Helen Friedrich

Helen Friedrich
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Helen verified their affiliation via an institutional email.
Verified
Helen verified their affiliation via an institutional email.
  • Bachelor of Science
  • Doctoral Student Medical Student at Brigham and Women's Hospital

About

9
Publications
2,115
Reads
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26
Citations
Introduction
Skills and Expertise
Current institution
Brigham and Women's Hospital
Current position
  • Doctoral Student Medical Student
Additional affiliations
April 2023 - present
Brigham and Women's Hospital
Position
  • Doctoral Student
Description
  • Doctoral Student at the Netstim Laboratory at the Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Harvard Medical School
Education
October 2019 - October 2025
University of Wuerzburg
Field of study
  • Translational Medicine
October 2019 - October 2025
University of Wuerzburg
Field of study
  • Medicine
February 2019 - July 2019
Vrije Universiteit Amsterdam
Field of study
  • Psychology

Publications

Publications (9)
Article
Full-text available
Deep Brain Stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific brain regions to treat brain disorders. Accurate reconstruction of electrode placement is crucial for treatment optimization. Several systems, such as Lead-DBS, have been developed to reconstruct DBS electrodes, and typically require expert u...
Preprint
Full-text available
Disorders of consciousness (DoC) are states of impaired arousal or awareness. Deep brain stimulation (DBS) is a potential treatment, but outcomes vary, possibly due to differences in patient characteristics, electrode placement, or stimulation of specific brain networks. We studied 40 patients with DoC who underwent DBS targeting the thalamic centr...
Preprint
Full-text available
Frontal-eyed species use a combination of conjugate and vergence eye movements, termed 3-D gaze, to scan their environment 1–3 . The neural circuits mediating conjugate gaze have been extensively characterized, but those governing vergence remain disproportionately obscure ⁴ . Here, we combine lesion and deep brain stimulation data from 67 humans a...
Article
Full-text available
Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson’s disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort of patients (N = 237 from five centers) to identify tracts associated with improvements in each of the...
Article
Full-text available
Background Disconjugate eye movements are essential for depth perception in frontal-eyed species, but their underlying neural substrates are largely unknown. Lesions in the midbrain can cause disconjugate eye movements. While vertically disconjugate eye movements have been linked to defective visuo-vestibular integration, the pathophysiology and ne...
Preprint
Full-text available
Background: Disconjugate eye movements play a crucial role in depth perception for frontal-eyed species. Midbrain lesions cause disconjugate eye movement deficits, such as skew deviation and hemi-seesaw nystagmus in the vertical plane or esodeviation and convergence-retraction nystagmus in the horizontal plane. While the former have been linked to...

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