Hector Munoz

Hector Munoz
University of California, Los Angeles | UCLA · Department of Bioengineering

Master of Science

About

23
Publications
2,184
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413
Citations
Introduction
Skills and Expertise

Publications

Publications (23)
Article
The emergence of epigenetic gene regulation and its role in disease have motivated a growing field of epigenetic diagnostics for risk assessment and screening. In particular, irregular cytosine DNA base methylation has been implicated in several diseases, yet the methods for detecting these epigenetic marks are limited to lengthy protocols requirin...
Article
Full-text available
Magnetic ratcheting cytometry is a promising approach to separate magnetically-labeled cells and magnetic particles based on the quantity of magnetic material. We have previously reported on the ability of this technique to separate magnetically-labeled cells. Here, with a new chip design, containing high aspect ratio permalloy micropillar arrays,...
Article
Full-text available
The mechanical phenotype of a cell is an inherent biophysical marker of its state and function, with many applications in basic and applied biological research. Microfluidics-based methods have enabled single-cell mechanophenotyping at throughputs comparable to those of flow cytometry. Here, we present a standardized cross-laboratory study comparin...
Article
Nucleic acid amplification assays including loop-mediated isothermal amplification (LAMP) are routinely used in diagnosing diseases and monitoring water and food quality. The results of amplification in these assays are commonly measured with an analog fluorescence readout, which requires specialized optical equipment and can lack quantitative prec...
Article
Imaging flow cytometry is a powerful tool by virtue of its capability for high-throughput cell analysis. The advent of high-speed optical imaging methods on a microfluidic platform has significantly improved cell throughput and brought many degrees of freedom to instrumentation and applications over the last decade, but it also poses a predicament...
Article
Background: The asthma-obesity syndrome represents a major public health concern that disproportionately contributes to asthma severity and induces insensitivity to therapy. To date, no study has shown an intrinsic difference between human airway smooth muscle (HASM) cells derived from non-obese subjects and those derived from obese subjects. The...
Article
Microalgal biofuels and biomass have eco-friendly advantages as feedstocks. Improved understanding and utilization of microalgae require large-scale analysis of the morphological and metabolic heterogeneity within populations. Here, with Euglena gracilis as a model microalgal species, we evaluate how fluorescence- and brightfield-derived image-base...
Article
Full-text available
Euglena gracilis (E. gracilis) has been proposed as one of the most attractive microalgae species for biodiesel and biomass production, which exhibits a number of shapes, such as spherical, spindle-shaped, and elongated. Shape is an important biomarker for E. gracilis, serving as an indicator of biological clock status, photosynthetic and respirato...
Article
Euglena gracilis (E. gracilis) has recently been attracting attention as a potential renewable source for the production of biofuels, livestock feed, cosmetics, and dietary supplements. Research has focused on strain isolation, productivity improvement, nutrient and resource allocation, and co-product production, key steps that ultimately determine...
Article
Purpose: To design and validate a fully automated computer system for the detection and anatomic localization of traumatic thoracic and lumbar vertebral body fractures at computed tomography (CT). Materials and methods: This retrospective study was HIPAA compliant. Institutional review board approval was obtained, and informed consent was waived...
Article
Here we highlight emerging technologies in the synthesis, handling, and application of encoded microparticles for multiplexed assays. Traditionally, in drug discovery and life sciences research, multiple reactions will be conducted in parallel using microwell plate formats or microfluidic implementations, in which volumes are confined and reactions...
Article
Full-text available
The vertebral body is the main axial load-bearing structure of the spinal vertebra. Assessment of acute injury and chronic deformity of the vertebral body is difficult to assess accurately and quantitatively by simple visual inspection. We propose a cortical shell unwrapping method to examine the vertebral body for injury such as fractures and dege...
Conference Paper
Degenerative disc disease (DDD) develops in the spine as vertebral discs degenerate and osseous excrescences or outgrowths naturally form to restabilize unstable segments of the spine. These osseous excrescences, or osteophytes, may progress or stabilize in size as the spine reaches a new equilibrium point. We have previously created a CAD system t...
Chapter
Osteophytes, a common degenerative change in the spine, are found in 90 % of the population over 60 years of age. We have developed an automated system to detect and assess spinal osteophytes on \(^{18}\)F-sodium fluoride (\(^{18}\)F-NaF) PET/CT studies. We first segment the cortical shell of the vertebral body and unwrap it to a 2D map. Multiple c...
Conference Paper
PURPOSE Vertebral degenerative disease can mimic metastatic disease on 18F-NaF PET/CT. The purpose of this study is to develop a computer system to automatically detect vertebral degenerative disease on 18F-NaF PET/CT. METHOD AND MATERIALS The dataset consisted of 46 18F-NaF PET/CT scans (36 men, 10 women, mean age 65±9 yrs). All patients were sca...
Conference Paper
Degenerative disc disease (DDD) can be identified as hyperdense regions of bone and osseous spur formation in the spine that become more prevalent with age. These regions can act as confounding factors in the search for alternative hyperdense foci such as neoplastic processes. We created a preliminary CAD system that detects DDD in the spine on CT...
Article
Purpose: To design and validate a computer system for automated detection and quantitative characterization of sclerotic metastases of the thoracolumbar spine on computed tomography (CT) images. Materials and methods: This retrospective study was approved by the institutional review board and was HIPAA compliant; informed consent was waived. The...
Conference Paper
PURPOSE Time-constrained assessment of multitrauma patients can be one of the most clinically challenging situations dealt with by the radiologist. The aim is to develop a fully automated method to detect acute vertebral body fractures on trauma CT studies. METHOD AND MATERIALS Our method is summarized as follows. Given a spine CT data set, the sp...
Conference Paper
Full-text available
Assessment of trauma patients with multiple injuries can be one of the most clinically challenging situations dealt with by the radiologist. We propose a fully automated method to detect acute vertebral body fractures on trauma CT studies. The spine is first segmented and partitioned into vertebrae. Then the cortical shell of the vertebral body is...

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