Hemalatha Sasidharakurup

Amrita Vishwa Vidyapeetham | AMRITA · School of Biotechnology

Biological systems are complex dynamical systems that include a diverse range of biomolecular species, as well as their interactions and interconnections. Subcellular systems are even more complicated due to the complex biomolecular interactions such as cross-talks, feedback mechanisms, bifurcations and so on that define the overall system’s behavi...

Systems biology modelling helps to develop large complex biochemical pathways of disease networks including biochemical components and the interactions towards a multi-scale understanding of complex diseases. Mathematical modelling with the applications of biochemical systems theory using time-dependent ordinary differential equations and reaction...

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a systemic disease affecting not only the lungs but also multiple organ systems. Clinical studies implicate that SARS-CoV-2 infection causes imbalance of cellular homeostasis and immune response that trigger cytokine storm, oxidat...

The application of systems theory to complex biological systems helps to rebuild complex biochemical reactions to study interactions between small biomolecules and how their dysfunctions lead to Parkinson’s disease (PD) and other complex diseases. Modeling of cellular pathways using biochemical system theory helps to reconstruct the biochemical rea...

Computational and mathematical modelling towards understanding the structure and dynamics of biological systems has significantly impacted on translational neuroscience to face novel approaches toward neurological disorders such as Alzheimer’s (AD) and Parkinson’s disease (PD). In this study, a computational model of AD and PD have been modelled us...

The paper aims developing a computational framework of signaling using the principles of biochemical systems theory as a model for Parkinson’s disease. Several molecular interactions aided by TNFα, a proinflammatory cytokine play key roles in mediating glutamate excitotoxicity and neuroinflammation, resulting in neuronal cell death. In this paper,...

Computational modeling has significantly impacted clinical assessment and treatment of diseases by improving diagnosis, prognosis, discovery of novel biomarkers and developing new drugs that assures treatment for incurable diseases. In this study, a biochemical systems theory model was developed to explore crucial pathways involved in shared mechan...

Information and Communication Technology (ICT)-enabled virtual laboratories provide an online learning experience with the aid of computer-based instructional materials (animation, simulation, and remote-trigger experiments) for improving the active learning process. The project reported on in this chapter was set up in order to enhance university...

Parkinson's disease (PD), a neurodegenerative disorder, affects millions of people and has gained attention because of its clinical roles affecting behaviors related to motor and nonmotor symptoms. Although studies on PD from various aspects are becoming popular, few rely on predictive systems modeling approaches. Using Biochemical Systems Theory (...

Figure S1 TA binds to the ATP binding domain of tyrosine kinases. The molecular docking study was done to different tyrosine kinases. The ATP binding domain of the receptors was docked with the ligand, TA using the autodock vina platform. (A) TA binding with Insulin receptor (IR, PDB ID for the molecule, 1IRK). (B) TA binding to the IGF?1R (IDB ID:...

Recent studies have indicated the additional role of cerebellum beyond motor coordination non-motor and socio-cognitive tasks. Exploration of cerebellar roles in timing and plasticity have been attributed specific roles in neurological conditions such as ataxia, severe disorders such as Parkinson's and epilepsy. Cerebellar dysfunctions elaborate th...

Tannic acid (TA), a naturally occurring polyphenol, is a potent anti-oxidant with anti-proliferative effects on multiple cancers. However, its ability to modulate gene-specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism of TA to regulate canonical and non-canonical STAT pathways t...

ICT-enabled virtual and remote labs have become a platform augmenting user engagement in blended education scenarios enhancing University education in rural India. A novel trend is the use of remote laboratories as learning and teaching tools in classrooms and elsewhere. This paper reports case studies based on our deployment of 20 web-based virtua...

With recent trends of using Information and Communication Technologies in education, virtual labs have become more prevalent in classrooms of most schools and universities, especially in South India. The purpose of this paper was to perform a comparative analysis of virtual learning components such as animations, simulations and real-time remotely...

In this paper, we implemented a virtual laboratory of neurons and synapses via dynamical models on a web-based platform to aid neurophysiology and computational neuroscience education. Online labs are one of the best alternatives to many universities confronting socio-economic issues in maintaining infrastructure for good laboratory practice. The n...

Blended learning has been popularized in many universities in the last decade due to the rapid advances in computer technologies and relative increase in the usage of internet connectivity. A major constraint in providing high quality laboratory resources in some universities and in economically challenged countries is high costs, training personne...

With recent advances in ICT, virtual and remote laboratories have become ubiquitous as a complementary tool allowing student users to access a mobile platform and utilize real-time shared equipment over the internet. In this paper, we explore the role of biotechnology remotely controlled labs in augmenting student education via allowing real time s...

Virtual labs are popularized as a visual education tool that offers diverse analysis of experiments through different components like graphics mediated animations, mathematically modeled simulations, user-interactive emulations, remote-triggered experiments and the use of augmented perception haptic devices. With the advances in ICT-based education...

With recent trends of using Information and Communication Technologies in education, virtual labs have become more prevalent in classrooms of most schools and universities, especially in South India. The purpose of this paper was to perform a comparative analysis of virtual learning components such as animations, simulations and real-time remotely...

Virtual laboratories, an ICT-based initiative, is a new venture that is becoming more prevalent in universities for improving classroom education. With geographically remote and economically constrained institutes in India as the focus, we developed web-based virtual labs for virtualizing the wet-lab techniques and experiments with the aid of graph...

Virtual laboratories are ICT tools that are becoming more prevalent in classroom education complementing the lack of resources or tutors while enabling anytime-anywhere student participation scenarios. Specifically disciplines such as biotechnology, which are interaction rich, have seen several types of virtual labs. In this paper, we explore an an...

With the world wide acceptance of virtual educational technologies, it has been shown that they play a vital role in the scientific arena. The purpose of this paper was to analyze the role of Biotechnology virtual laboratories in integrating student’s learning ability and introducing it as an effective instructional tool in biotechnology courses. A...

Information and Communication Technology (ICT)-enabled virtual laboratories provide an online learning experience with the aid of computer-based instructional materials (animation, simulation, and remote-trigger experiments) for improving the active learning process. The project reported on in this chapter was set up in order to enhance university...

Information and Communication Technology (ICT)-enabled virtual laboratories provide an online learning experience with the aid of computer-based instructional materials (animation, simulation, and remote-trigger experiments) for improving the active learning process. The project reported on in this chapter was set up in order to enhance university...