Heba Nageh

• associate professor of histology cell biology histochemistry and immunohistochemistry
• Professor (Associate) at Suez Canal University

Benzo(a)pyrene (BaP), a widespread polycyclic aromatic hydrocarbon, poses severe risks to terrestrial and aquatic organisms through oxidative damage and necroptosis in vital organs. This study explored the hepatotoxic effects of BaP in Nile tilapia (Oreochromis niloticus) and evaluated the protective potential of N-acetylcysteine-loaded starch nano...

Objective: Oxidative stress and inflammation play crucial roles in the onset of kidney injury and crystal formation caused by hyperoxaluria. Indapamide is a potent medication for treating renal calculi, but it has severe side effects such as hypokalemia, hypercalcemia, and hyperuricemia. Therefore, it is advisable to explore alternative treatments...

Doxorubicin (DOX) cancer therapy induces serious cardiotoxicity as a side effect. This study aimed to investigate the cardioprotective effects of grape seed extract (GSE) and L-Carnitine (L-CA) against DOX-induced cardiac toxicity in male rats. Six groups of male albino rats were used: G1 (control); G2 (GSE), given grape seed extract (100 mg/kg b.w...

The exposure of the African catfish (Clarias gariepinus) to various environmental contaminants leads to physiological and histological alterations. Therefore, the study aimed to assess the impact of seasonal variations of ecological contaminants as external stressors and internal stressors via helminth infections on oxidative stress and histopathol...

Ethnopharmacological relevance The popularity of herbal medicine is expanding globally due to the common belief that herbal products are natural and nontoxic. Thymelaea hirsuta leaves are traditionally used for the treatment of recurrent abortion in humans and animals. However, a lack of safety evaluation of the plant, particularly in pregnant wome...

Candidasis, an important cause of morbidity and death, has been on the rise globally in the last several decades, particularly among very sick patients. Because of its immunosuppressive effects, the metabolic disease diabetes mellitus (DM) makes patients more likely to contract fungal infections, such as those caused by Candida sp. Only a small num...

Even though kidney stones seem to be one of the oldest disorders recognized by medicine, the exact processes by which they form and grow remain unknown. Significant progress has been achieved in our understanding of the pathophysiology of ten different types of stones, including the most common type, the idiopathic calcium oxalate stone former...

Penconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops after collection with many hazardous effects on population including neurotoxicity. Withania somnifera leaves extract (WSLE) is known for its memory and brain fun...

Ethnopharmacological relevance: Cleome droserifolia treatment has potent antioxidant, antimicrobial, and immunomodulatory potentials, which can help recover the general health status. Aim of the study: This research aims to estimate the potential cardioprotective properties of the methanolic extract of Cleome droserifolia (MEC) against epinephrine-...

Obesity is a global public health issue. It is associated with a spectrum of liver abnormalities, like nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to investigate the effect of Vitamin D 3 on light microscopic changes in the liver, as well as hematology and some liver enzymes in experimentally overweight albino rats. Five...

Obesity's dangers are becoming more widely recognized around the world. Obese people are more likely to develop a variety of serious diseases, including fatty liver. The purpose of this study was to investigate the effect of Origanum majorana on light microscopic changes in the liver, as well as hematology and some liver enzymes in experimentally o...

The modulatory role of primrose oil (PO) supplementation enriched with γ-linolenic acid and D/L-alpha tocopherol acetate against a carbon tetrachloride (CCl4)-induced liver damage model was assessed in this study. Twenty male albino rats were divided into four groups. The control group received corn oil orally. The PO group received 10 mg/kg P O or...

The current research intended to evaluate the antitumor properties of Moringa oleifera oil extract (MOE). Fifty-six female Swiss albino mice were employed in this study. Animals were assigned into four groups: control (C) group, moringa oil extract (MOE) group administered (500 mg/kg b. wt) MOE daily via gavage, Ehrlich ascites carcinoma (EAC) grou...

Adrenaline is widely used drug to combat several conditions such as allergy and anaphylaxis. The current work was to investigate the renal and hepatic complications following adrenaline injection, in addition, the impact of Cleome (SAMWA) methanolic extract on adrenaline-induced renal and hepatic alterations. Twenty four male Wister rats were divid...

This study sought to determine whether lactoferrin supplementation could counteract the harm that cadmium (Cd) induced to the rats. The effect of Cd and lactoferrin were investigated in hematological, biochemical, his-tological, immunohistochemical expression and ultrastructural studies. After 30 days of treatment, rats exposed to Cd had significan...

A typical chemotherapy agent used to treat a number of tumors is called cisplatin. Male infertility is one of the side effects of cisplatin therapy, which is one of the drugs' side effects. Male mammalian germ cells have been shown to be protected by chlorella vulgaris supplementation. The goal of the current study was to examine, using light...

Knee joint abnormalities and the cause of induced knee pains that affected a large percentage of the population are explained in this chapter. However, the impact of this disease varies from person to person, and it has been discovered that several factors influence the degree of disability that ultimately manifests. Discussions are held regarding...

For poultry farmers and quails’ producers’, one of the biggest challenges is dealing with natural diet contaminants like mycotoxins. Worldwide, mycotoxins are present in all feed sources, primarily in corn, and they significantly reduce the health, immune function, and performance of birds. For this purpose, the effect of citric acid (CA) suppleme...

Despite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures. Finding potential alternative therapies is necessary because conventional therapies have associated side effects and poor efficacy. In this regard, a study was conducted that offered substitute therapeu...

forced swim for Depression

Evaluation of the efficacy of ashwagandha root extract to ameliorate the oxidative stress and depression resulting from diabetes in male rats was conducted in the current study. Thirty-six male albino rats were randomly grouped into two main groups: normal (n=18) and diabetic (n=18), diabetes was induced by a single dose of 150 mg/kg BW alloxan inj...

A Review on: Ashwagandha Root Extract Phenolic Compounds Counteract Alloxan's Effects on Oxidative Stress, Inflammation, and Peripheral Nerve Injury

Diabetes mellitus is a worldwide problem characterized by hyperglycemia as well as the damage of the microscopic structure of the beta cells of Langerhans pancreatic islets. In the present study, the histological, immunohistochemical, morphometric, and biochemical alterations to pancreatic beta cells in streptozocin (STZ)-induced diabetes were asse...

Thiacloprid (TH) is a neurotoxic agricultural insecticide and potential food contaminant. The purpose of this study was to investigate the relationship between TH exposure and memory dysfunction in rats, as well as the potential protective efect of piracetam and piracetam-loaded magnetic chitosan nanoparticles (PMC NPs). Rats were divided into fve...

Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fresh. Several strategies have been implemented in counteracting such toxicity. Objective: The goal of the current investigation was to determine if ascorbic acid and crude honey extract can protect male rats from the harmful biochemical and histopathologi...

The current study aimed to assess the impact of metal pollution in water on parasitic abundance, biology, and histopathological characteristics of Oreochromis niloticus in two different freshwater habitats in the Al Sharkia government. The fish were collected from the Mueweis canal area (A) which received industrial wastewater from factories and th...

Despite being one of Egypt's most significant fish production resources, Lake Manzalah (Northeast Egypt) is subject to substantial inputs of pollution from domestic, agricultural and industrial sources. The liver and gonads of Oreochromis niloticus were evaluated for histological and ultrastructural alterations in the current study to monitor t...

Diabetes mellitus is a worldwide problem characterized by hyperglycemia as well as the damage of the microscopic structure of the beta-cells of Langerhans pancreatic islets. In the present study, the histological, immunohistochemical, morphometric, and biochemical alterations to pancreatic beta-cells in streptozocin (STZ) induced diabetes were asse...

Consumption of plant-derived foods contaminated with afatoxin and their metabolites in animal products or exposure to contaminated mycotoxins air and dust caused kidney and liver damage. The purpose of this study was to evaluate the efect of fenugreek (Trigonella foenum graecum L.) upon afatoxin B1-induced damages to the liver and kidney of male al...

Background: Isoflavones are estrogenic compounds that exist in soy, clover, and peanuts. They are selective estrogen receptor modulators. Aim: The study was planned to explain the interactions of isoflavones with estrogen receptors alpha (ERα), beta (ERβ), and vascular endothelial growth factor (VEGF) expressions in ovarian and uterine tissues duri...

Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases. Objective: The aim of the current study is to investigate honey's ameliorative effect on...

This study assessed the effectiveness of an aqueous extract of Moringa Oleifera Lam. leaves (MOL) alone or in combination with praziquantel (PZQ) drug targeting-infected mice with Schistosoma mansoni-induced liver and spleen damage. Mice were divided into eight groups control mice group treated orally with saline. PZQ group: non-infected mice treat...

The present study investigated the possible ameliorative effect of Beta-MOS® on lead-induced toxicity in Nile tilapia. A total of ninety O. niloticus (34.43 ± 0.31 g and 7 weeks age) were used in this study. Fish of mixed sex were divided into 4 groups. The first group which served as control received a basal diet (0% Beta-MOS®). The second gro...

The goal of this study was to assess the harmful effects of heavy metal accumulation on Clarias gariepinus (catfish) in two different polluted areas in the Al Sharkia governorate and assess the impact on oxidative stress and histological changes. The results revealed a highly significant difference in heavy metal levels in the water and inside fish...

This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180-200 g) were allocated into four groups: control; date flesh (DF) group (oral 600 mg/kg MDFE for 21 days); Cis group (7.5 mg/kg i.p. at day 16); and date flesh/cisplatin (DF/Cis) group (o...

Acetamiprid (neonicotinoid insecticide) and azoxystrobin (fungicide) are widespread pesticides used for pest management, but they have the potential for toxicity to mammals. The goal of this study was to look for oxidative stress, metabolic alterations, and reproductive problems in male rats’ serum after 2 months of exposure to sub-lethal dosages o...

Endocrine-disrupting compounds as pesticides affect the hormonal balance, and this can result in several diseases. Therefore, the analysis of representative hormones with acetamiprid (AC) and azoxystrobin (AZ) was a good strategy for the investigation of the endocrine-disrupting activity of pesticides. Hence, a sensitive and rapid analytical method...

Lead (Pb) is a hazardous pollutant for living creatures including fish. This study addressed the possible ameliorating effect of dietary Beta-MOS® on Pb induced reproductive toxicity in Nile tilapia. One hundred eighty fish (35.43 ± 0.36 g, 8 weeks age) of mixed sex were randomly allocated into 4 equal groups (3 replicates/group). The first group w...

The goal of this study was to investigate the protective effect of licorice supplements in a rat model of Bleomycin-induced lung oxidative damage over a duration of one month. The rats were randomly divided into six groups (n = 10 per group). Control group;. Bleomycin group (B): rats were IP injected with bleomycin 5 mg/kg twice weekly. Licorice gr...

The goal of this study was to investigate the protective effect of licorice supplements in a rat model of Bleomycin-induced lung oxidative damage over a duration of one month. The rats were randomly divided into six groups (n = 10 per group). Control group;. Bleomycin group (B): rats were IP injected with bleomycin 5 mg/kg twice weekly. Licorice gr...

This study has investigated the effect of using the Uncaria tomentosa (UT) extract against immunotoxicity that induced by fipronil (FP) in male Wistar rats. Twenty-eight, male Wistar rats were assigned randomly into four groups (7 rats each). Control group received distilled water. FP group received FP 9.7 mg/kg b. wt orally via gastric tube. UT gr...

Monosodium glutamate (MSG) is a common flavor enhancer and stabilizer for ready-made or packaged foods. This research investigated the impact of MSG on the maternal and fetal liver. The present study was carried out on sixteen mature female Albino rats and eight male rats of reproductive age. The control group was dissected on day 20 of gestation....

IOI-Egypt Webinar under the title "Marine Water Resources" which was held on 15th July, 2021

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There is a constant need for baseline information on the mugil fish health present in the North-Eastern region of Manzala lake. This study deals with the determination of the limit of heavy metals in Manzala lake as a representation of the northeastern area of Egypt and studied its impact on mugil health. Assessment of the mugil health achieved by...

The work was aimed to assess the heavy metals concentrations in the Sharkia Governorate, Egypt. The determination of heavy metal bioaccumulation and their antioxidant alterations on Oreochromis niloticus were considered. The gonads and the liver of the fishes were analyzed for essential metals (Cu, Mn, Fe & Zn) and non-essential metals (Pb) levels...

This experiment aimed to investigate the effect of dietary Nigella sativa on the cell-mediated immune response. Eighteen male Wistar rats were divided equally into a control group and treated groups that received black seeds at rates of 30 and 50 g/kg in the diet (Sa30 and Sa50 groups, respectively, for 30 days. The weight gain, feed intake, feed c...

SPSR National Webinar on ‘COUNTERING THE RISE OF SUPERBUGS THROUGH ANTI-MICROBIAL RESISTANCE

Nature Research Academies workshop Successful Pre-submission Strategies

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The aim of this study was to evaluate the effect of combinations of Artemisia monospermia with Mentha piperita on male fertility. Treated rats with different doses of A. monosperma or M. piperita alone induced severe testes histopathological lesions and histochemical alteration associated with a reduction in epididymis weight, abnormality in the sp...

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Accumulation of heavy metals in fish is considered a critical problem for human health. Therefore, the study aimed to quantify the concentrations of iron (Fe), zinc (Zn), manganese (Mn), and lead (Pb) in Oreochromis niloticus and Clarias gariepinus from two areas in Al Sharqia governorate, Egypt, from September 2017 to August 2018. A human health r...

This experiment aimed to investigate the effect of dietary Nigella sativa on cell mediated immune response. A total of eighteen male Wistar rats were divided equally into control and black seeds at 30 and 50 g/kg/diet (Sa30 and Sa50), respectively for 30 days. Weight gain, feed intake, feed conversion ratio (FCR), cell mediated immune response was...

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The present review attempted to summarize the results of studies that examined the effects of overreaction on cytokines in the body with an emphasis on their effects on popular viruses. In general, most of the studies reviewed suggested beneficial effects of cytokines on the improvement of the immune system by increasing the expression of anti-infl...

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The current research study investigated the effect of 80 mg/kg b.wt./day curcumin (cur) against 50, 100, and 200 mg/kg copper oxychloride (COC) for 90 days induced testicular damage using histological, ultrastructural, and biochemical techniques. Histological and cellular abnormalities have been noted in seminiferous tubules of COC-treated group an...

the potential hepatotoxic effect of subchronic copper oxychloride treatment and the possible protective role of curcumin to modulate these effects in male albino rats.

Aluminum sulfate is known to create toxic effects on several systems of experimental animals.This research was undertaken to examine the absorption of aluminum confirmed by histological examination of rat´s organ after single intraperitoneal (IP) injection of Al2 (SO4)3. Male and female rats received a single (IP) injections of (23, 67, 200, 600, 1...

Vitamin E (α-tocopherol) is a potent antioxidant and possesses an important role in deactivating free radicals in the cells and preventing the hazardous effects of reactive oxygen species thus stopping the lipid peroxidation process. However, the overdosing of a vitamin is toxic and leads to many harmful effects. The current work aimed to assess th...

The aim of these investigations was to study vitamin E supplement effect in male albino rats after 30 days of repeated treatment. Four groups of six male rats were orally administered distilled water (control), 500, 1000 and 2000 mg/kg body weight vitamin E daily for 30 days. The impact of the treatment on percent body weight and mortality was dete...

The most significant pollutants are the heavy metals in the aquatic network due to their toxicity, accumulation, and bio-magnification. In an attempt to characterize the physical-chemical and demonstrate the potential water impact of the heavy metal content of wastes in two lakes in Sharkia province, Egypt, this study was developed to determine the...

Historically, natural products played a forceful role in human treatment ailments. Nowadays, natural products include a large part of current pharmaceutical agents, mostly in the field of cancer therapy. The main aim of this review is to provide a comprehensive summary of the most known natural product used as anticancer globally, including various...

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Vitamin E is widely used as a drug supplement in many diseases. The aim of these investigations was conducted to study vitamin E supplement effect on testicular tissues in male albino rats after 90 days of repeated treatment and after stopping treatment for 45 days. Seven groups of six male rats were orally administered 500, 1000 and 2000 mg/kg bod...

small note for the student and researcher beginner in understanding the meaning of stem cell and induced pluripotent stem cells.

The drawbacks of many pharmacological drugs can be modulated if the pharmacology and adverse effect of these drugs vary according to circadian time administration. The present study was conducted to investigate the possible protective effect of Moringa peregrina against diabetic nephropathy (DN) and whether its protective effect is circadian time d...

Background: The target of this animal study was to clarify the influence of Copper oxychloride (COC) (at concentrations of 50, 100 and 200 mg/kg b.wt.) administration for ninety days on the brain tissues to evaluate its possible neurotoxicity. Methods: Thirty male albino rats were divided up into control and four experimental groups. Group-II (rats...

The neurotoxic impact of subchronic exposure of male rats to copper oxychloride

The human gut microbiota is given as an especially complicated microbial community that are formed to possess a significant impact on human physiology. Additionally, comparative analysis of individual human gut microbiota has discovered numerous methods that the microbiota use to regulate to the enteric surroundings. Infections of the alimentary ca...

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Influence of injection mode and antioxidant dietary on the toxicity of Doxorubicin as a chemotherapy drug

Background: Copper oxychloride (COC) (50% of its component, copper) is copper-based fungicides. The present study aimed to investigate the possible protective effect of 80 mg/kg curcumin against the toxicity of 500, 1000, or 2000 mg COC per kilogram body weight for 90 days on the liver of a rat. Serum glutamic-pyruvic transaminase (SGPT), serum glu...

Antibiotic is a type of antimicrobial drug used for treating and preventing any infection caused by pathogenic bacteria. The widely accepted use of antibiotics has saved millions of human lives all over the world; however, they highly influenced the human microbiome. Human microbiome performs an array of important functions that help us to survive...