Hellen Weinschutz Mendes

Hellen Weinschutz Mendes
Yale University | YU · Child Study Center

Phd
Postdoc Associate

About

37
Publications
2,216
Reads
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249
Citations
Additional affiliations
September 2015 - present
University of Ottawa
Position
  • PhD Student
January 2013 - February 2015
Universidade Federal do Paraná
Position
  • Master's Student
June 2012 - January 2013
Universidade Federal do Paraná
Position
  • Research Assistant

Publications

Publications (37)
Article
Full-text available
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past or present HBV infection is unknown. We used sequencing and multiplex sequence-specific PCR to ge...
Article
Full-text available
Dysfunctions in the GABAergic system lead to various pathological conditions and impaired inhibitory function is one of the causes behind neuropathies characterized by neuronal hyper excitability. The Dlx homeobox genes are involved in the development of nervous system , neural crest, branchial arches and developing appendages. Dlx genes also take...
Article
Full-text available
Background Deposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement. Three proteins of the lectin pathway are produced from the gene MASP1: Mannan-binding lectin-associated serine protease 1 (MASP-1) and MASP-3 and mannan-binding lectin-associated protein o...
Article
Full-text available
Background: MBL-associated serine proteases (MASP-1, MASP-2, MASP-3, MAp-44, and MAp-19) are key factors in the activation of the lectin pathway of complement. Serum levels of these components have been associated with recurrence and poor survival of some types of cancer, such as colorectal and ovarian cancer. In this investigation, we determined t...
Article
Full-text available
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens for phagocytosis and induces the adaptive immune response. The lectin pathway is constituted by s...
Article
Full-text available
Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 59-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE p...
Article
Full-text available
Objective: To evaluate serum concentrations of mannose binding lectin (MBL) in women presenting with different human papilloma virus (HPV)-associated cervical lesions. Subjects and methods: A total of 364 women, who underwent screening for cervical cancer or treatment at Erasto Gaertner Cancer Hospital (HEG), Curitiba, Southern region, Brazil, w...
Article
Lineage tracing of specific populations of progenitor cells provides crucial information about developmental programs. Four members of the Dlx homeobox gene family, Dlx1,2, 5 and 6, are involved in the specification of γ-aminobutyric acid (GABA)ergic neurons in the vertebrate forebrain. Orthologous genes in mammals and teleost show similarities in...
Article
Full-text available
Spiders of the Loxosceles genus are cosmopolitan, and their venom components possess remarkable biological properties associated with their ability to act upon different molecules and receptors. Accidents with Loxosceles intermedia specimens are recognized as a public health problem in the south of Brazil. To describe the transcriptional profile of...

Questions

Question (1)
Question
Are there any suggestions on intraperitoneal injection to induce the recombination of CreERT2 in adult zebrafish using corn oil? Has anybody been successful? What is the concentration/final volume used for injection? Has anyone used canola oil?

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