Heba Kamal Nabih HanafiNational Research Center, Egypt | NRC · Department of Medical Biochemistry
Heba Kamal Nabih Hanafi
PhD
Looking for potential collaborators.
About
27
Publications
7,659
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Citations
Introduction
Heba Kamal Nabih Hanafi currently works as a researcher (PhD) at the Department of Medical Biochemistry, National Research Center, Egypt. She is so interested in solving health complications (with focusing on cancer) with scientific advanced research applications. She welcomes by national and international collaborations
Additional affiliations
March 2008 - present
Education
April 2014 - July 2017
Publications
Publications (27)
Background
Leukemia is one of the most lethal cancers worldwide and represents the sixth-leading cause of cancer deaths. The results of leukemia treatment have not been as positive as desired, and recurrence is common.
Purpose
Thus, there is an urgent requirement for the development of new therapeutic drugs. Salvia multicaulis (Bardakosh) is a wide...
Abstract
Sustained inflammatory responses can badly affect several vital organs and lead to chronic inflammation-related disorders, such as atherosclerosis, pneumonia, rheumatoid arthritis, obesity, diabetes, Alzheimer’s disease, and cancers. Salvia multicaulis is one of the widely distributed plants that contains several biologically active phytoc...
Sustained inflammatory responses can badly affect several vital organs and lead to chronic inflammation-related disorders, such as atherosclerosis, pneumonia, rheumatoid arthritis, obesity, diabetes, Alzheimer’s disease, and cancers. Salvia multicaulis is one of the widely distributed plants that contains several biologically active phytochemicals...
Purpose
Breast cancer is one of the leading types of cancer diagnosed in women. Despite the improvements in chemotherapeutic cure strategies, drug resistance is still an obstacle leading to disease aggressiveness. The small non-coding RNA molecules, miRNAs, have been implicated recently to be involved as regulators of gene expression through the s...
Pulicaria undulata is one of the species from the genus Pulicaria and among the most important medicinal plant species. The volatile components of P. undulata are widely used for herbal teas, fragrances, and as insect repellents. Saponins, steroids, triterpenes, coumarins, and tannins have been discovered in this plant, among other secondary metabo...
Abstract Hepatocellular carcinoma (HCC) is the major lethal primary liver malignant worldwide. Although, melatonin has various antitumor bioactivities; there is a requirement for more investigations to elucidate the not discussed effects, and the controversial responses of the treatment with melatonin on targets mediated in HCC. To achieve the aim...
Hepatocellular carcinoma (HCC) is the major life-threatening primary liver malignancy in both sexes all over the world. Unfortunately, the majority of patients are diagnosed at later stages because HCC does not elicit obvious symptoms during its early incidence. Consequently, most individuals escape the first-line HCC treatments and are treated wit...
Objective
Breast cancer (BC) is one of the most commonly diagnosed solid malignancies in women worldwide.
Purpose
Finding new non-invasive circulating diagnostic biomarkers will facilitate the early prediction of BC and provide valuable insight into disease progression and response to therapy using a safe and more accessible approach available eve...
Abstract
Objective Breast cancer (BC) is one of the most commonly diagnosed solid malignancies in women worldwide.
Purpose Finding new non-invasive circulating diagnostic biomarkers will facilitate the early prediction of BC and provide
valuable insight into disease progression and response to therapy using a safe and more accessible approach avai...
Acrylamide (AA) is probably carcinogenic to humans that may have an impact on human cancer risks. The World Health Organization (WHO) consultation endorsed the International Agency for Research on Cancer (IARC) classification of AA for Group 2A (probable human carcinogen). Everyone is exposed to AA
through diet and it is thought that it may be gen...
Acrylamide (AA) is probably carcinogenic to humans that may have an impact on human cancer risks. The World Health Organization (WHO) consultation endorsed the International Agency for Research on Cancer (IARC) classification of AA for Group 2A (probable human carcinogen). Everyone is exposed to AA through diet and it is thought that it may be geno...
Background
The global coronavirus disease 2019 (COVID-19) was announced as pandemic by the World Health Organization (WHO). With the increased number of infected and dead victims daily all over the world, it becomes necessary to stop or overcome its rapid spread.
Main body
Although the production of vaccine or even specified effective anti-virus ma...
Background
Hepatocellular carcinoma (HCC) is the fifth most common cancer, the third leading cause of cancer deaths worldwide with over 500,000 people affected. It is a major cause of death in patients with chronic hepatitis C virus (HCV) infection. Overwhelming lines of epidemiological evidence have indicated that persistent infection with HCV is...
The global coronavirus disease 2019 (COVID-19) was announced as pandemic by the World Health Organization (WHO). With the increased number of infected and dead victims daily all over the world, it is become necessary need to stop or overcome its rapid spread. Despite the production of vaccine or even specified effective antivirus may take about six...
RF2 is a master regulator of the anti-oxidative stress response through controlling the expression of anti-oxidative stress response proteins and detoxifying enzymes. Cancer cells also exploit NRF2 protective functions to thrive and resist anti-tumor drugs. NRF2 is highly active in several types of human cancers and is associated with aggressivenes...
Multidrug resistance (MDR) remains a burden in cancer chemotherapy. Several members of ATP-binding cassette (ABC transporters) are responsible for the efflux of anticancer drugs outside cells decreasing the drug’s effective intracellular concentration. Therefore, extensive efforts have been conducted by researcher to circumvent the activity of thes...
My Ph.D presentation : ” The Emerging Role of MicroRNA-122 in Intracellular Interactions of Hepatocellular Carcinoma”.
Hepatocellular carcinoma (HCC) is a hypervascular primary liver cancer characterized by rapid progression, besides, resistance to traditional chemotherapeutic agents. It has been shown that microRNAs play critical roles in regulation of tumor cell sensitivity to drugs through modulating the expression of genes involved in drug transport. The presen...
My published PhD paper in Der Pharmacia lettre.
Higher levels of morbidity and mortality are due to malignant tumors and Hepatocellular carcinoma (HCC) is
considered of a great percentage. The liver-specific microRNA-122 (mir-122) is frequently down-regulated in HCC
and is a promising biomarker for the early HCC diagnosis. Restoration of mir-122 renders HCC cells to be sensitive
to doxorubicin....
Questions
Questions (18)
Hello,
I want to add continuous line numbers for every line in my word document even for tables and figures. How can I do this process?. N.B. my Microsoft word consider the table and figure as single line, and I must do the numbering for every line. Thanks!
Cells in sub-G1 phase of cell cycle are described as cumulative apoptosis. Could anyone illustrare more details about this type of apoptosis?
Thanks!
It is universal to apply silica membrane spin columns for purification, and isolation of DNA, and RNA in the presence of elution buffer. Could I use these columns to get rid of unincorporated dye without using of any buffers (only my sample and microcentrifugation)?.
Thanks!
Dear colleagues who are experts in exosomes. I isolated exosomes by a kit in final elution buffer. After confirmation of the exosomes characterization by TEM, how can I prepare a sufficient total protein concentration of isolated exosomes to western blotting?
Dear. Experts
I have the mean normalized copy gene number for both Bax, and Bcl2 genes. How can I calculate Bax/Bcl2 ratio for each treatment?, and is there an indication range for the calculated ratios?...Thanks in advance.
I obtained 2 melting temperatures (75, and 82 C) for the same sample with specific confirmed primers (forward, and reverse) by RT-PCR. But, I have single Ct for each. Do you think there is a mutation or polymorphism within the detected gene?, or it may be a contamination knowing that, I applied the same samples with another primer pairs and I obtained single melting peak.
Thanks in advance.
I must use cat#4484449 (EXOSOME SPIN COLUMNS (MW 3000)) for an important current work. But unfortunately, Invitogen stopped its production. Could anyone (have it) help me with some of these columns or recommed an alternative product?...Thanks in advance.
I have 100ul of exosomes in XE buffer of isolating kit. I want a protocol to label this 100ul of exosomes with PKH67 fluorescent cell linker kit. Thanks!
My paper was available online as SSRN preprint. After its publishing in a journal, how can I perform a link between them to obtain the citations of the preprint to my published one?..Thanks!
Could any scientific researcher guide me to obtain SW480 or Human melanoma cell lines in Egypt. Thanks in advance
I have a substance that dissolve in at least 5% ethanol. I want to prepare a stock solution of this substance for further serial dilutions in 96 well plate for calculation of IC50 by MTT assay. knowing that, the conditin for ethanol concentration per well shouldn't exceed 0.4%. How can I prepare such stock solution and what about the serial dilutions in cell culture media?. Thanks!
I want to culture human HepG2 cells in serum free medium. Should I add all components of complete medium except FBS only?, and how long the cells will be alive in such free medium?
Why majority of journals be delay in their decision concerning paper publishing -that may elongate to be a year?
