Helani Hemamala Munasinghe

University of Sri Jayewardenepura · Department of Botany

Dharmasena WGBP, Silva ABG, Udugama SSTTA, Wijeyaratne SC, Munasinghe DHH 2024-Domestication potential, acute toxicity, and nutritional properties of a white strain of Pleurotus djamor Rumph. ex Fr. (Agaricales, Basidiomycota) from Sri Lanka. Abstract The industrial mushroom diversity in Sri Lanka lies within a narrow range; therefore, it is necess...

Pleurotus citrinopileatus is an edible mushroom industrially cultivated around the world. It has been recorded in tropical countries, but not in Sri Lanka. The objective of the present study was to optimise the industrial cultivation conditions of this mushroom that are suitable for cultivation in Sri Lanka. Rubber (Hevea) sawdust was used as the s...

Mikania cordata (wathu palu) is a plant which is traditionally used to treat wounds and its wound healing potential has been elucidated by scienti ic studies. The wound healing potential is due to the antimicrobial property of the plant and many studies have proven the antimicrobial potential of the plant. This antimicrobial property may be arising...

With the increasing world population, identifying additional food sources is crucial. Mushrooms have long been considered a nutraceutical and are consumed globally, including in Sri Lanka. Due to its abundant biodiversity, there is a significant potential for diverse wild edible mushrooms in Sri Lanka. However, the identification of these mushrooms...

Acetaminophen (paracetamol) is a commonly used analgesic Drug. The effect of continuous exposure to this drug on life span and the egg laying of Caenorhabditis elegans model organisms were observed in the present study. L1 larvae of N2(C. elegans wild type; Bristol isolate), CB1370daf-2 (a substitution mutant) and LT186sma-6(wk7) II (a null mutant)...

Acetaminophen (paracetamol) is a commonly used analgesic Drug. The effect of continuous exposure to this drug on life span and the egg laying of Caenorhabditis elegans model organisms were observed in the present study. L1 larvae of N2(C. elegans wild type; Bristol isolate), CB1370daf-2 (a substitution mutant) and LT186sma-6(wk7) II (a null mutant)...

The human pathogens, Epstein Barr virus, human papilloma virus, herpes simplex virus-2, hepatitis B virus and Leishmania species can cause persistent infections which cannot be cured with currently available treatments. The modern gene editing techniques, Transcription Activator Like Effector Nuclease (TALEN) and Clustered Regularly Interspaced Sho...

The emergence of antibiotic resistance is a global health crisis, thus the search for novel antimicrobial compounds has become a continuous necessity. Underexplored and extreme environments, such as cave ecosystems, have been identified as a promising potential source for the discovery of novel microorganisms with novel antimicrobial compounds (AMC...

Production of fungal bioactive metabolites is highly influenced by many physicochemical factors and thus optimization of the culture conditions is a crucial task in industrial applications to achieve higher yield in the production processes. In this study an underground cave wall isolated Aspergillus fumigatus strain (SKW 404) from Sthreepura Cave...

Herpes simplex virus 2 (HSV-2), also known as Human alphaherpesvirus 2, causes genital herpes and is one of the viruses that lead to chronic infections in human. Several complications occur due to this viral infection and proper medication is still not available to cure the disease. However, the modern gene editing technique, Transcription Activato...

Hepatitis B virus (HBV) is a potential viral pathogen of human and cause chronic infection leading to several health problems such as chronic hepatitis, cirrhosis and several types of liver cancers. Although the pathogen causes severe health issues, proper medication was not developed yet to cure the disease, rather than suppression. But there is a...

Human Herpesvirus 4 (Epstein-Barr virus) is a human pathogenic virus that causes chronic infection leading to severe health problems including cancer. Although, few control strategies are used, a proper medication has not been implemented. The novel gene editing techniques, which are ZFN, TALEN and CRISPR/Cas9 have a potential be used to control th...

Isolation and cloning of seven-band grouper (Epinephelus septemfasciatus) growth hormone cDNA from pituitary gland revealed an open reading frame of 612 bp coding for a pre-growth hormone of 204 amino acids with a 17 amino acid putative signal peptide. Deduced amino acid sequence showed that there was one possible N-glycosylation site at and four c...