Helene Banoun

Helene Banoun
French Institute of Health and Medical Research | Inserm · Gustave Roussy

PhD
Independent researcher https://twitter.com/BanounHelene

About

54
Publications
56,674
Reads
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602
Citations
Introduction
I've been thinking about immunology for several years now, especially concerning viral infections. And also on the implications of the theory of evolution in the field of immunology.
Skills and Expertise
Additional affiliations
September 1982 - October 1986
French Institute of Health and Medical Research
Position
  • charge de recherches

Publications

Publications (54)
Conference Paper
Full-text available
Résumé Les enfants sont moins susceptibles à la COVID-19 que les adultes : ils font souvent des formes asymptomatiques et très rarement des formes sévères. Cette protection est valable pour tous les variants du virus. Il s'agit ici de comparer la réaction immunitaire des enfants avec celle des adultes mais aussi celle des adultes asymptomatiques ou...
Article
Full-text available
Antibody-dependent enhancement (ADE) is an inadequate response to reinfection or vaccination. ADE was de- scribed for influenza and dengue fever: patients already exposed are likely to develop a more severe infection when exposed to a virus of another type than the first. Vaccine antibodies also appear to be responsible for an increased risk of sev...
Article
Full-text available
La facilitation dépendante des anticorps (ADE) est une réponse inadéquate à la réinfection ou à la vaccination. L'ADE a été décrite pour la grippe et la dengue : les patients déjà exposés sont susceptibles de développer une infection plus sévère lorsqu'ils sont exposés à un virus d'un autre type que le premier. Les anticorps vaccinaux semblent égal...
Preprint
Full-text available
The non-natural origin of SARS-CoV-2 has been raised and discussed for the past 2 years. It is important to discuss it to understand the inflection of biopolitics since the 2000s. In addition, structural features of the virus, new compared to other known coronaviruses, may explain some aspects of the Covid-19 clinic and therapy. SARS-CoV-2 is the o...
Preprint
Full-text available
L’origine non naturelle du SARS-CoV-2 a été évoquée et discutée depuis 2 ans. Il est important d’en parler pour comprendre l'inflexion de la biopolitique depuis les années 2000. De plus, des caractéristiques structurales du virus, nouvelles par rapport aux autres coronavirus connus, peuvent expliquer certains aspects de la clinique et de la thérape...
Presentation
Full-text available
Origins of SARS-CoV-2 Helene Banoun International Covid Summit, Marseille France Simultaneous translation https://www.bitchute.com/video/9f2hnef8xm6S/ French version https://crowdbunker.com/v/6GQSaZ41 (1h46’38’’) March 30, 2022
Preprint
Full-text available
Résumé Deux publications récentes ont fait beaucoup de bruit car elles laissent penser que la rétrotranscription de l'ARN viral ou vaccinal et son intégration dans le génome humain ne sont pas totalement impossibles. La transformation (rétrotranscription) de l'ARN en ADN a été reconnue comme possible dès 1956 par Francis Crick et a été prouvée il y...
Preprint
Full-text available
Abstract Knowing the origin of SARS-CoV-2 is important for understanding the inflection of biopolitics since the 2000s. In addition, the structural characteristics of the virus explain some aspects of the clinic and therapy. SARS-CoV-2 is the only human pathogenic coronavirus to possess a polybasic furin cleavage site and a human ACE2 binding site,...
Preprint
Full-text available
Résumé L'origine du virus de la Covid-19 Il est important de connaître l'origine du SARS-CoV-2 pour comprendre l'inflexion de la biopolitique depuis les années 2000. De plus, les caractéristiques structurales du virus expliquent certains aspects de la clinique et de la thérapeutique. Le SARS-CoV-2 est le seul parmi les coronavirus pathogènes pour l...
Preprint
Full-text available
Résumé Devant la menace d'un pass vaccinal en France et donc d'une obligation déguisée nombreux sont ceux qui attendent pour se soumettre à l'obligation l'arrivée des vaccins à virus inactivés qui seraient considérés comme plus classiques que les vaccins à ARNm. Sans discuter de l'intérêt actuel des vaccins Covid en général1, voici les données disp...
Preprint
Full-text available
Un « Projet de loi renforçant les outils de gestion de la crise sanitaire NOR : PRMX2138186L/Rose-1 » sera déposé début janvier 2022 devant le parlement français. Il s'agit d'établir un passe vaccinal à la place du pass sanitaire. L'exposé des motifs est critiquable scientifiquement. Ce projet repose sur la supposée explosion des « cas » : ces cas...
Preprint
Full-text available
It is important to evaluate natural immunity against Covid-19: it is stronger, longer lasting and of better quality than vaccine immunity Only humoral (antibody) or cellular adaptive immunity can be assessed; innate immunity is not measurable. Serology is the only routine test, it is the measurement of the antibody level. The measurement of the a...
Preprint
Full-text available
Il est important d'évaluer l'immunité naturelle contre la Covid-19 : elle est plus solide, plus durable et de meilleure qualité que l'immunité vaccinale Seule l'immunité adaptative humorale (anticorps) ou cellulaire peut être évaluée ; l'immunité innée n'est pas mesurable. La sérologie est seule pratiquée en routine, c'est la mesure du taux d'antic...
Preprint
Full-text available
It should not be necessary to write an article to demonstrate the superiority of natural immunity over vaccine immunity, but it is necessary in view of the many underhanded attacks that tend to make artificial immunity seem more effective. Furthermore, it is officially recommended to vaccinate people who have already been infected with Covid-19. Su...
Preprint
Full-text available
Il devrait être inutile d'écrire un article pour démontrer la supériorité de l'immunité naturelle sur la vaccinale, mais cela devient nécessaire devant les nombreuses attaques sournoises qui tendent à faire passer l'immunité artificielle comme plus performante. De plus il est officiellement recommandé de vacciner les personnes qui ont déjà été infe...
Article
A growing body of evidence indicates that neutrophil elastase (NE) is involved in the pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to analyze the dynamic changes in serum levels of NE associated with inflammation, disease activity, and mortality rate in patie...
Preprint
Full-text available
Les vaccins Pfizer et Moderna viennent d'être autorisés en Europe pour les enfants à partir de 12 ans. L'EMA (Agence Européenne du Médicament) ne semble pas avoir la même appréciation que la FDA (Food and Drug Administration, USA) qui n'a pas autorisé Moderna aux USA. L'EMA et la FDA ne publient pas les mêmes chiffres bruts concernant l'efficacité...
Preprint
Full-text available
Pfizer and Moderna vaccines just approved in Europe for children 12 years and older The EMA does not seem to have the same assessment as the FDA, which did not approve Moderna in the US. The EMA and the FDA do not publish the same raw numbers regarding the effectiveness of the Pfizer vaccine. Looking closely at the FDA data from the adolescent tria...
Article
Full-text available
The phenomenon of facilitation of viral infections by antibodies (ADE antibody dependent enhancement) as well as the resistance of agammaglobulinemia patients to certain viruses are in contradiction with the protective role of antibodies affirmed by classical immunology. This must be compared to the opsonizing antibodies that promote the specific p...
Conference Paper
Full-text available
Abstract Since the reporting of the first cases of coronavirus in China and the publication of the first sequence of SARS-CoV-2 in December 2019, the virus has undergone numerous mutations. In Europe, the spring outbreak (March–April) was followed by a drop in the number of cases and deaths. The disease may have evolved into a milder form. The incr...
Poster
Full-text available
About Evolution of SARS-CoV-2: review of mutations, role of the host immune system Banoun H, Nephron (2020) https://www.karger.com/Article/Abstract/515417 https://doi.org/10.1159/000515417 This article is part of Karger Editions COVID-19 topic article package (http://www.karger.com/Tap/Home/278492), where all articles are freely accessible. http...
Article
Full-text available
Since the reporting of the first cases of coronavirus in China and the publication of the first sequence of SARS-CoV-2 in December 2019, the virus has undergone numerous mutations. In Europe, the spring outbreak (March–April) was followed by a drop in the number of cases and deaths. The disease may have evolved into a milder form. The increase in P...
Preprint
Full-text available
J. et al. Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. Nat Med 27, 620-621 (2021). https://doi. This publication by Pfizer employees attempts to show that the antibodies of people vaccinated with Pfizer's anti-Covid-19 vaccine are effective against the UK (B.1.1.7) and SA (B.1.351) v...
Preprint
The phenomenon of facilitation of viral infections by antibodies (ADE antibody dependent enhancement) as well as the resistance of agammaglobulinemia patients to certain viruses are in contradiction with the protective role of antibodies affirmed by classical immunology. This must be compared to the opsonizing antibodies that promote the specific p...
Preprint
Full-text available
Le phénomène de facilitation des infections virales par les anticorps ainsi que la résistance des patients aγglobulinémiques à certains virus sont en contradiction avec le rôle protecteur des anticorps affirmé par l 'immunologie classique. Ceci doit être rapproché des anticorps opsonisants qui favorisent la phagocytose spécifique des bactéries extr...
Preprint
Full-text available
The phenomenon of facilitation of viral infections by antibodies (ADE antibody dependent enhancement) as well as the resistance of agammaglobulinemia patients to certain viruses are in contradiction with the protective role of antibodies affirmed by classical immunology. This must be compared to the opsonizing antibodies that promote the specific p...
Preprint
Full-text available
Le phénomène de facilitation des infections virales par les anticorps ainsi que la résistance des patients aγglobulinémiques à certains virus sont en contradiction avec le rôle protecteur des anticorps affirmé par l 'immunologie classique. Ceci doit être rapproché des anticorps opsonisants qui favorisent la phagocytose spécifique des bactéries extr...
Preprint
Full-text available
Since the reporting of the first cases of Covid-19 in China and the publication of the first sequence of SARS-Cov-2 in December 2019, the virus has undergone numerous mutations and the disease may have evolved into a milder form. The increase in PCR positive cases in late summer 2020 did not lead to the expected increase in hospitalizations, ICU ad...
Preprint
Full-text available
Dans un article datant de fin juin, j'essayais d'expliquer la perte de virulence apparente du SARS-CoV-2 par l'évolution du virus. Je rapporte ici les nouvelles observations qui viennent confirmer l'atténuation actuelle de la virulence du SARS-CoV-2. Je proposais que l'évolution du SARS-CoV-2 pouvait être mise en relation avec le système immunitair...
Preprint
Full-text available
In an article from the end of June, I tried to explain the apparent loss of virulence of SARS-CoV-2 by the evolution of the virus. I report here new observations that confirm the current attenuation of the virulence of SARS-CoV-2. I proposed that the evolution of CoV-2-SARSS can be related to the host immune system. This hypothesis was based on the...
Preprint
Full-text available
The low percentage of individuals in the population with symptomatic Covid-19 can be explained by cross-immunity with other coronaviruses. This phenomenon is based on cellular immunity. On the other hand, humoral immunity (antibody-mediated) could be partly responsible for some immunopathological phenomena. The balance between this beneficial cellu...
Preprint
Full-text available
Le faible pourcentage d'individus ayant développé une Covid-19 symptomatique dans la population peut s'expliquer par l'immunité croisée avec les autres coronavirus. Ce phénomène repose sur l'immunité cellulaire. L'immunité humorale (médiée par les anticorps) pourrait par contre être responsable en partie de certains phénomènes immunopathologiques....
Preprint
SUMMARY The low percentage of individuals in the population who developed symptomatic Covid-19 may be explained by cross-immunity with other coronaviruses. This phenomenon is based on cellular immunity. Humoral (antibody-mediated) immunity, on the other hand, may be partly responsible for some immunopathological phenomena. The balance between this...
Preprint
Full-text available
RÉSUMÉ Le faible pourcentage d'individus ayant développé une Covid-19 symptomatique dans la population peut s'expliquer par l'immunité croisée avec les autres coronavirus. Ce phénomène repose sur l'immunité cellulaire. L'immunité humorale (médiée par les anticorps) pourrait par contre être responsable en partie de certains phénomènes immunopatholog...
Preprint
Full-text available
ABSTRACT How can we explain the temporal evolution of the pandemic? An analysis of the curves of the epidemic at the late stage shows the evolution towards the benignity of the virus throughout the world. There is a prolonged increase in new cases with a steady decrease in severe cases and deaths. Cross-immunity with common cold coronaviruses has b...
Preprint
Full-text available
RÉSUMÉ Comment expliquer l'évolution temporelle de la pandémie ? Une analyse des courbes de l'épidémie au stade tardif montre dans le monde entier l'évolution vers la bénignité du virus. On observe une augmentation prolongée des nouveaux cas avec une baisse régulière des cas graves et des décès. Il a été suggéré une immunité croisée avec les corona...
Preprint
Full-text available
How can we explain the temporal evolution of the pandemic?The mutations in the viral RNA sequence observed in recent studies concern regions involvedin the interaction of the virus with cells of the host immune system. It therefore seems to be confirmed that the emerging virus has adapted to the host immune system by modifying its transmissibility...
Preprint
Full-text available
RÉSUMÉ Comment expliquer l'évolution temporelle de la pandémie ? Les mutations de la séquence de l'ARN viral observées dans de récentes études concernent des régions impliquées dans l'interaction du virus avec les cellules du système immunitaire de son hôte. Il semble donc se confirmer que le virus émergent s'est adapté au système immunitaire de so...
Conference Paper
Full-text available
Association pour l’Etude de l’Evolution Biologique (A.E.E.B) CafÉvol : thème Exobiologie 26 octobre Compte rendu des interventions de Robert Pascal Louis Le Sergeant d’Hendecourt . Par Hélène Banoun Intervention de Louis Le Sergeant d'Hendecourt « Généricités, astrochimie, contingences, paradoxe de Fermi » De l'astrochimie à l'astrobiologie I...
Article
Full-text available
Abstract How can we explain the temporal evolution of the pandemic? The mutations in the viral RNA sequence observed in recent studies concern regions involved in the interaction of the virus with cells of the host immune system. It therefore seems to be confirmed that the emerging virus has adapted to the host immune system by modifying its trans...
Article
Full-text available
The low percentage of individuals in the population with symptomatic Covid-19 can be explained by cross-immunity with other coronaviruses. This phenomenon is based on cellular immunity. On the other hand, humoral immunity (antibody-mediated) could be partly responsible for some immunopathological phenomena. The balance between this beneficial cellu...
Article
Full-text available
SUMMARY In an article from the end of June, I tried to explain the apparent loss of virulence of SARS- CoV-2 by the evolution of the virus. I report here new observations that confirm the current attenuation of the virulence of SARS- CoV-2. I proposed that the evolution of CoV-2-SARSS can be related to the host immune system. This hypothesis was ba...
Article
Full-text available
The phenomenon of facilitation of viral infections by antibodies (ADE antibody dependent enhancement) as well as the resistance of agammaglobulinemia patients to certain viruses are in contradiction with the protective role of antibodies affirmed by classical immunology. This must be compared to the opsonizing antibodies that promote the specific p...
Article
Oxazolopyridocarbazole derivatives (OPCd) are intercalating polycyclic molecules related to the anti-tumor drug 9-hydroxyellipticinium (Celiptium). From a pharmacological point of view, OPCd compounds are highly cytotoxic to malignant cultured cells but inactive or only weakly active against experimental tumors in vivo. Extensive physicochemical an...
Article
The possibility of introducing definite amounts of nonpermeant molecules into electropermeabilized living cells has been approached by quantifying the amounts of Lucifer Yellow (LY; a 457-Da highly fluorescent molecule) and Phytolacca americana (Pokeweed) antiviral protein (PAP; a 30,000-Da ribosome-inactivating protein) retained by the cells after...
Article
The ability of oxazolopyridocarbazole (OPC) derivatives to interact with DNA in living bacteria through reversible intercalation has been determined by using as probes their selective mutagenic effect on Salmonella typhimurium TA 1977 and TA 1537 as detected by frame-shift-1 reversion, the absence of intervention of the error-prone repair system on...
Article
Full-text available
As a general rule, ellipticine derivatives are mutagenic and intercalate into double-stranded nucleic acids. We have tested a new fluorescent ellipticine compound, 10[(1-carboxy-2-methylpropylidene)-amino]-9-hydroxy-2-methylell ipticinium (val-NMHE), for establishing the relationship between the amount of drug bound to nucleic acids in situ in Salm...
Article
Mit Aminosäuren (II) kondensiert (I) zu den Verbindungen (III), deren Ctotoxizität und Antitumor-Wirkun bestimmt werden.
Article
The fluorescence of the aliphatic (amino acido)-N2-methyl-9-hydroxyellipticinium (AA-NMHE) derivatives [Auclair, C., Voisin, E., Banoun, H., Bernardou, J., Meunier, B., & Paoletti, C. (1984) J. Med. Chem. 27, 1161-1166], namely, dehydroglycino-NMHE, dehydroalanino-NMHE, dehydrovalino-NMHE, and dehydroleucino-NMHE, has been characterized. The change...
Article
Aliphatic amino acids glycine, alanine, valine, and leucine were conjugated to the antitumor drug N2-methyl-9-hydroxyellipticinium (NMHE) through a peroxidase-catalyzed oxidation reaction. NMR studies of the adducts so obtained have indicated (i) that the amino acids were linked to NMHE between the nitrogen of their primary amine and the C-10 posit...
Article
Alkaline dimethylsulfoxide as a superoxide anion-generating system in association with cytochrome c as a superoxide anion-indicating scavenger has been used to develop a new assay for superoxide dismutase. The assay is sensitive (one unit of enzymatic activity is provided by 110 ng of purified copper-containing superoxide dismutase) and highly spec...

Questions

Question (1)
Question
Why is Researchgate stopping the "Covid-19" page as of March 14, 2022?
What is this date?

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Project (1)
Project
How to try to reinterpret certain observations in immunology in the light of the theory of evolution The accepted dogma is that the cells of the immune system are "programmed" to defend organisms against pathogens. This is not consistent with the theory of evolution: how could this programming have been selected at the cellular level? Could not the behaviour of these cells be explained more simply? They would seek to optimize their supply of nutrient resources.