relevance for crude and refined petroleum products, since oil compounds are known to cause DNA damage with severe consequences for aquatic biota as demonstrated in long-term monitoring studies. This study aimed at the optimization and evaluation of small-scale higher-throughput assays (Ames fluctuation, micronucle...
Article
In vitro bioassays have been used as a bioanalytical means of detecting dioxin-like compounds (DLCs) in environmental matrices and have been suggested as a tool for quantifying DLCs in sediments. The present study evaluated the relationship between bioanalytical results from the micro-7-ethoxyresorufin-O-deethylase (EROD) bioassay and chemical anal...
Article
Full-text available
Background While a dam is constructed to adjust and store water resources, it has negative impacts on biodiversity of the corresponding ecosystems. In particular, the dam regulation induces water-level fluctuations (WLFs), resulting in remarkable effects on the riparian vegetation succession of the drawdown zone ecosystem. These riparian plant resp...
Chapter
Sediments are a major issue for many scientists and authorities due to their close linkage to the aquatic food web and their potential to accumulate pollutants. In the present chapter, the method of exposure of zebrafish embryos to native sediment samples is described. Such exposure provides an ecologically highly relevant and realistic scenario wh...
Article
Full-text available