Haziz SINA

• PhD
• Professor (Associate) at University of Abomey-Calavi

Background The increasing importation of frozen poultry into Togo raises concerns about the microbiological safety and antimicrobial resistance of associated pathogens. Despite the public health risks posed by resistant foodborne bacteria, data on resistance profiles, resistance genes, and virulence factors in imported frozen chickens in Togo remai...

Monitoring the effectiveness of antiretroviral treatment by measuring viral load is a strong recommendation from the WHO following the intensification of this therapy, which, if well managed, improves patients’ quality of life. In children, treatment options are limited and virological non-suppression is high. Virological suppression among children...

Background The importation of chickens into Togo has raised concerns about the microbiological quality and antimicrobial resistance of the pathogenic strains they may contain. As food safety is a critical public health priority, the main objective of this study was to investigate the resistance profile of pathogenic strains and resistance genes iso...

Background: Water is an essential resource for life and health. Its sanitary quality is an ongoing public health issue. Indeed, water-borne diseases are constantly evolving. In underdeveloped countries, access to drinking water remains a major concern for populations. Due to water supply shortages in Daloa, residents are turning to different source...

Background Antiretroviral treatment increases the risk of accumulation of resistance mutations that negatively impact the possibilities of future treatment. This study aimed to present the frequency of HIV-1 antiretroviral resistance mutations and the genetic diversity among children with virological failure in five pediatric care facilities in Ben...

Background: The first clinical description of a new necrotizing skin disease appeared in 1948 with the work of Peter MacCallum. In fact, the latter described the causative agent for the first time by discovering acid-fast bacilli (AFB) in a biopsy taken from a leg ulcer in a child from Bairnsdale (Australia) in 1940. He would also publish eight yea...

Schistosomiasis is a public health concern in Benin. Freshwater snails of the genus Bulinus serve as intermediate hosts for schistosomes, trematode parasites responsible for bilharzia. The urinary form, caused by Schistosoma hae-matobium, is the most widespread and is transmitted to humans by these mol-lusks, with Bulinus truncatus and Bulinus glob...

In the current context of decline in soil fertility, soil degradation and climate change, the use of mycorrhizal inoculum is one of the alternatives for sustainable agriculture. This study aims to determine the best combination of Arbuscular Mycorrhizal Fungi (AMF) biostimulant and mineral fertilizer (NPK, Urea) to improve maize production and the...

Background To overcome the spread of high pyrethroid resistance in the main malaria vectors and malaria disease persistence, it is crucial to look for effective and better resistance management strategies. Understanding the phenotypic profile of Anopheles gambiae sl. against alternatives insecticides like organophosphates and carbamates is crucial....

Blighia sapida oil, a substance with a rich history of use for its nutritional, therapeutic, traditional, and cosmetic benefits, was the focus of our study. We investigated the impact of consuming edible oil from B. sapida arils on Wistar rats. The crude oil from unripe arils was extracted using cold pressing and then administered to the rats. The...

Resistance of animal-origin enterobacteria to antibiotics is experiencing a concerning global increase, with an escalating impact of extended-spectrum beta-lactamases (ESBL). Finding solutions to this problem requires reliable and diverse data. It is in this context that the present study was initiated to combat infections caused by Escherichia col...

Background The implementation of the WHO’s 2015 recommendations in Benin, requires an assessment of the progress made over time in preventing the transmission of the infection to exposed-infants, and the identification of its determinants. Methods This was a retrospective study of HIV-1 exposed-infants who underwent PCR between the 6th and 8th wee...

This study set out to identify plants and recipes used by herbalists in the municipalities of Abomey-Calavi and Cotonou to treat gastrointestinal ulcers and to characterize the distribution of their knowledge. An ethno-pharmacological survey was carried out in which informants who agreed freely were interviewed using a semi-structured questionnaire...

Background To overcome the spread of high pyrethroid resistance in the main malaria vectors and malaria disease persistence, it is crucial to look for effective and better resistance management strategies. Understanding the phenotypic profile of Anopheles gambiae sl. against alternatives insecticides like organophosphates and carbamates is crucial....

This literature review on dairy cattle rearing in sub-Saharan Africa aims to provide an in-depth analysis of the current situation of this activity in the region. It examines the various dimensions of dairy farming, such as its economic importance, its impact on food security and its role in poverty reduction. The review also looks at existing farm...

Aims: Due to the increase in purchasing power, milk and dairy products have increased steadily in recent years. However, milk production remains insufficient to satisfy the high local demand for milk and dairy products in Mauritius. Adding to the problem of the sector's extinction is the lack of information on the socioeconomic impact of dairy prod...

Lemongrass (Cymbopogon citratus) and bay leaf (Laurus nobilis) are condiments in food processing. This study aimed to assess the antimicrobial and anti-biofilm activities of lemongrass and bay leaf extract on the microorganisms isolated from cereal-based fermented porridges produced in northern Benin. The phytochemical components of lemongrass and...

The World Health Organization states that foodborne diseases are a worldwide public health issue. Although street foods can provide nutritious and affordable ready-to-eat meals for city dwellers, their health risks can outweigh the benefits. A cross-sectional study was conducted in the Bamako district, focusing on street food vendors near schools,...

Fermentation has been used for centuries to enhance the sensory and nutritional qualities and the antioxidant content of plant-based foods, making them benefcial for health. Tis study aims to investigate the microbiological and nutritional qualities of fermented porridges produced in northern Benin. Various nutritional tests and the identifcation o...

Vitex doniana belong to Verbernaceae family, has medicinal importance in West Africa. Based on its folkloric medicinal use in Benin, this study aimed to search for phytochemical constituents and evaluated antimicrobial and antioxydant activity of V. doniana plant extracts. Disc diffusion method was used to evaluate the antibacterial activity using...

Background and Objective: Plants have been traditionally used as an alternative option to treat infections when conventional treatments fail. The present study aimed to provide local knowledge ofplants used in Benin to treat urinary tract infections. Materials and Methods: The study involved questionnaires and interviews with medicinal plant seller...

Aims: Infant mortality linked to infectious diseases remains a major public health concern, especially in the context of antibiotic resistance. This work aimed to study the potential pathogenicity of Escherichia coli strains isolated from the stools of children suffering from diarrhea and healthy from 0 to 15 years old admitted to hospitals in sout...

Background: Group A beta-hemolytic streptococcus (ABHS) tonsillitis is an acute disease that is often benign but sometimes serious due to its locoregional and general complications. It is a frequent cause of consultation among general practitioners, ENT and paediatrics. The choice and interest of our work was motivated by the fact that one of the m...

Introduction: The term pharyngo-tonsillitis refers to inflammation and infection of the mucosa and lymphatic elements of the oropharynx:lymphoid structures and tonsils. It is common, especially in children. This work aimed to isolate, identify, evaluate the antibiotic resistance ofpathogenic bacteria responsible for tonsillitis in children at the P...

The term pharyngo-tonsillitis refers to inflammation and infection of the mucosa and lymphatic elements of the oropharynx: lymphoid structures and tonsils. This work aimed to determine in all tonsillitis, the proportion of bacterial tonsillitis, their clinical presentation in order to identify the germs involved and the treatment administered at th...

Jatropha multifida L., a plant from the Euphorbiaceae family, is commonly used in Benin’s traditional medicine due to its therapeutic benefits. This study aims to explore the medicinal efficacy of Jatropha multifida L. by evaluating its various biological activities. An initial phytochemical analysis was conducted, following which the polyphenols a...

Updated information on the distribution and abundance of Aedes aegypti and Aedes albopictus is crucial to prepare African countries, such as Benin, for possible arboviral disease outbreaks. This study aims to evaluate the geographical distribution, abundance and biting behaviour of these two vectors in Benin. Three sampling techniques were used in...

Introduction Etudier le portage digestif des entérobactéries productrices de BLSE chez les patients reçus en consultation externe à l'hôpital Saint Jean de Dieu d'Afagnan au sud du Togo, ainsi que la pathogénicité des souches E. coli isolées par la recherche du gène sxt1 codant pour l’élaboration de la « Shiga like » toxine. Méthodes Une étude tra...

This study aimed to characterize the pathogenicity of bacteria isolated from the starter of two traditional beers produced and consumed in Benin. After standard microbial identification, species were identified by specific biochemical tests such as catalase, coagulase, and API 20 E. Antibiotic sensitivity was tested according to the French Society...

Jatropha multifida L. is a plant belong to Euphorbiaceae family used in Benin pharmacopoeia because of its medicinal properties. The objective of this work is to appreciate the therapeutic power of this plant through the evaluation of some of its biological activities. After the preliminary phytochemistry, the polyphenols and flavonoids were quanti...

Given that cancer is a disease that is rampant in the world and especially in Africa, where the population has enormous difficulty treating it, plants are a safer and less expensive alternative. Cassava is a plant species valued in Benin because of its numerous medicinal and nutritional virtues. This study evaluated the biological activities of amy...

This study aimed to determine the pathogenicity of the bacteria isolated and characterized from the kpètè kpètè used to produce two fermented beers in Benin. Species were identified by specific biochemical tests such as catalase, coagulase, and API 20 E. Antibiotic sensitivity was tested according to the French Society of Microbiology Antibiogram C...

Spices and aromatic plants are products of plant origin used in food. They are used for the preparation of remedies, for seasoning dishes or for preserving food. This review takes stock of the diversity of spices and aromatic herbs, the chemical composition, the different properties and forms of use of six spices and aromatic herbs commonly used in...

Staphylococci can cause urinary tract infections (UTIs). These UTIs are among the significant causes of antibiotic resistance andthe spread of antibiotic-resistant diseases. The current study is aimed at establishing a resistance profile and determining thepathogenicity of Staphylococcus strains isolated from UTI samples collected in Benin. For thi...

Background and Objective: Nowadays, research on medicinal plants has intensified due to the diverse therapeutic potential of medicinal plants. The aim of this work is not only to go through the ethnobotanical knowledge of Sarcocephalus latifolius in Southern Benin but also to evaluate the antioxidant potential and toxicity of S. latifolius root ext...

: Given that cancer is a disease that is rampant in the world and especially in Africa where the population has enormous difficulty in treating it, plants are a safer and less expensive alterna-tive. Cassava is one of the plant species valued in Benin because of its numerous medicinal and nutritional virtues. This study evaluated the biological act...

This study aims to highlight the role of Panton and Valentine Leucocidin (PVL) in Staphylococcus aureus isolated from skin diseases in the peri-urban area of Benin. This study, conducted from November 2014 to December 2017, include 124 wound, abscess, furuncle, osteomyelitis and pyomyositis patients with staphylococcal in the commune of Zogbodomey....

Background: The emergence of insecticide resistance in Aedes mosquitoes could undermine efforts to control arboviruses. The present study aims to assess in some communes of Southern Benin, the susceptibility level of Aedes aegypti (Linnaeus, 1762) and Aedes albopictus (Skuse, 1894) to insecticides commonly used in public health, as well as mechani...

Background The emergence of insecticide resistance in Aedes mosquitoes could undermine efforts to control arboviruses. The present study aims to assess in some communes of Southern Benin, the susceptibility level of Aedes aegypti (Linnaeus, 1762) and Aedes albopictus (Skuse, 1894) to insecticides commonly used in public health, as well as mechanism...

Background and Objective: The manufacturing technology of porridges can be used to improve not only the organoleptic and nutritional qualities but also the shelf life of the finished products. The aim of this study was to establish the traditional manufacturing process of eight cereal-based fermented porridges consumed in the North of Benin, West-A...

The main objective of the present study is to assess the preferences in terms of vertebrate hosts of Anopheles coluzzii, the main malaria vector in the pastoral area of Malanville, Benin, where rice cultivation and livestock are the main source of income for the populations. Adult mosquitoes were collected through pyrethrum spray catch, and human l...

Over the years, hydroxyapatite (HAp) has been a well-researched biomaterial because of its bioactive and biocompatible properties with remarkable applications for bone tissue engineering. The robust structure of HAp allows for a host of applications in biomedicine. HAp is enriched in calcium and phosphate, can be sourced from synthetic or natural p...

Background Updated information on the distribution and abundance of Aedes aegypti and Aedes albopictus is crucial to prepare African countries like Benin for possible arbovirus outbreaks. This study aims to evaluate the geographical distribution, the abundance, and the biting behaviors of these two vectors in Benin. Methods Three sampling techniqu...

Momordica charantia Linn. (Cucurbitaceae), the wild variety of bitter melon, and Morinda lucida Benth (Rubiaceae) were commonly used as a popular folk medicine in Benin. This study aimed to appreciate the ethnopharmacological knowledge and evaluate the antioxidant and anti-inflammatory effects of M. charantia and M. lucida leaves extracts. Semi-str...

Excessive application of chemical fertilizers and other agrochemicals can cause significant imbalances in soils and agricultural ecosystems. To minimize these impacts, biofertilizers and organic fertilizers are needed to maintain a sustainable production system. The use of subterranean microorganisms in agriculture to stimulate plant growth and imp...

Enterobacteriaceae represent one of the main families of Gram-negative bacilli responsible for serious urinary tract infections (UTIs). The present study aimed to define the resistance profile and the virulence of Enterobacteriaceae strains isolated in urinary tract infections in Benin. A total of 390 urine samples were collected from patients with...

Aims: Ageratum conyzoides L. is a small annual herbaceous highly odorous plant use in traditional medicine. The aim of this study is to evaluate in vitro antioxidant potential, toxicity and antimicrobial activity of aerial part extracts of A. conyzoides on strains potentially involved in vaginal infections. Methodology: An ethnobotanical survey has...

n Benin, cockroaches are infesting urban environments and developing resistance to commonly used insecticides. Therefore, developing alternative insecticides is important for resistance management. The present study aims to test the efficacy of a gel bait formulation-2.15% imidacloprid against the common cockroach Periplaneta americana under labora...

This study evaluated the efficacy of Mosquilarv containing 0.4% S-methoprene in reducing population densities of Aedes spp. Oviposition traps treated with 1.5 mg Mosquilarv granules containing 0.4% Smethoprene and untreated controls were placed in houses where natural breeding sites of Aedes spp. are often found traps were collected 7 days later, e...

Aims: This work aims to evaluate the antimicrobial activity of Sarcocephalus latifolius extracts. Methodology: Thus, phytochemical screening was qualitatively accessed using colorations or precipitations methods. Ethanolic and aqueous extracts were used to evaluate the antimicrobial activity. The antimicrobial activity, using the diffusion method,...

Chronic non-communicable diseases are becoming more and more recurrent and require the addition of functional foods in our eating habits. Legumes due to their composition in biomolecules could meet this need. Much used in Chinese medicine, the mung bean arouses interest in Burkina Faso. The objective of this study is to perform phytochemical profil...

The cereal group occupies a prominent place in the dietary habits of the populations of southern Benin and there are few recent consumption data on cereals. This study aims to assess the consumption, acquisition and supply of cereals to households in Cotonou. A semi-directive survey with KoBoCollect was conducted with 345 households to collect indi...

Fermentation is an ancestral process and one of the most used economic methods in the preservation and transformation of cereal-based food raw materials. They are essentially rich in carbohydrates, but they can also be a source of micronutrients such as iron and are used in many traditional culinary preparations, in particular fermented porridges....

The objective of this work is to examine the microbiological quality of groundwater intended for consumption around Lake Toho while identifying the risks of contamination associated with it. To do this, nineteen (19) water samples, i.e. five wells and fourteen boreholes, were analyzed by the seeding method. Also, we carried out a field survey which...

Fruit juice production sector has been booming in Benin for a decade. The juice production enterprises seem to have both organisational and technical shortcomings. The objective of this study was to evaluate the manufacturing processes of the main fruit juices in South Benin in order to provide corrective measures for hygienic and technical shortco...

The quality of food sold in the street is a major public health concern. This research was conducted to study the sanitary quality of grilled fish sold in the streets of three districts of Daloa. Seasoned and unseasoned grilled fish were collected in 3 districts of Daloa, namely Commerce, Soleil and Tazibouo. A total of 150 unseasoned and 150 seaso...

Oils extracted from Blighia sapida fruits are usually consumed without any information on its chemical composition. However the bad quality of oil can be a source of toxicity. Thus, the aim of this study is to investigate the physicochemical quality of the oil extracted from B. sapida from Togolese flora. To reach the goal of the study, mature and...

In Benin, many families resort not only to consumption but also to the therapeutic use of cassava (Manihot esculenta). The study assessed the impact of socioeconomic factors on the use of cassava, and the perception of the actors involved in the value chain in Benin. Four areas of high production and processing, with 516 producers and processors of...

Nosocomial infections are increasingly recurrent in health facilities and represent a serious public health concern. Apart from patients, health workers are also at high risk of infection. The risk factors associated with this type of infection are still not fully characterized. The present study aimed at characterizing Gram-negative bacillus strai...

Mansonellosis is a vector-borne infection caused by different species of filarial nematodes of the genus Mansonella, including ozzardi, perstans, and streptocerca. The infection is mainly transmitted by bloodsucking midges of the genus Culicoides. All Mansonella species are known to induce little to no symptoms in humans. Due to the asymptomatic na...

Traditional cheese is the main milk derivative in Bénin. This traditional process is not efficient and generate a lot of whey which has no real use until now. It is just disposed without being environmentally treated. Its use as a source for lactobionic and lactic acids production by Pseudomonas taetrolens and Lactobacillus casei is studied in this...

Introduction: Polymorphisms are the main genetic factors associated withtoxicities of antituberculosis drugs. This literature review summarizes the po-lymorphisms of the genes that code for the enzymes of the metabolism of an-tituberculosis drugs and their transmembrane transporters. Some mechan-isms of drug-associated toxicities and strategies for...

Aims: Bacterial meningitis remains a public health problem due to an unfavorable geographical environment and socioeconomic context. Our study aimed to evaluate the epidemiological-clinical, therapeutic and evolutionary profile of children treated for bacterial meningitis in the pediatric department of CHU-MEL in Benin. Methodology: The methodology...

Widely used in traditional medicine in Asia and recently introduced in Burkina Faso under the name Beng-tigré, mung bean is a legume consumed throughout the world and more so in India. e objective of this study was to evaluate the cytotoxicity of the mung bean grown and consumed in Burkina Faso and to study its biological properties such as anti-in...

Aims: In Africa, and particularly in Togo, fruit trees occupy a special place because of their medicinal and food virtues,. This study aimed to identify the different uses of Blighia sapida in Togo. Methodology: investigations were conducted among 300 B. sapida users in nine villages in the prefectures of Tône, Kozah and Haho of Togo. The choice of...

e gut microbiota of mosquitoes is composed of a range of microorganisms. Among its microorganisms, some a‚ect the vectorial capacity of mosquitoes. e aim of this study was to characterize some bacteria of the intestinal microbiota in Anopheles gambiae (An. gambiae) females, a major vector of malaria transmission in Benin. e symbiote bacteria of t...

The coagulase-negative staphylococci (CoNS) have long been considered to be low pathogenicity. The possibility of a horizontal transfer of resistance and virulence genes from S. aureus to CoNS could increase the pathogenicity of these bacteria. The objective of this work is to contribute to a better knowledge of the pathogenicity of (CoNS) strains...

The objective of the study was to evaluate the fertilizing potential of two arbuscular mycorrhizal fungi (Glomeraceae and Acaulosporaceae) native to the rhizosphere soils of Benin in a controlled environment (under greenhouse) and in a field environment. For this purpose, corn seeds were coated with Glomeraceae and Acaulosporaceae strains and then...

Escherichia coli is a commensal bacterium and one of the rst bacteria to colonize the digestive tract of newborns after birth. It is characterized by great versatility and metabolic exibility that allows its survival in di erent niches. e present study aims at analyzing the diversity of E. coli strains isolated from the intestinal microbiota of chi...

The study aimed to characterize the influence of Mansonella perstans co-infection on immunity. This research was carried out in November, 2021 in the neighboring villages of Saint Camille de Davougon in the Abomey Commune. Blood samples were collected from both genders of all ages. Buruli ulcer was diagnosed by polymerase chain reaction (PCR), usin...

The bee A. mellifera L. is a key social insect, for its role in crop pollination and for the products generated in the hives. Nosema sp. Paenibacillus larvae and Melissococcus plutonius belong to the most important pests of A. mellifera Linnaeus bees (Hymenoptera: Apidae). The aim of this study was to identify the presence of Nosema Sp., Paenibacil...

Croton gratissimus Burch. and Schrankia leptocarpa DC. are two plants from the Beninese flora which are traditionally used for the treatment of arterial hypertension. The present study investigated the acute toxicity of ethanolic extracts of these plants. The experiment was conducted according to OECD guideline 423 categories 5 using a single dose...

Medicinal plants are endowed important pharmacological properties. Through their broad spectrum of biological activities, people use them for their primary health needs. Uncontrolled use can cause complications for these users. Thus, a study of the antimicrobial activities of pathogenic bacteria in humans would help to elucidate in part the field o...

Raw vegetables have been linked to many outbreaks of Salmonella foodborne; however there is few data on the presence of this bacteria in raw vegetables in Côte d'Ivoire. The objective of this study is to determine the prevalence, diversity and antibiotic resistance level of Salmonella strains in vegetables salads and ready-to-eat raw mixed vegetabl...

Fish is rich in essential nutrients but can remain a potential source of food poisoning. A study was, therefore, carried out with the general objective of highlighting the probable biological and chemical dangers associated with the consumption of fish and freshwater fruits from the Guéssabo river. The present study was conducted on 50 carp fish, 5...

In Benin, the preservation of maize is a real problem involving important physical and chemical properties losses. Physical losses are due by rodents, pests and insects and chemical losses are mainly due to fungal infection. Several methods, products and practices are used by farmers to overcome these problems. The methods used do not always contro...

Introduction: Hypertension is currently recognized as a global public health problem because of itsnfrequency and the associated risks of cardiovascular and renal disease. In this view, medicinal plants such as Croton gratissimus Burch (Crt) and Schrankia leptocarpa DC (Sch) are known to have many and various metabolites possessing potential for th...

The uncontrolled use of antimicrobials leads to an increase in the resistance of bacteria which becomes a public health problem. To overcome this problem, our study aims to establish a link between chemical composition and antimicrobial activity and then evaluate cytotoxicity, of seven essential oils. Antimicrobial activity of essential oils was as...

The aim of this study is to determine the distribution of the genotypic pathogenicity traits of vaginal high-risk infectious bacteria (HRIB) collected in the CHU-MEL of Cotonou (Benin). To achieve this, a recto-vaginal swab of 42 pregnant women in the third trimester of pregnancy was collected. Species identification was carried out by specific bio...

The hygiene and quality of food sold in restaurants have a strong impact on the health of the consumer. It is with this in mind that this study was carried out to assess the sanitary quality of the dishes sold in restaurants with high frequentation in the city of Daloa (Ivory Coast). As a prelude to this study, a survey was carried out to find out...

Aims: The aim of this study is to evaluate the antimicrobial activity of the R. brasiliensis aerial part extracts collected in southern-Benin. Methodology: The phytochemical screening was performed by a differential precipitation staining method. Aqueous and ethanolic extracts were made using conventional method with water and Original Research Art...