Hemant Gangurde

• Principal Professor at Abasaheb Kakade College of B. Pharmacy Bodhegaon

Folk remedies made from butterfly pea (Clitoria ternated Linn) are utilised. The seeds and roots are used as laxatives and digestive aids. The leaves and roots are used as anthelnustic, an antidote to animal sings, and a therapy for urogenital diseases. Butterfly pea flowers contain anthocyanins. Plant pigments called anthocyanins are what give pla...

Millets are a major food source in arid and semiarid parts of the world. Millet are drought tolerant crops. Extensively grown in Asia and semi-arid tropic of Africa. They provide protein, fatty acid, minerals, vitamin, dietary fibre and polyphenol. Typical millets protein contain high quantity of essential amino acid especially, the sulphur contain...

FORMULATION AND ASSESSMENT OF A NOVEL HERBAL CREAM FOR EYEBROW GROWTH ENHANCEMENT

This paper discusses the development of a directly compressible co-processed excipient by spray drying. The study investigates the use of spray drying as a method to co-process excipients with different functionalities, such as fillers and binders, into a single powder blend with improved tableting properties. The excipient was characterized for it...

Diabetes is the chronic condition occurs due to incapability of pancreas to synthesis insulin to metabolises excessive sugar present from daily food. Some factors also affect on diabetes occurrence like environmental, genetic, stress, insulin resistance, obesity. As per International Diabetes Federation (IDF), 387 million people worldwide were diag...

The drug delivery system is most important and preferable drug delivery system. This route has high patient acceptability, primarily due to easy of administration. Effective oral drug delivery depends upon the factors such as gastric emptying process, the gastrointestinal transit time of the dosage form drug release from the dosage form, and site o...

This research paper explains the isolation of gum from the seeds of Samanea saman . Mucoadhesive tablets of Valsartan were formulated using novel gum of Samanea saman as a mucoadhesive polymer and Instamodel 41 as a release retardant. The formulation parameters like the concentration of Samanea saman gum and Instamodel 41 were optimized by using de...

The present study is an effort to enhance solubility and to formulate and optimized BCS class II antihypertensive drug Nebivolol HCl a selective β1 blocker. Solid dispersions with binary and ternary ratios of drug: carrier: surfactant was developed by solvent evaporation method. Results confirmed solid dispersion comprising Nebivolol HCl: Poloxamer...

This article will give complete overview on recent development in co-process excipient technology and approaches involved in its development. The co-processed excipients help to overcome deficiencies occurring with use of single general grade excipients. Formulation scientist recognized that the single component excipient cannot always provide the...

Technological advancements have developed several novel approaches for the delivery of various types of drugs that could revolutionize the methods of medication and provide a number of therapeutic benefits. Oral controlled drug delivery forms a crucial facet among novel drug delivery systems. Rational approach to enhance bioavailability and improve...

Lot of research is undergoing in colon specific drug delivery as this drug delivery route is not only useful for targeting the drugs required in the treatment of diseases associated with colon, but also as a potential site for the local and systemic delivery of peptide and proteins and other therapeutic drugs. Precise colon drug delivery requires t...

Gastroretentive drug delivery systems (GRDDS) can overcome drawbacks associated with oral drug delivery, by defeating natural physiological principles. Various gastroretentive technologies have been developed in the past, but few of them achieved commercial success. Numerous mechanisms like floating, sinking, effervescence, swelling, bioadhesion, m...

The whole plant of Hydrolea zeylanica (HZ) (Hydrophyllaceae family) was coarsely powdered and extracted with ethanol using soxhlet apparatus. The ethanol extract was then fractionated successively using various polarity ranges of solvents and screened for in-vivo antidiabetic activity using streptozotocin induced diabetic male wistar rats. The phyt...

The effects of fractions of Hydrolea zeylanica (HZ) on ulcer was evaluated using pyloric ligation (PL) model in rats. PL is known to damage gastric mucosa, interferes with gastric mucosal resistance and alters the level of cytoprotective mediators and calcium level, which in turn stimulates free radical generation, acid secretion and causes tissue...

The present study is an attempt to design and optimize mesalamine loaded pulsatile release pH sensitive coated pellets for ileo-cecal targeted pulsatile drug delivery. The novelty of this formulation is to release drug specifically and instantly in ileo-cecal region without being released in upper gastrointestinal tract. Preliminary experimental ba...

A novel Propafenone HCl gastric-resident tablet was developed. A controlled release matrix tablet was prepared by using various controlled release polymers i.e. HPMC E5 and HPMC K100M. Pharmaceutical zinc oxide powder was used as a density-increasing agent. The formulations were evaluated for pharmacopoeial quality control tests and all the physica...

Targeting drug delivery into the lungs has become one of the most important aspects of systemic or local drug delivery. Consequently, in the last few years, techniques and new drug delivery devices intended to deliver drugs into the lungs have been widely developed. Currently, the main drug targeting regimens include direct application of a drug in...

India is gifted with great abundant variety of flora and fauna. Today, the whole world is increasingly interested in natural drugs and excipients. Natural materials have advantages over synthetic materials because they are non-toxic, less expensive and freely available. Various gums like gelatin, acacia, alginic acid, guar gum, maize starch, and po...

Swine influenza (SI) is a respiratory disease of pigs caused by type A influenza that regularly causes pandemics. SI viruses do not normally infect humans; however, human infections with SI do occur, and cases of human-to-human spread of swine flu viruses have been documented. Swine influenza also called as swine flu, hog flu, and pig flu that refe...

Peptide and protein drugs are increasingly becoming a very important class of therapeutic agents as a result of gaining more information of their role in pathophysiology, and the rapid advances in the field of pharmacy and biotechnology. Most pharmaceutical peptides and protein are currently formulated as solution or suspensions and delivered by in...

The main aim of this study was to develop a gastroretentive, multiple-unit floating drug delivery system for a drug which is poorly absorbed from the lower gastrointestinal tract. Such a dosage form may provide an extended retention of drug in the upper gastrointestinal tract resulting in enhanced absorption and improved bioavailability. Microspher...

The objective of this study was to investigate the influence of type of cross-linking method used on the properties of ambroxol hydrochloride microspheres such as encapsulation efficiency, particle size, and drug release. Microspheres were prepared by solvent evaporation technique using chitosan as a matrix-forming agent and cross-linked using form...

Floating Drug delivery system are designed to prolong the gastric residence time after oral administration, at particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. In recent years scientific and technological advancements have been made in the research and...

The effects of petroleum ether, chloroform, hexane, ethyl acetate and ethanol extracts of leaves of Butea monosperma were evaluated for its in vitro anti inflammatory activity by using HRBC membrane stabilizing method and diclofenac sodium was used as standard. All the data (mean + SEM) were evaluated by student "t" test and the probability was det...

The preliminary phytochemical screening was carried out on the crude extracts of the leaves of Butea Monosperma Lam along with ash values and extractive values on the powdered drug. The crude extracts were investigated for their anthelmintic activity against earthworms (Pheretima posthuma), roundworms (Ascardia galli.) and tapeworms (Raillietina sp...

In the present research an attempt has been made to develop antipsoriatic cream using combination of herbs like neem, sarsaparilla, bakuchi and daruhaldi. Psoriasis is an inflammatory disease of skin characterized by well defined erythematous plaque with large adherent silvery scales. Colonization and infection with S. aureus has been reported to e...

The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and also due to hypersecretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. The marketed polyherbal formulation (PHF) has been used for the treatment of gastrointestinal disorders. I...