Hazrina Yusof Hamdani

Hazrina Yusof Hamdani
Universiti Sains Malaysia | USM · Advanced Medical and Dental Institute (AMDI)

Doctor of Philosophy

About

26
Publications
8,380
Reads
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168
Citations
Additional affiliations
July 2010 - present
Universiti Kebangsaan Malaysia
Position
  • Student
July 2008 - February 2010
Universiti Sains Malaysia
Position
  • Student
January 2004 - June 2008
Universiti Teknologi PETRONAS
Position
  • Student

Publications

Publications (26)
Article
The emergence of multidrug resistance tuberculosis (MDR-TB) is caused by Mycobacterium tuberculosis (MTB) adaptation to survive in the presence of antibiotic, that were contributed by mutations in the MDR-associated genes. Previous research has indicated that the gene expression knockdown of fhaA leads to an accumulation of peptidoglycan (PG) precu...
Article
Leptospirosis is a potentially life-threatening zoonosis caused by pathogenic Leptospira. The major hurdle of the diagnosis of Leptospirosis lies in the issues associated with current methods of detection, which are time-consuming, tedious and the need for sophisticated, special equipments. Restrategizing the diagnostics of Leptospirosis may involv...
Article
Full-text available
The GrAfSS (Graph theoretical Applications for Substructure Searching) webserver is a platform to search for three-dimensional substructures of: (i) amino acid side chains in protein structures; and (ii) base arrangements in RNA structures. The webserver interfaces the functions of five different graph theoretical algorithms - ASSAM, SPRITE, IMAAAG...
Article
Full-text available
The increasing number and complexity of structures containing RNA chains in the Protein Data Bank (PDB) have led to the need for automated structure annotation methods to replace or complement expert visual curation. This is especially true when searching for tertiary base motifs and substructures. Such base arrangements and motifs have diverse rol...
Article
Full-text available
Ilmu bela diri khususnya silat begitu pentingdalam kehidupan kita kerana ia dapat digunakanuntuk menjaga diri sertamelindungi ahli keluarga daripada sebarang bentuk ancaman. Silat juga mampu membina sahsiah, memperkuat jati diri, mendidik jasmani dan rohani dengan sifat-sifat mulia kepada individu yang mempelajarinya dan ahli keluarganya. Hal ini d...
Article
Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that exhibit binding affinity and specificity against a wide variety of target molecules. Compared to RNA aptamers, DNA aptamers are much more stable and therefore are widely adopted in a number of applications especially in diagnostics. The tediousness and rigor associated...
Conference Paper
Full-text available
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a contagious disease among mankind. TB is an airborne disease generally affect the lungs. Drug resistance has become a major problem in TB treatment leading to multidrug resistance tuberculosis (MDR-TB) strain. World Health Organization defined MDR-TB as resistant to both isoni...
Conference Paper
Full-text available
Malaysia merupakan sebuah negara maju, sedang melalui pelbagai cabaran yang melibatkan sahsiah negatif. Contoh sahsiah negatif yang sering dilaporkan adalah seperti rasuah, salah guna kuasa, pecah amanah dan sebagainya. Perkara ini bukan sahaja melibatkan pihak pentadbiran negara, bahkan melibatkan rakyat biasa. Pelajar Insititut Pengajian Tinggi (...
Conference Paper
H.E.B.A.T. merupakan akronim bagi Holistic, Entrepreneurial, Balanced, Articulate dan Thinking untuk memperkasa jati diri sebagai modal insan yang bakal mewarisi kepimpinan masa depan negara. Elemen-elemen ini dapat dijanakan melalui penglibatan secara langsung pelajar dalam kegiatan kokurikulum, kelab, persatuan atau badan. Sebahagian besar elemen...
Article
Full-text available
RNA structural motifs can be identified using methods that analyze base–base interactions and the conformation of a structure’s backbone; however, these approaches do not necessarily take into consideration the hydrogen bonds that connect the bases or the networks of inter-connected hydrogen-bonded bases that are found in RNA structures. Large clus...
Conference Paper
Perubahan zaman telah mencetuskan evolusi peranan, sumbangan dan kedudukan wanita dalam pelbagai bidang yang bukan hanya diceburi oleh kaum lelaki. Demi melestarikan sesebuah organisasi atau persatuan, wanita juga mempunyai kepentingan tertentu. Kelestarian bermaksud sesuatu yang berkesinambungan tanpa menjejaskan keaslian sesuatu perkara. Namun be...
Conference Paper
Pembentukan pelajar yang holistik, memiliki sifat positif dan kuat jati dirinya merupakan salah satu komponen penting dalam Falsafah Pendidikan Kebangsaan. Seni Silat Cekak Malaysia (SSCM) telah berdaftar secara rasmi pada 23 September 1976 di Universiti Sains Malaysia, bergerak aktif sebagai Persatuan Seni Silat Cekak Malaysia Universiti Sains Mal...
Article
Full-text available
A major component of RNA structure stabilization are the hydrogen bonded interactions between the base residues. The importance and biological relevance for large clusters of base interactions can be much more easily investigated when their occurrences have been systematically detected, catalogued and compared. In this paper, we describe the databa...
Conference Paper
A fundamental understanding of the atomic level interactions in ribonucleic acid (RNA) and how they contribute towards RNA architecture is an important knowledge platform to develop through the discovery of motifs from simple arrangements base pairs, to more complex arrangements such as triples and larger patterns involving non-standard interaction...
Article
Hydrogen bonds are crucial factors that stabilize a complex ribonucleic acid (RNA) molecule's three-dimensional (3D) structure. Minute conformational changes can result in variations in the hydrogen bond interactions in a particular structure. Furthermore, networks of hydrogen bonds, especially those found in tight clusters, may be important elemen...
Article
Full-text available
Hydrogen bonds are crucial factors that stabilize a complex ribonucleic acid (RNA) molecule's three-dimensional (3D) structure. Minute conformational changes can result in variations in the hydrogen bond interactions in a particular structure. Furthermore, networks of hydrogen bonds, especially those found in tight clusters, may be important elemen...
Article
Full-text available
Similarities in the 3D patterns of RNA base interactions or arrangements can provide insights into their functions and roles in stabilization of the RNA 3D structure. Nucleic Acids Search for Substructures and Motifs (NASSAM) is a graph theoretical program that can search for 3D patterns of base arrangements by representing the bases as pseudo-atom...
Article
In this paper we investigate the advantages of multi-level parallelism on PhyloCon algorithm. The PhyloCon algorithm naturally possesses multi-levels of functions which cost the execution time took longer to complete. We showed that by applying parallelism to the selected level of functions may significantly reduce the execution time. The selected...
Article
Full-text available
The rapid growth of genomic databases and the increased of queries against those databases have lead to the needs of new and efficient search and compare techniques. Researcher in bioinformatics have concentrated on exploring into different approaches in order to solve the problem of cost associated with the exhaustive search techniques. One of the...
Article
Full-text available
This paper is to study and identify suitable algorithm that use in searching regulatory element where PhyloCon algorithm is one of the algorithms. Since PhyloCon has complexity limitation, the time performance is reduced. Therefore, a parallel technique is identified to improve performance of PhyloCon algorithm. The identified parallel technique is...
Conference Paper
This paper is to study and identify suitable algorithm that use in searching regulatory element where PhyloCon algorithm is one of the algorithms. Since PhyloCon has complexity limitation, the time performance is reduced. Therefore, a parallel technique is identified to improve performance of PhyloCon algorithm. The identified parallel technique is...
Conference Paper
With the increasingly popularity of genome sequencing, transforming such raw sequence data into knowledge remains a hard task. This project will develop an application for gene prediction using development tools such as Perl and PHP. The project will identify stretches of sequence for genomic DNA that is biologically functional including protein co...

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