Hendrik Napierala

Hendrik Napierala
Charité Universitätsmedizin Berlin | Charité · Institute of General Practice

Dr. med.

About

26
Publications
2,188
Reads
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144
Citations
Citations since 2016
18 Research Items
144 Citations
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2016201720182019202020212022051015202530
Introduction
Hendrik Napierala is a physician and works as a postdoctoral researcher in the institute of General Practice. He is currently pursuing a postgraduate degree in Medical Biometry and Biostatistics. His research interests lie in the area of intersectoral collaboration, continuity of care and digitalization in primary care with a strong focus on quantitative methods.
Additional affiliations
April 2019 - March 2020
Charité Universitätsmedizin Berlin
Position
  • Medical Doctor
Education
October 2020 - September 2022
Universität Heidelberg
Field of study
  • Medical Biometry/Biostatistics
October 2014 - November 2019
FernUniversität in Hagen
Field of study
  • Political Sciences, Public Administration and Sociology
April 2012 - December 2018

Publications

Publications (26)
Article
Full-text available
Im Mai 2022 konnte weltweit ein Anstieg von Affenpockeninfektionen beobachtet werden, und allein in Deutschland gab es bis zum 18.10.2022 insgesamt 3 656 registrierte Fälle (1). Der Infektionsweg verschob sich dabei von reiseassoziierten Fällen zu einer autochthonen Übertragung (2). Erste Veröffentlichungen zu bestätigten Affenpockeninfektionen zei...
Article
Full-text available
Background Due to the increasing use of online health information, symptom checkers have been developed to provide an individualized assessment of health complaints and provide potential diagnoses and an urgency estimation. It is assumed that they support patient empowerment and have a positive impact on patient-physician interaction and satisfacti...
Article
Full-text available
Introduction: Social prescribing (SP) aims to provide targeted psychosocial support and close the gap between medical and non-medical services. This review assesses the effectiveness of community-based SP interventions. Methods: We performed a systematic review and qualitative synthesis of interventional studies of community referral interventio...
Preprint
Background: While reporting of individual conflicts of interest is formalized, it is currently unclear to what extent the funding is reported in clinical practice guidelines (CPGs). The aim of this study therefore was to explore the quality of reporting on funding in German CPGs. Methods: We searched for available CPGs in the registry of the Associ...
Article
Full-text available
Purpose Artificial organs might serve as alternative solutions for whole organ transplantation. Decellularization of a liver provides a non-immunogenic matrix with the advantage of three afferent systems, the portal vein, the hepatic artery and the bile duct. This study aims to evaluate the recellularization of rat livers with islets of Langerhans...
Article
Full-text available
Background Digital health applications (DiGA) can be reimbursed by the statutory health insurance as an „app on prescription“ since the Digital Health Care Act (DVG) came into force. Currently, it is unclear how family physicians should be actively involved in the use of DiGAs in order to increase the health literacy of their patients, but at the s...
Article
Full-text available
Background Many patients suffering from peripheral arterial disease (PAD) are dependent on bypass surgery. However, in some patients no suitable replacements (i.e. autologous or prosthetic bypass grafts) are available. Advances have been made to develop autologous tissue engineered vascular grafts (TEVG) using endothelial colony forming cells (ECFC...
Article
Islet-based recellularization of decellularized, repurposed rat livers may form a transplantable Neo-Pancreas. The aim of this study is the establishment of the necessary protocols, the evaluation of the organ structure and the analysis of the islet functionality ex vivo. After perfusion-based decellularization of rat livers, matrices were repopula...
Article
Full-text available
Background The reliability of clinical practice guidelines has been disputed because guideline panel members are often burdened with financial conflicts of interest (COI). Current recommendations for COI regulation advise not only detailed declaration but also active management of conflicts. To continuously assess COI declaration and management in...
Article
Full-text available
Decellularization of pancreata and repopulation of these non-immunogenic matrices with islets and endothelial cells could provide transplantable, endocrine Neo- Pancreata. In this study, rat pancreata were perfusion decellularized and repopulated with intact islets, comparing three perfusion routes (Artery, Portal Vein, Pancreatic Duct). Decellular...
Article
Decellularization of livers is a well-established procedure. Data on different reseeding techniques or the functional evolution and re-organization processes of repopulated grafts remains limited. We established a proprietary, customized bioreactor to repopulate decellularized rat livers (n = 21) with primary rat hepatocytes (150 x 106 cells) via t...
Article
Full-text available
Background: Extrahepatic bile duct injuries remain severe complications during cholecystectomies and often require reconstruction by bilioenteric anastomosis (i.e., hepaticojejunostomy), which comes with further long-term complications (e.g., recurring ascending cholangitis, secondary biliary cirrhosis). In the case of inherent extrahepatic biliar...
Article
Primary human hepatocytes are widely used for basic research, pharmaceutical testing, and therapeutic concepts in regenerative medicine. Human hepatocytes can be isolated from resected liver tissue. Preoperative portal vein embolization (PVE) is increasingly used to decrease the risk of delayed postoperative liver regeneration by induction of selec...
Article
Full-text available
Decellularization and recellularization of parenchymal organs may enable the generation of functional organs in vitro, and several protocols for rodent liver decellularization have already been published. We aimed to improve the decellularization process by construction of a proprietary perfusion device enabling selective perfusion via the portal v...
Conference Paper
Introduction: A cell based treatment for type 1 diabetes can significantly reduce the occurence of life-threatening complications, like hypoglycemic episodes, and progression of diesease-associated co-morbidities. Islet cell transplantation is able to achieve insulin independence in 40 – 60% of cases. But unfortunately graft-site-specific issues st...
Conference Paper
Introduction: Repopulation of decellularized pancreas extracellular matrices (dPECMs) with islets offers the possibility to generatefunctional endocrine pancreata. Transplantation of these in vitro engineered organs implicates several advantages compared to conventional pancreas or islet transplantation like e.g. prevention of post-transplantation...
Conference Paper
Full-text available
Issue/problem Pharmaceutical pricing is a key issue in public health. A commonly used pricing policy is external reference pricing (ERP), which links pharmaceutical prices to prices in selected other countries. A well-studied effect of ERP is that price reductions in one country result in price reductions in all those countries which use this coun...

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Projects

Projects (4)
Project
The aim of the SPI_RE project is to examine intervention studies on "social prescribing" with regard to effectiveness on health and/or quality of life by means of a systematic literature review of the current state of studies.
Project
The project aims to assess the impact of DiGA on primary care provision.
Project
The aim of the SPI_RE project is to examine intervention studies on "social prescribing" with regard to effectiveness on health and/or quality of life by means of a systematic literature review of the current state of studies.