Héctor Manuel Sánchez Castellanos

Héctor Manuel Sánchez Castellanos
University of California, Berkeley | UCB · Biostatistics and Epidemiology, School of Public Health

Ph.D. in Computer Science
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About

88
Publications
13,380
Reads
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914
Citations
Citations since 2017
74 Research Items
903 Citations
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Introduction
I'm a Computer Scientist/Mechatronics Engineer working in modeling processes related to the spread/control of mosquito-borne diseases. My main lines of research focus on simulating the spatial spread of gene-drives in mosquito populations, and modeling the effects of mosquito-control interventions in mathematical/computational frameworks. I am particularly interested in the application of CS/Engineering methodologies (network theory, optimization techniques, individual-based modeling, etcetera) to stop the spread of vector-borne diseases. In the past I've worked in animal vocalizations analysis, robotics, computer vision, electronics instrumentation and automotive industry.
Additional affiliations
April 2018 - August 2020
Tecnológico de Monterrey
Position
  • Professor (Assistant)
July 2017 - August 2020
University of California, Berkeley
Position
  • PostDoc Position
December 2016 - June 2017
University of Washington Seattle
Position
  • Consultant
Description
  • Core Development of the simulation "Modular Analysis and Simulation for Health"
Education
August 2012 - May 2017
Tecnológico de Monterrey
Field of study
  • Computer Science
August 2005 - December 2009
Tecnológico de Monterrey
Field of study
  • Mechatronics Engineering

Publications

Publications (88)
Article
The use of a site-specific homing-based gene drive for insect pest control has long been discussed, but the easy design of such systems has become possible only with the recent establishment of CRISPR/Cas9 technology. In this respect, novel targets for insect pest management are provided by new discoveries regarding sex determination. Here, we pres...
Article
Full-text available
The recent development of a CRISPR-Cas9-based homing system for the suppression of Anopheles gambiae is encouraging; however, with current designs, the slow emergence of homing-resistant alleles is expected to result in suppressed populations rapidly rebounding, as homing-resistant alleles have a significant fitness advantage over functional, popul...
Article
Full-text available
As Africa-wide malaria prevalence declines, an understanding of human movement patterns is essential to inform how best to target interventions. We fitted movement models to trip data from surveys conducted at 3–5 sites throughout each of Mali, Burkina Faso, Zambia and Tanzania. Two models were compared in terms of their ability to predict the obse...
Preprint
Full-text available
The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed "precision guided SIT" (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facili...
Preprint
Full-text available
The Ross-Macdonald model has exerted enormous influence over the study of malaria transmission dynamics and control, but it lacked features to describe parasite dispersal, travel, and other important aspects of heterogeneous transmission. Here, we present a patch-based differential equation modeling framework that extends the Ross-Macdonald model w...
Preprint
Full-text available
Malaria is among the world's deadliest diseases, predominantly affecting sub-Saharan Africa, and killing over half a million people annually. Controlling the principal vector, the mosquito Anopheles gambiae, as well as other anophelines, is among the most effective methods to control disease spread. Here we develop an innovative genetic population...
Technical Report
Full-text available
Mosquito-borne diseases kill 1 million people each year. Some efforts have been made to reduce or control the spread of this infectious. The Marshall Laboratory, in the University of California, Berkeley, with the aim of reducing the impact caused has developed mathematical and computational models that can be visualized in order to provide insight...
Technical Report
Full-text available
A pesar de un incremento en las aplicaciones de algoritmos de optimización en los últimos años, no existen muchas aplicaciones en el ámbito del control y monitoreo de mosquitos. Actualmente sólo existe MGSurvE, un paquete diseñado para optimizar la posición de trampas para mosquito, sin embargo, su algoritmo de optimización no es el más adecuado pa...
Presentation
Full-text available
Surveillance of released genetically-modified organisms is expected to be crucial and costly as we move forward in field trials aimed at eliminating mosquito-transmitted diseases. MGSurvE (Mosquito Gene SurveillancE) is a python package created to optimize the positioning of traps in complex heterogeneous environments. Through the use of spatial ne...
Article
Full-text available
As gene drive mosquito projects advance from contained laboratory testing to semi-field testing and small-scale field trials, there is a need to assess monitoring requirements to: i) assist with the effective introduction of the gene drive system at field sites, and ii) detect unintended spread of gene drive mosquitoes beyond trial sites, or resist...
Technical Report
Full-text available
De acuerdo con la organización mundial de la salud, los mosquitos son una de las principales causas de transmisión de enfermedades. Por lo que muchas organizaciones trabajan en conjunto para intentar erradicar estas enfermedades en el futuro. Marshal Labs de la universidad de Berkeley es uno de estos organismos que, por medio de simulaciones, apoya...
Article
Full-text available
CRISPR-based genetic engineering tools aimed to bias sex ratios, or drive effector genes into animal populations, often integrate the transgenes into autosomal chromosomes. However, in species with heterogametic sex chromsomes (e.g. XY, ZW), sex linkage of endonucleases could be beneficial to drive the expression in a sex-specific manner to produce...
Technical Report
Full-text available
New techniques for the control of mosquito-borne diseases, which turns to be a great challenge on the developing world, need the usage of computer simulation which requires a great amount of computing resources. We compare distinct machine learning models for the prediction the behavior of specific mosquito features within a mosquito population net...
Poster
Full-text available
Vector-borne diseases such as malaria continue to pose a major global health burden, accounting for over 700,000 deaths annually. Despite the success of long-lasting insecticide-treated nets (LLINs) at reducing the malaria burden, the impact of these and other currently available tools is now stagnating. Consequently, there is interest in novel vec...
Presentation
Full-text available
Distributing mosquito traps over landscapes that present heterogeneous environmental resources is a challenging task. Mosquitoes traverse these geographies based on the distance to resources and their biological needs. At the same time, mosquito traps cover a range in which they can attract insects. Given the interaction between these two factors,...
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules: A) a genetic inheritance module accommodates the dynamics of gene drive systems, B) a population dynamic module accounts for mosquito life history, D) a land...
Chapter
Full-text available
Deep Learning has achieved great successes in various complex tasks such as image classification, detection and natural language processing. This work describes the process of designing and implementing seven deep learning approaches to perform regressions on mosquito populations from a specific region, given co-variables such as humidity, uv-index...
Article
Full-text available
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular ge...
Preprint
Full-text available
A rare example of a successful long-term elimination of the mosquito Aedes aegypti is in Brisbane, Queensland, where the legislatively-enforced removal of rainwater tanks drove its disappearance by the mid-1950s. However, a decade-long drought led to the mass installation of rainwater tanks throughout the region, re-introducing critical breeding si...
Article
Full-text available
Cas9/guide RNA (gRNA)-based gene drive systems are expected to play a transformative role in malaria elimination efforts., whether through population modification, in which the drive system contains parasite-refractory genes, or population suppression, in which the drive system induces a severe fitness load resulting in population decline or extinc...
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules (right): i) a genetic inheritance module accommodates the dynamics of gene drive systems, ii) a population dynamic module accounts for mosquito life history,...
Article
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Article
Full-text available
Significance Newly available large-scale datasets of human population movement represent an opportunity to model how diseases spread between different locations. Combining infectious disease models with mechanistic models of host movement enables studies of how movement drives disease transmission and importation. Here we explore how modeled epidem...
Presentation
Full-text available
Informal talk to CS students at ITESM, Campus Querétaro (https://chipdelmal.github.io/MGDrivE_Presentations/ITESM2021/)
Preprint
Full-text available
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and zika, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic...
Preprint
Full-text available
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and zika, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic...
Preprint
The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and zika, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic...
Poster
Full-text available
Models that simulate the effects of interventions on malaria vectors and transmission make assumptions about how mosquitoes move in the environment, such as isotropic behavior and no sex-related differences. These are applied to dispersal between households and villages and processes such as host-seeking and oviposition. Most models use mathematica...
Poster
Full-text available
CRISPR/Cas9-based technologies have revitalized interest in gene-editing technologies as means to control mosquito-borne diseases. Amongst candidate disease-control mechanisms, gene- replacement strategies are considered some of the most promising due to their resilience to generation of resistant alleles (caused by errors in homology-directed repa...
Preprint
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Presentation
Full-text available
Comparing mosquito replacement gene-drive technology against population suppression in São Tomé and Príncipe in the presence of genetic standing variation and resistant allele formation rates. https://chipdelmal.github.io/MGDrivE_Presentations/MMC2020/
Article
Full-text available
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness and potential irreversibility of a release. Gene drive systems that display threshold-dependent behavior could pot...
Article
Full-text available
Mosquitoes are important vectors for pathogens that infect humans and other vertebrate animals. Some aspects of adult mosquito behavior and mosquito ecology play an important role in determining the capacity of vector populations to transmit pathogens. Here, we re-examine factors affecting the transmission of pathogens by mosquitoes using a new app...
Preprint
Full-text available
Newly available data sets present exciting opportunities to investigate how human population movement contributes to the spread of infectious diseases across large geographical distances. It is now possible to construct realistic models of infectious disease dynamics for the purposes of understanding global-scale epidemics. Nevertheless, a remainin...
Article
Full-text available
CRISPR-based gene drives can spread through wild populations by biasing their own transmission above the 50% value predicted by Mendelian inheritance. These technologies offer population-engineering solutions for combating vector-borne diseases, managing crop pests, and supporting ecosystem conservation efforts. Current technologies raise safety co...
Article
Full-text available
Aedes aegypti, the principal mosquito vector for many arboviruses that increasingly infect millions of people every year. With an escalating burden of infections and the relative failure of traditional control methods, the development of innovative control measures has become of paramount importance. The use of gene drives has sparked significant e...
Thesis
Full-text available
Mosquitoes are the deadliest animals on the planet causing more than one million human deaths every year. Having estimates of vector population can help focus resources in a given time and space due to constraints. This work objective is to describe the process of designing and developing a model to predict mosquito populations based on satellite i...
Article
Full-text available
1.Malaria, dengue, Zika, and other mosquito‐borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide‐based tools and antimalarial drugs. The advent of CRISPR/Cas9‐based gene editing and its demonstrated ability to streamline the development of gene drive systems has r...
Preprint
Full-text available
Mosquitoes are important vectors for pathogens of humans and other vertebrate animals. Some aspects of adult mosquito behavior and mosquito ecology play an important role in determining the capacity of vector populations to transmit pathogens. Here, we re-examine factors affecting the transmission of pathogens by mosquitoes using a new approach. Un...
Preprint
Full-text available
CRISPR-based gene drives spread through populations bypassing the dictates of Mendelian genetics, offering a population-engineering tool for tackling vector-borne diseases, managing crop pests, and helping island conservation efforts; unfortunately, current technologies raise safety concerns for unintended gene propagation. Herein, we address this...
Preprint
Full-text available
Aedes aegypti , the principal mosquito vector for many arboviruses that causes yellow fever, dengue, Zika, and chikungunya, increasingly infects millions of people every year. With an escalating burden of infections and the relative failure of traditional control methods, the development of innovative control measures has become of paramount import...
Thesis
Full-text available
The recent discovery of CRISPR-Cas9 and its use in gene drive systems has sparked global interest in their use to control the spread of mosquito-borne pathogens. In particular, the discovery of the Mutagenic Chain Reaction (MCR), which ensures homozygous inheritance of a desired homing allele, has rendered gene drive as a viable technology. However...
Thesis
Full-text available
Mosquito-borne diseases account for over 1 million deaths yearly. Most of these diseases (dengue, chikungunya, yellow-fever, Zika) are transmitted by the Aedes aegypti mosquito. Recent changes in demographics have resulted in the rise of yearly cases of these diseases over the last decades. Amongst these diseases dengue has been the disease with...
Presentation
Full-text available
Presentation of our work: "Confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations" (https://www.researchgate.net/publication/332380657_Confinement_and_reversibility_of_threshold-dependent_gene_drive_systems_in_spatially-explicit_Aedes_aegypti_populations); as part of the DARPA: "Safe...
Preprint
Full-text available
The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness and potential irreversibility of a release. Gene drive systems that display threshold-dependent behavior could pot...
Article
Full-text available
The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilita...
Presentation
Full-text available
In this work, we present our framework with applications to various novel gene-drive systems such as: reciprocal chromosomal translocations, toxin-antidote-based underdominant systems. In doing so, we show how our model can be used to answer relevant questions in the field of mosquito-borne diseases elimination, such as: how to make fair comparison...
Poster
Full-text available
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has reignited interest in the application of this technology to the control of mosquitoes and...
Presentation
Full-text available
In this work, we present MGDrivE with example applications to threshold-dependent drives (reciprocal chromosomal translocations and toxin-antidote-based underdominant systems). We show how the timing of the releases can be optimized for the drives to fixate in the population with a minimum cost, and how this information can be applied to simulate r...
Preprint
Full-text available
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide-based tools and antimalarial drugs. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has rei...
Poster
Full-text available
The control of malaria and other vector-borne diseases represents a significant challenge to public health worldwide. Sustained transmission of malaria requires mosquitoes to carry parasites from one host to another. Here, we model the movement of mosquitoes, and by consequence the transmission of parasites, as an emergent property of the distribut...
Presentation
Talk given to mechatronics engineering students in "Tecnológico de Monterrey" university (campus Querétaro).